Lista de obras - Rehana K. Leak - Dominio Público Uruguay

A new era for stroke therapy: Integrating neurovascular protection with optimal reperfusion

artículo científico publicado en 2018

APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury.

artículo científico publicado en 2016

ATP induces mild hypothermia in rats but has a strikingly detrimental impact on focal cerebral ischemia.

artículo científico publicado en 2012

Adaptation and sensitization to proteotoxic stress.

artículo científico publicado en 2013

Adaptation to chronic MG132 reduces oxidative toxicity by a CuZnSOD-dependent mechanism

artículo científico publicado en 2008

Adoptive regulatory T-cell therapy preserves systemic immune homeostasis after cerebral ischemia

artículo científico publicado en 2013

Aging of cerebral white matter.

artículo científico publicado en 2016

Alpha-synuclein: prion or prion-like?

artículo científico publicado en 2019

Apurinic/apyrimidinic endonuclease 1 upregulation reduces oxidative DNA damage and protects hippocampal neurons from ischemic injury

artículo científico publicado en 2015

Astrocyte plasticity revealed by adaptations to severe proteotoxic stress ⬇️

artículo científico publicado el 19 de febrero de 2013

Astrocytes Do Not Forfeit Their Neuroprotective Roles After Surviving Intense Oxidative Stress

artículo científico publicado en 2019

Astrocytes Surviving Severe Stress Can Still Protect Neighboring Neurons from Proteotoxic Injury

artículo científico publicado en 2015

Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation.

artículo científico publicado en 2018

Calbindin-D28K cells in the hamster SCN express light-induced Fos

artículo científico publicado en 1996

Corrigendum to "Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation" [Redox Biol. 17 (2018) 323-337]

artículo científico publicado en 2018

Critical appraisal of pathology transmission in the α-synuclein fibril model of Lewy body disorders.

artículo científico publicado en 2017

Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization

artículo científico publicado en 2017

Cytotoxicity models of Huntington's disease and relevance of hormetic mechanisms: A critical assessment of experimental approaches and strategies

artículo científico publicado en 2019

Delivery of neurotherapeutics across the blood brain barrier in stroke.

artículo científico

Diabetes Mellitus Impairs White Matter Repair and Long-Term Functional Deficits After Cerebral Ischemia

artículo científico publicado en 2018

Dietary supplementation with omega-3 polyunsaturated fatty acids robustly promotes neurovascular restorative dynamics and improves neurological functions after stroke.

artículo científico publicado en 2015

Drug conjugates—an emerging approach to treat breast cancer.

artículo científico publicado en 2018

Drug-induced hypothermia in stroke models: does it always protect?

artículo científico publicado en 2013

Effect of sublethal 6-hydroxydopamine on the response to subsequent oxidative stress in dopaminergic cells: evidence for preconditioning

artículo científico publicado en 2006

Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury.

artículo científico publicado en 2017

Enhancing and Extending Biological Performance and Resilience

scientific article published on 01 July 2018

Ethyl pyruvate protects against blood-brain barrier damage and improves long-term neurological outcomes in a rat model of traumatic brain injury

artículo científico publicado en 2015

Evidence for cross-hemispheric preconditioning in experimental Parkinson's disease.

artículo científico publicado en 2017

Fast free-of-acrylamide clearing tissue (FACT)-an optimized new protocol for rapid, high-resolution imaging of three-dimensional brain tissue

artículo científico

From apoplexy to stroke: historical perspectives and new research frontiers.

artículo científico publicado en 2013

Galectin-1-secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury

artículo científico publicado en 2015

Gene transcripts associated with BMI in the motor cortex and caudate nucleus of calorie restricted rhesus monkeys ⬇️

artículo científico publicado el 29 de diciembre de 2011

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis.

artículo científico publicado en 2015

HSP27 Protects the Blood-Brain Barrier Against Ischemia-Induced Loss of Integrity ⬇️

artículo científico publicado el 1 de mayo de 2013

Heat shock proteins in neurodegenerative disorders and aging

artículo científico publicado en 2014

Hormesis Mediates Dose-Sensitive Shifts in Macrophage Activation Patterns

scientific article published on 13 October 2018

IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice

scientific article published on 08 December 2020

Identification of retinal ganglion cells projecting to the lateral hypothalamic area of the rat ⬇️

artículo científico publicado el 3 de octubre de 1997

Impact of aging on heat shock protein expression in the substantia nigra and striatum of the female rat.

artículo científico publicado en 2014

Implantation of Brain-Derived Extracellular Matrix Enhances Neurological Recovery after Traumatic Brain Injury.

artículo científico publicado en 2017

Innervation of ventricular and periventricular brain compartments.

artículo científico publicado en 2012

Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia

artículo científico publicado en 2016

Intracerebroventricular Delivery of Recombinant NAMPT Deters Inflammation and Protects Against Cerebral Ischemia

scientific article published on 28 February 2019

Investigation of the therapeutic potential of N-acetyl cysteine and the tools used to define nigrostriatal degeneration in vivo.

artículo científico publicado en 2016

Ischemic post-conditioning partially reverses cell cycle reactivity following ischemia/reperfusion injury: a genome-wide survey.

artículo científico publicado en 2013

Ischemic preconditioning provides long-lasting neuroprotection against ischemic stroke: The role of Nrf2

scientific article published on 05 December 2019

Long weekend sleep is linked to stronger academic performance in male but not female pharmacy students

scientific article published on 01 September 2020

Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia.

artículo científico publicado en 2012

Microglial and macrophage polarization—new prospects for brain repair

artículo científico publicado en 2014

Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning

artículo científico publicado en 2012

Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair

artículo científico publicado en 2013

N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner.

artículo científico publicado en 2013

N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione

artículo científico publicado en 2017

N-acetyl cysteine prevents synergistic, severe toxicity from two hits of oxidative stress.

artículo científico publicado en 2013

Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo

artículo científico publicado en 2013

Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles

artículo científico publicado en 2014

Neurobiology of stroke: Research progress and perspectives

scientific article published on 01 April 2018

Neuronal NAMPT is released after cerebral ischemia and protects against white matter injury

artículo científico publicado en 2014

Neuroprotection against stroke and CNS injury: new mechanisms, targets, and controversies

artículo científico publicado en 2013

Neurorestorative effect of urinary bladder matrix-mediated neural stem cell transplantation following traumatic brain injury in rats.

artículo científico publicado en 2013

Neurotransmitter receptors on microglia

artículo científico publicado en 2016

Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1.

artículo científico publicado en 2014

Omega-3 polyunsaturated fatty acid supplementation improves neurologic recovery and attenuates white matter injury after experimental traumatic brain injury.

artículo científico publicado en 2013

Omega-3 polyunsaturated fatty acids enhance cerebral angiogenesis and provide long-term protection after stroke

artículo científico publicado en 2014

Omega-3 polyunsaturated fatty acids mitigate blood-brain barrier disruption after hypoxic-ischemic brain injury

artículo científico publicado en 2016

Organization of suprachiasmatic nucleus projections in Syrian hamsters (Mesocricetus auratus): an anterograde and retrograde analysis.

artículo científico publicado en 2004

Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery

artículo científico publicado en 2017

Peroxiredoxin 2 battles poly(ADP-ribose) polymerase 1- and p53-dependent prodeath pathways after ischemic injury.

artículo científico publicado en 2013

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

artículo científico publicado en 2017

Perspective for stroke and brain injury research: mechanisms and potential therapeutic targets

artículo científico publicado en 2015

Physical activity is linked to ceruloplasmin in the striatum of intact but not MPTP-treated primates.

artículo científico publicado en 2012

Physical activity-associated gene expression signature in nonhuman primate motor cortex.

scientific article published on 20 October 2011

Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3

scientific journal article

Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance.

artículo científico publicado en 2014

Preventive and protective roles of dietary Nrf2 activators against central nervous system diseases

artículo científico publicado en 2017

Procalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction.

artículo científico publicado en 2018

Promises and limitations of immune cell-based therapies in neurological disorders

artículo científico publicado en 2018

Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke

scientific article published on 17 April 2019

RNA sequencing reveals novel macrophage transcriptome favoring neurovascular plasticity after ischemic stroke

artículo científico publicado en 2019

Rapid activation of ERK by 6-hydroxydopamine promotes survival of dopaminergic cells.

artículo científico publicado en 2008

Rapid and sustained antidepressant properties of an NMDA antagonist/monoamine reuptake inhibitor identified via transporter-based virtual screening.

artículo científico publicado en 2016

Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury

artículo científico publicado en 2016

Regulation of Neuroinflammation through Programed Death-1/Programed Death Ligand Signaling in Neurological Disorders

artículo científico publicado en 2014

Regulatory T cells ameliorate tissue plasminogen activator-induced brain haemorrhage after stroke.

artículo científico publicado en 2017

Remote Ischemic Preconditioning-Mediated Neuroprotection against Stroke is Associated with Significant Alterations in Peripheral Immune Responses

artículo científico publicado en 2015

Rescue from a two hit, high-throughput model of neurodegeneration with N-acetyl cysteine ⬇️

artículo científico publicado el 9 de junio de 2012

Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia.

artículo científico publicado en 2015

ST2/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury

artículo científico publicado en 2017

Scriptaid, a novel histone deacetylase inhibitor, protects against traumatic brain injury via modulation of PTEN and AKT pathway : scriptaid protects against TBI via AKT.

artículo científico publicado en 2013

Splenic responses in ischemic stroke: new insights into stroke pathology.

artículo científico publicado en 2014

Stem cell therapies in age-related neurodegenerative diseases and stroke

artículo científico publicado en 2016

Suprachiasmatic pacemaker organization analyzed by viral transynaptic transport.

artículo científico publicado en 1999

Synergistic stress exacerbation in hippocampal neurons: Evidence favoring the dual-hit hypothesis of neurodegeneration.

artículo científico publicado en 2016

TGFα preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia

scientific article published on 05 March 2019

Teaching Pharmacology Graduate Students how to Write an NIH Grant Application

artículo científico publicado en 2015

The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization.

artículo científico publicado en 2016

The Role of Nicotinamide Phosphoribosyltransferase in Cerebral Ischemia

artículo científico

The center of olfactory bulb-seeded α-synucleinopathy is the limbic system and the ensuing pathology is higher in male than in female mice

scientific article published on 10 April 2019

The dynamics of the mitochondrial organelle as a potential therapeutic target

artículo científico publicado en 2013

The impact of cerebrovascular aging on vascular cognitive impairment and dementia.

artículo científico publicado en 2016

The interleukin-4/PPARγ signaling axis promotes oligodendrocyte differentiation and remyelination after brain injury

artículo científico publicado en 2019

The molecular chaperone Hsc70 interacts with the vesicular monoamine transporter-2

scientific journal article

The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems.

artículo científico publicado en 2001

Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury

scientific article published on 10 September 2018

Transient selective brain cooling confers neurovascular and functional protection from acute to chronic stages of ischemia/reperfusion brain injury

scientific article published on 18 October 2018

Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals.

artículo científico publicado en 2016

Transmission of α-synucleinopathy from olfactory structures deep into the temporal lobe

artículo científico publicado en 2016

Triggering endogenous neuroprotective processes through exercise in models of dopamine deficiency.

artículo científico publicado en 2009

Ventricular fibrillation cardiac arrest produces a chronic striatal hyperdopaminergic state that is worsened by methylphenidate treatment.

artículo científico publicado en 2017

Viability assays for cells in culture.

artículo científico publicado en 2014

White matter injury and microglia/macrophage polarization are strongly linked with age-related long-term deficits in neurological function after stroke.

artículo científico publicado en 2015

n-3 PUFA supplementation benefits microglial responses to myelin pathology.

artículo científico publicado en 2014

n-3 Polyunsaturated Fatty Acids Reduce Neonatal Hypoxic/Ischemic Brain Injury by Promoting Phosphatidylserine Formation and Akt Signaling.

artículo científico publicado en 2015

Lista de obras de Rehana K. Leak

A new era for stroke therapy: Integrating neurovascular protection with optimal reperfusion

APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury.

ATP induces mild hypothermia in rats but has a strikingly detrimental impact on focal cerebral ischemia.

Adaptation and sensitization to proteotoxic stress.

Adaptation to chronic MG132 reduces oxidative toxicity by a CuZnSOD-dependent mechanism

Adoptive regulatory T-cell therapy preserves systemic immune homeostasis after cerebral ischemia

Aging of cerebral white matter.

Alpha-synuclein: prion or prion-like?

Apurinic/apyrimidinic endonuclease 1 upregulation reduces oxidative DNA damage and protects hippocampal neurons from ischemic injury

Astrocyte plasticity revealed by adaptations to severe proteotoxic stress ⬇️

Astrocytes Do Not Forfeit Their Neuroprotective Roles After Surviving Intense Oxidative Stress

Astrocytes Surviving Severe Stress Can Still Protect Neighboring Neurons from Proteotoxic Injury

Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation.

Calbindin-D28K cells in the hamster SCN express light-induced Fos

Corrigendum to "Brain ischemic preconditioning protects against ischemic injury and preserves the blood-brain barrier via oxidative signaling and Nrf2 activation" [Redox Biol. 17 (2018) 323-337]

Critical appraisal of pathology transmission in the α-synuclein fibril model of Lewy body disorders.

Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization

Cytotoxicity models of Huntington's disease and relevance of hormetic mechanisms: A critical assessment of experimental approaches and strategies

Delivery of neurotherapeutics across the blood brain barrier in stroke.

Diabetes Mellitus Impairs White Matter Repair and Long-Term Functional Deficits After Cerebral Ischemia

Dietary supplementation with omega-3 polyunsaturated fatty acids robustly promotes neurovascular restorative dynamics and improves neurological functions after stroke.

Drug conjugates—an emerging approach to treat breast cancer.

Drug-induced hypothermia in stroke models: does it always protect?

Effect of sublethal 6-hydroxydopamine on the response to subsequent oxidative stress in dopaminergic cells: evidence for preconditioning

Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury.

Enhancing and Extending Biological Performance and Resilience

Ethyl pyruvate protects against blood-brain barrier damage and improves long-term neurological outcomes in a rat model of traumatic brain injury

Evidence for cross-hemispheric preconditioning in experimental Parkinson's disease.

Fast free-of-acrylamide clearing tissue (FACT)-an optimized new protocol for rapid, high-resolution imaging of three-dimensional brain tissue

From apoplexy to stroke: historical perspectives and new research frontiers.

Galectin-1-secreting neural stem cells elicit long-term neuroprotection against ischemic brain injury

Gene transcripts associated with BMI in the motor cortex and caudate nucleus of calorie restricted rhesus monkeys ⬇️

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis.

HSP27 Protects the Blood-Brain Barrier Against Ischemia-Induced Loss of Integrity ⬇️

Heat shock proteins in neurodegenerative disorders and aging

Hormesis Mediates Dose-Sensitive Shifts in Macrophage Activation Patterns

IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice

Identification of retinal ganglion cells projecting to the lateral hypothalamic area of the rat ⬇️

Impact of aging on heat shock protein expression in the substantia nigra and striatum of the female rat.

Implantation of Brain-Derived Extracellular Matrix Enhances Neurological Recovery after Traumatic Brain Injury.

Innervation of ventricular and periventricular brain compartments.

Interleukin-4 Is Essential for Microglia/Macrophage M2 Polarization and Long-Term Recovery After Cerebral Ischemia

Intracerebroventricular Delivery of Recombinant NAMPT Deters Inflammation and Protects Against Cerebral Ischemia

Investigation of the therapeutic potential of N-acetyl cysteine and the tools used to define nigrostriatal degeneration in vivo.

Ischemic post-conditioning partially reverses cell cycle reactivity following ischemia/reperfusion injury: a genome-wide survey.

Ischemic preconditioning provides long-lasting neuroprotection against ischemic stroke: The role of Nrf2

Long weekend sleep is linked to stronger academic performance in male but not female pharmacy students

Microglia/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia.

Microglial and macrophage polarization—new prospects for brain repair

Mitochondrial biogenesis contributes to ischemic neuroprotection afforded by LPS pre-conditioning

Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair

N-Acetyl cysteine blunts proteotoxicity in a heat shock protein-dependent manner.

N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione

N-acetyl cysteine prevents synergistic, severe toxicity from two hits of oxidative stress.

Neocortex and allocortex respond differentially to cellular stress in vitro and aging in vivo

Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles

Neurobiology of stroke: Research progress and perspectives

Neuronal NAMPT is released after cerebral ischemia and protects against white matter injury

Neuroprotection against stroke and CNS injury: new mechanisms, targets, and controversies

Neurorestorative effect of urinary bladder matrix-mediated neural stem cell transplantation following traumatic brain injury in rats.

Neurotransmitter receptors on microglia

Omega-3 fatty acids protect the brain against ischemic injury by activating Nrf2 and upregulating heme oxygenase 1.

Omega-3 polyunsaturated fatty acid supplementation improves neurologic recovery and attenuates white matter injury after experimental traumatic brain injury.

Omega-3 polyunsaturated fatty acids enhance cerebral angiogenesis and provide long-term protection after stroke

Omega-3 polyunsaturated fatty acids mitigate blood-brain barrier disruption after hypoxic-ischemic brain injury

Organization of suprachiasmatic nucleus projections in Syrian hamsters (Mesocricetus auratus): an anterograde and retrograde analysis.

Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery

Peroxiredoxin 2 battles poly(ADP-ribose) polymerase 1- and p53-dependent prodeath pathways after ischemic injury.

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

Perspective for stroke and brain injury research: mechanisms and potential therapeutic targets

Physical activity is linked to ceruloplasmin in the striatum of intact but not MPTP-treated primates.

Physical activity-associated gene expression signature in nonhuman primate motor cortex.

Physical and functional interaction between the dopamine transporter and the synaptic vesicle protein synaptogyrin-3

Preconditioning provides neuroprotection in models of CNS disease: paradigms and clinical significance.

Preventive and protective roles of dietary Nrf2 activators against central nervous system diseases

Procalcitonin as a Biomarker for Malignant Cerebral Edema in Massive Cerebral Infarction.

Promises and limitations of immune cell-based therapies in neurological disorders

Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke

RNA sequencing reveals novel macrophage transcriptome favoring neurovascular plasticity after ischemic stroke