Lista de obras - Eric A. Ortlund - Dominio Público Uruguay

A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1).

artículo científico publicado en 2016

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects ⬇️

artículo científico publicado el 25 de mayo de 2011

A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis

artículo científico publicado en 2014

A supergene-linked estrogen receptor drives alternative phenotypes in a polymorphic songbird

artículo científico publicado en 2020

Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

artículo científico publicado en 2015

Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine

artículo científico publicado en 2020

Alterations in the Human Plasma Lipidome in Response to Tularemia Vaccination

artículo científico publicado en 2020

An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

artículo científico publicado en 2009

Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling

artículo científico publicado en 2021

Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate

artículo científico publicado en 2014

Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements.

artículo científico publicado en 2018

Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of Activation

artículo científico publicado en 2016

Crystal structure of a covalent intermediate of endogenous human arylsulfatase A

artículo científico publicado en 2003

Crystal structure of an ancient protein: evolution by conformational epistasis

artículo científico publicado en 2007

Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site

artículo científico publicado en 2002

Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.

artículo científico publicado en 2014

Crystallization and preliminary X-ray diffraction analysis of Sfh3, a member of the Sec14 protein superfamily.

artículo científico publicado en 2011

Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors

artículo científico publicado en 2019

Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design

artículo científico publicado en 2019

Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation

scientific article published on 07 September 2012

Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment

scientific article published on 11 September 2020

Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.

artículo científico publicado en 2015

Divergent Sequence Tunes Ligand Sensitivity in Phospholipid-regulated Hormone Receptors

artículo científico publicado en 2013

Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes

scientific article published on 13 January 2014

Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module

artículo científico publicado en 2014

Evolution of minimal specificity and promiscuity in steroid hormone receptors

artículo científico publicado en 2012

Evolutionary history and metabolic insights of ancient mammalian uricases

artículo científico publicado en 2014

First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-Activated γ Coactivator 1-α Complex with Endogenous and Synthetic Glucocorticoids

scientific article published on 07 August 2019

Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily

artículo científico publicado en 2008

Glucocorticoid receptor control of transcription: precision and plasticity via allostery.

artículo científico publicado en 2017

Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons

artículo científico publicado en 2020

Identification of a lipid scrambling domain in ANO6/TMEM16F.

artículo científico publicado en 2015

Identification of a small molecular insulin receptor agonist with potent antidiabetes activity

artículo científico publicado en 2014

Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14).

artículo científico publicado en 2015

Interleukin-13 drives metabolic conditioning of muscle to endurance exercise

artículo científico publicado en 2020

Mechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid Receptor ⬇️

artículo científico publicado el 16 de junio de 2011

Microbial metabolite delta-valerobetaine is a diet-dependent obesogen

artículo científico publicado en 2021

Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

artículo científico publicado en 2005

Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin.

artículo científico publicado en 2017

Phospholipid--driven gene regulation

artículo científico publicado en 2013

Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor

artículo científico publicado en 2010

Rapid generation of neutralizing antibody responses in COVID-19 patients

artículo científico publicado en 2020

Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution

artículo científico publicado en 2011

Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner

artículo científico publicado en 2017

Structural Basis for Ligand Regulation of the Fatty Acid-binding Protein 5, Peroxisome Proliferator-activated Receptor / (FABP5-PPAR / ) Signaling Pathway

artículo científico publicado en 2014

Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.

artículo científico publicado en 2017

Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element

artículo científico publicado en 2021

Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex.

artículo científico

Structure of glycerol dehydrogenase from Serratia.

scientific article published on 21 January 2014

Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.

artículo científico

The Effect of Anticoagulants, Temperature, and Time on the Human Plasma Metabolome and Lipidome from Healthy Donors as Determined by Liquid Chromatography-Mass Spectrometry.

artículo científico publicado en 2019

The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells

artículo científico publicado en 2020

The nuclear receptor superfamily: A structural perspective

artículo científico publicado en 2018

The structure, function and evolution of proteins that bind DNA and RNA

artículo científico publicado en 2014

Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice

artículo científico publicado en 2021

Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.

artículo científico publicado en 2015

Vestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone Receptor

artículo científico publicado en 2014

X-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding Interface

artículo científico publicado en 2013

Lista de obras de Eric A. Ortlund

A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1).

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects ⬇️

A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis

A supergene-linked estrogen receptor drives alternative phenotypes in a polymorphic songbird

Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans

Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine

Alterations in the Human Plasma Lipidome in Response to Tularemia Vaccination

An epistatic ratchet constrains the direction of glucocorticoid receptor evolution

Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling

Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate

Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements.

Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of Activation

Crystal structure of a covalent intermediate of endogenous human arylsulfatase A

Crystal structure of an ancient protein: evolution by conformational epistasis

Crystal structure of human complement protein C8gamma at 1.2 A resolution reveals a lipocalin fold and a distinct ligand binding site

Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.

Crystallization and preliminary X-ray diffraction analysis of Sfh3, a member of the Sec14 protein superfamily.

Development of a Versatile and Sensitive Direct Ligand Binding Assay for Human NR5A Nuclear Receptors

Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design

Discovery of a new class of liver receptor homolog-1 (LRH-1) antagonists: virtual screening, synthesis and biological evaluation

Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment

Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.

Divergent Sequence Tunes Ligand Sensitivity in Phospholipid-regulated Hormone Receptors

Estrogen receptor α polymorphism in a species with alternative behavioral phenotypes

Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module

Evolution of minimal specificity and promiscuity in steroid hormone receptors

Evolutionary history and metabolic insights of ancient mammalian uricases

First High-Resolution Crystal Structures of the Glucocorticoid Receptor Ligand-Binding Domain-Peroxisome Proliferator-Activated γ Coactivator 1-α Complex with Endogenous and Synthetic Glucocorticoids

Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily

Glucocorticoid receptor control of transcription: precision and plasticity via allostery.

Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons

Identification of a lipid scrambling domain in ANO6/TMEM16F.

Identification of a small molecular insulin receptor agonist with potent antidiabetes activity

Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14).

Interleukin-13 drives metabolic conditioning of muscle to endurance exercise

Mechanisms for the Evolution of a Derived Function in the Ancestral Glucocorticoid Receptor ⬇️

Microbial metabolite delta-valerobetaine is a diet-dependent obesogen

Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP

Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin.

Phospholipid--driven gene regulation

Protein evolution by molecular tinkering: diversification of the nuclear receptor superfamily from a ligand-dependent ancestor

Rapid generation of neutralizing antibody responses in COVID-19 patients

Resurrection of a functional phosphatidylinositol transfer protein from a pseudo-Sec14 scaffold by directed evolution

Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner

Structural Basis for Ligand Regulation of the Fatty Acid-binding Protein 5, Peroxisome Proliferator-activated Receptor / (FABP5-PPAR / ) Signaling Pathway

Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.

Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element

Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex.

Structure of glycerol dehydrogenase from Serratia.

Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.

The Effect of Anticoagulants, Temperature, and Time on the Human Plasma Metabolome and Lipidome from Healthy Donors as Determined by Liquid Chromatography-Mass Spectrometry.

The Rho-GEF PIX-1 directs assembly or stability of lateral attachment structures between muscle cells

The nuclear receptor superfamily: A structural perspective

The structure, function and evolution of proteins that bind DNA and RNA

Thioesterase superfamily member 1 undergoes stimulus-coupled conformational reorganization to regulate metabolism in mice

Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.

Vestigialization of an Allosteric Switch: Genetic and Structural Mechanisms for the Evolution of Constitutive Activity in a Steroid Hormone Receptor

X-Ray Crystal Structure of the Ancestral 3-Ketosteroid Receptor–Progesterone–Mifepristone Complex Shows Mifepristone Bound at the Coactivator Binding Interface