Lista de obras - Emily Flashman - Dominio Público Uruguay

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

artículo científico publicado en 2009

Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability.

artículo científico publicado en 2014

Cardiac myosin binding protein C: its role in physiology and disease

artículo científico publicado en 2004

Catalytic strategies of the non-heme iron dependent oxygenases and their roles in plant biology

artículo científico publicado en 2016

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

artículo científico publicado en 2006

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants

scientific article published on 01 July 2019

Critical role for IL-4 in the development of transplant arteriosclerosis in the absence of CD40-CD154 costimulation

artículo científico publicado en 2001

Crystal structure of the C1 domain of cardiac myosin binding protein-C: implications for hypertrophic cardiomyopathy

artículo científico publicado en 2008

Direct analysis of enzyme-catalyzed DNA demethylation

artículo científico publicado en 2009

Dynamic states of the DNA repair enzyme AlkB regulate product release

artículo científico publicado en 2008

ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site

artículo científico publicado en 2008

Epigenetic regulation by histone demethylases in hypoxia

artículo científico publicado en 2015

Evidence for a stereoelectronic effect in human oxygen sensing.

artículo científico publicado en 2009

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

artículo científico publicado en 2010

Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications

artículo científico publicado en 2020

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

artículo científico publicado en 2005

Identification of novel interactions between domains of Myosin binding protein-C that are modulated by hypertrophic cardiomyopathy missense mutations

artículo científico publicado en 2002

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

artículo científico publicado en 2014

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

artículo científico publicado en 2010

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase.

artículo científico publicado en 2013

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.

artículo científico publicado en 2015

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases

artículo científico publicado en 2007

Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod

artículo científico publicado en 2007

Lysine-241 has a role in coupling 2OG turnover with substrate oxidation during KDM4-catalysed histone demethylation

artículo científico publicado en 2018

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

artículo científico publicado en 2017

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.

artículo científico publicado en 2014

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

artículo científico publicado en 2014

OS-9: another piece in the HIF complex story

artículo científico publicado en 2005

Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity

artículo científico publicado en 2020

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

artículo científico publicado en 2017

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

artículo científico publicado en 2017

Secondary binding sites for triplex-forming oligonucleotides containing bulges, loops, and mismatches in the third strand.

artículo científico publicado en 2000

Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture

artículo científico publicado en 2019

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

artículo científico publicado en 2009

Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase

artículo científico publicado en 2015

Structures of Arabidopsis thaliana oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity

scientific article published on 31 August 2020

Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.

artículo científico publicado en 2014

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.

artículo científico publicado en 2017

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

artículo científico publicado en 2007

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)

artículo científico publicado en 2011

Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, 19F-labelling, crystallisation, data collection, and structure de

artículo científico publicado en 2014

Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle

artículo científico publicado en 2008

The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations

artículo científico publicado en 2017

The most versatile of all reactive intermediates?

The plant cysteine oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors

scientific article published on 30 May 2018

Use of ferrous iron by metallo-β-lactamases

artículo científico publicado en 2016

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.

artículo científico publicado en 2009

Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions

artículo científico publicado en 2010

YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase

artículo científico publicado en 2018

Lista de obras de Emily Flashman

Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure.

Biochemical characterization of New Delhi metallo-β-lactamase variants reveals differences in protein stability.

Cardiac myosin binding protein C: its role in physiology and disease

Catalytic strategies of the non-heme iron dependent oxygenases and their roles in plant biology

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants

Critical role for IL-4 in the development of transplant arteriosclerosis in the absence of CD40-CD154 costimulation

Crystal structure of the C1 domain of cardiac myosin binding protein-C: implications for hypertrophic cardiomyopathy

Direct analysis of enzyme-catalyzed DNA demethylation

Dynamic states of the DNA repair enzyme AlkB regulate product release

ESI-MS studies on prolyl hydroxylase domain 2 reveal a new metal binding site

Epigenetic regulation by histone demethylases in hypoxia

Evidence for a stereoelectronic effect in human oxygen sensing.

Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen

Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications

Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

Identification of novel interactions between domains of Myosin binding protein-C that are modulated by hypertrophic cardiomyopathy missense mutations

Investigating the contribution of the active site environment to the slow reaction of hypoxia-inducible factor prolyl hydroxylase domain 2 with oxygen

Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase.

Kinetic Investigations of the Role of Factor Inhibiting Hypoxia-inducible Factor (FIH) as an Oxygen Sensor.

Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases

Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod

Lysine-241 has a role in coupling 2OG turnover with substrate oxidation during KDM4-catalysed histone demethylation

Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials

Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases.

OGFOD1 catalyzes prolyl hydroxylation of RPS23 and is involved in translation control and stress granule formation

OS-9: another piece in the HIF complex story

Oxygen-sensing mechanisms across eukaryotic kingdoms and their roles in complex multicellularity

Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

Secondary binding sites for triplex-forming oligonucleotides containing bulges, loops, and mismatches in the third strand.

Small-molecules that covalently react with a human prolyl hydroxylase – towards activity modulation and substrate capture

Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

Structure and Mechanism of a Viral Collagen Prolyl Hydroxylase

Structures of Arabidopsis thaliana oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity

Studies on deacetoxycephalosporin C synthase support a consensus mechanism for 2-oxoglutarate dependent oxygenases.

Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates.

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1)

Studying the active-site loop movement of the São Paolo metallo-β-lactamase-1†Electronic supplementary information (ESI) available: Procedures for protein expression and purification, 19F-labelling, crystallisation, data collection, and structure de

Support for a trimeric collar of myosin binding protein C in cardiac and fast skeletal muscle, but not in slow skeletal muscle

The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations

The most versatile of all reactive intermediates?

The plant cysteine oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors

Use of ferrous iron by metallo-β-lactamases

Use of mass spectrometry to probe the nucleophilicity of cysteinyl residues of prolyl hydroxylase domain 2.

Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions

YcfDRM is a thermophilic oxygen-dependent ribosomal protein uL16 oxygenase