Lista de obras - Martijn Brugman - Dominio Público Uruguay

Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.

artículo científico publicado en 2012

Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.

artículo científico publicado en 2012

Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery

artículo científico publicado en 2011

Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery

Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.

artículo científico publicado en 2011

Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK.

artículo científico publicado en 2010

Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning

artículo científico publicado en 2011

Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.

artículo científico publicado en 2007

Eliminating HIV-1 Packaging Sequences from Lentiviral Vector Proviruses Enhances Safety and Expedites Gene Transfer for Gene Therapy

artículo científico publicado en 2017

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

artículo científico publicado en 2007

Gene therapy: is IL2RG oncogenic in T-cell development?

artículo científico publicado en 2006

Hepatic lentiviral gene transfer is associated with clonal selection, but not with tumor formation in serially transplanted rodents.

artículo científico publicado en 2013

Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential.

artículo científico publicado en 2005

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy

artículo científico publicado en 2011

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

artículo científico publicado en 2008

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors

artículo científico publicado en 2009

Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia

artículo científico publicado en 2011

Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.

artículo científico publicado en 2011

Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells.

artículo científico publicado en 2011

Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16

artículo científico publicado en 2008

Leukemias induced by altered TRK-signaling are sensitive to mTOR inhibitors in preclinical models.

artículo científico publicado en 2010

Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors.

artículo científico publicado en 2009

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages.

artículo científico publicado en 2013

Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutations

artículo científico publicado en 2012

Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.

artículo científico publicado en 2011

Resistance of mature T cells to oncogene transformation

artículo científico publicado en 2008

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways

artículo científico publicado en 2006

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis

artículo científico publicado en 2014

Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance

artículo científico publicado en 2008

Sustained Engraftment of Cryopreserved Human Bone Marrow CD34(+) Cells in Young Adult NSG Mice.

artículo científico publicado en 2014

TRIF signaling drives homeostatic intestinal epithelial antimicrobial peptide expression

artículo científico publicado en 2014

The genomic risk of somatic gene therapy

scientific article published on July 2010

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

artículo científico publicado en 2007

Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development ⬇️

artículo científico publicado el 15 de diciembre de 2011

Lista de obras de Martijn Brugman

Activation of Evi1 inhibits cell cycle progression and differentiation of hematopoietic progenitor cells.

Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity.

Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery

Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery

Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion.

Correction of B-cell development in Btk-deficient mice using lentiviral vectors with codon-optimized human BTK.

Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning

Ectopic retroviral expression of LMO2, but not IL2Rgamma, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy.

Eliminating HIV-1 Packaging Sequences from Lentiviral Vector Proviruses Enhances Safety and Expedites Gene Transfer for Gene Therapy

Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo

Gene therapy: is IL2RG oncogenic in T-cell development?

Hepatic lentiviral gene transfer is associated with clonal selection, but not with tumor formation in serially transplanted rodents.

Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential.

Insertion sites in engrafted cells cluster within a limited repertoire of genomic areas after gammaretroviral vector gene therapy

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors

Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia

Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming.

Lentiviral vectors for induction of self-differentiation and conditional ablation of dendritic cells.

Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16

Leukemias induced by altered TRK-signaling are sensitive to mTOR inhibitors in preclinical models.

Mechanisms controlling titer and expression of bidirectional lentiviral and gammaretroviral vectors.

Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti-inflammatory macrophages.

Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutations

Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells.

Resistance of mature T cells to oncogene transformation

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis

Stem cell marking with promotor-deprived self-inactivating retroviral vectors does not lead to induced clonal imbalance

Sustained Engraftment of Cryopreserved Human Bone Marrow CD34(+) Cells in Young Adult NSG Mice.

TRIF signaling drives homeostatic intestinal epithelial antimicrobial peptide expression

The genomic risk of somatic gene therapy

Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy

Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development ⬇️