Lista de obras - Louis M. Luttrell - Dominio Público Uruguay

'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass?

artículo científico publicado en 2011

5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells.

artículo científico publicado en 2006

A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.

artículo científico publicado en 2009

A high-content, live-cell, and real-time approach to the quantitation of ligand-induced β-Arrestin2 and Class A/Class B GPCR mobilization.

artículo científico publicado en 2013

Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors.

artículo científico publicado en 2002

Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders.

artículo científico publicado en 2009

Angiotensin II receptors and peritoneal dialysis-induced peritoneal fibrosis

artículo científico publicado en 2016

Angiotensin II-induced cyclooxygenase 2 expression in rat aorta vascular smooth muscle cells does not require heterotrimeric G protein activation.

artículo científico publicado en 2009

Arrestin pathways as drug targets.

artículo científico

Arrestin-dependent activation of ERK and Src family kinases.

artículo científico publicado en 2014

Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis.

artículo científico publicado en 2014

Arrestins as regulators of kinases and phosphatases.

artículo científico

Autologous Mesenchymal Stem Cell and Islet Cotransplantation: Safety and Efficacy

artículo científico publicado en 2017

Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.

artículo científico publicado en 2005

Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression.

artículo científico publicado en 2007

Beyond desensitization: physiological relevance of arrestin-dependent signaling.

artículo científico publicado en 2010

Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangement

artículo científico publicado en 2010

Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity.

artículo científico publicado en 2005

Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes.

artículo científico publicado en 2008

Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.

artículo científico publicado en 2002

Delineation of a conserved arrestin-biased signaling repertoire in vivo.

artículo científico publicado en 2015

Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

artículo científico publicado en 2006

Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation

artículo científico publicado en 1995

Diversity in arrestin function

artículo científico publicado en 2009

Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo.

artículo científico publicado en 2003

Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I.

artículo científico publicado en 2004

Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling.

artículo científico publicado en 1995

Endocrine function in aging.

artículo científico publicado en 2012

Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding

scientific article published on 04 April 2001

Epidermal growth factor-induced proliferation of collecting duct cells from Oak Ridge polycystic kidney mice involves activation of Na+/H+ exchanger.

artículo científico publicado en 2014

Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.

artículo científico publicado en 1998

Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics

artículo científico publicado en 2015

Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases

artículo científico publicado en 1999

Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.

artículo científico publicado en 2015

Functional signaling biases in G protein-coupled receptors: Game Theory and receptor dynamics.

artículo científico

G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor

scientific article published on 01 July 1995

G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases

artículo científico publicado en 1997

G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.

artículo científico publicado en 1996

GIT2-a keystone in ageing and age-related disease.

artículo científico publicado en 2018

GPCR Signaling Rides a Wave of Conformational Changes.

artículo científico publicado en 2016

Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetes

artículo científico publicado en 2010

Heptahelical terpsichory. Who calls the tune?

scientific article published on 01 January 2008

Hyperparathyroidism-jaw Tumor Syndrome: An Overlooked Cause of Severe Hypercalcemia.

artículo científico publicado en 2016

Identification of a putative nuclear localization sequence within ANG II AT(1A) receptor associated with nuclear activation.

artículo científico publicado en 2006

Informatic deconvolution of biased GPCR signaling mechanisms from in vivo pharmacological experimentation.

artículo científico publicado en 2015

Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel

artículo científico publicado en 2015

Insulin-like growth factor-2/mannose-6 phosphate receptors.

artículo científico publicado en 2009

Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors.

artículo científico publicado en 2006

Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells.

artículo científico publicado en 2012

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

scientific article published on 25 September 2018

Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.

artículo científico publicado en 2014

Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane.

artículo científico publicado en 2010

Pasteurella multocida toxin stimulates mitogen-activated protein kinase via G(q/11)-dependent transactivation of the epidermal growth factor receptor.

artículo científico publicado en 2000

Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation

artículo científico publicado en 2011

Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity

artículo científico publicado en 2000

Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases

artículo científico publicado en 1999

Preface. The molecular biology of arrestins.

artículo científico publicado en 2013

Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.

artículo científico publicado en 2003

Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system

artículo científico publicado en 2002

Refining efficacy: allosterism and bias in G protein-coupled receptor signaling.

artículo científico

Refining efficacy: exploiting functional selectivity for drug discovery.

artículo científico publicado en 2011

Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

artículo científico publicado en 1999

Regulator of G protein signaling 2 is a key regulator of pancreatic β-cell mass and function

artículo científico publicado en 2017

Reply to Schierwagen et al.: β-Arrestins in liver disease

artículo científico publicado en 2020

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors

artículo científico publicado en 2008

Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.

artículo científico publicado en 2000

S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization.

artículo científico publicado en 2016

Signal switching, crosstalk, and arrestin scaffolds: novel G protein-coupled receptor signaling in cardiovascular disease.

artículo científico publicado en 2006

Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor

scientific journal article

Stimulation of Cyclooxygenase 2 Expression in Rat Peritoneal Mesothelial Cells

artículo científico publicado en 2014

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

artículo científico publicado en 1997

Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy

artículo científico publicado en 1998

The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling

artículo científico publicado en 2017

The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

artículo científico publicado en 2000

The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism.

artículo científico publicado en 1999

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions.

artículo científico publicado en 2016

The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells.

artículo científico publicado en 2007

The origins of diversity and specificity in g protein-coupled receptor signaling

artículo científico publicado en 2005

Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells

scientific article published on 01 July 2000

Transactivation of the epidermal growth factor receptor mediates parathyroid hormone and prostaglandin F2 alpha-stimulated mitogen-activated protein kinase activation in cultured transgenic murine osteoblasts.

artículo científico publicado en 2003

Transcriptomic characterization of signaling pathways associated with osteoblastic differentiation of MC-3T3E1 cells

artículo científico publicado en 2019

Translating in vitro ligand bias into in vivo efficacy

artículo científico publicado en 2017

Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation

artículo científico publicado en 2007

beta-Arrestin 2 expression determines the transcriptional response to lysophosphatidic acid stimulation in murine embryo fibroblasts.

artículo científico publicado en 2005

beta-Arrestin scaffolding of the ERK cascade enhances cytosolic ERK activity but inhibits ERK-mediated transcription following angiotensin AT1a receptor stimulation

artículo científico publicado en 2002

β-Arrestin2 is a critical component of the GPCR-eNOS signalosome

scientific article published on 13 May 2020

β-arrestin-selective G protein-coupled receptor agonists engender unique biological efficacy in vivo

artículo científico publicado en 2013

Lista de obras de Louis M. Luttrell

'Biasing' the parathyroid hormone receptor: a novel anabolic approach to increasing bone mass?

5-HT2A receptor induces ERK phosphorylation and proliferation through ADAM-17 tumor necrosis factor-alpha-converting enzyme (TACE) activation and heparin-bound epidermal growth factor-like growth factor (HB-EGF) shedding in mesangial cells.

A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation.

A high-content, live-cell, and real-time approach to the quantitation of ligand-induced β-Arrestin2 and Class A/Class B GPCR mobilization.

Activation and targeting of mitogen-activated protein kinases by G-protein-coupled receptors.

Allosteric modulators of g protein-coupled receptors: future therapeutics for complex physiological disorders.

Angiotensin II receptors and peritoneal dialysis-induced peritoneal fibrosis

Angiotensin II-induced cyclooxygenase 2 expression in rat aorta vascular smooth muscle cells does not require heterotrimeric G protein activation.

Arrestin pathways as drug targets.

Arrestin-dependent activation of ERK and Src family kinases.

Arrestin-dependent angiotensin AT1 receptor signaling regulates Akt and mTor-mediated protein synthesis.

Arrestins as regulators of kinases and phosphatases.

Autologous Mesenchymal Stem Cell and Islet Cotransplantation: Safety and Efficacy

Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization.

Beta-arrestins 1 and 2 differentially regulate LPS-induced signaling and pro-inflammatory gene expression.

Beyond desensitization: physiological relevance of arrestin-dependent signaling.

Bradykinin decreases podocyte permeability through ADAM17-dependent epidermal growth factor receptor activation and zonula occludens-1 rearrangement

Composition and function of g protein-coupled receptor signalsomes controlling mitogen-activated protein kinase activity.

Connective tissue growth factor and susceptibility to renal and vascular disease risk in type 1 diabetes.

Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity.

Delineation of a conserved arrestin-biased signaling repertoire in vivo.

Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.

Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation

Diversity in arrestin function

Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo.

Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I.

Effect of cellular expression of pleckstrin homology domains on Gi-coupled receptor signaling.

Endocrine function in aging.

Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding

Epidermal growth factor-induced proliferation of collecting duct cells from Oak Ridge polycystic kidney mice involves activation of Na+/H+ exchanger.

Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.

Exploring G protein-coupled receptor signaling networks using SILAC-based phosphoproteomics

Feedback regulation of beta-arrestin1 function by extracellular signal-regulated kinases

Fulfilling the Promise of "Biased" G Protein-Coupled Receptor Agonism.

Functional signaling biases in G protein-coupled receptors: Game Theory and receptor dynamics.

G beta gamma subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor

G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases

G(o)-protein alpha-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism.

GIT2-a keystone in ageing and age-related disease.

GPCR Signaling Rides a Wave of Conformational Changes.

Genetic variant in the promoter of connective tissue growth factor gene confers susceptibility to nephropathy in type 1 diabetes

Heptahelical terpsichory. Who calls the tune?

Hyperparathyroidism-jaw Tumor Syndrome: An Overlooked Cause of Severe Hypercalcemia.

Identification of a putative nuclear localization sequence within ANG II AT(1A) receptor associated with nuclear activation.

Informatic deconvolution of biased GPCR signaling mechanisms from in vivo pharmacological experimentation.

Inhibition of Sphingosine Kinase 1 Ameliorates Angiotensin II-Induced Hypertension and Inhibits Transmembrane Calcium Entry via Store-Operated Calcium Channel

Insulin-like growth factor-2/mannose-6 phosphate receptors.

Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors.

Low-density lipoprotein induced expression of connective tissue growth factor via transactivation of sphingosine 1-phosphate receptors in mesangial cells.

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

Minireview: More than just a hammer: ligand "bias" and pharmaceutical discovery.

Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane.

Pasteurella multocida toxin stimulates mitogen-activated protein kinase via G(q/11)-dependent transactivation of the epidermal growth factor receptor.

Phospholipase C and protein kinase C-β 2 mediate insulin-like growth factor II-dependent sphingosine kinase 1 activation

Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity

Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases

Preface. The molecular biology of arrestins.

Protein kinase A and G protein-coupled receptor kinase phosphorylation mediates beta-1 adrenergic receptor endocytosis through different pathways.

Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system

Refining efficacy: allosterism and bias in G protein-coupled receptor signaling.

Refining efficacy: exploiting functional selectivity for drug discovery.

Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

Regulator of G protein signaling 2 is a key regulator of pancreatic β-cell mass and function

Reply to Schierwagen et al.: β-Arrestins in liver disease

Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors

Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors.

S1P in HDL promotes interaction between SR-BI and S1PR1 and activates S1PR1-mediated biological functions: calcium flux and S1PR1 internalization.

Signal switching, crosstalk, and arrestin scaffolds: novel G protein-coupled receptor signaling in cardiovascular disease.

Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor

Stimulation of Cyclooxygenase 2 Expression in Rat Peritoneal Mesothelial Cells

Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy

The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling

The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor

The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism.

The conformational signature of β-arrestin2 predicts its trafficking and signalling functions.

The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells.

The origins of diversity and specificity in g protein-coupled receptor signaling

Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells