Filtros de búsqueda

Lista de obras de Theo M C M de Kok

'Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans

artículo científico publicado en 2012

A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data

scientific article published on 03 October 2019

A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine.

artículo científico publicado en 2008

A multi-omics approach to investigate the inflammatory response to life course socioeconomic position

artículo científico publicado en 2020

A sex-specific blood transcriptome signature predicts particulate matter exposure among middle-aged men and women ⬇️

scholarly article

Adipose tissue in health and disease through the lens of its building blocks

artículo científico publicado en 2020

Antioxidative and antigenotoxic properties of vegetables and dietary phytochemicals: the value of genomics biomarkers in molecular epidemiology

artículo científico publicado en 2010

Biological marks of early-life socioeconomic experience is detected in the adult inflammatory transcriptome

artículo científico publicado en 2016

Blood Transcriptome Response to Environmental Metal Exposure Reveals Potential Biological Processes Related to Alzheimer's Disease

artículo científico publicado en 2020

Blood gene expression of candidate genes in environmental carcinogenesis in association with particulate air pollution ⬇️

scholarly article

Blood transcriptional and microRNA responses to short-term exposure to disinfection by-products in a swimming pool

artículo científico publicado en 2017

Blood-based omic profiling supports female susceptibility to tobacco smoke-induced cardiovascular diseases ⬇️

artículo científico publicado en 2017

CYP1A2 and NAT2 genotype/phenotype relations and urinary excretion of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in a human dietary intervention study

artículo científico publicado en 2004

Can transcriptomics provide insight into the chemopreventive mechanisms of complex mixtures of phytochemicals in humans?

artículo científico publicado en 2014

Comparison of statistical methods and the use of quality control samples for batch effect correction in human transcriptome data

scientific article published on 30 August 2018

Consumption of Nitrate-Rich Beetroot Juice with or without Vitamin C Supplementation Increases the Excretion of Urinary Nitrate, Nitrite, and N-nitroso Compounds in Humans. ⬇️

artículo científico publicado en 2019

DNA methylation profiling implicates exposure to PCBs in the pathogenesis of B-cell chronic lymphocytic leukemia

scientific article published on 15 February 2019

Development and application of an electron spin resonance spectrometry method for the determination of oxygen free radical formation by particulate matter

artículo científico publicado en 2005

Development and regulatory application of microRNA biomarkers

artículo científico publicado en 2015

Development of novel tools for the in vitro investigation of drug-induced liver injury.

artículo científico

Distinct genotype-dependent differences in transcriptome responses in humans exposed to environmental carcinogens

artículo científico publicado en 2015

Does the evidence about health risks associated with nitrate ingestion warrant an increase of the nitrate standard for drinking water?

artículo científico publicado en 2006

Drinking Water Nitrate and Human Health: An Updated Review

article

Drug-induced gene expression profile changes in relation to intestinal toxicity: State-of-the-art and new approaches

scientific article published on 27 June 2019

Elimination of heparin interference during microarray processing of fresh and biobank-archived blood samples.

artículo científico

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis

artículo científico publicado en 2014

Epigenome-wide association study of adiposity and future risk of obesity-related diseases

article by Gianluca Campanella et al published 1 May 2018 in International Journal of Obesity

Estimating real cell size distribution from cross-section microscopy imaging

artículo científico publicado en 2016

Estimation of incidence and social cost of colon cancer due to nitrate in drinking water in the EU: a tentative cost-benefit assessment ⬇️

artículo científico publicado el 6 de octubre de 2010

Evolving DNA methylation and gene expression markers of B-cell chronic lymphocytic leukemia are present in pre-diagnostic blood samples more than 10 years prior to diagnosis

artículo científico publicado en 2017

Exploring the cellular network of metabolic flexibility in the adipose tissue.

artículo científico publicado en 2018

Exploring the nature of prediagnostic blood transcriptome markers of chronic lymphocytic leukemia by assessing their overlap with the transcriptome at the clinical stage

artículo científico publicado en 2017

Fecapentaenes and risk for colorectal cancer ⬇️

GSTM1 and GSTT1 polymorphism influences protection against induced oxidative DNA damage by quercetin and ascorbic acid in human lymphocytes in vitro.

artículo científico publicado en 2007

Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171).

artículo científico publicado en 2017

Generation of free radicals and induction of DNA adducts by activation of heterocyclic aromatic amines via different metabolic pathways in vitro.

artículo científico publicado en 2002

Genomics-based identification of molecular mechanisms behind the cancer preventive action of phytochemicals: potential and challenges

scientific article published on January 2012

Genotoxicity and physicochemical characteristics of traffic-related ambient particulate matter.

artículo científico publicado en 2005

Global MicroRNA Analysis in Primary Hepatocyte Cultures

artículo científico publicado en 2015

Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells

artículo científico publicado en 2009

Human fecal water modifies adhesion of intestinal bacteria to Caco-2 cells.

artículo científico publicado en 2005

Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs)

artículo científico publicado en 2019

Impact of high drinking water nitrate levels on the endogenous formation of apparent N-nitroso compounds in combination with meat intake in healthy volunteers

artículo científico publicado en 2019

Improved Preventive Effects of Combined Bioactive Compounds Present in Different Blueberry Varieties as Compared to Single Phytochemicals

artículo científico publicado en 2018

Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator

scientific article published on 28 June 2019

In vitro and in vivo studies on oxygen free radical and DNA adduct formation in rat lung and liver during benzo[a]pyrene metabolism.

artículo científico publicado en 2004

In vitro investigations into the interaction of beta-carotene with DNA: evidence for the role of carbon-centered free radicals.

artículo científico publicado en 2004

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain

artículo científico publicado en 2015

Influence of TCDD and natural Ah receptor agonists on benzo[a]pyrene-DNA adduct formation in the Caco-2 human colon cell line.

artículo científico publicado en 2007

Integrative "-Omics" Analysis in Primary Human Hepatocytes Unravels Persistent Mechanisms of Cyclosporine A-Induced Cholestasis.

artículo científico publicado en 2016

Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction

artículo científico publicado en 2017

Lead-exposure associated miRNAs in humans and Alzheimer’s disease as potential biomarkers of the disease and disease processes

Logical modelling reveals the PDC-PDK interaction as the regulatory switch driving metabolic flexibility at the cellular level

artículo científico publicado en 2019

Mechanisms of colorectal and lung cancer prevention by vegetables: a genomic approach

artículo científico publicado en 2007

Mechanisms of combined action of different chemopreventive dietary compounds: a review

scientific article published on May 2008

MicroRNA profile for health risk assessment: Environmental exposure to persistent organic pollutants strongly affects the human blood microRNA machinery.

artículo científico publicado en 2017

Molecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis

artículo científico

N-nitroso compound exposure-associated transcriptomic profiles are indicative of an increased risk for colorectal cancer

scientific article published on 12 June 2011

New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids

artículo científico publicado en 2021

Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort

artículo científico publicado en 2017

Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes

artículo científico publicado en 2017

Ophthalmic acid as a read-out for hepatic glutathione metabolism in humans

artículo científico publicado en 2018

Pattern recognition methods to relate time profiles of gene expression with phenotypic data: a comparative study

artículo científico publicado en 2015

Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing biobanks in environmental health research

artículo científico publicado en 2013

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens

artículo científico publicado en 2018

Possible Adverse Effects of Food Additive E171 (Titanium Dioxide) Related to Particle Specific Human Toxicity, Including the Immune System

artículo científico publicado en 2020

Pre-diagnostic blood immune markers, incidence and progression of B-cell lymphoma and multiple myeloma: Univariate and functionally informed multivariate analyses.

artículo científico publicado en 2018

Profiling Cellular Processes in Adipose Tissue during Weight Loss Using Time Series Gene Expression

article

Radical mechanisms in nitrosamine- and nitrosamide-induced whole-genome gene expression modulations in Caco-2 cells

artículo científico publicado en 2010

Red meat intake-induced increases in fecal water genotoxicity correlate with pro-carcinogenic gene expression changes in the human colon.

artículo científico publicado en 2011

Relationship between radical generation by urban ambient particulate matter and pulmonary function of school children.

artículo científico publicado en 2006

Replacement of Nitrite in Meat Products by Natural Bioactive Compounds Results in Reduced Exposure to N-Nitroso Compounds: The PHYTOME Project

artículo científico publicado en 2021

Response to cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity.

artículo científico publicado en 2015

Risk assessment of endogenous formation of carcinogenic N-nitroso compounds in response to intake of NO-aspirin

artículo científico publicado en 2004

Serum microRNA signatures as "liquid biopsies" for interrogating hepatotoxic mechanisms and liver pathogenesis in human.

artículo científico publicado en 2017

Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women.

artículo científico publicado en 2016

Short-term exposure to traffic-related air pollution reveals a compound-specific circulating miRNA profile indicating multiple disease risks

scientific article published on 03 May 2019

Short-term transcriptome and microRNAs responses to exposure to different air pollutants in two population studies

artículo científico publicado en 2018

Smart Combinations of Bioactive Compounds in Fruits and Vegetables May Guide New Strategies for Personalized Prevention of Chronic Diseases

artículo científico publicado en 2017

Spatial Systems Lipidomics Reveals Nonalcoholic Fatty Liver Disease Heterogeneity.

artículo científico publicado en 2018

Stakeholder and consumer reactions towards innovative processed meat products: Insights from a qualitative study about nitrite reduction and phytochemical addition

article

Stratifying cellular metabolism during weight loss: an interplay of metabolism, metabolic flexibility and inflammation

artículo científico publicado en 2020

Teaching Basic Environmental Health in Universities Utilizing an Interdisciplinary Holistic Approach and Interactive Learning Methods

artículo científico publicado en 1997

The CYP1A2-164A-->C polymorphism (CYP1A2*1F) is associated with the risk for colorectal adenomas in humans

artículo científico publicado en 2005

The application of omics-based human liver platforms for investigating the mechanism of drug-induced hepatotoxicity in vitro

scientific article published on 05 October 2019

The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution

artículo científico publicado en 2018

Time course gene expression data in colon of mice after exposure to food-grade E171.

artículo científico publicado en 2017

Time-series analysis of gene expression profiles induced by nitrosamides and nitrosamines elucidates modes of action underlying their genotoxicity in human colon cells.

artículo científico publicado en 2011

Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions

artículo científico publicado en 2016

Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions

artículo científico publicado en 2018

Toxicological assessment of ambient and traffic-related particulate matter: a review of recent studies

artículo científico publicado en 2006

Transcriptome changes in undifferentiated Caco-2 cells exposed to food-grade titanium dioxide (E171): contribution of the nano- and micro- sized particles

scientific article published on 04 December 2019

Transcriptome-wide analyses indicate mitochondrial responses to particulate air pollution exposure

artículo científico

Transcriptomics analysis reveals new insights in E171-induced molecular alterations in a mouse model of colon cancer.

artículo científico publicado en 2018

Use of deep learning methods to translate drug-induced gene expression changes from rat to human primary hepatocytes

scientific article published on 11 August 2020

Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells.

artículo científico publicado en 2011

Witch hazel (Hamamelis virginiana) fractions and the importance of gallate moieties--electron transfer capacities in their antitumoral properties.

artículo científico publicado en 2008

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda