Lista de obras - Michael Nassal - Dominio Público Uruguay

100 kHz MAS Proton-Detected NMR Spectroscopy of Hepatitis B Virus Capsids

scientific article published on 24 July 2019

A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments

artículo científico publicado en 2022

A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation-and Beyond?

artículo científico publicado en 2017

A SELEX-screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replication.

artículo científico publicado en 2011

A Tyr Residue in the Reverse Transcriptase Domain Can Mimic the Protein-Priming Tyr Residue in the Terminal Protein Domain of a Hepadnavirus P Protein ⬇️

artículo científico publicado el 18 de mayo de 2011

A carbene-generating photoaffinity probe for beta-adrenergic receptors.

artículo científico publicado en 1983

A fusion product of the complete Borrelia burgdorferi outer surface protein A (OspA) and the hepatitis B virus capsid protein is highly immunogenic and induces protective immunity similar to that seen with an effective lipidated OspA vaccine formula

artículo científico publicado en 2005

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

artículo científico publicado en 2020

A high level of mutation tolerance in the multifunctional sequence encoding the RNA encapsidation signal of an avian hepatitis B virus and slow evolution rate revealed by in vivo infection

artículo científico publicado en 2011

A novel hepatitis B virus species discovered in capuchin monkeys sheds new light on the evolution of primate hepadnaviruses

artículo científico publicado en 2018

A sensitive procedure for mapping the boundaries of RNA elements binding in vitro translated proteins defines a minimal hepatitis B virus encapsidation signal.

artículo científico publicado en 1996

A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses.

artículo científico publicado en 2015

An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion

scientific article published on 30 December 2018

Ca2+: the clue to hepatitis B virus X protein function?

artículo científico publicado en 2002

Carbon-13-N.M.R.-spectra of antamanide, several analogues and their alkali ion complexes

scientific article published on 01 January 1980

Carbonyl J acid derivatives block protein priming of hepadnaviral P protein and DNA-dependent DNA synthesis activity of hepadnaviral nucleocapsids.

artículo científico publicado en 2012

Chaperones activate hepadnavirus reverse transcriptase by transiently exposing a C-proximal region in the terminal protein domain that contributes to epsilon RNA binding

artículo científico

Chronic hepatitis B: divide and conquer?

artículo científico publicado en 2017

Cis -preferential recruitment of duck hepatitis B virus core protein to the RNA/polymerase preassembly complex ⬇️

artículo científico publicado el 1 de enero de 2002

Combining Cell-Free Protein Synthesis and NMR Into a Tool to Study Capsid Assembly Modulation

artículo científico publicado en 2019

Conserved cysteines of the hepatitis B virus core protein are not required for assembly of replication-competent core particles nor for their envelopment

artículo científico publicado el 1 de septiembre de 1992

Core Particles of Hepatitis B Virus as Carrier for Foreign Epitopes

artículo científico publicado el 1 de enero de 1998

Detection of HBV DNA in HBsAg-positive sera after amplification using the polymerase chain reaction

artículo científico publicado en 1989

Displaying Whole-Chain Proteins on Hepatitis B Virus Capsid-Like Particles

artículo científico publicado en 2018

Distinct requirements for primary sequence in the 5'- and 3'-part of a bulge in the hepatitis B virus RNA encapsidation signal revealed by a combined in vivo selection/in vitro amplification system.

artículo científico publicado en 1995

Duck hepatitis B virus: an invaluable model system for HBV infection.

artículo científico publicado en 2004

Effect of a combination of clevudine and emtricitabine with adenovirus-mediated delivery of gamma interferon in the woodchuck model of hepatitis B virus infection.

artículo científico publicado en 2004

Efficient Hsp90-independent in vitro activation by Hsc70 and Hsp40 of duck hepatitis B virus reverse transcriptase, an assumed Hsp90 client protein.

artículo científico publicado en 2003

Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells.

artículo científico publicado en 1995

Epitopes recognized by antibodies to denatured core protein of hepatitis B virus.

artículo científico publicado en 1993

Evidence for multiple distinct interactions between hepatitis B virus P protein and its cognate RNA encapsidation signal during initiation of reverse transcription

artículo científico publicado en 2013

Evolutionary conservation in the hepatitis B virus core structure: comparison of human and duck cores.

artículo científico publicado en 1995

Extensive mutagenesis of the conserved box E motif in duck hepatitis B virus P protein reveals multiple functions in replication and a common structure with the primer grip in HIV-1 reverse transcriptase

artículo científico publicado en 2012

Few basepairing-independent motifs in the apical half of the avian HBV ε RNA stem-loop determine site-specific initiation of protein-priming.

artículo científico publicado en 2017

Formation of a functional hepatitis B virus replication initiation complex involves a major structural alteration in the RNA template.

artículo científico publicado en 1998

Full-length hepatitis B virus core protein packages viral and heterologous RNA with similarly high levels of cooperativity

artículo científico publicado en 2010

Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner.

artículo científico publicado en 2010

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B.

artículo científico

Hepatitis B Virus-Infected HepG2hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+ T Cells In Vitro

artículo científico publicado en 2015

Hepatitis B and C virus coinfection: a novel model system reveals the absence of direct viral interference

artículo científico publicado en 2009

Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes.

artículo científico

Hepatitis B und C: von der molekularen Virologie zu neuen Perspektiven in der Therapie

Hepatitis B virus capsid-like particles can display the complete, dimeric outer surface protein C and stimulate production of protective antibody responses against Borrelia burgdorferi infection.

artículo científico publicado en 2006

Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure

artículo científico publicado en 2018

Hepatitis B virus induces expression of antioxidant response element-regulated genes by activation of Nrf2.

artículo científico publicado en 2010

Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis in primary Tupaia hepatocytes.

artículo científico publicado en 2005

Hepatitis B virus nucleocapsids formed by carboxy-terminally mutated core proteins contain spliced viral genomes but lack full-size DNA.

artículo científico publicado en 2004

Hepatitis B virus replication.

artículo científico publicado en 1993

Hepatitis B virus replication: novel roles for virus-host interactions.

artículo científico publicado en 1999

Hepatitis B viruses: reverse transcription a different way.

scientific article published on 12 March 2008

Hepatitis C virus hypervariable region 1 variants presented on hepatitis B virus capsid-like particles induce cross-neutralizing antibodies

artículo científico publicado en 2014

High plasticity of the hepatitis B virus capsid revealed by conformational stress.

artículo científico publicado en 2005

Host-targeting agents for treatment of hepatitis B virus infection.

artículo científico

Human hepatitis B virus production in avian cells is characterized by enhanced RNA splicing and the presence of capsids containing shortened genomes

artículo científico publicado en 2012

In vitro assembly of mosaic hepatitis B virus capsid-like particles (CLPs): rescue into CLPs of assembly-deficient core protein fusions and FRET-suited CLPs.

artículo científico publicado en 2005

Inhibition of Alpha Interferon Signaling by Hepatitis B Virus

artículo científico publicado en 2007

Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication

scientific article published on 18 December 2019

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses

artículo científico publicado en 2014

Localizing Conformational Hinges by NMR: Where Do Hepatitis B Virus Core Proteins Adapt for Capsid Assembly?

artículo científico publicado en 2018

Mapping of homologous interaction sites in the hepatitis B virus core protein.

artículo científico publicado en 1998

Molecular epidemiology and immunology of hepatitis B virus infection - an update.

artículo científico publicado en 2002

Monoclonal antibodies providing topological information on the duck hepatitis B virus core protein and avihepadnaviral nucleocapsid structure.

artículo científico publicado en 2007

Native display of complete foreign protein domains on the surface of hepatitis B virus capsids.

artículo científico publicado en 1999

Novel molecular approaches toward therapy of chronic hepatitis B ⬇️

artículo científico publicado el 1 de enero de 1997

PCR-based site-directed mutagenesis using primers with mismatched 3'-ends.

artículo científico publicado en 1990

Packaging of up to 240 subunits of a 17 kDa nuclease into the interior of recombinant hepatitis B virus capsids.

artículo científico publicado en 2000

Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

artículo científico publicado en 2019

Phenotyping hepatitis B virus variants: from transfection towards a small animal in vivo infection model.

artículo científico publicado en 2005

Phosphorylation and Alternative Translation on Wheat Germ Cell-Free Protein Synthesis of the DHBV Large Envelope Protein

artículo científico publicado en 2019

Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis.

artículo científico publicado en 1993

Preparative merits of the mixed anhydride (MA) method in the excess use of DDZ-amino acids in the peptide synthesis of biologically active new antamanide analogues.

artículo científico publicado en 1979

Quantitative assessment of the antiviral potencies of 21 shRNA vectors targeting conserved, including structured, hepatitis B virus sites

artículo científico publicado en 2010

Quaternary structure is critical for protein display on capsid-like particles (CLPs): efficient generation of hepatitis B virus CLPs presenting monomeric but not dimeric and tetrameric fluorescent proteins.

artículo científico publicado en 2005

Replication-Competent Infectious Hepatitis B Virus Vectors Carrying Substantially Sized Transgenes by Redesigned Viral Polymerase Translation ⬇️

artículo científico publicado el 2 de abril de 2013

Restriction endonuclease Alw NI is blocked by overlapping Dcm methylation

artículo científico publicado en 1993

Sequence- and structure-specific determinants in the interaction between the RNA encapsidation signal and reverse transcriptase of avian hepatitis B viruses

artículo científico publicado en 1997

Significant interference with hepatitis B virus replication by a core-nuclease fusion protein.

artículo científico publicado en 2000

Simple confirmatory assay for anti-HBc reactivity.

artículo científico publicado en 2011

Slowly folding surface extension in the prototypic avian hepatitis B virus capsid governs stability

scientific article published on 14 August 2020

Solid-State NMR for Studying the Structure and Dynamics of Viral Assemblies

artículo científico publicado en 2020

Solid-state [13C-15N] NMR resonance assignment of hepatitis B virus core protein.

artículo científico publicado en 2018

Soluble cysteine-rich tick saliva proteins Salp15 and Iric-1 from E. coli

artículo científico publicado en 2014

SplitCore: An exceptionally versatile viral nanoparticle for native whole protein display regardless of 3D structure ⬇️

artículo científico publicado el 14 de junio de 2011

Stable HepG2- and Huh7-based human hepatoma cell lines for efficient regulated expression of infectious hepatitis B virus.

artículo científico publicado en 2006

Stable Human Hepatoma Cell Lines for Efficient Regulated Expression of Nucleoside/Nucleotide Analog Resistant and Vaccine Escape Hepatitis B Virus Variants and Woolly Monkey Hepatitis B Virus

artículo científico publicado en 2015

Structure of Mutant Hepatitis B Core Protein Capsids with Premature Secretion Phenotype

scientific article published on 27 October 2018

Suppression of hepatitis B virus antigen production and replication by wild-type HBV dependently replicating HBV shRNA vectors in vitro and in vivo

artículo científico publicado en 2016

The arginine-rich domain of the hepatitis B virus core protein is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly ⬇️

artículo científico publicado el 1 de julio de 1992

The encapsidation signal on the hepatitis B virus RNA pregenome forms a stem-loop structure that is critical for its function ⬇️

artículo científico publicado el 25 de agosto de 1993

The level of viral antigen presented by hepatocytes influences CD8 T-cell function.

artículo científico publicado en 2007

The tupaia model for the study of hepatitis B virus: direct infection and HBV genome transduction of primary tupaia hepatocytes.

artículo científico publicado en 2004

Topological analysis of the hepatitis B virus core particle by cysteine-cysteine cross-linking.

artículo científico publicado en 1992

Towards structural studies of self-assembled subviral particles: combining cell-free expression with 100 kHz MAS NMR.

artículo científico publicado en 2018

Truncated active human matrix metalloproteinase-8 delivered by a chimeric adenovirus-hepatitis B virus vector ameliorates rat liver cirrhosis

artículo científico publicado en 2013

Whole-Chain Tick Saliva Proteins Presented on Hepatitis B Virus Capsid-Like Particles Induce High-Titered Antibodies with Neutralizing Potential

artículo científico publicado en 2015

dNTP versus NTP discrimination by phenylalanine 451 in duck hepatitis B virus P protein indicates a common structure of the dNTP-binding pocket with other reverse transcriptases.

artículo científico publicado en 2002

hRUL138, a novel human RNA-binding RING-H2 ubiquitin-protein ligase

artículo científico publicado en 2003

Lista de obras de Michael Nassal

100 kHz MAS Proton-Detected NMR Spectroscopy of Hepatitis B Virus Capsids

A 33-residue peptide tag increases solubility and stability of Escherichia coli produced single-chain antibody fragments

A Role for the Host DNA Damage Response in Hepatitis B Virus cccDNA Formation-and Beyond?

A SELEX-screened aptamer of human hepatitis B virus RNA encapsidation signal suppresses viral replication.

A Tyr Residue in the Reverse Transcriptase Domain Can Mimic the Protein-Priming Tyr Residue in the Terminal Protein Domain of a Hepadnavirus P Protein ⬇️

A carbene-generating photoaffinity probe for beta-adrenergic receptors.

A fusion product of the complete Borrelia burgdorferi outer surface protein A (OspA) and the hepatitis B virus capsid protein is highly immunogenic and induces protective immunity similar to that seen with an effective lipidated OspA vaccine formula

A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor

A high level of mutation tolerance in the multifunctional sequence encoding the RNA encapsidation signal of an avian hepatitis B virus and slow evolution rate revealed by in vivo infection

A novel hepatitis B virus species discovered in capuchin monkeys sheds new light on the evolution of primate hepadnaviruses

A sensitive procedure for mapping the boundaries of RNA elements binding in vitro translated proteins defines a minimal hepatitis B virus encapsidation signal.

A targeted functional RNA interference screen uncovers glypican 5 as an entry factor for hepatitis B and D viruses.

An E. coli-produced single-chain variable fragment (scFv) targeting hepatitis B virus surface protein potently inhibited virion secretion

Ca2+: the clue to hepatitis B virus X protein function?

Carbon-13-N.M.R.-spectra of antamanide, several analogues and their alkali ion complexes

Carbonyl J acid derivatives block protein priming of hepadnaviral P protein and DNA-dependent DNA synthesis activity of hepadnaviral nucleocapsids.

Chaperones activate hepadnavirus reverse transcriptase by transiently exposing a C-proximal region in the terminal protein domain that contributes to epsilon RNA binding

Chronic hepatitis B: divide and conquer?

Cis -preferential recruitment of duck hepatitis B virus core protein to the RNA/polymerase preassembly complex ⬇️

Combining Cell-Free Protein Synthesis and NMR Into a Tool to Study Capsid Assembly Modulation

Conserved cysteines of the hepatitis B virus core protein are not required for assembly of replication-competent core particles nor for their envelopment

Core Particles of Hepatitis B Virus as Carrier for Foreign Epitopes

Detection of HBV DNA in HBsAg-positive sera after amplification using the polymerase chain reaction

Displaying Whole-Chain Proteins on Hepatitis B Virus Capsid-Like Particles

Distinct requirements for primary sequence in the 5'- and 3'-part of a bulge in the hepatitis B virus RNA encapsidation signal revealed by a combined in vivo selection/in vitro amplification system.

Duck hepatitis B virus: an invaluable model system for HBV infection.

Effect of a combination of clevudine and emtricitabine with adenovirus-mediated delivery of gamma interferon in the woodchuck model of hepatitis B virus infection.

Efficient Hsp90-independent in vitro activation by Hsc70 and Hsp40 of duck hepatitis B virus reverse transcriptase, an assumed Hsp90 client protein.

Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells.

Epitopes recognized by antibodies to denatured core protein of hepatitis B virus.

Evidence for multiple distinct interactions between hepatitis B virus P protein and its cognate RNA encapsidation signal during initiation of reverse transcription

Evolutionary conservation in the hepatitis B virus core structure: comparison of human and duck cores.

Extensive mutagenesis of the conserved box E motif in duck hepatitis B virus P protein reveals multiple functions in replication and a common structure with the primer grip in HIV-1 reverse transcriptase

Few basepairing-independent motifs in the apical half of the avian HBV ε RNA stem-loop determine site-specific initiation of protein-priming.

Formation of a functional hepatitis B virus replication initiation complex involves a major structural alteration in the RNA template.

Full-length hepatitis B virus core protein packages viral and heterologous RNA with similarly high levels of cooperativity

Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner.

HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B.

Hepatitis B Virus-Infected HepG2hNTCP Cells Serve as a Novel Immunological Tool To Analyze the Antiviral Efficacy of CD8+ T Cells In Vitro

Hepatitis B and C virus coinfection: a novel model system reveals the absence of direct viral interference

Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes.

Hepatitis B und C: von der molekularen Virologie zu neuen Perspektiven in der Therapie

Hepatitis B und C: von der molekularen Virologie zu neuen Perspektiven in der Therapie

Hepatitis B virus capsid-like particles can display the complete, dimeric outer surface protein C and stimulate production of protective antibody responses against Borrelia burgdorferi infection.

Hepatitis B virus core protein phosphorylation: Identification of the SRPK1 target sites and impact of their occupancy on RNA binding and capsid structure

Hepatitis B virus induces expression of antioxidant response element-regulated genes by activation of Nrf2.

Hepatitis B virus mutations associated with fulminant hepatitis induce apoptosis in primary Tupaia hepatocytes.

Hepatitis B virus nucleocapsids formed by carboxy-terminally mutated core proteins contain spliced viral genomes but lack full-size DNA.

Hepatitis B virus replication.

Hepatitis B virus replication: novel roles for virus-host interactions.

Hepatitis B viruses: reverse transcription a different way.

Hepatitis C virus hypervariable region 1 variants presented on hepatitis B virus capsid-like particles induce cross-neutralizing antibodies

High plasticity of the hepatitis B virus capsid revealed by conformational stress.

Host-targeting agents for treatment of hepatitis B virus infection.

Human hepatitis B virus production in avian cells is characterized by enhanced RNA splicing and the presence of capsids containing shortened genomes

In vitro assembly of mosaic hepatitis B virus capsid-like particles (CLPs): rescue into CLPs of assembly-deficient core protein fusions and FRET-suited CLPs.

Inhibition of Alpha Interferon Signaling by Hepatitis B Virus

Interferon-inducible MX2 is a host restriction factor of hepatitis B virus replication

Involvement of the host DNA-repair enzyme TDP2 in formation of the covalently closed circular DNA persistence reservoir of hepatitis B viruses

Localizing Conformational Hinges by NMR: Where Do Hepatitis B Virus Core Proteins Adapt for Capsid Assembly?

Mapping of homologous interaction sites in the hepatitis B virus core protein.

Molecular epidemiology and immunology of hepatitis B virus infection - an update.

Monoclonal antibodies providing topological information on the duck hepatitis B virus core protein and avihepadnaviral nucleocapsid structure.

Native display of complete foreign protein domains on the surface of hepatitis B virus capsids.

Novel molecular approaches toward therapy of chronic hepatitis B ⬇️

PCR-based site-directed mutagenesis using primers with mismatched 3'-ends.

Packaging of up to 240 subunits of a 17 kDa nuclease into the interior of recombinant hepatitis B virus capsids.

Phenotypic and functional differences of HBV core-specific versus HBV polymerase-specific CD8+ T cells in chronically HBV-infected patients with low viral load

Phenotyping hepatitis B virus variants: from transfection towards a small animal in vivo infection model.

Phosphorylation and Alternative Translation on Wheat Germ Cell-Free Protein Synthesis of the DHBV Large Envelope Protein

Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis.

Preparative merits of the mixed anhydride (MA) method in the excess use of DDZ-amino acids in the peptide synthesis of biologically active new antamanide analogues.

Quantitative assessment of the antiviral potencies of 21 shRNA vectors targeting conserved, including structured, hepatitis B virus sites

Quaternary structure is critical for protein display on capsid-like particles (CLPs): efficient generation of hepatitis B virus CLPs presenting monomeric but not dimeric and tetrameric fluorescent proteins.

Replication-Competent Infectious Hepatitis B Virus Vectors Carrying Substantially Sized Transgenes by Redesigned Viral Polymerase Translation ⬇️

Restriction endonuclease Alw NI is blocked by overlapping Dcm methylation

Sequence- and structure-specific determinants in the interaction between the RNA encapsidation signal and reverse transcriptase of avian hepatitis B viruses

Significant interference with hepatitis B virus replication by a core-nuclease fusion protein.

Simple confirmatory assay for anti-HBc reactivity.