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Lista de obras de Oliver T Fackler

A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities.

artículo científico publicado en 2015

A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.

artículo científico publicado en 2001

Activation of the Rac-binding partner FHOD1 induces actin stress fibers via a ROCK-dependent mechanism

artículo científico publicado en 2003

Adding new dimensions: towards an integrative understanding of HIV-1 spread.

artículo científico

Antagonism of CD317 restriction of human immunodeficiency virus type 1 (HIV-1) particle release and depletion of CD317 are separable activities of HIV-1 Vpu.

artículo científico publicado en 2010

Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins

artículo científico publicado en 2014

Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.

artículo científico publicado en 1997

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex

artículo científico publicado en 2015

Biochemical characterization of the diaphanous autoregulatory interaction in the formin homology protein FHOD1

artículo científico publicado en 2006

CTL-Mediated Selective Pressure Influences Dynamic Evolution and Pathogenic Functions of HIV-1 Nef

article

Cell Surface Downregulation of NK Cell Ligands by Patient-Derived HIV-1 Vpu and Nef Alleles

artículo científico publicado en 2015

Cell motility through plasma membrane blebbing

artículo científico publicado en 2008

Construction and characterization of a fluorescently labeled infectious human immunodeficiency virus type 1 derivative

artículo científico publicado en 2004

Construction and characterization of an HIV-1 group O infectious molecular clone and analysis of vpr- and nef-negative derivatives

artículo científico publicado en 2004

Contact-dependent inhibition of HIV-1 replication in <i>ex vivo</i> human tonsil cultures by polymorphonuclear neutrophils

artículo científico publicado en 2021

Correction: The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles

scientific article published on 01 December 2019

D186/D190 is an allele-dependent determinant of HIV-1 Nef function

artículo científico publicado en 2016

DDX60L Is an Interferon-Stimulated Gene Product Restricting Hepatitis C Virus Replication in Cell Culture

artículo científico publicado en 2015

Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivo

artículo científico publicado en 2009

Differing and isoform-specific roles for the formin DIAPH3 in plasma membrane blebbing and filopodia formation

artículo científico publicado en 2011

Endocytic entry of HIV-1.

artículo científico publicado en 2000

Erratum for Roth et al., "Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses".

artículo científico publicado en 2017

Evidence for the association of Nef protein with HIV-2 virions

article

Experimental and computational analyses reveal that environmental restrictions shape HIV-1 spread in 3D cultures

article

Experimental systems for studying Plasmodium/HIV coinfection

artículo científico publicado en 2016

Expression of HIV-1 pathogenesis factor NEF in CD4 T cells impairs antigen-specific B-cell function

artículo científico publicado en 2020

Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection

artículo científico publicado en 2006

Ex vivo and in vivo suppression of SARS-CoV-2 with combinatorial AAV/RNAi expression vectors

artículo científico publicado en 2022

FHOD1 coordinates actin filament and microtubule alignment to mediate cell elongation

artículo científico publicado en 2005

FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement

artículo científico publicado en 2014

FHOD1 is a combined actin filament capping and bundling factor that selectively associates with actin arcs and stress fibers

scientific article published on 26 February 2013

Flavivirus Infection Uncouples Translation Suppression from Cellular Stress Responses

artículo científico publicado en 2017

Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα.

artículo científico publicado en 2015

Functional characterization of HIV-1 Nef mutants in the context of viral infection

artículo científico publicado en 2006

Functional characterization of HIV-1 Nef proteins with heterologous membrane targeting signals

artículo científico publicado en 2013

GPCR-induced calcium transients trigger nuclear actin assembly for chromatin dynamics

artículo científico publicado en 2019

HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection

scientific article published on 19 October 2016

HIV-1 Nef Disrupts CD4 T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface

article

HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins

artículo científico publicado en 2014

HIV-1 Nef compensates for disorganization of the Immunological Synapse by inducing TGN-associated Lck signaling.

artículo científico publicado en 2011

HIV-1 Nef compensates for disorganization of the immunological synapse by inducing trans-Golgi network-associated Lck signaling

artículo científico publicado en 2011

HIV-1 Nef disrupts membrane-microdomain-associated anterograde transport for plasma membrane delivery of selected Src family kinases

artículo científico publicado en 2013

HIV-1 Nef employs two distinct mechanisms to modulate Lck subcellular localization and TCR induced actin remodeling

artículo científico publicado en 2007

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo

artículo científico publicado en 2012

HIV-1 Nef interferes with host cell motility by deregulation of Cofilin

artículo científico publicado en 2009

HIV-1 Nef limits communication between linker of activated T cells and SLP-76 to reduce formation of SLP-76-signaling microclusters following TCR stimulation.

artículo científico publicado en 2012

HIV-1 Nef perturbs artificial membranes: investigation of the contribution of the myristoyl anchor

artículo científico publicado en 2009

HIV-1 Nef: a multifaceted modulator of T cell receptor signaling

artículo científico publicado en 2012

HIV-1 Vpu Antagonizes CD317/Tetherin by Adaptor Protein-1-Mediated Exclusion from Virus Assembly Sites

artículo científico publicado en 2016

HIV-1 Vpu affects the anterograde transport and the glycosylation pattern of NTB-A.

artículo científico publicado en 2013

HIV-1 Vpu blocks recycling and biosynthetic transport of the intrinsic immunity factor CD317/tetherin to overcome the virion release restriction ⬇️

artículo científico publicado en 2011

HIV-1 Vpu's lipid raft association is dispensable for counteraction of the particle release restriction imposed by CD317/Tetherin

artículo científico publicado en 2012

HIV-1 antagonism of CD317 is species specific and involves Vpu-mediated proteasomal degradation of the restriction factor

artículo científico publicado en 2009

HIV-1 antagonism of CD317/tetherin is species-specific and involves Vpu-mediated proteasomal degradation of the intrinsic immunity factor

article

HIV-1 at the immunological and T-lymphocytic virological synapse

artículo científico publicado en 2008

HIV-1 p24 but not proviral load is increased in the intestinal mucosa compared with the peripheral blood in HIV-infected patients

article

HIV-1 reprograms the migration of macrophages

artículo científico publicado en 2014

HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection

artículo científico publicado en 2016

Heterologous Src homology 4 domains support membrane anchoring and biological activity of HIV-1 Nef

artículo científico publicado en 2014

How HIV takes advantage of the cytoskeleton in entry and replication

artículo científico publicado en 2011

Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec

scientific article (publication date: 16 February 2009)

Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts

artículo científico publicado en 2004

Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains

artículo científico publicado en 2007

Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity

artículo científico publicado en 2007

Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein

artículo científico publicado en 2012

Hydrophilic trans-Cyclooctenylated Noncanonical Amino Acids for Fast Intracellular Protein Labeling

artículo científico publicado en 2016

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function

artículo científico publicado en 2012

Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B.

artículo científico publicado en 2008

Inhibition of T-cell receptor-induced actin remodeling and relocalization of Lck are evolutionarily conserved activities of lentiviral Nef proteins

artículo científico publicado en 2009

Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody.

artículo científico publicado en 2011

Integrative analysis of pathogen replication and spread: zooming into increasing complexity

artículo científico publicado en 2016

Interactions of human retroviruses with the host cell cytoskeleton

artículo científico publicado en 2006

Intrinsic properties and plasma membrane trafficking route of Src family kinase SH4 domains sensitive to retargeting by HIV-1 Nef.

artículo científico publicado en 2018

Involvement of Clathrin-Mediated Endocytosis in Human Immunodeficiency Virus Type 1 Entry

artículo científico publicado en 2005

Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling

artículo científico publicado en 2010

Lessons from HIV: movement of macromolecules inside the cell.

artículo científico publicado en 2001

Live and let die: Nef functions beyond HIV replication

artículo científico publicado en 2002

Microstructured Blood Vessel Surrogates Reveal Structural Tropism of Motile Malaria Parasites.

artículo científico publicado en 2017

Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma

artículo científico publicado en 2015

Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1.

artículo científico publicado en 2005

Modulation of the immunological synapse: a key to HIV-1 pathogenesis?

artículo científico publicado en 2007

Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef

artículo científico publicado en 2011

Molecular effects in tritiumβdecay. II. Rotation-vibration excitation, dissociation, and rotational predissociation in the decay of theT2and TH molecules

article

Multifunctional Roles of the N-Terminal Region of HIV-1SF2Nef Are Mediated by Three Independent Protein Interaction Sites

artículo científico publicado en 2019

MxB/Mx2: the latest piece in HIV's interferon puzzle

artículo científico publicado en 2013

NHC-gold compounds mediate immune suppression through induction of AHR-TGFβ1 signalling in vitro and in scurfy mice

scientific article published on 03 January 2020

Nef binds p6* in GagPol during replication of human immunodeficiency virus type 1.

artículo científico publicado en 2004

Nef does not inhibit F-actin remodelling and HIV-1 cell–cell transmission at the T lymphocyte virological synapse

article

Nef interferes with development of thymic T cell precursors: differential mechanisms in HIV and SIV.

artículo científico publicado en 2011

Nef proteins of epidemic HIV-1 group O strains antagonize human tetherin

artículo científico publicado en 2014

Novel (n)PKC kinases phosphorylate Nef for increased HIV transcription, replication and perinuclear targeting

artículo científico publicado en 2007

Observation of Muon Neutrino Disappearance with the MINOS Detectors in the NuMI Neutrino Beam

artículo científico publicado en 2006

Oligomerization of the diaphanous-related formin FHOD1 requires a coiled-coil motif critical for its cytoskeletal and transcriptional activities

artículo científico publicado en 2005

Patient-derived HIV-1 Nef alleles reveal uncoupling of CD4 downregulation and SERINC5 antagonism functions of the viral pathogenesis factor

artículo científico publicado en 2020

Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion

artículo científico publicado en 2007

Potential impact of the antirheumatic agent auranofin on proviral HIV-1 DNA in individuals under intensified antiretroviral therapy: Results from a randomised clinical trial

scientific article published on 05 August 2019

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

artículo científico publicado en 2013

Proceedings of the Frontiers of Retrovirology Conference 2016.

artículo científico publicado en 2016

Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4<sup>+</sup> T cells allows complex functional analyses

artículo científico publicado en 2021

Reacquisition of Nef-mediated tetherin antagonism in a single in vivo passage of HIV-1 through its original chimpanzee host

artículo científico publicado en 2012

Reinforcing the LINC complex connection to actin filaments: the role of FHOD1 in TAN line formation and nuclear movement

artículo científico publicado en 2015

Replication of M-tropic HIV-1 in activated human intestinal lamina propria lymphocytes is the main reason for increased virus load in the intestinal mucosa

artículo científico publicado en 2005

Restrictions to HIV-1 replication in resting CD4 T lymphocytes

Restrictions to HIV-1 replication in resting CD4+ T lymphocytes

artículo científico publicado en 2013

Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef

artículo científico publicado en 2005

Role of the C-terminal domain of the HIV-1 glycoprotein in cell-to-cell viral transmission between T lymphocytes

artículo científico publicado en 2010

SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.

artículo científico publicado en 2012

SAMHD1's protein expression profile in humans

artículo científico publicado en 2015

SERINC5 Is an Unconventional HIV Restriction Factor That Is Upregulated during Myeloid Cell Differentiation

scientific article published on 14 January 2020

SH4-domain-induced plasma membrane dynamization promotes bleb-associated cell motility.

artículo científico publicado en 2007

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue

article

Sensing of HIV-1 Infection in Tzm-bl Cells with Reconstituted Expression of STING.

artículo científico publicado en 2015

Similar proviral load but increased HIV-1 p24 in the intestinal mucosa compared to the peripheral blood in HIV-infected patients.

artículo científico publicado en 1998

Spatiotemporal organization of Aurora-B by APC/CCdh1 after mitosis coordinates cell spreading through FHOD1.

artículo científico publicado en 2013

Specific and distinct determinants mediate membrane binding and lipid raft incorporation of HIV-1(SF2) Nef.

artículo científico publicado en 2006

Spotlight on HIV-1 Nef: SERINC3 and SERINC5 Identified as Restriction Factors Antagonized by the Pathogenesis Factor

artículo científico publicado en 2015

Structure--function relationships in HIV-1 Nef.

artículo científico publicado en 2001

Subunit H of the V-ATPase binds to the medium chain of adaptor protein complex 2 and connects Nef to the endocytic machinery

artículo científico publicado en 2002

Subunit H of the V-ATPase involved in endocytosis shows homology to beta-adaptins

artículo científico publicado en 2002

Tailored environments to study motile cells and pathogens.

artículo científico publicado en 2018

The Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor

artículo científico publicado en 2016

The Diaphanous-related Formin FHOD1 associates with ROCK1 and promotes Src-dependent plasma membrane blebbing

artículo científico publicado en 2008

The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication <i>In Vitro</i> and Decreases Viral Titers and Disease Progression in Syrian Hamsters

artículo científico publicado en 2022

The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity

artículo científico publicado en 2006

The Nef protein of human immunodeficiency virus establishes superinfection immunity by a dual strategy to downregulate cell-surface CCR5 and CD4.

artículo científico publicado en 2005

The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling

artículo científico publicado en 2006

The Pro78 residue regulates the capacity of the human immunodeficiency virus type 1 Nef protein to inhibit recycling of major histocompatibility complex class I molecules in an SH3-independent manner

artículo científico publicado en 2006

The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists

artículo científico publicado en 2018

The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles

artículo científico publicado en 2017

The human formin FHOD1 contains a bipartite structure of FH3 and GTPase-binding domains required for activation

artículo científico publicado en 2008

The identification of a small molecule compound that reduces HIV-1 Nef-mediated viral infectivity enhancement

artículo científico publicado en 2011

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

artículo científico publicado en 2017

cDNA cloning and chromosomal mapping of a predicted coiled-coil proline-rich protein immunogenic in meningioma patients

artículo científico publicado en 1997

p21-activated kinase 1 plays a critical role in cellular activation by Nef.

artículo científico publicado en 2000

β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release

artículo científico publicado en 2011

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