Lista de obras - Emily M. Mace - Dominio Público Uruguay

A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms.

artículo científico publicado en 2017

A novel Rab27a mutation binds melanophilin, but not Munc13-4, causing immunodeficiency without albinism.

artículo científico publicado en 2016

A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function

artículo científico publicado en 2019

A research-driven approach to the identification of novel natural killer cell deficiencies affecting cytotoxic function

artículo científico publicado en 2020

Acquisition of cell migration defines NK cell differentiation from hematopoietic stem cell precursors

artículo científico publicado en 2017

Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma

artículo científico publicado en 2012

Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1.

artículo científico publicado en 2011

Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening

artículo científico publicado en 2021

Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.

artículo científico publicado en 2014

Biallelic mutations in IRF8 impair human NK cell maturation and function ⬇️

artículo científico publicado en 2016

CD2 promotes human natural killer cell membrane nanotube formation

artículo científico publicado en 2012

CD56 regulates human NK cell cytotoxicity through Pyk2 ⬇️

artículo científico publicado en 2020

COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis

artículo científico publicado en 2015

Cell biological steps and checkpoints in accessing NK cell cytotoxicity

artículo científico publicado en 2014

Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy

artículo científico publicado en 2014

Cytoskeletal abnormalities and neutrophil dysfunction in WDR1 deficiency

artículo científico publicado en 2016

Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.

artículo científico publicado en 2013

Discovering the Cause of Wiskott-Aldrich Syndrome and Laying the Foundation for Understanding Immune Cell Structuring

artículo científico publicado en 2018

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

artículo científico publicado en 2020

Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network

artículo científico publicado en 2015

Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations

artículo científico publicado en 2015

Emerging insights into human health and NK cell biology from the study of NK cell deficiencies

artículo científico publicado en 2019

GATA2 deficiency underlying severe blastomycosis and fatal herpes simplex virus-associated hemophagocytic lymphohistiocytosis

artículo científico publicado en 2015

GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity.

artículo científico publicado en 2013

Generation of cell-derived matrices that support human NK cell migration and differentiation

scientific article published on 11 May 2020

Genetic Causes of Human NK Cell Deficiency and Their Effect on NK Cell Subsets

artículo científico publicado en 2016

Genome-wide analyses and functional profiling of human NK cell lines

artículo científico publicado en 2018

HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease

scientific article published on 01 July 2020

HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response.

artículo científico publicado en 2016

High- and Super-Resolution Microscopy Imaging of the NK Cell Immunological Synapse

artículo científico publicado en 2016

High-resolution phenotyping identifies NK cell subsets that distinguish healthy children from adults

artículo científico publicado en 2017

Human NK cell development requires CD56-mediated motility and formation of the developmental synapse.

artículo científico publicado en 2016

IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.

artículo científico publicado en 2011

Insights into primary immune deficiency from quantitative microscopy.

artículo científico

Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A

artículo científico publicado en 2014

Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling

artículo científico publicado en 2015

Multiple distinct NK-cell synapses ⬇️

artículo científico publicado el 15 de diciembre de 2011

Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.

artículo científico publicado en 2013

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.

artículo científico publicado en 2013

Mutations in PI3K110δ cause impaired NK cell function partially rescued by rapamycin treatment

artículo científico publicado en 2018

NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence

artículo científico publicado en 2012

NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing.

artículo científico publicado en 2016

Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells.

artículo científico publicado en 2018

PTEN is a negative regulator of NK cell cytolytic function.

artículo científico publicado en 2015

Phosphoinositide-3-Kinase Signaling in Human Natural Killer Cells: New Insights from Primary Immunodeficiency.

artículo científico publicado en 2018

Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity

artículo científico publicado en 2011

Practical NK cell phenotyping and variability in healthy adults

artículo científico publicado en 2015

Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders

artículo científico publicado en 2016

Quantification of natural killer cell polarization and visualization of synaptic granule externalization by imaging flow cytometry

artículo científico publicado en 2016

Quantitative Imaging Approaches to Study the CAR Immunological Synapse.

artículo científico publicado en 2017

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics.

artículo científico publicado en 2016

Requirements for human natural killer cell development informed by primary immunodeficiency.

artículo científico publicado en 2016

Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations

artículo científico publicado en 2017

Schistosome Soluble Egg Antigen Decreases Mycobacterium tuberculosis-Specific CD4+ T-Cell Effector Function With Concomitant Arrest of Macrophage Phago-Lysosome Maturation.

artículo científico publicado en 2016

Severe cutaneous human papillomavirus infection associated with natural killer cell deficiency following stem cell transplantation for severe combined immunodeficiency

artículo científico publicado en 2014

The Role of AIRE in the Immunity Against Candida Albicans in a Model of Human Macrophages.

artículo científico publicado en 2018

The coordinating role of IQGAP1 in the regulation of local, endosome-specific actin networks

artículo científico publicado en 2017

Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation.

artículo científico publicado en 2014

Tumor-priming converts NK cells to memory-like NK cells.

artículo científico publicado en 2017

Tumorigenic adenovirus 12 cells evade NK cell lysis by reducing the expression of NKG2D ligands.

artículo científico publicado en 2012

Visualization of the immunological synapse by dual color time-gated stimulated emission depletion (STED) nanoscopy.

artículo científico publicado en 2014

Lista de obras de Emily M. Mace

A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms.

A novel Rab27a mutation binds melanophilin, but not Munc13-4, causing immunodeficiency without albinism.

A novel disorder involving dyshematopoiesis, inflammation, and HLH due to aberrant CDC42 function

A research-driven approach to the identification of novel natural killer cell deficiencies affecting cytotoxic function

Acquisition of cell migration defines NK cell differentiation from hematopoietic stem cell precursors

Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma

Autoimmune regulator (AIRE) contributes to Dectin-1-induced TNF-α production and complexes with caspase recruitment domain-containing protein 9 (CARD9), spleen tyrosine kinase (Syk), and Dectin-1.

Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening

Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity.

Biallelic mutations in IRF8 impair human NK cell maturation and function ⬇️

CD2 promotes human natural killer cell membrane nanotube formation

CD56 regulates human NK cell cytotoxicity through Pyk2 ⬇️

COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis

Cell biological steps and checkpoints in accessing NK cell cytotoxicity

Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy

Cytoskeletal abnormalities and neutrophil dysfunction in WDR1 deficiency

Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.

Discovering the Cause of Wiskott-Aldrich Syndrome and Laying the Foundation for Understanding Immune Cell Structuring

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Early Signaling in Primary T Cells Activated by Antigen Presenting Cells Is Associated with a Deep and Transient Lamellal Actin Network

Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations

Emerging insights into human health and NK cell biology from the study of NK cell deficiencies

GATA2 deficiency underlying severe blastomycosis and fatal herpes simplex virus-associated hemophagocytic lymphohistiocytosis

GATA2 deficiency: a protean disorder of hematopoiesis, lymphatics, and immunity.

Generation of cell-derived matrices that support human NK cell migration and differentiation

Genetic Causes of Human NK Cell Deficiency and Their Effect on NK Cell Subsets

Genome-wide analyses and functional profiling of human NK cell lines

HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease

HIV Progression Perturbs the Balance of the Cell-Mediated and Anti-Inflammatory Adaptive and Innate Mycobacterial Immune Response.

High- and Super-Resolution Microscopy Imaging of the NK Cell Immunological Synapse

High-resolution phenotyping identifies NK cell subsets that distinguish healthy children from adults

Human NK cell development requires CD56-mediated motility and formation of the developmental synapse.

IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function.

Insights into primary immune deficiency from quantitative microscopy.

Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A

Modest Interference with Actin Dynamics in Primary T Cell Activation by Antigen Presenting Cells Preferentially Affects Lamellal Signaling

Multiple distinct NK-cell synapses ⬇️

Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.

Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.

Mutations in PI3K110δ cause impaired NK cell function partially rescued by rapamycin treatment

NK cell lytic granules are highly motile at the immunological synapse and require F-actin for post-degranulation persistence

NK cells converge lytic granules to promote cytotoxicity and prevent bystander killing.

Nanoscale Dynamism of Actin Enables Secretory Function in Cytolytic Cells.

PTEN is a negative regulator of NK cell cytolytic function.

Phosphoinositide-3-Kinase Signaling in Human Natural Killer Cells: New Insights from Primary Immunodeficiency.

Phosphorylation of the myosin IIA tailpiece regulates single myosin IIA molecule association with lytic granules to promote NK-cell cytotoxicity

Practical NK cell phenotyping and variability in healthy adults

Primary immunodeficiency diseases: Genomic approaches delineate heterogeneous Mendelian disorders

Quantification of natural killer cell polarization and visualization of synaptic granule externalization by imaging flow cytometry

Quantitative Imaging Approaches to Study the CAR Immunological Synapse.

RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics.

Requirements for human natural killer cell development informed by primary immunodeficiency.

Ruxolitinib partially reverses functional natural killer cell deficiency in patients with signal transducer and activator of transcription 1 (STAT1) gain-of-function mutations

Schistosome Soluble Egg Antigen Decreases Mycobacterium tuberculosis-Specific CD4+ T-Cell Effector Function With Concomitant Arrest of Macrophage Phago-Lysosome Maturation.

Severe cutaneous human papillomavirus infection associated with natural killer cell deficiency following stem cell transplantation for severe combined immunodeficiency

The Role of AIRE in the Immunity Against Candida Albicans in a Model of Human Macrophages.

The coordinating role of IQGAP1 in the regulation of local, endosome-specific actin networks

Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation.

Tumor-priming converts NK cells to memory-like NK cells.

Tumorigenic adenovirus 12 cells evade NK cell lysis by reducing the expression of NKG2D ligands.

Visualization of the immunological synapse by dual color time-gated stimulated emission depletion (STED) nanoscopy.