Lista de obras - Joachim Brouwers - Dominio Público Uruguay

A review of drug solubility in human intestinal fluids: implications for the prediction of oral absorption.

artículo científico publicado en 2013

An In-Depth View into Human Intestinal Fluid Colloids: Intersubject Variability in Relation to Composition

artículo científico publicado en 2016

An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation

artículo científico publicado en 2015

Assessment of Passive Intestinal Permeability Using an Artificial Membrane Insert System

artículo científico publicado en 2017

Bile Salt Micelles and Phospholipid Vesicles Present in Simulated and Human Intestinal Fluids: Structural Analysis by Flow Field-Flow Fractionation/Multiangle Laser Light Scattering.

artículo científico publicado en 2016

CADA, a Potential Anti-HIV Microbicide that Specifically Targets the Cellular CD4 Receptor

article

CADA, a potential anti-HIV microbicide that specifically targets the cellular CD4 receptor

artículo científico publicado en 2008

Capillary zone electrophoresis method development for the analysis of Hippeastrum hybrid agglutinin samples.

artículo científico publicado en 2008

Characterization of Human Duodenal Fluids in Fasted and Fed State Conditions.

artículo científico publicado en 2015

Determination of intraluminal theophylline concentrations after oral intake of an immediate- and a slow-release dosage form.

artículo científico publicado en 2005

Development and characterization of a solid dispersion film for the vaginal application of the anti-HIV microbicide UAMC01398.

artículo científico publicado en 2014

Development and in vitro evaluation of a vaginal microbicide gel formulation for UAMC01398, a novel diaryltriazine NNRTI against HIV-1.

artículo científico publicado en 2013

Development and in vitro evaluation of chloroquine gels as microbicides against HIV-1 infection

artículo científico publicado en 2008

Drug permeability profiling using cell-free permeation tools: Overview and applications

artículo científico publicado en 2018

Drug precipitation–permeation interplay: Supersaturation in an absorptive environment ⬇️

artículo científico publicado el 25 de julio de 2012

Drug supersaturation in simulated and human intestinal fluids representing different nutritional states.

artículo científico publicado en 2010

Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir

artículo científico publicado en 2011

Effect of pH and Comedication on Gastrointestinal Absorption of Posaconazole

artículo científico publicado en 2011

Ethanol concentrations in the human gastrointestinal tract after intake of alcoholic beverages

artículo científico publicado en 2016

Evaluation of fasted and fed state simulated and human intestinal fluids as solvent system in the Ussing chambers model to explore food effects on intestinal permeability.

artículo científico publicado en 2014

Evaluation of fasted state human intestinal fluid as apical solvent system in the Caco-2 absorption model and comparison with FaSSIF.

artículo científico publicado en 2014

Evaluation of gastrointestinal drug supersaturation and precipitation: strategies and issues.

artículo científico publicado en 2012

Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption

artículo científico publicado en 2009

Excipient-Mediated Supersaturation Stabilization in Human Intestinal Fluids

artículo científico publicado en 2011

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

artículo científico publicado en 2016

Exploring the Effect of Esomeprazole on Gastric and Duodenal Fluid Volumes and Absorption of Ritonavir

scientific article published on 17 July 2020

Exploring the link between gastric motility and intragastric drug distribution in man

scientific article published on 16 November 2016

Food-dependent disintegration of immediate release fosamprenavir tablets: in vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system.

artículo científico publicado en 2010

Gastric and Duodenal Ethanol Concentrations after Intake of Alcoholic Beverages in Postprandial Conditions.

artículo científico

Gastrointestinal Behavior of Weakly Acidic BCS Class II Drugs in Man—Case Study of Diclofenac Potassium

artículo científico publicado en 2016

Gastrointestinal and Systemic Disposition of Diclofenac under Fasted and Fed State Conditions Supporting the Evaluation of in Vitro Predictive Tools

artículo científico publicado en 2017

Gastrointestinal and Systemic Monitoring of Posaconazole in Humans After Fasted and Fed State Administration of a Solid Dispersion.

artículo científico publicado en 2016

Gastrointestinal behavior of itraconazole in humans - Part 1: Supersaturation from a solid dispersion and a cyclodextrin-based solution

artículo científico publicado en 2017

Gastrointestinal behavior of itraconazole in humans - Part 2: The effect of intraluminal dilution on the performance of a cyclodextrin-based solution.

artículo científico publicado en 2017

Gastrointestinal behavior of nano- and microsized fenofibrate: In vivo evaluation in man and in vitro simulation by assessment of the permeation potential

artículo científico publicado en 2015

Gastrointestinal dissolution, supersaturation and precipitation of the weak base indinavir in healthy volunteers

artículo científico publicado en 2016

Gastrointestinal transfer: in vivo evaluation and implementation in in vitro and in silico predictive tools.

artículo científico publicado en 2014

In Silico Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation and Precipitation of Posaconazole.

artículo científico publicado en 2017

In Vitro Evaluation of Viability, Integrity, and Inflammation in Genital Epithelia upon Exposure to Pharmaceutical Excipients and Candidate Microbicides ⬇️

artículo científico publicado el 4 de octubre de 2010

In situ perfusion in rodents to explore intestinal drug absorption: challenges and opportunities.

artículo científico publicado en 2014

In vitro behavior of a phosphate ester prodrug of amprenavir in human intestinal fluids and in the Caco-2 system: Illustration of intraluminal supersaturation

scientific article published on 14 December 2006

In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT.

artículo científico publicado en 2016

In vitro models for the prediction of in vivo performance of oral dosage forms

artículo científico publicado en 2013

In vitro profiling of the vaginal permeation potential of anti-HIV microbicides and the influence of formulation excipients

article

In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects.

artículo científico

Intestinal behavior of the ester prodrug tenofovir DF in humans

artículo científico publicado en 2015

Intestinal drug solubility estimation based on simulated intestinal fluids: Comparison with solubility in human intestinal fluids ⬇️

artículo científico publicado el 17 de julio de 2011

Llama antibody fragments have good potential for application as HIV type 1 topical microbicides.

artículo científico publicado en 2011

MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques

artículo científico publicado en 2012

Parallel monitoring of plasma and intraluminal drug concentrations in man after oral administration of fosamprenavir in the fasted and fed state.

artículo científico publicado en 2007

Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs.

artículo científico publicado en 2009

Rapid conversion of the ester prodrug abiraterone acetate results in intestinal supersaturation and enhanced absorption of abiraterone: In vitro, rat in situ and human in vivo studies

artículo científico publicado en 2015

Resolving intraluminal drug and formulation behavior: Gastrointestinal concentration profiling in humans

artículo científico

Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability?

artículo científico publicado en 2009

Supersaturation and Precipitation of Posaconazole Upon Entry in the Upper Small Intestine in Humans.

artículo científico publicado en 2016

Supersaturation in human gastric fluids

artículo científico publicado en 2012

The Effect of Sparkling Water on Intraluminal Formulation Behavior and Systemic Drug Performance

artículo científico publicado en 2017

The artificial membrane insert system as predictive tool for formulation performance evaluation.

artículo científico publicado en 2017

The dynamic gastric environment and its impact on drug and formulation behaviour.

artículo científico publicado en 2016

The use of supersaturation for the vaginal application of microbicides: a case study with dapivirine.

artículo científico publicado en 2014

Vaginal expression of efflux transporters and the potential impact on the disposition of microbicides in vitro and in rabbits.

artículo científico publicado en 2014

Lista de obras de Joachim Brouwers

A review of drug solubility in human intestinal fluids: implications for the prediction of oral absorption.

An In-Depth View into Human Intestinal Fluid Colloids: Intersubject Variability in Relation to Composition

An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation

Assessment of Passive Intestinal Permeability Using an Artificial Membrane Insert System

Bile Salt Micelles and Phospholipid Vesicles Present in Simulated and Human Intestinal Fluids: Structural Analysis by Flow Field-Flow Fractionation/Multiangle Laser Light Scattering.

CADA, a Potential Anti-HIV Microbicide that Specifically Targets the Cellular CD4 Receptor

CADA, a potential anti-HIV microbicide that specifically targets the cellular CD4 receptor

Capillary zone electrophoresis method development for the analysis of Hippeastrum hybrid agglutinin samples.

Characterization of Human Duodenal Fluids in Fasted and Fed State Conditions.

Determination of intraluminal theophylline concentrations after oral intake of an immediate- and a slow-release dosage form.

Development and characterization of a solid dispersion film for the vaginal application of the anti-HIV microbicide UAMC01398.

Development and in vitro evaluation of a vaginal microbicide gel formulation for UAMC01398, a novel diaryltriazine NNRTI against HIV-1.

Development and in vitro evaluation of chloroquine gels as microbicides against HIV-1 infection

Drug permeability profiling using cell-free permeation tools: Overview and applications

Drug precipitation–permeation interplay: Supersaturation in an absorptive environment ⬇️

Drug supersaturation in simulated and human intestinal fluids representing different nutritional states.

Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir

Effect of pH and Comedication on Gastrointestinal Absorption of Posaconazole

Ethanol concentrations in the human gastrointestinal tract after intake of alcoholic beverages

Evaluation of fasted and fed state simulated and human intestinal fluids as solvent system in the Ussing chambers model to explore food effects on intestinal permeability.

Evaluation of fasted state human intestinal fluid as apical solvent system in the Caco-2 absorption model and comparison with FaSSIF.

Evaluation of gastrointestinal drug supersaturation and precipitation: strategies and issues.

Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption

Excipient-Mediated Supersaturation Stabilization in Human Intestinal Fluids

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Exploring the Effect of Esomeprazole on Gastric and Duodenal Fluid Volumes and Absorption of Ritonavir

Exploring the link between gastric motility and intragastric drug distribution in man

Food-dependent disintegration of immediate release fosamprenavir tablets: in vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system.

Gastric and Duodenal Ethanol Concentrations after Intake of Alcoholic Beverages in Postprandial Conditions.

Gastrointestinal Behavior of Weakly Acidic BCS Class II Drugs in Man—Case Study of Diclofenac Potassium

Gastrointestinal and Systemic Disposition of Diclofenac under Fasted and Fed State Conditions Supporting the Evaluation of in Vitro Predictive Tools

Gastrointestinal and Systemic Monitoring of Posaconazole in Humans After Fasted and Fed State Administration of a Solid Dispersion.

Gastrointestinal behavior of itraconazole in humans - Part 1: Supersaturation from a solid dispersion and a cyclodextrin-based solution

Gastrointestinal behavior of itraconazole in humans - Part 2: The effect of intraluminal dilution on the performance of a cyclodextrin-based solution.

Gastrointestinal behavior of nano- and microsized fenofibrate: In vivo evaluation in man and in vitro simulation by assessment of the permeation potential

Gastrointestinal dissolution, supersaturation and precipitation of the weak base indinavir in healthy volunteers

Gastrointestinal transfer: in vivo evaluation and implementation in in vitro and in silico predictive tools.

In Silico Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation and Precipitation of Posaconazole.

In Vitro Evaluation of Viability, Integrity, and Inflammation in Genital Epithelia upon Exposure to Pharmaceutical Excipients and Candidate Microbicides ⬇️

In situ perfusion in rodents to explore intestinal drug absorption: challenges and opportunities.

In vitro behavior of a phosphate ester prodrug of amprenavir in human intestinal fluids and in the Caco-2 system: Illustration of intraluminal supersaturation

In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT.

In vitro models for the prediction of in vivo performance of oral dosage forms

In vitro profiling of the vaginal permeation potential of anti-HIV microbicides and the influence of formulation excipients

In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects.

Intestinal behavior of the ester prodrug tenofovir DF in humans

Intestinal drug solubility estimation based on simulated intestinal fluids: Comparison with solubility in human intestinal fluids ⬇️

Llama antibody fragments have good potential for application as HIV type 1 topical microbicides.

MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques

Parallel monitoring of plasma and intraluminal drug concentrations in man after oral administration of fosamprenavir in the fasted and fed state.

Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs.

Rapid conversion of the ester prodrug abiraterone acetate results in intestinal supersaturation and enhanced absorption of abiraterone: In vitro, rat in situ and human in vivo studies

Resolving intraluminal drug and formulation behavior: Gastrointestinal concentration profiling in humans

Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability?

Supersaturation and Precipitation of Posaconazole Upon Entry in the Upper Small Intestine in Humans.

Supersaturation in human gastric fluids

The Effect of Sparkling Water on Intraluminal Formulation Behavior and Systemic Drug Performance

The artificial membrane insert system as predictive tool for formulation performance evaluation.

The dynamic gastric environment and its impact on drug and formulation behaviour.

The use of supersaturation for the vaginal application of microbicides: a case study with dapivirine.

Vaginal expression of efflux transporters and the potential impact on the disposition of microbicides in vitro and in rabbits.