Lista de obras - Domenico Spina - Dominio Público Uruguay

A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects

scientific article published on 01 January 2000

A comparison of sensory nerve function in human, guinea-pig, rabbit and marmoset airways

artículo científico publicado en 1998

A comparison of the pharmacological modulation of hyperalgesia and bronchial hyperresponsiveness.

artículo científico publicado en 2003

A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis

article

A novel animal model for investigating persistent airway hyperresponsiveness

artículo científico publicado en 1993

A role for mitogen kinase kinase 3 in pulmonary inflammation validated from a proteomic approach.

artículo científico publicado en 2014

Adenosine monophosphate is elevated in the bronchoalveolar lavage fluid of mice with acute respiratory toxicity induced by nanoparticles with high surface hydrophobicity

artículo científico publicado en 2014

Adenosine receptors and asthma

artículo científico publicado en 2009

Adenosine receptors and asthma.

artículo científico publicado en 2008

Airway irritability--a burning issue?

scientific article published on 20 July 2009

Airway nerves and protein phosphatases.

artículo científico publicado en 1999

Airway nerves: neurotransmitter release.

artículo científico publicado en 2002

Airway responsiveness in an allergic rabbit model

artículo científico publicado en 2011

Airway sensory nerves in asthma--targets for therapy?

artículo científico publicado en 1996

Antigen-induced bronchial hyperresponsiveness in the rabbit is not dependent on M(2)-receptor dysfunction

scientific article published on 01 January 1999

Asthma -- a need for a rethink?

artículo científico publicado en 2002

Bronchial hyperresponsiveness induced by chronic treatment with albuterol: Role of sensory nerves.

artículo científico publicado en 2002

Bronchial hyperresponsiveness: a rather irritable subject

artículo científico publicado en 2009

Current and novel bronchodilators in respiratory disease

artículo científico

Cytokines in airway inflammation.

artículo científico publicado en 2000

Dose-related effects of formoterol on airway responsiveness to adenosine 5'-monophosphate and histamine.

artículo científico publicado en 2002

Editorial overview: Respiratory: Cough: a burning issue.

artículo científico publicado en 2015

Effect of Mycobacterium tuberculosis chaperonins on bronchial eosinophilia and hyper-responsiveness in a murine model of allergic inflammation.

artículo científico publicado en 2004

Effect of chronic theophylline treatment on the methacholine dose-response curve in allergic asthmatic subjects

artículo científico publicado en 1998

Effect of the Mixed Phosphodiesterase 3/4 Inhibitor RPL554 on Human Isolated Bronchial Smooth Muscle Tone

artículo científico publicado en 2013

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

artículo científico publicado en 2013

Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects.

artículo científico publicado en 2007

Experimental design and analysis and their reporting: new guidance for publication in BJP.

artículo científico publicado en 2015

Fucosylated chondroitin sulfates from the body wall of the sea cucumber Holothuria forskali: conformation, selectin binding, and biological activity

artículo científico publicado en 2014

Getting to the heart of asthma: can "beta blockers" be useful to treat asthma?

artículo científico publicado en 2007

Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system

artículo científico publicado en 2006

Immunohistochemical localization of transient receptor potential vanilloid subtype 1 in the trachea of ovalbumin-sensitized Guinea pigs

scientific article published on 27 May 2008

Immunohistochemical localization of vanilloid receptor subtype 1 (TRPV1) in the guinea pig respiratory system.

artículo científico publicado en 2005

In vivo biocompatibility, clearance, and biodistribution of albumin vehicles for pulmonary drug delivery

artículo científico publicado en 2015

Long-term effects of anti-tumour necrosis factor therapy on weight in patients with rheumatoid arthritis ⬇️

artículo científico publicado el 19 de octubre de 2011

Mechanism of adenosine-induced airways obstruction in allergic guinea pigs.

artículo científico publicado en 2006

Modulation of sensory nerve function in the airways

artículo científico publicado en 1998

Mycobacterium tuberculosis chaperonin 60.1 inhibits leukocyte diapedesis in a murine model of allergic lung inflammation

artículo científico publicado en 2012

Nociceptin inhibits non‐adrenergic non‐cholinergic contraction in guinea‐pig airway ⬇️

artículo científico publicado el 1 de octubre de 1998

Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock

artículo científico publicado en 2014

Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs.

artículo científico publicado en 2016

P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.

artículo científico publicado en 2014

PDE4-inhibitors: A novel, targeted therapy for obstructive airways disease ⬇️

artículo científico publicado el 19 de enero de 2011

Peripheral mechanisms II: the pharmacology of peripherally active antitussive drugs.

artículo científico publicado en 2009

Phosphodiesterase inhibitors in the treatment of inflammatory diseases.

artículo científico publicado en 2011

Phosphodiesterase inhibitors.

artículo científico publicado en 2006

Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease.

artículo científico publicado en 2003

Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation

artículo científico publicado en 2004

Platelets are essential for leukocyte recruitment in allergic inflammation.

artículo científico publicado en 2003

Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation

artículo científico publicado en 2003

Protease inhibitors in respiratory disease: focus on asthma and chronic obstructive pulmonary disease.

artículo científico publicado en 2007

Quantification of microcirculatory blood flow: a sensitive and clinically relevant prognostic marker in murine models of sepsis.

artículo científico publicado en 2014

Quantitative assessment of nanoparticle surface hydrophobicity and its influence on pulmonary biocompatibility

artículo científico publicado en 2014

Regulating cough through modulation of sensory nerve function in the airways ⬇️

artículo científico publicado el 21 de marzo de 2013

Relationship of airway responsiveness with airway morphometry in normal and immunized rabbits.

artículo científico publicado en 2001

Selective PDE inhibitors as novel treatments for respiratory diseases.

artículo científico publicado en 2012

Sensory nerves and airway irritability.

artículo científico publicado en 2009

Special issue of BJP on respiratory pharmacology.

artículo científico publicado en 2011

Statistical Methods in Research ⬇️

artículo científico publicado el 1 de enero de 2011

Sublingual absorption of salbutamol in the guinea-pig

artículo científico publicado en 1997

TNF‐α‐induces airway hyperresponsiveness to cholinergic stimulation in guinea pig airways ⬇️

artículo científico publicado el 1 de marzo de 2012

The Role of Phosphodiesterase Enzymes in Allergy and Asthma ⬇️

artículo científico publicado el 1 de enero de 1998

The effect duration of selective phosphodiesterase inhibitors in the guinea pig ⬇️

artículo científico publicado el 1 de enero de 1998

The effect of 15‐HPETE on airway responsiveness and pulmonary cell recruitment in rabbits ⬇️

artículo científico publicado el 1 de septiembre de 1997

The effect of phytocannabinoids on airway hyper-responsiveness, airway inflammation, and cough.

artículo científico publicado en 2015

The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diis

artículo científico publicado en 2006

The potential of PDE4 inhibitors in respiratory disease

artículo científico publicado en 2004

The rabbit as an experimental and production animal: from genomics to proteomics

artículo científico publicado en 2014

The role of CD23 on allergen-induced IgE levels, pulmonary eosinophilia and bronchial hyperresponsiveness in mice

artículo científico publicado en 2000

The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus

artículo científico publicado en 2015

The role of sensory nerves in propranolol-induced bronchial hyperresponsiveness in the guinea-pig

artículo científico publicado en 1999

The use of bronchodilators in stable chronic obstructive pulmonary disease.

artículo científico publicado en 1997

Theophylline and PDE4 inhibitors in asthma.

artículo científico publicado en 2003

Use of within-group designs to test anti-tussive drugs in conscious guinea-pigs.

artículo científico publicado en 2010

What have transgenic and knockout animals taught us about respiratory disease?

artículo científico publicado en 2000

Lista de obras de Domenico Spina

A biochemical and functional assessment of monocyte phosphodiesterase activity in healthy and asthmatic subjects

A comparison of sensory nerve function in human, guinea-pig, rabbit and marmoset airways

A comparison of the pharmacological modulation of hyperalgesia and bronchial hyperresponsiveness.

A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor α-induced inflammatory hyperalgesia and Freund's complete adjuvant-induced monarthritis

A novel animal model for investigating persistent airway hyperresponsiveness

A role for mitogen kinase kinase 3 in pulmonary inflammation validated from a proteomic approach.

Adenosine monophosphate is elevated in the bronchoalveolar lavage fluid of mice with acute respiratory toxicity induced by nanoparticles with high surface hydrophobicity

Adenosine receptors and asthma

Adenosine receptors and asthma.

Airway irritability--a burning issue?

Airway nerves and protein phosphatases.

Airway nerves: neurotransmitter release.

Airway responsiveness in an allergic rabbit model

Airway sensory nerves in asthma--targets for therapy?

Antigen-induced bronchial hyperresponsiveness in the rabbit is not dependent on M(2)-receptor dysfunction

Asthma -- a need for a rethink?

Bronchial hyperresponsiveness induced by chronic treatment with albuterol: Role of sensory nerves.

Bronchial hyperresponsiveness: a rather irritable subject

Current and novel bronchodilators in respiratory disease

Cytokines in airway inflammation.

Dose-related effects of formoterol on airway responsiveness to adenosine 5'-monophosphate and histamine.

Editorial overview: Respiratory: Cough: a burning issue.

Effect of Mycobacterium tuberculosis chaperonins on bronchial eosinophilia and hyper-responsiveness in a murine model of allergic inflammation.

Effect of chronic theophylline treatment on the methacholine dose-response curve in allergic asthmatic subjects

Effect of the Mixed Phosphodiesterase 3/4 Inhibitor RPL554 on Human Isolated Bronchial Smooth Muscle Tone

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials

Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects.

Experimental design and analysis and their reporting: new guidance for publication in BJP.

Fucosylated chondroitin sulfates from the body wall of the sea cucumber Holothuria forskali: conformation, selectin binding, and biological activity

Getting to the heart of asthma: can "beta blockers" be useful to treat asthma?

Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system

Immunohistochemical localization of transient receptor potential vanilloid subtype 1 in the trachea of ovalbumin-sensitized Guinea pigs

Immunohistochemical localization of vanilloid receptor subtype 1 (TRPV1) in the guinea pig respiratory system.

In vivo biocompatibility, clearance, and biodistribution of albumin vehicles for pulmonary drug delivery

Long-term effects of anti-tumour necrosis factor therapy on weight in patients with rheumatoid arthritis ⬇️

Mechanism of adenosine-induced airways obstruction in allergic guinea pigs.

Modulation of sensory nerve function in the airways

Mycobacterium tuberculosis chaperonin 60.1 inhibits leukocyte diapedesis in a murine model of allergic lung inflammation

Nociceptin inhibits non‐adrenergic non‐cholinergic contraction in guinea‐pig airway ⬇️

Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock

Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs.

P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation.

PDE4-inhibitors: A novel, targeted therapy for obstructive airways disease ⬇️

Peripheral mechanisms II: the pharmacology of peripherally active antitussive drugs.

Phosphodiesterase inhibitors in the treatment of inflammatory diseases.

Phosphodiesterase inhibitors.

Phosphodiesterase-4 inhibitors in the treatment of inflammatory lung disease.

Platelet P-selectin is required for pulmonary eosinophil and lymphocyte recruitment in a murine model of allergic inflammation

Platelets are essential for leukocyte recruitment in allergic inflammation.

Platelets are necessary for airway wall remodeling in a murine model of chronic allergic inflammation

Protease inhibitors in respiratory disease: focus on asthma and chronic obstructive pulmonary disease.

Quantification of microcirculatory blood flow: a sensitive and clinically relevant prognostic marker in murine models of sepsis.

Quantitative assessment of nanoparticle surface hydrophobicity and its influence on pulmonary biocompatibility

Regulating cough through modulation of sensory nerve function in the airways ⬇️

Relationship of airway responsiveness with airway morphometry in normal and immunized rabbits.

Selective PDE inhibitors as novel treatments for respiratory diseases.

Sensory nerves and airway irritability.

Special issue of BJP on respiratory pharmacology.

Statistical Methods in Research ⬇️

Sublingual absorption of salbutamol in the guinea-pig

TNF‐α‐induces airway hyperresponsiveness to cholinergic stimulation in guinea pig airways ⬇️

The Role of Phosphodiesterase Enzymes in Allergy and Asthma ⬇️

The effect duration of selective phosphodiesterase inhibitors in the guinea pig ⬇️

The effect of 15‐HPETE on airway responsiveness and pulmonary cell recruitment in rabbits ⬇️

The effect of phytocannabinoids on airway hyper-responsiveness, airway inflammation, and cough.

The pharmacology of two novel long-acting phosphodiesterase 3/4 inhibitors, RPL554 [9,10-dimethoxy-2(2,4,6-trimethylphenylimino)-3-(n-carbamoyl-2-aminoethyl)-3,4,6,7-tetrahydro-2H-pyrimido[6,1-a]isoquinolin-4-one] and RPL565 [6,7-dihydro-2-(2,6-diis

The potential of PDE4 inhibitors in respiratory disease

The rabbit as an experimental and production animal: from genomics to proteomics

The role of CD23 on allergen-induced IgE levels, pulmonary eosinophilia and bronchial hyperresponsiveness in mice

The role of heparanase in pulmonary cell recruitment in response to an allergic but not non-allergic stimulus

The role of sensory nerves in propranolol-induced bronchial hyperresponsiveness in the guinea-pig

The use of bronchodilators in stable chronic obstructive pulmonary disease.

Theophylline and PDE4 inhibitors in asthma.

Use of within-group designs to test anti-tussive drugs in conscious guinea-pigs.

What have transgenic and knockout animals taught us about respiratory disease?