Lista de obras - Bart O Williams - Dominio Público Uruguay

(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice

artículo científico publicado en 2015

A Dynamic WNT/β-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells

artículo científico publicado en 2016

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling

artículo científico publicado en 2002

A subset of p53-deficient embryos exhibit exencephaly

artículo científico publicado en 1995

APC inhibits ERK pathway activation and cellular proliferation induced by RAS

scientific journal article

Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury.

artículo científico publicado en 2014

Activation of Wnt/β-catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia.

artículo científico publicado en 2014

Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models

artículo científico publicado en 2009

An osteocalcin-deficient mouse strain without endocrine abnormalities

artículo científico publicado en 2020

Biomechanical evaluation of fracture fixation constructs using a variable-angle locked periprosthetic femur plate system

artículo científico publicado en 2014

CRISPR/CAS9 Technologies

artículo científico publicado en 2017

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

artículo científico publicado en 2012

Characterization of genetically engineered mouse models carrying Col2a1-cre-induced deletions of Lrp5 and/or Lrp6.

artículo científico publicado en 2016

Concurrent Hepsin overexpression and adenomatous polyposis coli deletion causes invasive prostate carcinoma in mice.

artículo científico publicado en 2015

Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium

scientific journal article

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

scientific journal article

Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia

scientific journal article

Delivery of short hairpin RNA sequences by using a replication-competent avian retroviral vector.

artículo científico publicado en 2004

Disruption of tubular Flcn expression as a mouse model for renal tumor induction.

artículo científico publicado en 2015

Fracture healing in mice lacking Pten in osteoblasts: a micro-computed tomography image-based analysis of the mechanical properties of the femur.

artículo científico publicado en 2014

Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells

artículo científico publicado en 1993

Genetically engineered mouse models to evaluate the role of Wnt secretion in bone development and homeostasis

artículo científico publicado en 2016

Inactivation of Apc in the mouse prostate causes prostate carcinoma

scientific journal article

Independent validation of experimental results requires timely and unrestricted access to animal models and reagents

artículo científico publicado en 2020

Integration of cellular adhesion and Wnt signaling: Interactions between N-cadherin and LRP5 and their role in regulating bone mass.

artículo científico publicado en 2012

LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin

artículo científico publicado en 2007

LRP6 Mediates cAMP Generation by G Protein–Coupled Receptors Through Regulating the Membrane Targeting of Gα s ⬇️

artículo científico publicado el 15 de marzo de 2011

Lifelong accumulation of bone in mice lacking Pten in osteoblasts

artículo científico publicado en 2007

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

artículo científico publicado en 1998

Loss of Lgals3 Protects Against Gonadectomy-Induced Cortical Bone Loss in Mice

scientific article published on 19 November 2019

Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma.

artículo científico publicado en 2010

Mice with a heterozygous Lrp6 deletion have impaired fracture healing

artículo científico publicado en 2016

Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation

scientific article published on 01 October 2007

Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.

artículo científico publicado en 2007

Myeloid-specific TGF-β signaling in bone promotes basic-FGF and breast cancer bone metastasis.

artículo científico publicado en 2015

Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development.

artículo científico publicado en 2000

Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations

artículo científico publicado en 2015

Parafibromin inhibits cancer cell growth and causes G1 phase arrest

artículo científico publicado en 2006

Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice

scientific journal article

Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

artículo científico publicado en 2005

Rad6B is a positive regulator of beta-catenin stabilization

artículo científico publicado en 2008

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

artículo científico publicado en 2005

Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin

scientific journal article

Regulation of Wnt/β-catenin signaling within and from osteocytes

artículo científico publicado en 2013

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells

artículo científico publicado en 2011

Response to Wnt Signaling Pathways

artículo científico publicado en 2015

Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex

artículo científico publicado en 2013

TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance.

artículo científico publicado en 2013

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

artículo científico publicado en 2006

Targeted disruption of p107: functional overlap between p107 and Rb

scientific article published on 01 July 1996

Targeting the giant cell tumor stromal cell: functional characterization and a novel therapeutic strategy

artículo científico publicado en 2013

The Rb tumor suppressor is required for stress erythropoiesis.

scientific article published on 30 September 2004

The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development

scientific journal article

The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis

scientific journal article

Tumor spectrum analysis in p53-mutant mice

artículo científico publicado en 1994

Tumor suppression by a severely truncated species of retinoblastoma protein

artículo científico publicado en 2002

Tumorigenic and Developmental Effects of Combined Germ-line Mutations in Rb and p53 ⬇️

artículo científico publicado el 1 de enero de 1994

Use of Primary Calvarial Osteoblasts to Evaluate the Function of Wnt Signaling in Osteogenesis

artículo científico publicado en 2016

Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals

artículo científico publicado en 2015

Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone

artículo científico publicado en 2009

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

artículo científico publicado en 2015

Wnt signaling in bone and muscle

artículo científico publicado en 2015

Wnt signaling, stem cells, and the cellular origin of breast cancer.

artículo científico publicado en 2007

Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein

artículo científico publicado en 2005

Wnt/β-catenin Signaling in Normal and Cancer Stem Cells.

artículo científico publicado en 2011

Wntless spatially regulates bone development through β-catenin-dependent and independent mechanisms.

artículo científico publicado en 2015

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

artículo científico publicado en 2009

β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation!

artículo científico publicado en 2014

Lista de obras de Bart O Williams

(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice

A Dynamic WNT/β-CATENIN Signaling Environment Leads to WNT-Independent and WNT-Dependent Proliferation of Embryonic Intestinal Progenitor Cells

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling

A subset of p53-deficient embryos exhibit exencephaly

APC inhibits ERK pathway activation and cellular proliferation induced by RAS

Accelerated and increased joint damage in young mice with global inactivation of mitogen-inducible gene 6 after ligament and meniscus injury.

Activation of Wnt/β-catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia.

Activation of the PI3K/AKT pathway induces urothelial carcinoma of the renal pelvis: identification in human tumors and confirmation in animal models

An osteocalcin-deficient mouse strain without endocrine abnormalities

Biomechanical evaluation of fracture fixation constructs using a variable-angle locked periprosthetic femur plate system

CRISPR/CAS9 Technologies

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

Characterization of genetically engineered mouse models carrying Col2a1-cre-induced deletions of Lrp5 and/or Lrp6.

Concurrent Hepsin overexpression and adenomatous polyposis coli deletion causes invasive prostate carcinoma in mice.

Cystic renal neoplasia following conditional inactivation of apc in mouse renal tubular epithelium

Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6

Deficiency of FLCN in mouse kidney led to development of polycystic kidneys and renal neoplasia

Delivery of short hairpin RNA sequences by using a replication-competent avian retroviral vector.

Disruption of tubular Flcn expression as a mouse model for renal tumor induction.

Fracture healing in mice lacking Pten in osteoblasts: a micro-computed tomography image-based analysis of the mechanical properties of the femur.

Generation of normal lymphocyte populations by Rb-deficient embryonic stem cells

Genetically engineered mouse models to evaluate the role of Wnt secretion in bone development and homeostasis

Inactivation of Apc in the mouse prostate causes prostate carcinoma

Independent validation of experimental results requires timely and unrestricted access to animal models and reagents

Integration of cellular adhesion and Wnt signaling: Interactions between N-cadherin and LRP5 and their role in regulating bone mass.

LRP5 and LRP6 are not required for protective antigen-mediated internalization or lethality of anthrax lethal toxin

LRP6 Mediates cAMP Generation by G Protein–Coupled Receptors Through Regulating the Membrane Targeting of Gα s ⬇️

Lifelong accumulation of bone in mice lacking Pten in osteoblasts

Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

Loss of Lgals3 Protects Against Gonadectomy-Induced Cortical Bone Loss in Mice

Mammalian target of rapamycin-dependent acinar cell neoplasia after inactivation of Apc and Pten in the mouse salivary gland: implications for human acinic cell carcinoma.

Mice with a heterozygous Lrp6 deletion have impaired fracture healing

Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation

Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways.

Myeloid-specific TGF-β signaling in bone promotes basic-FGF and breast cancer bone metastasis.

Neural crest-directed gene transfer demonstrates Wnt1 role in melanocyte expansion and differentiation during mouse development.

Oculoectodermal syndrome is a mosaic RASopathy associated with KRAS alterations

Parafibromin inhibits cancer cell growth and causes G1 phase arrest

Parafibromin, a component of the human PAF complex, regulates growth factors and is required for embryonic development and survival in adult mice

Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

Rad6B is a positive regulator of beta-catenin stabilization

Reduced affinity to and inhibition by DKK1 form a common mechanism by which high bone mass-associated missense mutations in LRP5 affect canonical Wnt signaling

Regulation of Wnt signaling by Sox proteins: XSox17 alpha/beta and XSox3 physically interact with beta-catenin

Regulation of Wnt/β-catenin signaling within and from osteocytes

Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells

Response to Wnt Signaling Pathways

Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex

TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance.

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

Targeted disruption of p107: functional overlap between p107 and Rb

Targeting the giant cell tumor stromal cell: functional characterization and a novel therapeutic strategy

The Rb tumor suppressor is required for stress erythropoiesis.

The Wnt co-receptor Lrp6 is required for normal mouse mammary gland development

The Wnt signaling receptor Lrp5 is required for mammary ductal stem cell activity and Wnt1-induced tumorigenesis

Tumor spectrum analysis in p53-mutant mice

Tumor suppression by a severely truncated species of retinoblastoma protein

Tumorigenic and Developmental Effects of Combined Germ-line Mutations in Rb and p53 ⬇️

Use of Primary Calvarial Osteoblasts to Evaluate the Function of Wnt Signaling in Osteogenesis

Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals

Where Wnts went: the exploding field of Lrp5 and Lrp6 signaling in bone

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

Wnt signaling in bone and muscle

Wnt signaling, stem cells, and the cellular origin of breast cancer.

Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein

Wnt/β-catenin Signaling in Normal and Cancer Stem Cells.

Wntless spatially regulates bone development through β-catenin-dependent and independent mechanisms.

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

β-catenin signaling in murine liver zonation and regeneration: a Wnt-Wnt situation!