Lista de obras - Robert G. Salomon - Dominio Público Uruguay

(Carboxyalkyl)pyrroles in human plasma and oxidized low-density lipoproteins

artículo científico publicado en 1997

2-(ω-Carboxyethyl)pyrrole Antibody as a New Inhibitor of Tumor Angiogenesis and Growth.

artículo científico publicado en 2016

4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Biologically Active Precursor for the Generation of 2-(ω-Carboxyethyl)pyrrole (CEP) Derivatives of Proteins and Ethanolamine Phospholipids

artículo científico publicado en 2015

4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Induces Angiogenesis through Several Different Molecular Pathways

artículo científico publicado en 2016

4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells

artículo científico publicado en 2018

A 13-Oxo-9,10-epoxytridecenoate phospholipid analogue of the genotoxic 4,5-epoxy-2E-decenal: detection in vivo, chemical synthesis, and adduction with DNA.

artículo científico publicado en 2010

A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration

scientific article published on 12 March 2010

A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions.

artículo científico publicado en 2002

A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products.

artículo científico publicado en 2006

An efficient synthesis of γ-hydroxy-α,β-unsaturated aldehydic esters of 2-lysophosphatidylcholine ⬇️

artículo científico publicado el 31 de octubre de 2010

An1O2Route to γ-Hydroxyalkenal Phospholipids by Vitamin E-Induced Fragmentation of Hydroperoxydiene-Derived Endoperoxides ⬇️

artículo científico publicado el 31 de mayo de 2011

Anhydrolevuglandin D2 inhibits the uterotonic acivity of prostaglandins F2α and D2

artículo científico publicado en 1988

Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers.

artículo científico publicado en 2009

Bioactive 4-Oxoheptanedioic Monoamide Derivatives of Proteins and Ethanolaminephospholipids: Products of Docosahexaenoate Oxidation.

artículo científico publicado en 2016

Brain tissue injury and blood-brain barrier opening induced by injection of LGE2 or PGE2

artículo científico publicado el 1 de octubre de 1992

CEP biomarkers as potential tools for monitoring therapeutics

artículo científico publicado en 2013

Carboxyethylpyrrole adducts, age-related macular degeneration and neovascularization.

artículo científico publicado en 2008

Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration.

artículo científico publicado en 2003

Carboxyethylpyrroles: From Hypothesis to the Discovery of Biologically Active Natural Products

artículo científico publicado en 2016

Cardiolipin: characterization of distinct oxidized molecular species

artículo científico publicado en 2011

Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse

scientific article published on 01 May 2005

Conformation of an endogenous ligand in a membrane bilayer for the macrophage scavenger receptor CD36

artículo científico publicado en 2007

Critical Insights into Cardiovascular Disease from Basic Research on the Oxidation of Phospholipids: The γ-Hydroxyalkenal Phospholipid Hypothesis ⬇️

artículo científico publicado el 30 de septiembre de 2011

Detection and biological activities of carboxyethylpyrrole ethanolamine phospholipids (CEP-EPs).

artículo científico publicado en 2014

Discovery of carboxyethylpyrroles (CEPs): critical insights into AMD, autism, cancer, and wound healing from basic research on the chemistry of oxidized phospholipids

artículo científico publicado en 2011

Distinguishing levuglandins produced through the cyclooxygenase and isoprostane pathways.

artículo científico publicado en 2005

Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

artículo científico publicado en 2002

Effects of E2 levuglandins on the contractile activity of the rat uterus

artículo científico publicado en 1987

Efficient Quantitative Analysis of Carboxyalkylpyrrole Ethanolamine Phospholipids: Elevated Levels in Sickle Cell Disease Blood

artículo científico publicado en 2016

Electrophilic levuglandin E2-protein adducts bind glycine: a model for protein crosslinking

artículo científico publicado en 1990

Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis.

artículo científico publicado en 2012

Fe2+ catalyzes vitamin E-induced fragmentation of hydroperoxy and hydroxy endoperoxides that generates gamma-hydroxy alkenals

artículo científico publicado en 2007

Formation and stability of pyrrole adducts in the reaction of levuglandin E2 with proteins

artículo científico publicado en 1995

Formation of gamma-ketoaldehyde-protein adducts during ethanol-induced liver injury in mice.

artículo científico publicado en 2009

Fragmentation of a linoleate-derived γ-hydroperoxy-α,β-unsaturated epoxide to γ-hydroxy- and γ-oxo-alkenals involves a unique pseudo-symmetrical diepoxycarbinyl radical.

artículo científico publicado en 2011

Fragmentation of β-Hydroxy Hydroperoxides ⬇️

artículo científico publicado el 24 de enero de 2012

Gamma-hydroxyalkenals are oxidatively cleaved through Michael addition of acylperoxy radicals and fragmentation of intermediate beta-hydroxyperesters.

artículo científico publicado en 2004

HNE-derived 2-pentylpyrroles are generated during oxidation of LDL, are more prevalent in blood plasma from patients with renal disease or atherosclerosis, and are present in atherosclerotic plaques

artículo científico publicado en 2000

High-resolution dynamic oxygen-17 MR imaging of mouse brain with golden-ratio-based radial sampling and k-space-weighted image reconstruction.

artículo científico publicado en 2017

Hydroxy alkenal phospholipids regulate inflammatory functions of endothelial cells.

artículo científico publicado en 2002

Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36

scientific journal article

Identification of extremely reactive gamma-ketoaldehydes (isolevuglandins) as products of the isoprostane pathway and characterization of their lysyl protein adducts

artículo científico publicado en 1999

Identification of oxidatively truncated ethanolamine phospholipids in retina and their generation from polyunsaturated phosphatidylethanolamines

artículo científico publicado en 2006

Immunochemical evidence supporting 2-pentylpyrrole formation on proteins exposed to 4-hydroxy-2-nonenal

artículo científico publicado en 1996

Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration.

artículo científico publicado en 2013

Isolevuglandin adducts in disease

artículo científico publicado en 2015

Isolevuglandin-modified proteins, including elevated levels of inactive calpain-1, accumulate in glaucomatous trabecular meshwork

artículo científico publicado en 2007

Isolevuglandin-protein adducts in humans: products of free radical-induced lipid oxidation through the isoprostane pathway

scientific article published on 01 May 2000

Isolevuglandin-protein adducts in oxidized low density lipoprotein and human plasma: a strong connection with cardiovascular disease.

artículo científico publicado en 2000

Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1

artículo científico publicado en 2011

Isolevuglandins, a novel class of isoprostenoid derivatives, function as integrated sensors of oxidant stress and are generated by myeloperoxidase in vivo.

artículo científico publicado en 2003

Leukocytes utilize myeloperoxidase-generated nitrating intermediates as physiological catalysts for the generation of biologically active oxidized lipids and sterols in serum

artículo científico publicado en 1999

Levuglandin E2 crosslinks proteins

artículo científico publicado en 1989

Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions.

artículo científico publicado en 2005

Lysophosphatidylcholine is Generated by Spontaneous Deacylation of Oxidized Phospholipids ⬇️

artículo científico publicado el 25 de octubre de 2010

Macrophage recognition of LDL modified by levuglandin E2, an oxidation product of arachidonic acid

artículo científico publicado en 1997

Measurement of oxidation in plasma Lp(a) in CAPD patients using a novel ELISA.

artículo científico publicado en 1998

Metabolism of 4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone by Retinal Pigmented Epithelial Cells

artículo científico publicado en 2016

Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate.

artículo científico publicado en 2012

Molecular Structures of Isolevuglandin-Protein Cross-Links.

artículo científico publicado en 2016

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

artículo científico publicado en 2012

Neuroprotection in glaucoma using calpain-1 inhibitors: regional differences in calpain-1 activity in the trabecular meshwork, optic nerve and implications for therapeutics

artículo científico publicado en 2008

Novel bioactive phospholipids: practical total syntheses of products from the oxidation of arachidonic and linoleic esters of 2-lysophosphatidylcholine(1).

artículo científico publicado en 2002

Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE-/- mice and activate platelets via TLR2.

artículo científico publicado en 2016

Oxidation of low-density lipoproteins produces levuglandin-protein adducts

scientific article published on 01 July 1997

Oxidative damage-induced inflammation initiates age-related macular degeneration.

scientific article published on 27 January 2008

Oxidative fragmentation of hydroxy octadecadienoates generates biologically active gamma-hydroxyalkenals.

artículo científico publicado en 2004

Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

artículo científico publicado en 2010

Phospholipid hydroxyalkenals, a subset of recently discovered endogenous CD36 ligands, spontaneously generate novel furan-containing phospholipids lacking CD36 binding activity in vivo

artículo científico publicado en 2006

Phospholipid hydroxyalkenals: biological and chemical properties of specific oxidized lipids present in atherosclerotic lesions.

artículo científico publicado en 2003

Physiological evidence for the possible existence of anhydrolevuglandin E2-like activity in extracts and media from uteri of rats

artículo científico publicado en 1992

Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype.

artículo científico publicado en 2007

Polyunsaturated phospholipids promote the oxidation and fragmentation of gamma-hydroxyalkenals: formation and reactions of oxidatively truncated ether phospholipids

artículo científico publicado en 2007

Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1

artículo científico publicado en 2013

Preparative singlet oxygenation of linoleate provides doubly allylic dihydroperoxides: putative intermediates in the generation of biologically active aldehydes in vivo

artículo científico publicado en 2006

Preservation of cardiolipin content during aging in rat heart interfibrillar mitochondria.

artículo científico publicado en 2002

Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

artículo científico publicado en 2013

Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

artículo científico publicado en 2013

Prostaglandin endoperoxides 21. Covalent binding of levuglandin E2 with proteins

scientific article published on 01 November 1987

Protective role of HO-1 and carbon monoxide in ethanol-induced hepatocyte cell death and liver injury in mice

artículo científico publicado en 2014

Protein adducts of iso[4]levuglandin E2, a product of the isoprostane pathway, in oxidized low density lipoprotein

artículo científico publicado en 1999

Proteomic and genomic biomarkers for age-related macular degeneration.

artículo científico publicado en 2010

Pyrrole formation from 4-hydroxynonenal and primary amines

artículo científico publicado en 1993

Receptor-Mediated Mechanism Controlling Tissue Levels of Bioactive Lipid Oxidation Products

artículo científico publicado en 2015

Retinal pigment epithelium lipofuscin proteomics.

artículo científico publicado en 2008

Serum vitamin E and oxidative protein modification in hemodialysis: a randomized clinical trial

scientific article published on 01 August 2007

Specific oxidized phospholipids inhibit scavenger receptor bi-mediated selective uptake of cholesteryl esters.

artículo científico publicado en 2008

Stereospecific total synthesis of prostaglandins via reaction of alpha-alkylcyclopentenones with organocuprates

artículo científico publicado en 1975

Structural identification and cardiovascular activities of oxidized phospholipids.

artículo científico publicado en 2012

Synthesis and structural characterization of carboxyethylpyrrole-modified proteins: mediators of age-related macular degeneration.

artículo científico publicado en 2009

Synthesis of thermal reactivity of some 2,3-dioxabicyclo[2.2.1]heptane models of prostaglandin endoperoxides

scientific article published on 01 January 1977

T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration

artículo científico publicado en 2014

The lipid whisker model of the structure of oxidized cell membranes

artículo científico publicado en 2007

The mechanism of fenretinide (4-HPR) inhibition of β-carotene monooxygenase 1. New suspect for the visual side effects of fenretinide

scientific article published on 01 January 2012

The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophages

artículo científico publicado en 2014

Total Synthesis Confirms the Molecular Structure Proposed for Oxidized Levuglandin D2.

artículo científico publicado en 2017

Total syntheses of bioactive oxidized ethanolamine phospholipids

scientific article published on 01 August 2003

Total synthesis of 17-isoLevuglandin E4 and the structure of C22-PGF4alpha

scientific article published on 01 August 2000

Total synthesis of anhydro levug̀landin D2

Total synthesis of oxidized phospholipids. 3. The (11E)-9-hydroxy-13-oxotridec-11-enoate ester of 2-lysophosphatidylcholine.

artículo científico publicado en 2000

Total synthesis of prostaglandins. II. Prostaglandin E 1

article by C J Sih et al published 1 May 1972 in Journal of the American Chemical Society

Lista de obras de Robert G. Salomon

(Carboxyalkyl)pyrroles in human plasma and oxidized low-density lipoproteins

2-(ω-Carboxyethyl)pyrrole Antibody as a New Inhibitor of Tumor Angiogenesis and Growth.

4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Biologically Active Precursor for the Generation of 2-(ω-Carboxyethyl)pyrrole (CEP) Derivatives of Proteins and Ethanolamine Phospholipids

4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Induces Angiogenesis through Several Different Molecular Pathways

4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells

A 13-Oxo-9,10-epoxytridecenoate phospholipid analogue of the genotoxic 4,5-epoxy-2E-decenal: detection in vivo, chemical synthesis, and adduction with DNA.

A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration

A novel family of atherogenic oxidized phospholipids promotes macrophage foam cell formation via the scavenger receptor CD36 and is enriched in atherosclerotic lesions.

A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products.

An efficient synthesis of γ-hydroxy-α,β-unsaturated aldehydic esters of 2-lysophosphatidylcholine ⬇️

An1O2Route to γ-Hydroxyalkenal Phospholipids by Vitamin E-Induced Fragmentation of Hydroperoxydiene-Derived Endoperoxides ⬇️

Anhydrolevuglandin D2 inhibits the uterotonic acivity of prostaglandins F2α and D2

Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers.

Bioactive 4-Oxoheptanedioic Monoamide Derivatives of Proteins and Ethanolaminephospholipids: Products of Docosahexaenoate Oxidation.

Brain tissue injury and blood-brain barrier opening induced by injection of LGE2 or PGE2

CEP biomarkers as potential tools for monitoring therapeutics

Carboxyethylpyrrole adducts, age-related macular degeneration and neovascularization.

Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration.

Carboxyethylpyrroles: From Hypothesis to the Discovery of Biologically Active Natural Products

Cardiolipin: characterization of distinct oxidized molecular species

Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse

Conformation of an endogenous ligand in a membrane bilayer for the macrophage scavenger receptor CD36

Critical Insights into Cardiovascular Disease from Basic Research on the Oxidation of Phospholipids: The γ-Hydroxyalkenal Phospholipid Hypothesis ⬇️

Detection and biological activities of carboxyethylpyrrole ethanolamine phospholipids (CEP-EPs).

Discovery of carboxyethylpyrroles (CEPs): critical insights into AMD, autism, cancer, and wound healing from basic research on the chemistry of oxidized phospholipids

Distinguishing levuglandins produced through the cyclooxygenase and isoprostane pathways.

Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

Effects of E2 levuglandins on the contractile activity of the rat uterus

Efficient Quantitative Analysis of Carboxyalkylpyrrole Ethanolamine Phospholipids: Elevated Levels in Sickle Cell Disease Blood

Electrophilic levuglandin E2-protein adducts bind glycine: a model for protein crosslinking

Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis.

Fe2+ catalyzes vitamin E-induced fragmentation of hydroperoxy and hydroxy endoperoxides that generates gamma-hydroxy alkenals

Formation and stability of pyrrole adducts in the reaction of levuglandin E2 with proteins

Formation of gamma-ketoaldehyde-protein adducts during ethanol-induced liver injury in mice.

Fragmentation of a linoleate-derived γ-hydroperoxy-α,β-unsaturated epoxide to γ-hydroxy- and γ-oxo-alkenals involves a unique pseudo-symmetrical diepoxycarbinyl radical.

Fragmentation of β-Hydroxy Hydroperoxides ⬇️

Gamma-hydroxyalkenals are oxidatively cleaved through Michael addition of acylperoxy radicals and fragmentation of intermediate beta-hydroxyperesters.

HNE-derived 2-pentylpyrroles are generated during oxidation of LDL, are more prevalent in blood plasma from patients with renal disease or atherosclerosis, and are present in atherosclerotic plaques

High-resolution dynamic oxygen-17 MR imaging of mouse brain with golden-ratio-based radial sampling and k-space-weighted image reconstruction.

Hydroxy alkenal phospholipids regulate inflammatory functions of endothelial cells.

Identification of a novel family of oxidized phospholipids that serve as ligands for the macrophage scavenger receptor CD36

Identification of extremely reactive gamma-ketoaldehydes (isolevuglandins) as products of the isoprostane pathway and characterization of their lysyl protein adducts

Identification of oxidatively truncated ethanolamine phospholipids in retina and their generation from polyunsaturated phosphatidylethanolamines

Immunochemical evidence supporting 2-pentylpyrrole formation on proteins exposed to 4-hydroxy-2-nonenal

Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration.

Isolevuglandin adducts in disease

Isolevuglandin-modified proteins, including elevated levels of inactive calpain-1, accumulate in glaucomatous trabecular meshwork

Isolevuglandin-protein adducts in humans: products of free radical-induced lipid oxidation through the isoprostane pathway

Isolevuglandin-protein adducts in oxidized low density lipoprotein and human plasma: a strong connection with cardiovascular disease.

Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1

Isolevuglandins, a novel class of isoprostenoid derivatives, function as integrated sensors of oxidant stress and are generated by myeloperoxidase in vivo.

Leukocytes utilize myeloperoxidase-generated nitrating intermediates as physiological catalysts for the generation of biologically active oxidized lipids and sterols in serum

Levuglandin E2 crosslinks proteins

Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions.

Lysophosphatidylcholine is Generated by Spontaneous Deacylation of Oxidized Phospholipids ⬇️

Macrophage recognition of LDL modified by levuglandin E2, an oxidation product of arachidonic acid

Measurement of oxidation in plasma Lp(a) in CAPD patients using a novel ELISA.

Metabolism of 4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone by Retinal Pigmented Epithelial Cells

Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate.

Molecular Structures of Isolevuglandin-Protein Cross-Links.

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

Neuroprotection in glaucoma using calpain-1 inhibitors: regional differences in calpain-1 activity in the trabecular meshwork, optic nerve and implications for therapeutics

Novel bioactive phospholipids: practical total syntheses of products from the oxidation of arachidonic and linoleic esters of 2-lysophosphatidylcholine(1).

Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE-/- mice and activate platelets via TLR2.

Oxidation of low-density lipoproteins produces levuglandin-protein adducts

Oxidative damage-induced inflammation initiates age-related macular degeneration.

Oxidative fragmentation of hydroxy octadecadienoates generates biologically active gamma-hydroxyalkenals.

Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

Phospholipid hydroxyalkenals, a subset of recently discovered endogenous CD36 ligands, spontaneously generate novel furan-containing phospholipids lacking CD36 binding activity in vivo

Phospholipid hydroxyalkenals: biological and chemical properties of specific oxidized lipids present in atherosclerotic lesions.

Physiological evidence for the possible existence of anhydrolevuglandin E2-like activity in extracts and media from uteri of rats

Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype.

Polyunsaturated phospholipids promote the oxidation and fragmentation of gamma-hydroxyalkenals: formation and reactions of oxidatively truncated ether phospholipids

Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1

Preparative singlet oxygenation of linoleate provides doubly allylic dihydroperoxides: putative intermediates in the generation of biologically active aldehydes in vivo

Preservation of cardiolipin content during aging in rat heart interfibrillar mitochondria.

Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

Prostaglandin endoperoxides 21. Covalent binding of levuglandin E2 with proteins