Lista de obras - Paavo Honkakoski - Dominio Público Uruguay

A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine

artículo científico publicado en 2016

A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR).

artículo científico publicado en 2001

Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines

artículo científico publicado en 2005

Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy.

artículo científico publicado en 2007

Amino acids important for ligand specificity of the human constitutive androstane receptor

artículo científico publicado en 2004

Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene.

artículo científico publicado en 1997

Characterization of human cytochrome P450 induction by pesticides.

artículo científico publicado en 2012

Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons

artículo científico publicado en 2015

Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes.

artículo científico publicado en 1996

Comparative studies on coumarin and testosterone metabolism in mouse and human livers

artículo científico publicado en 1991

Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes

artículo científico publicado en 1993

Comparison of homology models and X-ray structures of the nuclear receptor CAR: assessing the structural basis of constitutive activity

artículo científico publicado en 2006

Cytochrome P450 isoforms in human fetal tissues related to phenobarbital-inducible forms in the mouse

artículo científico publicado en 1993

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.

artículo científico publicado en 2017

Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes

artículo científico publicado en 2014

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

artículo científico publicado en 2008

Distinct induction profiles of three phenobarbital-responsive mouse liver cytochrome P450 isozymes

scientific article published on 01 May 1992

Effects of triaryl phosphates on mouse and human nuclear receptors.

artículo científico publicado en 2004

Effluxing ABC transporters in human corneal epithelium.

artículo científico publicado en 2010

Evaluating collaborative planning methods supporting programme-based planning in natural resource management

artículo científico

Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation.

artículo científico publicado en 2015

Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells.

artículo científico publicado en 2005

Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle

artículo científico publicado en 2019

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity.

artículo científico publicado en 2016

Highly homologous cytochromes P-450 and b5: a model to study protein-protein interactions in a reconstituted monooxygenase system

article

Human and mouse liver coumarin 7-hydroxylases do not metabolize warfarin in vitro ⬇️

artículo científico publicado el 1 de marzo de 1992

Identification of Key Amino Acids that Impact Organic Solute Transporter <i>α</i>/<i>β</i> (OSTα/β)

scientific article published on 01 October 2021

Immunochemical detection of human liver cytochrome P450 forms related to phenobarbital-inducible forms in the mouse

artículo científico publicado en 1990

Improved assays for xenosensor activation based on reverse transfection

artículo científico publicado en 2015

In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin.

artículo científico publicado en 2006

Inhibition of BET bromodomains alleviates inflammation in human RPE cells.

artículo científico publicado en 2016

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

artículo científico publicado en 2008

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.

artículo científico publicado en 2013

Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies.

artículo científico publicado en 2006

Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.

artículo científico publicado en 2008

Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors

artículo científico publicado en 2006

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

artículo científico publicado en 2020

Microarray Analysis of the Global Alterations in the Gene Expression in the Placentas From Cigarette-smoking Mothers

article

Molecular Cloning and Characterization of a Novel Nuclear Protein Kinase in Mice ⬇️

artículo científico publicado el 1 de abril de 1998

Molecular determinants of steroid inhibition for the mouse constitutive androstane receptor.

artículo científico publicado en 2003

Molecular dynamics simulations for human CAR inverse agonists.

artículo científico publicado en 2012

Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity

artículo científico publicado en 2004

Monocarboxylate transport in human corneal epithelium and cell lines.

artículo científico publicado en 2009

Mouse steroid 15.alpha.-hydroxylase gene family: identification of type II P-45015.alpha. as coumarin 7-hydroxylase

article

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

artículo científico publicado en 2011

Novel in Vitro Method Reveals Drugs That Inhibit Organic Solute Transporter Alpha/Beta (OSTα/β)

scientific article published on 14 December 2018

Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions

artículo científico publicado en 2019

Polyplex-mediated gene transfer and cell cycle: effect of carrier on cellular uptake and intracellular kinetics, and significance of glycosaminoglycans

article

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator.

artículo científico publicado en 2014

Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells

scientific article published on 24 January 2019

Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells

artículo científico publicado en 2015

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models.

artículo científico publicado en 2016

Regulation of cytochrome P450 (CYP) genes by nuclear receptors.

artículo científico publicado en 2000

Regulation of gene expression by CAR: an update

artículo científico

Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding site

artículo científico publicado en 2012

Retina-specific gene expression and improved DNA transfection in WERI-Rb1 retinoblastoma cells

article

Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor alpha and beta agonists.

artículo científico publicado en 2010

Synthesis and evaluation of estrogen agonism of diaryl 4,5-dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: a compound set forming a 4D molecular library

artículo científico publicado en 2008

The Basis for Strain-Dependent Rat Aldehyde Dehydrogenase 1A7 (ALDH1A7) Gene Expression

scientific article published on 01 October 2019

The EDCMET Project: Metabolic Effects of Endocrine Disruptors

artículo científico publicado en 2020

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system ⬇️

artículo científico publicado el 18 de marzo de 2012

Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells.

artículo científico publicado en 2017

Use of comprehensive screening methods to detect selective human CAR activators.

artículo científico publicado en 2011

Lista de obras de Paavo Honkakoski

A liquid chromatography-tandem mass spectrometry analysis of nine cytochrome P450 probe drugs and their corresponding metabolites in human serum and urine

A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR).

Absorption properties and P-glycoprotein activity of modified Caco-2 cell lines

Alginate-based microencapsulation of retinal pigment epithelial cell line for cell therapy.

Amino acids important for ligand specificity of the human constitutive androstane receptor

Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene.

Characterization of human cytochrome P450 induction by pesticides.

Characterization of ligand-dependent activation of bovine and pig constitutive androstane (CAR) and pregnane X receptors (PXR) with interspecies comparisons

Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes.

Comparative studies on coumarin and testosterone metabolism in mouse and human livers

Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes

Comparison of homology models and X-ray structures of the nuclear receptor CAR: assessing the structural basis of constitutive activity

Cytochrome P450 isoforms in human fetal tissues related to phenobarbital-inducible forms in the mouse

DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.

Direct and Rapid Transcript Analysis Assay for CYP mRNA Expression and Inducibility in Human Primary Hepatocytes

Discovery of substituted sulfonamides and thiazolidin-4-one derivatives as agonists of human constitutive androstane receptor

Distinct induction profiles of three phenobarbital-responsive mouse liver cytochrome P450 isozymes

Effects of triaryl phosphates on mouse and human nuclear receptors.

Effluxing ABC transporters in human corneal epithelium.

Evaluating collaborative planning methods supporting programme-based planning in natural resource management

Fisetin and luteolin protect human retinal pigment epithelial cells from oxidative stress-induced cell death and regulate inflammation.

Freeze-drying of cationic polymer DNA complexes enables their long-term storage and reverse transfection of post-mitotic cells.

Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle

Genetically Modified Caco-2 Cells With Improved Cytochrome P450 Metabolic Capacity.

Highly homologous cytochromes P-450 and b5: a model to study protein-protein interactions in a reconstituted monooxygenase system

Human and mouse liver coumarin 7-hydroxylases do not metabolize warfarin in vitro ⬇️

Identification of Key Amino Acids that Impact Organic Solute Transporter <i>α</i>/<i>β</i> (OSTα/β)

Immunochemical detection of human liver cytochrome P450 forms related to phenobarbital-inducible forms in the mouse

Improved assays for xenosensor activation based on reverse transfection

In vivo and mechanistic evidence of nuclear receptor CAR induction by artemisinin.

Inhibition of BET bromodomains alleviates inflammation in human RPE cells.

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system.

Ligand recognition by drug-activated nuclear receptors PXR and CAR: structural, site-directed mutagenesis and molecular modeling studies.

Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.

Metabolic and Efflux Properties of Caco-2 Cells Stably Transfected with Nuclear Receptors

Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR

Microarray Analysis of the Global Alterations in the Gene Expression in the Placentas From Cigarette-smoking Mothers

Molecular Cloning and Characterization of a Novel Nuclear Protein Kinase in Mice ⬇️

Molecular determinants of steroid inhibition for the mouse constitutive androstane receptor.

Molecular dynamics simulations for human CAR inverse agonists.

Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity

Monocarboxylate transport in human corneal epithelium and cell lines.

Mouse steroid 15.alpha.-hydroxylase gene family: identification of type II P-45015.alpha. as coumarin 7-hydroxylase

New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists

Novel in Vitro Method Reveals Drugs That Inhibit Organic Solute Transporter Alpha/Beta (OSTα/β)

Optimization of Canalicular ABC Transporter Function in HuH-7 Cells by Modification of Culture Conditions

Polyplex-mediated gene transfer and cell cycle: effect of carrier on cellular uptake and intracellular kinetics, and significance of glycosaminoglycans

Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator.

Protein expression and function of organic anion transporters in short-term and long-term cultures of Huh7 human hepatoma cells

Quercetin alleviates 4-hydroxynonenal-induced cytotoxicity and inflammation in ARPE-19 cells

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models.

Regulation of cytochrome P450 (CYP) genes by nuclear receptors.

Regulation of gene expression by CAR: an update

Regulation of the human tyrosinase gene in retinal pigment epithelium cells: the significance of transcription factor orthodenticle homeobox 2 and its polymorphic binding site

Retina-specific gene expression and improved DNA transfection in WERI-Rb1 retinoblastoma cells

Synthesis and biological evaluation of phenolic 4,5-dihydroisoxazoles and 3-hydroxy ketones as estrogen receptor alpha and beta agonists.

Synthesis and evaluation of estrogen agonism of diaryl 4,5-dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: a compound set forming a 4D molecular library

The Basis for Strain-Dependent Rat Aldehyde Dehydrogenase 1A7 (ALDH1A7) Gene Expression

The EDCMET Project: Metabolic Effects of Endocrine Disruptors

Towards personalized medicine with a three-dimensional micro-scale perfusion-based two-chamber tissue model system ⬇️

Two dietary polyphenols, fisetin and luteolin, reduce inflammation but augment DNA damage-induced toxicity in human RPE cells.

Use of comprehensive screening methods to detect selective human CAR activators.