Lista de obras - Ramón Mangues - Dominio Público Uruguay

A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model

artículo científico publicado en 2022

A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells

artículo científico publicado en 2007

A novel inhibitor of focal adhesion signaling induces caspase-independent cell death in diffuse large B-cell lymphoma.

artículo científico publicado en 2011

A novel orally available inhibitor of focal adhesion signaling increases survival in a xenograft model of diffuse large B-cell lymphoma with central nervous system involvement ⬇️

artículo científico publicado el 28 de mayo de 2013

Absence of MDM-2 gene amplification in experimentally induced tumors regardless of p53 status.

artículo científico publicado en 1994

Activated N-ras oncogene and N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis

scientific article published on 01 September 1996

An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

artículo científico publicado en 2020

An overexpressed N-ras proto-oncogene cooperates with N-methylnitrosourea in mouse mammary carcinogenesis.

artículo científico publicado en 1994

Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice

artículo científico publicado en 1998

Assembly of histidine-rich protein materials controlled through divalent cations

artículo científico publicado en 2018

Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs.

artículo científico publicado en 2016

Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials

artículo científico publicado en 2015

Brain interleukin-1 beta in Alzheimer's disease and vascular dementia.

artículo científico publicado en 1994

CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival.

artículo científico publicado en 2014

CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis.

artículo científico publicado en 2016

CXCR7 expression in diffuse large B-cell lymphoma identifies a subgroup of CXCR4+ patients with good prognosis.

artículo científico publicado en 2018

Carbon metabolism and the sign of control coefficients in metabolic adaptations underlying K-ras transformation.

artículo científico publicado en 2010

Celecoxib induces anoikis in human colon carcinoma cells associated with the deregulation of focal adhesions and nuclear translocation of p130Cas.

artículo científico publicado en 2006

Codon 12 and codon 13 mutations at the K-ras gene induce different soft tissue sarcoma types in nude mice

scientific article published on 07 August 2002

Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer

scientific article published on 05 September 2019

Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH.

artículo científico publicado en 2014

Complex effects of Ras proto-oncogenes in tumorigenesis.

artículo científico publicado en 2003

Conformational Conversion during Controlled Oligomerization into Nonamylogenic Protein Nanoparticles

scientific article published on 13 August 2018

Core binding factor acute myeloid leukemia: the impact of age, leukocyte count, molecular findings, and minimal residual disease.

artículo científico publicado en 2013

Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells.

artículo científico publicado en 2017

Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

artículo científico publicado en 2012

Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma

scientific article published on 12 December 2018

Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy

scientific article published on 28 March 2019

Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks

artículo científico publicado en 2017

Engineering tumor cell targeting in nanoscale amyloidal materials.

artículo científico publicado en 2016

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

artículo científico publicado en 2020

Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia

article

Focal adhesion protein expression in human diffuse large B-cell lymphoma

artículo científico publicado en 2014

Functional recruitment for drug delivery through protein-based nanotechnologies.

artículo científico publicado en 2016

Gated Mesoporous Silica Nanoparticles Using a Double-Role Circular Peptide for the Controlled and Target-Preferential Release of Doxorubicin in CXCR4-Expresing Lymphoma Cells

Heterotopic implantation alters the regulation of apoptosis and the cell cycle and generates a new metastatic site in a human pancreatic tumor xenograft model

artículo científico publicado en 2002

Improved performance of protein-based recombinant gene therapy vehicles by tuning downstream procedures

artículo científico publicado en 2013

In vivo architectonic stability of fully de novo designed protein-only nanoparticles

artículo científico publicado en 2014

Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas.

artículo científico publicado en 1997

Intracellular CXCR4⁺ cell targeting with T22-empowered protein-only nanoparticles.

artículo científico publicado en 2012

Intrinsic functional and architectonic heterogeneity of tumor-targeted protein nanoparticles

artículo científico publicado en 2017

Isolation of high molecular weight DNA for reliable genotyping of transgenic mice.

artículo científico publicado en 1997

K-ras and p16 aberrations confer poor prognosis in human colorectal cancer

K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression.

artículo científico publicado en 2000

Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models.

artículo científico publicado en 2016

Mouse models in oncogenesis and cancer therapy.

artículo científico publicado en 2006

NEDD9, an independent good prognostic factor in intermediate-risk acute myeloid leukemia patients.

artículo científico publicado en 2017

NF1 inactivation cooperates with N-Ras in in vivo lymphogenesis activating Erk by a mechanism independent of its Ras-GTPase accelerating activity ⬇️

artículo científico publicado el 1 de octubre de 1998

Non-amyloidogenic peptide tags for the regulatable self-assembling of protein-only nanoparticles

artículo científico publicado en 2012

Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease

Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cells inhibited by Myc.

artículo científico publicado en 2006

Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites.

artículo científico publicado en 2007

Overexpression of the N-ras proto-oncogene, not somatic mutational activation, associated with malignant tumors in transgenic mice

artículo científico publicado en 1992

Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma

artículo científico publicado en 2018

Potent Anticancer Activity of CXCR4-Targeted Nanostructured Toxins in Aggressive Endometrial Cancer Models

Promoter demethylation in MMTV/N-rasN transgenic mice required for transgene expression and tumorigenesis

scientific article published on 01 October 1995

Protein-Based Therapeutic Killing for Cancer Therapies.

artículo científico publicado en 2017

Protein-driven nanomedicines in oncotherapy.

artículo científico publicado en 2019

Protein-only, antimicrobial peptide-containing recombinant nanoparticles with inherent built-in antibacterial activity.

artículo científico publicado en 2017

Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles.

artículo científico publicado en 2016

Recombinant pharmaceuticals from microbial cells: a 2015 update

artículo científico publicado en 2016

Recruiting potent membrane penetrability in tumor cell-targeted protein-only nanoparticles

artículo científico publicado en 2018

S49 cells endogenously express subtype 2 somatostatin receptors which couple to increase protein tyrosine phosphatase activity in membranes and down-regulate Raf-1 activity in situ.

artículo científico publicado en 1997

STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer

artículo científico publicado en 2012

Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin

artículo científico publicado en 2018

Selective delivery of T22-PE24-H6 to CXCR4+ diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model

scientific article published on 06 April 2020

Selective depletion of metastatic stem cells as therapy for human colorectal cancer

artículo científico publicado en 2018

Self-assembling as regular nanoparticles dramatically minimizes photobleaching of tumour-targeted GFP

scientific article published on 06 December 2019

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs.

artículo científico publicado en 2018

Sheltering DNA in self-organizing, protein-only nano-shells as artificial viruses for gene delivery.

artículo científico publicado en 2013

Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case

artículo científico publicado en 2004

Site-dependent E-cadherin cleavage and nuclear translocation in a metastatic colorectal cancer model.

artículo científico publicado en 2010

Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors

artículo científico publicado en 2017

Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.

artículo científico publicado en 2016

Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides.

artículo científico publicado en 2018

Targeting in Cancer Therapies.

artículo científico publicado en 2016

The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene

artículo científico publicado en 2002

The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial-like head and neck carcinoma subtypes

scientific article published on 16 January 2019

The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles.

artículo científico publicado en 2017

The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse

artículo científico publicado en 2011

Towards protein-based viral mimetics for cancer therapies.

artículo científico publicado en 2015

Tumorigenesis and male sterility in transgenic mice expressing a MMTV/N-ras oncogene

artículo científico publicado en 1990

[Molecular genetics of human pancreatic cancer]

artículo científico publicado en 1999

[Requirements in parenteral nutrition. Design and preparation of the diets]

artículo científico publicado en 1984

ras activation in experimental carcinogenesis.

artículo científico publicado en 1992

uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy

artículo científico publicado en 2016

Lista de obras de Ramón Mangues

A Novel CXCR4-Targeted Diphtheria Toxin Nanoparticle Inhibits Invasion and Metastatic Dissemination in a Head and Neck Squamous Cell Carcinoma Mouse Model

A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells

A novel inhibitor of focal adhesion signaling induces caspase-independent cell death in diffuse large B-cell lymphoma.

A novel orally available inhibitor of focal adhesion signaling increases survival in a xenograft model of diffuse large B-cell lymphoma with central nervous system involvement ⬇️

Absence of MDM-2 gene amplification in experimentally induced tumors regardless of p53 status.

Activated N-ras oncogene and N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis

An Auristatin nanoconjugate targeting CXCR4+ leukemic cells blocks acute myeloid leukemia dissemination

An overexpressed N-ras proto-oncogene cooperates with N-methylnitrosourea in mouse mammary carcinogenesis.

Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice

Assembly of histidine-rich protein materials controlled through divalent cations

Bacterial mimetics of endocrine secretory granules as immobilized in vivo depots for functional protein drugs.

Bottom-Up Instructive Quality Control in the Biofabrication of Smart Protein Materials

Brain interleukin-1 beta in Alzheimer's disease and vascular dementia.

CXCR4 expression enhances diffuse large B cell lymphoma dissemination and decreases patient survival.

CXCR4(+)-targeted protein nanoparticles produced in the food-grade bacterium Lactococcus lactis.

CXCR7 expression in diffuse large B-cell lymphoma identifies a subgroup of CXCR4+ patients with good prognosis.

Carbon metabolism and the sign of control coefficients in metabolic adaptations underlying K-ras transformation.

Celecoxib induces anoikis in human colon carcinoma cells associated with the deregulation of focal adhesions and nuclear translocation of p130Cas.

Codon 12 and codon 13 mutations at the K-ras gene induce different soft tissue sarcoma types in nude mice

Collaborative membrane activity and receptor-dependent tumor cell targeting for precise nanoparticle delivery in CXCR4+ colorectal cancer

Colon cancer cells colonize the lung from established liver metastases through p38 MAPK signalling and PTHLH.

Complex effects of Ras proto-oncogenes in tumorigenesis.

Conformational Conversion during Controlled Oligomerization into Nonamylogenic Protein Nanoparticles

Core binding factor acute myeloid leukemia: the impact of age, leukocyte count, molecular findings, and minimal residual disease.

Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells.

Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

Effect of serpinE1 overexpression on the primary tumor and lymph node, and lung metastases in head and neck squamous cell carcinoma

Efficient bioactive oligonucleotide-protein conjugation for cell-targeted cancer therapy

Engineering multifunctional protein nanoparticles by in vitro disassembling and reassembling of heterologous building blocks

Engineering tumor cell targeting in nanoscale amyloidal materials.

Fluorescent Dye Labeling Changes the Biodistribution of Tumor-Targeted Nanoparticles

Focal Adhesion Genes Refine the Intermediate-Risk Cytogenetic Classification of Acute Myeloid Leukemia

Focal adhesion protein expression in human diffuse large B-cell lymphoma

Functional recruitment for drug delivery through protein-based nanotechnologies.

Gated Mesoporous Silica Nanoparticles Using a Double-Role Circular Peptide for the Controlled and Target-Preferential Release of Doxorubicin in CXCR4-Expresing Lymphoma Cells

Heterotopic implantation alters the regulation of apoptosis and the cell cycle and generates a new metastatic site in a human pancreatic tumor xenograft model

Improved performance of protein-based recombinant gene therapy vehicles by tuning downstream procedures

In vivo architectonic stability of fully de novo designed protein-only nanoparticles

Inactivation of the cyclin-dependent kinase inhibitor p15INK4b by deletion and de novo methylation with independence of p16INK4a alterations in murine primary T-cell lymphomas.

Intracellular CXCR4⁺ cell targeting with T22-empowered protein-only nanoparticles.

Intrinsic functional and architectonic heterogeneity of tumor-targeted protein nanoparticles

Isolation of high molecular weight DNA for reliable genotyping of transgenic mice.

K-ras and p16 aberrations confer poor prognosis in human colorectal cancer

K-ras codon 12 mutation induces higher level of resistance to apoptosis and predisposition to anchorage-independent growth than codon 13 mutation or proto-oncogene overexpression.

Lurbinectedin induces depletion of tumor-associated macrophages, an essential component of its in vivo synergism with gemcitabine, in pancreatic adenocarcinoma mouse models.

Mouse models in oncogenesis and cancer therapy.

NEDD9, an independent good prognostic factor in intermediate-risk acute myeloid leukemia patients.

NF1 inactivation cooperates with N-Ras in in vivo lymphogenesis activating Erk by a mechanism independent of its Ras-GTPase accelerating activity ⬇️

Non-amyloidogenic peptide tags for the regulatable self-assembling of protein-only nanoparticles

Novel Endometrial Cancer Models Using Sensitive Metastasis Tracing for CXCR4-Targeted Therapy in Advanced Disease

Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cells inhibited by Myc.

Orthotopic microinjection of human colon cancer cells in nude mice induces tumor foci in all clinically relevant metastatic sites.

Overexpression of the N-ras proto-oncogene, not somatic mutational activation, associated with malignant tumors in transgenic mice

Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma

Potent Anticancer Activity of CXCR4-Targeted Nanostructured Toxins in Aggressive Endometrial Cancer Models

Promoter demethylation in MMTV/N-rasN transgenic mice required for transgene expression and tumorigenesis

Protein-Based Therapeutic Killing for Cancer Therapies.

Protein-driven nanomedicines in oncotherapy.

Protein-only, antimicrobial peptide-containing recombinant nanoparticles with inherent built-in antibacterial activity.

Rational engineering of single-chain polypeptides into protein-only, BBB-targeted nanoparticles.

Recombinant pharmaceuticals from microbial cells: a 2015 update

Recruiting potent membrane penetrability in tumor cell-targeted protein-only nanoparticles

S49 cells endogenously express subtype 2 somatostatin receptors which couple to increase protein tyrosine phosphatase activity in membranes and down-regulate Raf-1 activity in situ.

STC1 expression by cancer-associated fibroblasts drives metastasis of colorectal cancer

Selective CXCR4+ Cancer Cell Targeting and Potent Antineoplastic Effect by a Nanostructured Version of Recombinant Ricin

Selective delivery of T22-PE24-H6 to CXCR4+ diffuse large B-cell lymphoma cells leads to wide therapeutic index in a disseminated mouse model

Selective depletion of metastatic stem cells as therapy for human colorectal cancer

Self-assembling as regular nanoparticles dramatically minimizes photobleaching of tumour-targeted GFP

Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs.

Sheltering DNA in self-organizing, protein-only nano-shells as artificial viruses for gene delivery.

Short amino acid stretches can mediate amyloid formation in globular proteins: the Src homology 3 (SH3) case

Site-dependent E-cadherin cleavage and nuclear translocation in a metastatic colorectal cancer model.

Stroma-derived HGF drives metabolic adaptation of colorectal cancer to angiogenesis inhibitors

Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli.

Switching cell penetrating and CXCR4-binding activities of nanoscale-organized arginine-rich peptides.

Targeting in Cancer Therapies.

The N-ras proto-oncogene can suppress the malignant phenotype in the presence or absence of its oncogene

The combined use of EFS, GPX2, and SPRR1A expression could distinguish favorable from poor clinical outcome among epithelial-like head and neck carcinoma subtypes

The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles.