Lista de obras - William J. Ray - Dominio Público Uruguay

A complex of iron and nucleic acid catabolites is a signal that triggers differentiation in a freshwater protozoan

artículo científico publicado en 2000

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

artículo científico publicado en 2000

Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase

artículo científico publicado en 2014

Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways.

artículo científico publicado en 2004

Beyond amyloid: the next generation of Alzheimer's disease therapeutics.

artículo científico publicado en 2007

CYP26, a Novel Mammalian Cytochrome P450, Is Induced by Retinoic Acid and Defines a New Family ⬇️

artículo científico publicado el 25 de julio de 1997

Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs)

scientific article published on 01 August 2009

Development of a microplate fluorescence assay for kynurenine aminotransferase

artículo científico publicado en 2010

Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.

artículo científico publicado en 2011

Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators

artículo científico publicado en 2014

ES cell neural differentiation reveals a substantial number of novel ESTs.

artículo científico publicado en 2000

Enhanced histamine H2 excitation of striatal cholinergic interneurons in L-DOPA-induced dyskinesia

artículo científico

Expression of ionotropic glutamate receptor genes by P19 embryonal carcinoma cells.

artículo científico publicado en 1993

Fused heterocyclic M1 positive allosteric modulators

artículo científico publicado en 2010

Gene expression analyses in cynomolgus monkeys provides mechanistic insight into high-density lipoprotein-cholesterol reduction by androgens in primates.

artículo científico publicado en 2008

High Throughput Monitoring of Amyloid-β42 Assembly into Soluble Oligomers Achieved by Sensitive Conformation State-Dependent Immunoassays ⬇️

artículo científico publicado el 1 de enero de 2011

High-throughput screening by RNA interference: control of two distinct types of variance

artículo científico publicado en 2007

Hydroxy cycloalkyl fused pyridone carboxylic acid M(1) positive allosteric modulators

artículo científico publicado en 2010

Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.

artículo científico publicado en 2014

Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators

artículo científico publicado en 2012

Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells

artículo científico publicado en 2014

Identification of genetic pathways activated by the androgen receptor during the induction of proliferation in the ventral prostate gland.

artículo científico

Induction of Alzheimer’s-like changes in brain of mice expressing mutant APP fed excess methionine ⬇️

artículo científico publicado el 2 de diciembre de 2010

LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease

artículo científico publicado en 2006

MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate

artículo científico publicado en 2018

Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging

artículo científico publicado en 2011

Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease.

artículo científico publicado en 1998

N-heterocyclic derived M1 positive allosteric modulators.

artículo científico publicado en 2010

Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein.

artículo científico publicado en 2008

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators

artículo científico publicado en 2009

Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing

artículo científico publicado en 2015

Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

artículo científico publicado en 2000

Probability of Alzheimer's disease in breast cancer survivors based on gray-matter structural network efficiency

artículo científico publicado en 2017

Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.

artículo científico publicado en 2009

Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series.

artículo científico publicado en 2011

Quinolizidinone carboxylic acids as CNS penetrant, selective m1 allosteric muscarinic receptor modulators

artículo científico publicado en 2010

Retinoic acid promotes neural and represses mesodermal gene expression in mouse embryonic stem cells in culture.

artículo científico publicado en 1996

Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.

artículo científico publicado en 2007

Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis.

artículo científico publicado en 2006

The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque.

artículo científico publicado en 2012

Lista de obras de William J. Ray

A complex of iron and nucleic acid catabolites is a signal that triggers differentiation in a freshwater protozoan

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase

Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways.

Beyond amyloid: the next generation of Alzheimer's disease therapeutics.

CYP26, a Novel Mammalian Cytochrome P450, Is Induced by Retinoic Acid and Defines a New Family ⬇️

Design, synthesis, and biological evaluation of 16-substituted 4-azasteroids as tissue-selective androgen receptor modulators (SARMs)

Development of a microplate fluorescence assay for kynurenine aminotransferase

Discovery of a selective allosteric M1 receptor modulator with suitable development properties based on a quinolizidinone carboxylic acid scaffold.

Discovery of naphthyl-fused 5-membered lactams as a new class of m1 positive allosteric modulators

ES cell neural differentiation reveals a substantial number of novel ESTs.

Enhanced histamine H2 excitation of striatal cholinergic interneurons in L-DOPA-induced dyskinesia

Expression of ionotropic glutamate receptor genes by P19 embryonal carcinoma cells.

Fused heterocyclic M1 positive allosteric modulators

Gene expression analyses in cynomolgus monkeys provides mechanistic insight into high-density lipoprotein-cholesterol reduction by androgens in primates.

High Throughput Monitoring of Amyloid-β42 Assembly into Soluble Oligomers Achieved by Sensitive Conformation State-Dependent Immunoassays ⬇️

High-throughput screening by RNA interference: control of two distinct types of variance

Hydroxy cycloalkyl fused pyridone carboxylic acid M(1) positive allosteric modulators

Identification of a methoxynaphthalene scaffold as a core replacement in quinolizidinone amide M(1) positive allosteric modulators.

Identification of amides as carboxylic Acid surrogates for quinolizidinone-based m1 positive allosteric modulators

Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells

Identification of genetic pathways activated by the androgen receptor during the induction of proliferation in the ventral prostate gland.

Induction of Alzheimer’s-like changes in brain of mice expressing mutant APP fed excess methionine ⬇️

LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease

MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate

Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging

Molecular pathogenesis of sporadic and familial forms of Alzheimer's disease.

N-heterocyclic derived M1 positive allosteric modulators.

Oxysterol-binding protein-1 (OSBP1) modulates processing and trafficking of the amyloid precursor protein.

Parallel synthesis of N-biaryl quinolone carboxylic acids as selective M(1) positive allosteric modulators

Pathway-based analysis of genome-wide siRNA screens reveals the regulatory landscape of APP processing

Posttranslational modification and plasma membrane localization of the Drosophila melanogaster presenilin.

Probability of Alzheimer's disease in breast cancer survivors based on gray-matter structural network efficiency

Pyridine containing M(1) positive allosteric modulators with reduced plasma protein binding.

Quinolizidinone carboxylic acid selective M1 allosteric modulators: SAR in the piperidine series.

Quinolizidinone carboxylic acids as CNS penetrant, selective m1 allosteric muscarinic receptor modulators

Retinoic acid promotes neural and represses mesodermal gene expression in mouse embryonic stem cells in culture.

Role of STAT5a in regulation of sex-specific gene expression in female but not male mouse liver revealed by microarray analysis.

Sex-dependent liver gene expression is extensive and largely dependent upon signal transducer and activator of transcription 5b (STAT5b): STAT5b-dependent activation of male genes and repression of female genes revealed by microarray analysis.

The muscarinic M1 receptor positive allosteric modulator PQCA improves cognitive measures in rat, cynomolgus macaque, and rhesus macaque.