Lista de obras - Isabelle Plo - Dominio Público Uruguay

A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma

scientific article published on 28 December 2016

AKT1 represses gene conversion induced by different genotoxic stresses and induces supernumerary centrosomes and aneuploidy in hamster ovary cells.

artículo científico publicado en 2009

ATG2B and GSKIP: 2 new genes predisposing to myeloid malignancies

artículo científico publicado en 2015

Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0

artículo científico publicado en 2016

An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia

scientific article published on 20 July 2009

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.

artículo científico publicado en 2016

Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms

scientific article published on 29 June 2009

Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals.

artículo científico publicado en 2004

BRCA1-Ku80 Protein Interaction Enhances End-joining Fidelity of Chromosomal Double-strand Breaks in the G1 Phase of the Cell Cycle ⬇️

artículo científico publicado el 23 de enero de 2013

CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner

artículo científico publicado en 2016

CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress

artículo científico publicado en 2016

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

artículo científico publicado en 2015

Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineage.

artículo científico publicado en 2008

Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect.

artículo científico publicado en 2017

DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation.

artículo científico publicado en 2014

Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: implication in drug-induced ceramide generation and apoptosis

artículo científico publicado en 1999

Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells

scientific article published on 01 December 2019

Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms

artículo científico publicado en 2020

Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution

scientific article published on 12 September 2014

Differential contributions of STAT5A and STAT5B to stress protection and tyrosine kinase inhibitor resistance of chronic myeloid leukemia stem/progenitor cells

artículo científico publicado en 2013

Disrupted filamin A/αβ interaction induces macrothrombocytopenia by increasing RhoA activity

artículo científico publicado en 2019

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

artículo científico publicado en 2017

EZH2: a molecular switch of the MPN phenotype

artículo científico publicado en 2016

Eltrombopag, a potent stimulator of megakaryopoiesis.

artículo científico publicado en 2016

Emergence of a BCR-ABL translocation in a patient with the JAK2V617F mutation: evidence for secondary acquisition of BCR-ABL in the JAK2V617F clone.

artículo científico publicado en 2014

Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis

artículo científico publicado en 2017

Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors

scientific article published on 07 January 2014

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies

artículo científico publicado en 2015

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis

artículo científico publicado en 2018

Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients

artículo científico publicado en 2013

Identification of MPL R102P Mutation in Hereditary Thrombocytosis.

artículo científico publicado en 2017

Impact of interferon on a triple positive polycythemia vera

artículo científico publicado en 2019

Inherited transmission of the CSF3R T618I mutational hotspot in familial chronic neutrophilic leukemia

scientific article published on 01 December 2019

JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders.

artículo científico publicado en 2018

JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

artículo científico publicado en 2008

Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cγ ⬇️

artículo científico publicado el 11 de octubre de 2001

Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect.

artículo científico publicado en 2002

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.

artículo científico publicado en 2014

Molecular and genetic bases of myeloproliferative disorders: questions and perspectives.

artículo científico publicado en 2009

Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond-like syndrome

artículo científico publicado en 2018

Myeloproliferative neoplasms: JAK2 signaling pathway as a central target for therapy.

artículo científico

New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis.

artículo científico publicado en 2017

Not just another kinase mutation!

artículo científico publicado en 2019

P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.

artículo científico publicado en 2016

P53 deletion and NrasG12D cooperate for AML

artículo científico publicado en 2017

Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin.

artículo científico publicado en 2016

Ph(-) myeloproliferative neoplasm red blood cells display deregulation of IQGAP1-Rho GTPase signaling depending on CALR/JAK2 status

artículo científico publicado en 2016

Phosphatidylcholine‐derived phosphatidic acid and diacylglycerol are involved in the signaling pathways activated by docetaxel ⬇️

artículo científico publicado el 1 de enero de 2003

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients

artículo científico publicado en 2015

Properties and biological roles of TET proteins during embryogenesis and in hematopoiesis

artículo científico publicado en 2015

Quantitative Proteome Heterogeneity in Myeloproliferative Neoplasm Subtypes and Association with JAK2 Mutation Status.

artículo científico publicado en 2017

Recent advances in understanding myelofibrosis and essential thrombocythemia

artículo científico publicado en 2016

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.

artículo científico publicado en 2014

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

scientific journal article

TET2 loss, a rescue of JAK2V617F HSCs.

artículo científico publicado en 2015

TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis.

artículo científico publicado en 2016

Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms.

artículo científico publicado en 2013

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.

artículo científico publicado en 2015

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands

artículo científico

Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint

artículo científico publicado en 2016

Use of the 46/1 haplotype to model JAK2(V617F) clonal architecture in PV patients: clonal evolution and impact of IFNα treatment.

artículo científico publicado en 2013

p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging

artículo científico publicado en 2014

p53 at the crossroads of MPN treatment.

artículo científico publicado en 2014

Lista de obras de Isabelle Plo

A driver role for GABA metabolism in controlling stem and proliferative cell state through GHB production in glioma

AKT1 represses gene conversion induced by different genotoxic stresses and induces supernumerary centrosomes and aneuploidy in hamster ovary cells.

ATG2B and GSKIP: 2 new genes predisposing to myeloid malignancies

Acquired TET2 mutation in one patient with familial platelet disorder with predisposition to AML led to the development of pre-leukaemic clone resulting in T2-ALL and AML-M0

An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia

An incomplete trafficking defect to the cell-surface leads to paradoxical thrombocytosis for human and murine MPL P106L.

Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms

Apoptotic topoisomerase I-DNA complexes induced by staurosporine-mediated oxygen radicals.

BRCA1-Ku80 Protein Interaction Enhances End-joining Fidelity of Chromosomal Double-strand Breaks in the G1 Phase of the Cell Cycle ⬇️

CXCL12/CXCR4 pathway is activated by oncogenic JAK2 in a PI3K-dependent manner

CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress

Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis

Constitutive JunB expression, associated with the JAK2 V617F mutation, stimulates proliferation of the erythroid lineage.

Critical role of the HDAC6-cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect.

DNA binding of the p21 repressor ZBTB2 is inhibited by cytosine hydroxymethylation.

Daunorubicin- and mitoxantrone-triggered phosphatidylcholine hydrolysis: implication in drug-induced ceramide generation and apoptosis

Description of a knock-in mouse model of JAK2V617F MPN emerging from a minority of mutated hematopoietic stem cells

Different impact of calreticulin mutations on human hematopoiesis in myeloproliferative neoplasms

Differential association of calreticulin type 1 and type 2 mutations with myelofibrosis and essential thrombocytemia: relevance for disease evolution

Differential contributions of STAT5A and STAT5B to stress protection and tyrosine kinase inhibitor resistance of chronic myeloid leukemia stem/progenitor cells

Disrupted filamin A/αβ interaction induces macrothrombocytopenia by increasing RhoA activity

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

EZH2: a molecular switch of the MPN phenotype

Eltrombopag, a potent stimulator of megakaryopoiesis.

Emergence of a BCR-ABL translocation in a patient with the JAK2V617F mutation: evidence for secondary acquisition of BCR-ABL in the JAK2V617F clone.

Genetic Alterations of the Thrombopoietin/MPL/JAK2 Axis Impacting Megakaryopoiesis

Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors

Germline duplication of ATG2B and GSKIP predisposes to familial myeloid malignancies

HSP27 is a partner of JAK2-STAT5 and a potential therapeutic target in myelofibrosis

Heterozygous and homozygous JAK2(V617F) states modeled by induced pluripotent stem cells from myeloproliferative neoplasm patients

Identification of MPL R102P Mutation in Hereditary Thrombocytosis.

Impact of interferon on a triple positive polycythemia vera

Inherited transmission of the CSF3R T618I mutational hotspot in familial chronic neutrophilic leukemia

JAK inhibitors for the treatment of myeloproliferative neoplasms and other disorders.

JAK2 stimulates homologous recombination and genetic instability: potential implication in the heterogeneity of myeloproliferative disorders.

Kit signaling and negative regulation of daunorubicin-induced apoptosis: role of phospholipase Cγ ⬇️

Kit signaling inhibits the sphingomyelin-ceramide pathway through PLC gamma 1: implication in stem cell factor radioprotective effect.

Level of RUNX1 activity is critical for leukemic predisposition but not for thrombocytopenia.

Molecular and genetic bases of myeloproliferative disorders: questions and perspectives.

Mutations in the SRP54 gene cause severe congenital neutropenia as well as Shwachman-Diamond-like syndrome

Myeloproliferative neoplasms: JAK2 signaling pathway as a central target for therapy.

New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis.

Not just another kinase mutation!

P53 activation inhibits all types of hematopoietic progenitors and all stages of megakaryopoiesis.

P53 deletion and NrasG12D cooperate for AML

Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin.

Ph(-) myeloproliferative neoplasm red blood cells display deregulation of IQGAP1-Rho GTPase signaling depending on CALR/JAK2 status

Phosphatidylcholine‐derived phosphatidic acid and diacylglycerol are involved in the signaling pathways activated by docetaxel ⬇️

Presence of atypical thrombopoietin receptor (MPL) mutations in triple-negative essential thrombocythemia patients

Properties and biological roles of TET proteins during embryogenesis and in hematopoiesis

Quantitative Proteome Heterogeneity in Myeloproliferative Neoplasm Subtypes and Association with JAK2 Mutation Status.

Recent advances in understanding myelofibrosis and essential thrombocythemia

TET2 deficiency inhibits mesoderm and hematopoietic differentiation in human embryonic stem cells.

TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis

TET2 loss, a rescue of JAK2V617F HSCs.

TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis.

Thrombocytopenia induced by the histone deacetylase inhibitor abexinostat involves p53-dependent and -independent mechanisms.

Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants.

Tuning cytokine receptor signaling by re-orienting dimer geometry with surrogate ligands

Uncoupling of the Hippo and Rho pathways allows megakaryocytes to escape the tetraploid checkpoint

Use of the 46/1 haplotype to model JAK2(V617F) clonal architecture in PV patients: clonal evolution and impact of IFNα treatment.

p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging

p53 at the crossroads of MPN treatment.