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Lista de obras de Matthias Bauer

2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells

artículo científico publicado en 2016

A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C

scientific article published on 01 October 2019

A type III complement factor D deficiency: Structural insights for inhibition of the alternative pathway ⬇️

artículo científico publicado en 2018

Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines

artículo científico publicado en 2018

Applying DEKOIS 2.0 in structure-based virtual screening to probe the impact of preparation procedures and score normalization

artículo científico publicado en 2015

DEKOIS: Demanding Evaluation Kits for Objective in Silico Screening — A Versatile Tool for Benchmarking Docking Programs and Scoring Functions ⬇️

artículo científico publicado el 18 de agosto de 2011

Electrostatic Complementarity as a Fast and Effective Tool to Optimize Binding and Selectivity of Protein-Ligand Complexes

scientific article published on 13 March 2019

Evaluation and Optimization of Virtual Screening Workflows with DEKOIS 2.0 – A Public Library of Challenging Docking Benchmark Sets ⬇️

artículo científico publicado el 12 de junio de 2013

Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

artículo científico publicado en 2015

Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant p53.

artículo científico publicado en 2015

Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of p53 Mutant Y220C Rescue Drugs

artículo científico publicado en 2016

Hitting a moving target: targeting transient protein states.

artículo científico publicado en 2013

Inferring multi-target QSAR models with taxonomy-based multi-task learning.

artículo científico publicado en 2013

Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2.

artículo científico publicado en 2012

Machine learning estimates of natural product conformational energies

artículo científico publicado en 2014

Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007.

artículo científico publicado en 2017

Probing the impact of protein and ligand preparation procedures on chemotype enrichment in structure-based virtual screening using DEKOIS 2.0 benchmark sets.

artículo científico publicado en 2014

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma

artículo científico publicado en 2019

Synthesis and molecular modeling of novel tetrahydro-β-carboline derivatives with phosphodiesterase 5 inhibitory and anticancer properties.

artículo científico publicado en 2010

Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm

scientific article published on 21 February 2020

The curcumin analog HO-3867 selectively kills cancer cells by converting mutant p53 protein to transcriptionally active wildtype p53.

artículo científico publicado en 2018

Use of DEKOIS 2.0 to gain insights for virtual screening.

artículo científico publicado en 2014

pROC-Chemotype Plots Enhance the Interpretability of Benchmarking Results in Structure-Based Virtual Screening.

artículo científico publicado en 2015

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