Lista de obras - Mikael Altun - Dominio Público Uruguay

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases

artículo científico publicado en 2011

A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance

artículo científico publicado en 2012

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes

artículo científico publicado en 2011

Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle.

artículo científico publicado en 2006

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

artículo científico publicado en 2015

Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics

scientific article published on 12 February 2020

Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells

artículo científico publicado en 2017

Detection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor development

artículo científico publicado en 2012

Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probes

artículo científico publicado en 2013

Development of a chemical probe against NUDT15

artículo científico publicado en 2020

Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairment

scientific journal article

Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells

artículo científico publicado en 2005

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

artículo científico publicado en 2001

Factors contributing to neuromuscular impairment and sarcopenia during aging.

artículo científico publicado en 2007

Fluorescence-based active site probes for profiling deubiquitinating enzymes

scientific article published on 28 March 2012

Impact of vitamin D and vitamin D receptor TaqI polymorphism in primary human myoblasts

scientific article published on 29 July 2019

Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound

artículo científico publicado en 2021

Iron load and redox stress in skeletal muscle of aged rats

artículo científico publicado en 2007

Label-free quantitative proteomics reveals regulation of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 (XRN2) during respiratory syncytial virus infection

artículo científico

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

artículo científico publicado en 2014

Muscle atrophy and regeneration associated with behavioural loss and recovery of function after sciatic nerve crush

artículo científico publicado en 2019

Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway

artículo científico publicado en 2010

Photoactivable peptides for identifying enzyme–substrate and protein–protein interactions

artículo científico publicado en 2010

Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion

artículo científico publicado en 2010

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

artículo científico publicado en 2018

Structural basis and specificity of human otubain 1-mediated deubiquitination

artículo científico publicado en 2009

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.

artículo científico publicado en 2018

The Next Step Forward in Ubiquitin-Specific Protease 7 Selective Inhibition

artículo científico publicado en 2017

The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia

artículo científico publicado en 2018

The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation

scientific article published on 25 July 2018

The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages

artículo científico publicado en 2015

Ubiquitin-specific Protease 19 (USP19) Regulates Hypoxia-inducible Factor 1α (HIF-1α) during Hypoxia ⬇️

artículo científico publicado el 29 de noviembre de 2011

hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia

artículo científico publicado en 2016

Lista de obras de Mikael Altun

A photoreactive small-molecule probe for 2-oxoglutarate oxygenases

A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance

Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes

Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle.

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities

Cell Cycle Profiling Reveals Protein Oscillation, Phosphorylation, and Localization Dynamics

Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells

Detection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor development

Deubiquitinating enzyme specificity for ubiquitin chain topology profiled by di-ubiquitin activity probes

Development of a chemical probe against NUDT15

Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairment

Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits

Factors contributing to neuromuscular impairment and sarcopenia during aging.

Fluorescence-based active site probes for profiling deubiquitinating enzymes

Impact of vitamin D and vitamin D receptor TaqI polymorphism in primary human myoblasts

Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound

Iron load and redox stress in skeletal muscle of aged rats

Label-free quantitative proteomics reveals regulation of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5'-3'-exoribonuclease 2 (XRN2) during respiratory syncytial virus infection

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Muscle atrophy and regeneration associated with behavioural loss and recovery of function after sciatic nerve crush

Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway

Photoactivable peptides for identifying enzyme–substrate and protein–protein interactions

Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Structural basis and specificity of human otubain 1-mediated deubiquitination

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.

The Next Step Forward in Ubiquitin-Specific Protease 7 Selective Inhibition

The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia

The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation

The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages

Ubiquitin-specific Protease 19 (USP19) Regulates Hypoxia-inducible Factor 1α (HIF-1α) during Hypoxia ⬇️

hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia