Lista de obras - Stuart A Nicklin - Dominio Público Uruguay

A Novel Mechanism of Action for Angiotensin-(1–7) via the Angiotensin Type 1 Receptor

artículo científico publicado en 2016

AAV-based gene transfer

artículo científico publicado el 1 de agosto de 2003

Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery

artículo científico publicado en 2012

Adeno-associated virus (AAV)-7 and -8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation.

artículo científico publicado en 2005

Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin type 2 receptor

artículo científico publicado en 2012

Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo.

artículo científico publicado en 2004

Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective

artículo científico publicado en 2022

Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop

artículo científico

Adenovirus serotype 5 hexon mediates liver gene transfer

artículo científico publicado en 2008

Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodelling

artículo científico publicado en 2014

Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor

scientific journal article

Angiotensin1-9 antagonises pro-hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor

scientific journal article

Antagonists of GPR35 display high species ortholog selectivity and varying modes of action

artículo científico publicado en 2012

Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion

artículo científico publicado en 2019

Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

artículo científico publicado en 2012

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

artículo científico publicado en 2010

Capsid modification strategies for detargeting adenoviral vectors

artículo científico publicado en 2014

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance

artículo científico publicado en 2015

Cell-selective viral gene delivery vectors for the vasculature

artículo científico publicado en 2004

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function.

artículo científico publicado en 2014

Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum

artículo científico publicado en 2017

Development of efficient viral vectors selective for vascular smooth muscle cells

artículo científico publicado en 2004

Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p.

artículo científico publicado en 2007

Dual targeting of gene delivery by genetic modification of adenovirus serotype 5 fibers and cell-selective transcriptional control.

artículo científico publicado en 2004

Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats

artículo científico publicado en 2004

Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer

artículo científico publicado en 2008

Efficient Vascular Endothelial Gene Transfer Following Intravenous Adenovirus Delivery

article

Efficient transduction of primary vascular cells by the rare adenovirus serotype 49 vector

artículo científico publicado en 2015

Electrical consequences of cardiac myocyte: fibroblast coupling

artículo científico

Engineering adeno-associated virus 2 vectors for targeted gene delivery to atherosclerotic lesions.

artículo científico publicado en 2007

Enhanced gene transfer activity of peptide-targeted gene-delivery vectors

artículo científico publicado en 2005

FX and host defense evasion tactics by adenovirus

artículo científico publicado en 2013

G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease

artículo científico

G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation

artículo científico publicado en 2016

GPR35 as a Novel Therapeutic Target.

artículo científico publicado en 2011

Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction

artículo científico publicado en 2016

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension

artículo científico publicado en 2010

Human Adenovirus Serotype 5 Is Sensitive to IgM-Independent Neutralization In Vitro and In Vivo

scientific article published on 05 July 2019

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

artículo científico publicado en 2009

Identification of peptides that target the endothelial cell-specific LOX-1 receptor.

artículo científico publicado en 2001

In vitro and in vivo characterisation of endothelial cell selective adenoviral vectors.

artículo científico

Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors

artículo científico publicado en 2009

Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.

artículo científico publicado en 2007

Interactions of adenovirus vectors with blood: implications for intravascular gene therapy applications.

artículo científico publicado en 2008

Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo

artículo científico publicado en 2015

Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting

artículo científico publicado en 2009

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

artículo científico publicado en 2006

Novel vectors for in vivo gene delivery to vascular tissue

artículo científico publicado en 2007

Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2.

artículo científico publicado en 2009

Overexpression of p53 increases lumen size and blocks neointima formation in porcine interposition vein grafts

artículo científico publicado en 2004

Prevention of coronary in-stent restenosis and vein graft failure: does vascular gene therapy have a role?

artículo científico

Promoters and control elements: designing expression cassettes for gene therapy.

artículo científico publicado en 2004

Regulation of cardiovascular remodeling by the counter-regulatory axis of the renin-angiotensin system

artículo científico

Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X

artículo científico publicado en 2010

Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop

artículo científico publicado en 2016

Runx1 Deficiency Protects Against Adverse Cardiac Remodeling After Myocardial Infarction.

artículo científico publicado en 2017

Simple Methods for Preparing Recombinant Adenoviruses for High-Efficiency Transduction of Vascular Cells

artículo científico publicado el 1 de enero de 1999

Special focus issue on the annual meeting of the British Society for Gene and Cell Therapy

artículo científico publicado en 2015

Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment.

artículo científico publicado en 2019

Targeted gene delivery to vascular tissue in vivo by tropism-modified adeno-associated virus vectors

artículo científico publicado en 2004

Targeting gene therapy vectors to the vascular endothelium

artículo científico publicado en 2003

Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.

artículo científico publicado en 2007

The Orphan Receptor GPR35 Contributes to Angiotensin II-Induced Hypertension and Cardiac Dysfunction in Mice

The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35

scientific article published on 10 October 2013

The frequency of hemochromatosis-associated alleles is increased in British patients with sporadic porphyria cutanea tarda

The frequency of the haemochromatosis-associated genotype D6S265-1:D6S105-8 in blood donors

artículo científico publicado en 1996

The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery

artículo científico

The influence of adenovirus fiber structure and function on vector development for gene therapy

artículo científico publicado en 2005

The relevance of coagulation factor X protection of adenoviruses in human sera.

scientific article published on 25 March 2016

Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy

artículo científico publicado en 2003

Transductional and transcriptional targeting of cancer cells using genetically engineered viral vectors

artículo científico publicado en 2003

Tropism-modification strategies for targeted gene delivery using adenoviral vectors

artículo científico publicado en 2010

Tropism-modified adenoviral and adeno-associated viral vectors for gene therapy

artículo científico publicado en 2002

Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature

artículo científico publicado en 2009

Use of phage display to identify novel peptides for targeted gene therapy

artículo científico publicado en 2002

Utilizing proteomics to understand and define hypertension: where are we and where do we go?

scientific article published on 12 July 2018

Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses

artículo científico publicado en 2006

Vector systems for prenatal gene therapy: principles of adenovirus design and production

artículo científico publicado en 2012

Lista de obras de Stuart A Nicklin

A Novel Mechanism of Action for Angiotensin-(1–7) via the Angiotensin Type 1 Receptor

AAV-based gene transfer

Ad5:Ad48 hexon hypervariable region substitutions lead to toxicity and increased inflammatory responses following intravenous delivery

Adeno-associated virus (AAV)-7 and -8 poorly transduce vascular endothelial cells and are sensitive to proteasomal degradation.

Adenoviral delivery of angiotensin-(1-7) or angiotensin-(1-9) inhibits cardiomyocyte hypertrophy via the mas or angiotensin type 2 receptor

Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo.

Adenoviral vectors for cardiovascular gene therapy applications: a clinical and industry perspective

Adenovirus 5 fibers mutated at the putative HSPG-binding site show restricted retargeting with targeting peptides in the HI loop

Adenovirus serotype 5 hexon mediates liver gene transfer

Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodelling

Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor

Angiotensin1-9 antagonises pro-hypertrophic signalling in cardiomyocytes via the angiotensin type 2 receptor

Antagonists of GPR35 display high species ortholog selectivity and varying modes of action

Assessing the effects of Ang-(1-7) therapy following transient middle cerebral artery occlusion

Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors

Capsid modification strategies for detargeting adenoviral vectors

Cardiac Hypertrophy Is Inhibited by a Local Pool of cAMP Regulated by Phosphodiesterase 2Novelty and Significance

Cell-selective viral gene delivery vectors for the vasculature

Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function.

Defining a Novel Role for the Coxsackievirus and Adenovirus Receptor in Human Adenovirus Serotype 5 Transduction In Vitro in the Presence of Mouse Serum

Development of efficient viral vectors selective for vascular smooth muscle cells

Development of renal-targeted vectors through combined in vivo phage display and capsid engineering of adenoviral fibers from serotype 19p.

Dual targeting of gene delivery by genetic modification of adenovirus serotype 5 fibers and cell-selective transcriptional control.

Effect of adenovirus serotype 5 fiber and penton modifications on in vivo tropism in rats

Effect of neutralizing sera on factor x-mediated adenovirus serotype 5 gene transfer

Efficient Vascular Endothelial Gene Transfer Following Intravenous Adenovirus Delivery

Efficient transduction of primary vascular cells by the rare adenovirus serotype 49 vector

Electrical consequences of cardiac myocyte: fibroblast coupling

Engineering adeno-associated virus 2 vectors for targeted gene delivery to atherosclerotic lesions.

Enhanced gene transfer activity of peptide-targeted gene-delivery vectors

FX and host defense evasion tactics by adenovirus

G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease

G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation

GPR35 as a Novel Therapeutic Target.

Gene Therapy With Angiotensin-(1-9) Preserves Left Ventricular Systolic Function After Myocardial Infarction

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension

Human Adenovirus Serotype 5 Is Sensitive to IgM-Independent Neutralization In Vitro and In Vivo

Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer

Identification of peptides that target the endothelial cell-specific LOX-1 receptor.

In vitro and in vivo characterisation of endothelial cell selective adenoviral vectors.

Influence of coagulation factor x on in vitro and in vivo gene delivery by adenovirus (Ad) 5, Ad35, and chimeric Ad5/Ad35 vectors

Influence of coagulation factor zymogens on the infectivity of adenoviruses pseudotyped with fibers from subgroup D.

Interactions of adenovirus vectors with blood: implications for intravascular gene therapy applications.

Manipulating adenovirus hexon hypervariable loops dictates immune neutralisation and coagulation factor X-dependent cell interaction in vitro and in vivo

Mouse adenovirus type 1 and human adenovirus type 5 differ in endothelial cell tropism and liver targeting

Multiple vitamin K-dependent coagulation zymogens promote adenovirus-mediated gene delivery to hepatocytes

Novel vectors for in vivo gene delivery to vascular tissue

Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2.

Overexpression of p53 increases lumen size and blocks neointima formation in porcine interposition vein grafts

Prevention of coronary in-stent restenosis and vein graft failure: does vascular gene therapy have a role?

Promoters and control elements: designing expression cassettes for gene therapy.

Regulation of cardiovascular remodeling by the counter-regulatory axis of the renin-angiotensin system

Requirements for receptor engagement during infection by adenovirus complexed with blood coagulation factor X

Retargeting FX-binding-ablated HAdV-5 to vascular cells by inclusion of the RGD-4C peptide in hexon hypervariable region 7 and the HI loop

Runx1 Deficiency Protects Against Adverse Cardiac Remodeling After Myocardial Infarction.

Simple Methods for Preparing Recombinant Adenoviruses for High-Efficiency Transduction of Vascular Cells

Special focus issue on the annual meeting of the British Society for Gene and Cell Therapy

Systems biology identifies cytosolic PLA2 as a target in vascular calcification treatment.

Targeted gene delivery to vascular tissue in vivo by tropism-modified adeno-associated virus vectors

Targeting gene therapy vectors to the vascular endothelium

Targeting of adenovirus serotype 5 (Ad5) and 5/47 pseudotyped vectors in vivo: fundamental involvement of coagulation factors and redundancy of CAR binding by Ad5.

The Orphan Receptor GPR35 Contributes to Angiotensin II-Induced Hypertension and Cardiac Dysfunction in Mice

The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35

The frequency of hemochromatosis-associated alleles is increased in British patients with sporadic porphyria cutanea tarda

The frequency of the haemochromatosis-associated genotype D6S265-1:D6S105-8 in blood donors

The importance of coagulation factors binding to adenovirus: historical perspectives and implications for gene delivery

The influence of adenovirus fiber structure and function on vector development for gene therapy

The relevance of coagulation factor X protection of adenoviruses in human sera.

Third-generation lentivirus vectors efficiently transduce and phenotypically modify vascular cells: implications for gene therapy

Transductional and transcriptional targeting of cancer cells using genetically engineered viral vectors

Tropism-modification strategies for targeted gene delivery using adenoviral vectors

Tropism-modified adenoviral and adeno-associated viral vectors for gene therapy

Use of in vivo phage display to engineer novel adenoviruses for targeted delivery to the cardiac vasculature

Use of phage display to identify novel peptides for targeted gene therapy

Utilizing proteomics to understand and define hypertension: where are we and where do we go?

Vascular bed-targeted in vivo gene delivery using tropism-modified adeno-associated viruses

Vector systems for prenatal gene therapy: principles of adenovirus design and production