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Lista de obras de Rogier Versteeg

A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma

scientific article published on 04 April 2019

A NOTCH3 transcriptional module induces cell motility in neuroblastoma

artículo científico publicado en 2013

A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities

artículo científico publicado en 2020

A top-down analysis of Xa- and Xi-territories reveals differences of higher order structure at ≥ 20 Mb genomic length scales.

artículo científico publicado en 2011

ALK positively regulates MYCN activity through repression of HBP1 expression

scientific article published on 11 December 2018

Aberrant methylation in cancer.

artículo científico publicado en 1997

Allelic loss of chromosome 1p as a predictor of unfavorable outcome in patients with neuroblastoma

scientific article published on 01 January 1996

Allelic loss of chromosome 1p36 in neuroblastoma is of preferential maternal origin and correlates with N-myc amplification

scientific article published on 01 June 1993

Allelic loss of the short arm of chromosome 4 in neuroblastoma suggests a novel tumour suppressor gene locus

scientific article published on 01 June 1996

Analysis of 1;17 translocation breakpoints in neuroblastoma: implications for mapping of neuroblastoma genes.

artículo científico publicado en 1997

Arrangement of nuclear structures is not transmitted through mitosis but is identical in sister cells.

artículo científico publicado en 2012

ArrayCGH-based classification of neuroblastoma into genomic subgroups

artículo científico publicado en 2007

Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism.

artículo científico publicado en 2015

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

artículo científico publicado en 2016

Balanced translocation in a neuroblastoma patient disrupts a cluster of small nuclear RNA U1 and tRNA genes in chromosomal band 1p36

article

Biochemistry meets nuclear architecture: multicolor immuno-FISH for co-localization analysis of chromosome segments and differentially expressed gene loci with various histone methylations.

artículo científico publicado en 2007

Biological effects of TrkA and TrkB receptor signaling in neuroblastoma.

artículo científico publicado en 2005

CASP8 SNP D302H (rs1045485) is associated with worse survival in MYCN-amplified neuroblastoma patients

artículo científico publicado en 2014

CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status

artículo científico publicado en 2013

Cancer: Tumours outside the mutation box.

artículo científico publicado en 2014

Chromosome bands 1p35-36 contain two distinct neuroblastoma tumor suppressor loci, one of which is imprinted

artículo científico publicado en 2001

Cloning a cDNA for the lysosomal alpha-glucosidase

artículo científico publicado en 1984

Comparative genomic hybridization analysis of human neuroblastomas: detection of distal 1p deletions and further molecular genetic characterization of neuroblastoma cell lines.

artículo científico publicado en 1997

Comparison of RNAi efficiency mediated by tetracycline-responsive H1 and U6 promoter variants in mammalian cell lines

artículo científico publicado en 2007

Copy number defects of G1-cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis

artículo científico publicado en 2011

Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.

artículo científico publicado en 2018

Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma

artículo científico publicado en 2008

Cyclin D1 is a direct transcriptional target of GATA3 in neuroblastoma tumor cells

Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma

artículo científico publicado en 2015

DHODH is an independent prognostic marker and potent therapeutic target in neuroblastoma

artículo científico publicado en 2022

DNA-Dependent Protein Kinase As Molecular Target for Radiosensitization of Neuroblastoma Cells

artículo científico publicado en 2015

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

artículo científico publicado en 2014

Deletion mapping in neuroblastoma cell lines suggests two distinct tumor suppressor genes in the 1p35-36 region, only one of which is associated with N-myc amplification.

artículo científico publicado en 1995

Design of a multi-signature ensemble classifier predicting neuroblastoma patients' outcome

artículo científico publicado en 2012

Detecting minimal residual disease in neuroblastoma: the superiority of a panel of real-time quantitative PCR markers

artículo científico publicado en 2009

Detection of recurrent chromosome abnormalities in Ewing's sarcoma and peripheral neuroectodermal tumor cells using bivariate flow karyotyping ⬇️

artículo científico publicado el 1 de noviembre de 1992

Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation

artículo científico

Dickkopf-3 expression is a marker for neuroblastic tumor maturation and is down-regulated by MYCN.

artículo científico publicado en 2008

Direct regulation of the minichromosome maintenance complex by MYCN in neuroblastoma

artículo científico publicado en 2007

Discovery and visualization of miRNA-mRNA functional modules within integrated data using bicluster analysis

artículo científico publicado en 2013

Dissection of the oncogenic MYCN transcriptional network reveals a large set of clinically relevant cell cycle genes as drivers of neuroblastoma tumorigenesis

artículo científico publicado en 2010

Domain-wide regulation of gene expression in the human genome

artículo científico publicado en 2007

ERBB3 is a marker of a ganglioneuroblastoma/ganglioneuroma-like expression profile in neuroblastic tumours.

scientific article published on 08 July 2013

Efficient double fragmentation ChIP-seq provides nucleotide resolution protein-DNA binding profiles

artículo científico publicado en 2010

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

artículo científico publicado en 2014

Enhancer of zeste homologue 2 plays an important role in neuroblastoma cell survival independent of its histone methyltransferase activity

artículo científico publicado en 2017

Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome

artículo científico publicado en 2012

Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation

artículo científico publicado en 2007

FOXO3a is a major target of inactivation by PI3K/AKT signaling in aggressive neuroblastoma

artículo científico publicado en 2013

Functional MYCN signature predicts outcome of neuroblastoma irrespective of MYCN amplification

artículo científico publicado en 2012

Galectin-1 is a major effector of TrkB-mediated neuroblastoma aggressiveness.

artículo científico publicado en 2009

Genes and regulatory sequences of bacteriophage phi X174

artículo científico publicado en 1983

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

artículo científico publicado en 2014

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

artículo científico publicado en 2012

Genome-wide DNA methylation analysis of neuroblastic tumors reveals clinically relevant epigenetic events and large-scale epigenomic alterations localized to telomeric regions

article

Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells

artículo científico publicado en 2008

Genomic Amplifications and Distal 6q Loss: Novel Markers for Poor Survival in High-risk Neuroblastoma Patients.

artículo científico publicado en 2018

Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: an approach to identify candidate genes involved in tumor development

artículo científico publicado en 2009

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome

artículo científico publicado en 2016

Glycerophosphodiesterase GDE2 Promotes Neuroblastoma Differentiation through Glypican Release and Is a Marker of Clinical Outcome

High delta-like 1 expression in a subset of neuroblastoma cell lines corresponds to a differentiated chromaffin cell type

artículo científico publicado en 2003

High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition

artículo científico publicado en 2016

High-resolution fluorescence mapping of 46 DNA markers to the short arm of human chromosome 1.

artículo científico publicado en 1993

Histone chaperone CHAF1A inhibits differentiation and promotes aggressive neuroblastoma

artículo científico publicado en 2013

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

artículo científico publicado en 2012

Hypermutation of the inactive X chromosome is a frequent event in cancer

artículo científico publicado en 2013

Identification of BIRC6 as a novel intervention target for neuroblastoma therapy

artículo científico publicado en 2012

Identification of a novel recurrent 1q42.2-1qter deletion in high risk MYCN single copy 11q deleted neuroblastomas

artículo científico publicado en 2011

Identification of two distinct chromosome 12-derived amplification units in neuroblastoma cell line NGP ⬇️

artículo científico publicado el 15 de julio de 1995

Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells

scholarly article

Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response

artículo científico publicado en 2017

Individual patient risk stratification of high-risk neuroblastomas using a two-gene score suited for clinical use.

artículo científico publicado en 2015

Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes.

artículo científico publicado en 2005

Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features

artículo científico publicado en 2008

Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer

artículo científico publicado en 2015

Intratumour diversity of chromosome copy numbers in neuroblastoma mediated by on-going chromosome loss from a polyploid state

artículo científico publicado en 2013

Joint binding of OTX2 and MYC in promotor regions is associated with high gene expression in medulloblastoma

artículo científico publicado en 2011

Knockdown of survivin (BIRC5) causes apoptosis in neuroblastoma via mitotic catastrophe

artículo científico publicado en 2011

LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR)

artículo científico publicado en 2012

LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression.

artículo científico publicado en 2012

Lack of association between MDM2 promoter SNP309 and clinical outcome in patients with neuroblastoma.

artículo científico publicado en 2014

Lack of class I HLA expression in neuroblastoma is associated with high N-myc expression and hypomethylation due to loss of the MEMO-1 locus

scientific article published on 01 October 1996

Lack of interstitial chromosome 1p deletions in clinically-detected neuroblastoma

scientific article published on 01 July 2002

Localization of the 17q breakpoint of a constitutional 1;17 translocation in a patient with neuroblastoma within a 25-kb segment located between the ACCN1 and TLK2 genes and near the distal breakpoints of two microdeletions in neurofibromatosis type

artículo científico publicado en 2002

Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

artículo científico publicado en 2009

MEIS homeobox genes in neuroblastoma

artículo científico publicado en 2005

MEK inhibition causes Bim stabilization and sensitivity to Bcl2 family member inhibitors in RAS-MAPK mutated neuroblastoma

MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3.

artículo científico publicado en 2009

MYCN and ALKF1174L are sufficient to drive neuroblastoma development from neural crest progenitor cells

artículo científico publicado en 2012

MYCN and HDAC5 transcriptionally repress CD9 to trigger invasion and metastasis in neuroblastoma

artículo científico publicado en 2016

MYCN transcriptionally represses CD9 to trigger an invasion-metastasis cascade in neuroblastoma

artículo científico publicado en 2015

Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes

artículo científico publicado en 2022

Meta-analysis of neuroblastomas reveals a skewed ALK mutation spectrum in tumors with MYCN amplification

artículo científico publicado en 2010

Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients

artículo científico publicado en 2011

Modulation of neuroblastoma disease pathogenesis by an extensive network of epigenetically regulated microRNAs

artículo científico publicado en 2012

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

artículo científico publicado en 2015

Molecular cytogenetic analysis of 1;17 translocations in neuroblastoma.

artículo científico publicado en 1995

Molecular risk stratification of medulloblastoma patients based on immunohistochemical analysis of MYC, LDHB, and CCNB1 expression

artículo científico publicado en 2008

Mutations in the Ras-Raf Axis underlie the prognostic value of CD133 in colorectal cancer

artículo científico publicado en 2012

Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors

artículo científico publicado en 2015

N-ras mutations in human cutaneous melanoma from sun-exposed body sites.

artículo científico publicado en 1989

NF1 is a tumor suppressor in neuroblastoma that determines retinoic acid response and disease outcome

artículo científico publicado en 2010

NK cells and T cells: mirror images?

artículo científico publicado el 1 de julio de 1992

Neuroblastoma is composed of two super-enhancer-associated differentiation states.

artículo científico publicado en 2017

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

artículo científico publicado en 2016

Newly-derived neuroblastoma cell lines propagated in serum-free media recapitulate the genotype and phenotype of primary neuroblastoma tumours

artículo científico publicado en 2013

No mutations found by RET mutation scanning in sporadic and hereditary neuroblastoma

scientific article published on 01 March 1996

OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas

artículo científico publicado en 2006

OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells

artículo científico publicado en 2011

OTX2 sustains a bivalent-like state of OTX2-bound promoters in medulloblastoma by maintaining their H3K27me3 levels

artículo científico publicado en 2012

Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastoma

artículo científico publicado en 2011

Pediatric neuroblastomas: genetic and epigenetic 'danse macabre'.

artículo científico publicado en 2004

Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma

artículo científico publicado en 2013

Prevalence of congenital heart defects in neuroblastoma patients: a cohort study and systematic review of literature.

scientific article published on 17 December 2008

Prospective derivation of a living organoid biobank of colorectal cancer patients.

artículo científico publicado en 2015

Read-through transcript from NM23-H1 into the neighboring NM23-H2 gene encodes a novel protein, NM23-LV.

artículo científico publicado en 2006

Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma

artículo científico publicado en 2003

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

artículo científico publicado en 2013

Refined physical mapping and genomic structure of the EXTL1 gene

artículo científico publicado en 1999

Regulation of cell cycle genes and induction of senescence by overexpression of OTX2 in medulloblastoma cell lines

artículo científico publicado en 2010

Regulation of type III iodothyronine deiodinase expression in human cell lines.

artículo científico publicado en 2006

Relapsed neuroblastomas show frequent RAS-MAPK pathway mutations

artículo científico publicado en 2015

Robust selection of cancer survival signatures from high-throughput genomic data using two-fold subsampling

artículo científico publicado en 2014

Selection of personalized patient therapy through the use of knowledge-based computational models that identify tumor-driving signal transduction pathways.

artículo científico publicado en 2014

Sensitivity of melanoma cell lines to natural killer cells: a role for oncogene-modulated HLA class I expression?

artículo científico publicado en 1991

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

artículo científico publicado en 2012

Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene

artículo científico publicado en 2010

Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells.

artículo científico publicado en 2010

TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

artículo científico publicado en 2018

TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors.

artículo científico publicado en 2015

Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth

artículo científico publicado en 2012

Targeted BIRC5 silencing using YM155 causes cell death in neuroblastoma cells with low ABCB1 expression

artículo científico publicado en 2011

Targeting ALK: The Ten Lives of a Tumor

artículo científico publicado en 2016

Targeting CDKs with Roscovitine Increases Sensitivity to DNA Damaging Drugs of Human Osteosarcoma Cells

artículo científico publicado en 2016

Targeting polo-like kinase 1 by NMS-P937 in osteosarcoma cell lines inhibits tumor cell growth and partially overcomes drug resistance

artículo científico publicado en 2014

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

artículo científico publicado en 2012

The MEIS1 oncogene is highly expressed in neuroblastoma and amplified in cell line IMR32

artículo científico publicado en 2001

The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma

artículo científico publicado en 2008

The Phox2B homeobox gene is mutated in sporadic neuroblastomas

artículo científico publicado en 2004

The construction of genome-based transcriptional units.

artículo científico publicado en 2009

The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes

artículo científico publicado en 2003

The human transcriptome map: clustering of highly expressed genes in chromosomal domains

artículo científico publicado en 2001

The hypoxia target adrenomedullin is aberrantly expressed in multiple myeloma and promotes angiogenesis.

artículo científico publicado en 2013

The low-affinity neurotrophin receptor, p75, is upregulated in ganglioneuroblastoma/ganglioneuroma and reduces tumorigenicity of neuroblastoma cells in vivo

artículo científico publicado en 2009

The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

artículo científico publicado en 2010

The prognostic value of fast molecular response of marrow disease in patients aged over 1year with stage 4 neuroblastoma ⬇️

artículo científico publicado el 21 de marzo de 2011

The role of histone demethylase KDM4B in Myc signaling in neuroblastoma

artículo científico publicado en 2015

The role of the MEIS homeobox genes in neuroblastoma

artículo científico publicado en 2003

The three-dimensional structure of human interphase chromosomes is related to the transcriptome map.

artículo científico publicado en 2007

Tumor-specific down-regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation.

artículo científico publicado en 2002

Use of Attribute Driven Incremental Discretization and Logic Learning Machine to build a prognostic classifier for neuroblastoma patients

artículo científico publicado en 2014

Whole-Genome Sequencing Identifies Patient-Specific DNA Minimal Residual Disease Markers in Neuroblastoma

scholarly article by Esther M. van Wezel et al published January 2015 in The Journal of Molecular Diagnostics

ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome

artículo científico publicado en 2009

c-myc down-regulates class I HLA expression in human melanomas ⬇️

artículo científico publicado el 1 de abril de 1988

miRNA expression profiling enables risk stratification in archived and fresh neuroblastoma tumor samples

artículo científico publicado en 2011

snoRNPs Regulate Telomerase Activity in Neuroblastoma and Are Associated with Poor Prognosis.

artículo científico

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