Lista de obras - Christian A. Olsen - Dominio Público Uruguay

A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation

artículo científico publicado en 2016

A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel

artículo científico publicado en 2018

Alpha-peptide/beta-peptoid chimeras

scientific article published on 13 March 2007

Aminolysis of Resin-BoundN-Nosylaziridine-2-carboxylic Acids

artículo científico publicado en 2006

An NAD+-Dependent Sirtuin Depropionylase and Deacetylase (Sir2La) from the Probiotic Bacterium Lactobacillus acidophilus NCFM

artículo científico publicado en 2018

An update on lysine deacylases targeting the expanding "acylome".

artículo científico

Antimicrobial, Hemolytic, and Cytotoxic Activities of β-Peptoid-Peptide Hybrid Oligomers: Improved Properties Compared to Natural AMPs

artículo científico publicado en 2010

Antiplasmodial and Prehemolytic Activities of α-Peptide–β-Peptoid Chimeras

artículo científico publicado en 2007

Arylfluorosulfate-Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal.

artículo científico publicado en 2018

Backbone-Fluorinated 1,2,3-Triazole-Containing Dipeptide Surrogates

artículo científico publicado en 2017

Beta-peptoid "foldamers"--why the additional methylene unit?

artículo científico publicado en 2011

Cellular uptake and membrane-destabilising properties of alpha-peptide/beta-peptoid chimeras: lessons for the design of new cell-penetrating peptides

artículo científico publicado en 2008

Chemical Editing of Macrocyclic Natural Products and Kinetic Profiling Reveal Slow, Tight-Binding Histone Deacetylase Inhibitors with Picomolar Affinities

artículo científico publicado en 2017

Cis-trans amide bond rotamers in β-peptoids and peptoids: evaluation of stereoelectronic effects in backbone and side chains.

artículo científico publicado en 2013

Class I histone deacetylases (HDAC1-3) are histone lysine delactylases

artículo científico publicado en 2022

Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System

artículo científico publicado en 2016

Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells.

artículo científico publicado en 2017

Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures.

artículo científico publicado en 2009

Direct Peptide Cyclization and One-Pot Modification Using the MeDbz Linker

artículo científico publicado en 2018

Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group.

artículo científico publicado en 2012

Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides

artículo científico publicado en 2009

Effect of Co-inhabiting Coagulase Negative Staphylococci on S. aureus agr Quorum Sensing, Host Factor Binding, and Biofilm Formation

scientific article published on 27 September 2019

Effects of thionation and fluorination on cis-trans isomerization in tertiary amides: an investigation of N-alkylglycine (peptoid) rotamers.

artículo científico publicado en 2015

Expansion of the lysine acylation landscape

scientific article published on 28 February 2012

Expedient protocol for solid-phase synthesis of secondary and tertiary amines

scientific article published on 01 June 2004

Finding the gas pedal on a slow sirtuin

artículo científico publicado en 2020

Functionalized Helical β-Peptoids

artículo científico publicado en 2019

Guanidino groups greatly enhance the action of antimicrobial peptidomimetics against bacterial cytoplasmic membranes

artículo científico publicado en 2014

Histone Deacetylase 11 Is an ε-N-Myristoyllysine Hydrolase

artículo científico publicado en 2018

Identification of autoinducing thiodepsipeptides from staphylococci enabled by native chemical ligation

artículo científico publicado en 2019

Increasing the Functional Group Diversity in Helical β-Peptoids: Achievement of Solvent- and pH-Dependent Folding

artículo científico publicado en 2020

Innovative Strategies for Selective Inhibition of Histone Deacetylases

artículo científico publicado en 2016

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH

artículo científico publicado en 2016

Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression

artículo científico publicado en 2019

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

artículo científico publicado en 2016

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

artículo científico publicado en 2014

Macrocyclic peptoid-Peptide hybrids as inhibitors of class I histone deacetylases.

artículo científico publicado en 2012

Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight

artículo científico publicado en 2017

Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

artículo científico publicado en 2021

Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles

artículo científico publicado en 2014

Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes

artículo científico publicado en 2016

Optoepigenetics: An acetylation photoswitch

artículo científico publicado en 2016

Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction

artículo científico publicado en 2020

Peptoid-Peptide hybrid backbone architectures.

artículo científico publicado en 2010

Photo Cross-Linking Probes Containing ϵ-N-Thioacyllysine and ϵ-N-Acyl-(δ-aza)lysine Residues

artículo científico publicado en 2020

Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR

artículo científico publicado en 2011

Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides.

artículo científico publicado en 2009

Profiling of substrates for zinc-dependent lysine deacylase enzymes: HDAC3 exhibits decrotonylase activity in vitro

artículo científico publicado en 2012

Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy.

artículo científico publicado en 2006

Random Mutagenesis Analysis of the Influenza A M2 Proton Channel Reveals Novel Resistance Mutants

artículo científico publicado en 2018

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

artículo científico publicado en 2017

Selectively N-protected enantiopure 2,5-disubstituted piperazines: avoiding the pitfalls in solid-phase Fukuyama-Mitsunobu cyclizations

artículo científico publicado en 2009

Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

artículo científico publicado en 2005

Solid-phase peptide synthesis and circular dichroism study of chiral beta-peptoid homooligomers

scientific article published on 23 May 2007

Solid-phase polyamine synthesis using piperazine and piperidine building blocks

artículo científico publicado en 2003

Solid-phase synthesis of rigid acylpolyamines using temporary N-4,4'-dimethoxytrityl protection in the presence of trityl linkers.

artículo científico publicado en 2004

Structure-Activity Relationship Study Based on Autoinducing Peptide (AIP) from Dog Pathogen S. schleiferi

artículo científico publicado en 2017

Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme

scientific article published on 24 May 2012

Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives

artículo científico publicado en 2012

The effect of various zinc binding groups on inhibition of histone deacetylases 1-11.

artículo científico publicado en 2013

Total Synthesis and Full Histone Deacetylase Inhibitory Profiling of Azumamides A–E as Well as β2- epi-Azumamide E and β3-epi-Azumamide E

artículo científico publicado en 2013

Total synthesis and structural validation of cyclodepsipeptides solonamide A and B

artículo científico publicado en 2014

Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds

artículo científico publicado en 2015

Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers

artículo científico publicado en 2006

β-Peptoid Foldamers at Last.

artículo científico publicado en 2015

Lista de obras de Christian A. Olsen

A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation

A Robust Proton Flux (pHlux) Assay for Studying the Function and Inhibition of the Influenza A M2 Proton Channel

Alpha-peptide/beta-peptoid chimeras

Aminolysis of Resin-BoundN-Nosylaziridine-2-carboxylic Acids

An NAD+-Dependent Sirtuin Depropionylase and Deacetylase (Sir2La) from the Probiotic Bacterium Lactobacillus acidophilus NCFM

An update on lysine deacylases targeting the expanding "acylome".

Antimicrobial, Hemolytic, and Cytotoxic Activities of β-Peptoid-Peptide Hybrid Oligomers: Improved Properties Compared to Natural AMPs

Antiplasmodial and Prehemolytic Activities of α-Peptide–β-Peptoid Chimeras

Arylfluorosulfate-Based Electrophiles for Covalent Protein Labeling: A New Addition to the Arsenal.

Backbone-Fluorinated 1,2,3-Triazole-Containing Dipeptide Surrogates

Beta-peptoid "foldamers"--why the additional methylene unit?

Cellular uptake and membrane-destabilising properties of alpha-peptide/beta-peptoid chimeras: lessons for the design of new cell-penetrating peptides

Chemical Editing of Macrocyclic Natural Products and Kinetic Profiling Reveal Slow, Tight-Binding Histone Deacetylase Inhibitors with Picomolar Affinities

Cis-trans amide bond rotamers in β-peptoids and peptoids: evaluation of stereoelectronic effects in backbone and side chains.

Class I histone deacetylases (HDAC1-3) are histone lysine delactylases

Cross-Talk between Staphylococcus aureus and Other Staphylococcal Species via the agr Quorum Sensing System

Cyclic tetrapeptide HDAC inhibitors as potential therapeutics for spinal muscular atrophy: Screening with iPSC-derived neuronal cells.

Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures.

Direct Peptide Cyclization and One-Pot Modification Using the MeDbz Linker

Discovery of HDAC Inhibitors That Lack an Active Site Zn(2+)-Binding Functional Group.

Discovery of potent and selective histone deacetylase inhibitors via focused combinatorial libraries of cyclic alpha3beta-tetrapeptides

Effect of Co-inhabiting Coagulase Negative Staphylococci on S. aureus agr Quorum Sensing, Host Factor Binding, and Biofilm Formation

Effects of thionation and fluorination on cis-trans isomerization in tertiary amides: an investigation of N-alkylglycine (peptoid) rotamers.

Expansion of the lysine acylation landscape

Expedient protocol for solid-phase synthesis of secondary and tertiary amines

Finding the gas pedal on a slow sirtuin

Functionalized Helical β-Peptoids

Guanidino groups greatly enhance the action of antimicrobial peptidomimetics against bacterial cytoplasmic membranes

Histone Deacetylase 11 Is an ε-N-Myristoyllysine Hydrolase

Identification of autoinducing thiodepsipeptides from staphylococci enabled by native chemical ligation

Increasing the Functional Group Diversity in Helical β-Peptoids: Achievement of Solvent- and pH-Dependent Folding

Innovative Strategies for Selective Inhibition of Histone Deacetylases

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH

Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

Macrocyclic peptoid-Peptide hybrids as inhibitors of class I histone deacetylases.

Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight

Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration

Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles

Natural and Synthetic Macrocyclic Inhibitors of the Histone Deacetylase Enzymes

Optoepigenetics: An acetylation photoswitch

Peptide Inhibitors of the α-Cobratoxin-Nicotinic Acetylcholine Receptor Interaction

Peptoid-Peptide hybrid backbone architectures.

Photo Cross-Linking Probes Containing ϵ-N-Thioacyllysine and ϵ-N-Acyl-(δ-aza)lysine Residues

Potential Agents for Treating Cystic Fibrosis: Cyclic Tetrapeptides that Restore Trafficking and Activity of ΔF508-CFTR

Probing the bioactive conformation of an archetypal natural product HDAC inhibitor with conformationally homogeneous triazole-modified cyclic tetrapeptides.

Profiling of substrates for zinc-dependent lysine deacylase enzymes: HDAC3 exhibits decrotonylase activity in vitro

Protolytic properties of polyamine wasp toxin analogues studied by 13C NMR spectroscopy.

Random Mutagenesis Analysis of the Influenza A M2 Proton Channel Reveals Novel Resistance Mutants

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

Selectively N-protected enantiopure 2,5-disubstituted piperazines: avoiding the pitfalls in solid-phase Fukuyama-Mitsunobu cyclizations

Side-chain-anchored N(alpha)-Fmoc-Tyr-OPfp for bidirectional solid-phase synthesis

Solid-phase peptide synthesis and circular dichroism study of chiral beta-peptoid homooligomers

Solid-phase polyamine synthesis using piperazine and piperidine building blocks

Solid-phase synthesis of rigid acylpolyamines using temporary N-4,4'-dimethoxytrityl protection in the presence of trityl linkers.

Structure-Activity Relationship Study Based on Autoinducing Peptide (AIP) from Dog Pathogen S. schleiferi

Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme

Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives

The effect of various zinc binding groups on inhibition of histone deacetylases 1-11.

Total Synthesis and Full Histone Deacetylase Inhibitory Profiling of Azumamides A–E as Well as β2- epi-Azumamide E and β3-epi-Azumamide E

Total synthesis and structural validation of cyclodepsipeptides solonamide A and B

Triangular prism-shaped β-peptoid helices as unique biomimetic scaffolds

Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers

β-Peptoid Foldamers at Last.