Lista de obras - Brian J. Abraham - Dominio Público Uruguay

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

artículo científico publicado en 2017

APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

artículo científico publicado en 2017

ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression

artículo científico publicado en 2020

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

scientific article published on 09 December 2019

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.

artículo científico publicado en 2017

Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.

artículo científico publicado en 2017

CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

artículo científico publicado en 2014

CDK7-dependent transcriptional addiction in triple-negative breast cancer.

artículo científico publicado en 2015

Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions

artículo científico publicado en 2015

Coactivator condensation at super-enhancers links phase separation and gene control

artículo científico publicado en 2018

Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits

artículo científico publicado en 2020

Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes

artículo científico publicado en 2014

Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers

artículo científico publicado en 2015

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

scientific article published on 29 August 2016

Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.

artículo científico publicado en 2018

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

artículo científico publicado en 2022

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

artículo científico publicado en 2018

Erratum to: Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3.

artículo científico publicado en 2016

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.

artículo científico publicado en 2015

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis

artículo científico publicado en 2016

Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3.

artículo científico publicado en 2013

High MITF Expression is Associated with Super-enhancers and Suppressed by CDK7 Inhibition in Melanoma.

artículo científico publicado en 2018

Integrated genomic analyses of de novo pathways underlying atypical meningiomas

artículo científico publicado en 2017

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.

artículo científico publicado en 2018

LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors

scientific article published on 29 June 2020

MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification

scientific article published on 28 December 2017

Models of human core transcriptional regulatory circuitries

artículo científico publicado en 2016

Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements.

artículo científico publicado en 2013

Novel mechanism of positive versus negative regulation by thyroid hormone receptor β1 (TRβ1) identified by genome-wide profiling of binding sites in mouse liver

artículo científico publicado en 2013

O-GlcNAcase Is an RNA Polymerase II Elongation Factor Coupled to Pausing Factors SPT5 and TIF1β.

artículo científico publicado en 2016

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

artículo científico publicado en 2014

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

artículo científico publicado en 2016

RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells

scientific article published on 30 March 2020

Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas

artículo científico publicado en 2016

SEAseq: a portable and cloud-based chromatin occupancy analysis suite

artículo científico publicado en 2022

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

article

Small genomic insertions form enhancers that misregulate oncogenes

artículo científico publicado en 2017

Super-enhancers in the control of cell identity and disease

artículo científico publicado en 2013

Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression.

artículo científico publicado en 2017

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia

artículo científico publicado en 2017

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

artículo científico publicado en 2014

Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor

artículo científico publicado en 2014

The developmental potential of iPSCs is greatly influenced by reprogramming factor selection

artículo científico publicado en 2014

The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

artículo científico publicado en 2017

Transcription factor trapping by RNA in gene regulatory elements

artículo científico publicado en 2015

YY1 Is a Structural Regulator of Enhancer-Promoter Loops

artículo científico publicado en 2017

Lista de obras de Brian J. Abraham

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer

APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

ARID1A loss in neuroblastoma promotes the adrenergic-to-mesenchymal transition by regulating enhancer-mediated gene expression

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

Activation of the LMO2 oncogene through a somatically acquired neomorphic promoter in T-cell acute lymphoblastic leukemia.

Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.

CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

CDK7-dependent transcriptional addiction in triple-negative breast cancer.

Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions

Coactivator condensation at super-enhancers links phase separation and gene control

Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits

Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes

Convergence of developmental and oncogenic signaling pathways at transcriptional super-enhancers

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Cross-Cohort Analysis Identifies a TEAD4-MYCN Positive Feedback Loop as the Core Regulatory Element of High-Risk Neuroblastoma.

EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

Erratum to: Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3.

Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis

Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3.

High MITF Expression is Associated with Super-enhancers and Suppressed by CDK7 Inhibition in Melanoma.

Integrated genomic analyses of de novo pathways underlying atypical meningiomas

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia.

LIN28B regulates transcription and potentiates MYCN-induced neuroblastoma through binding to ZNF143 at target gene promotors

MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification

Models of human core transcriptional regulatory circuitries

Multiple structural maintenance of chromosome complexes at transcriptional regulatory elements.

Novel mechanism of positive versus negative regulation by thyroid hormone receptor β1 (TRβ1) identified by genome-wide profiling of binding sites in mouse liver

O-GlcNAcase Is an RNA Polymerase II Elongation Factor Coupled to Pausing Factors SPT5 and TIF1β.

Oncogene regulation. An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells

Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas

SEAseq: a portable and cloud-based chromatin occupancy analysis suite

Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry

Small genomic insertions form enhancers that misregulate oncogenes

Super-enhancers in the control of cell identity and disease

Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression.

TOX Regulates Growth, DNA Repair, and Genomic Instability in T-cell Acute Lymphoblastic Leukemia

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor

The developmental potential of iPSCs is greatly influenced by reprogramming factor selection

The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

Transcription factor trapping by RNA in gene regulatory elements

YY1 Is a Structural Regulator of Enhancer-Promoter Loops