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Lista de obras de Klara Valko

2,5-diketopiperazines as potent, selective, and orally bioavailable oxytocin antagonists. 3. Synthesis, pharmacokinetics, and in vivo potency.

artículo científico publicado en 2006

A cell-based approach for the early assessment of the phospholipidogenic potential in pharmaceutical research and drug development.

artículo científico publicado en 2003

A comparative study of the reversed-phase HPLC retention behaviour of S-adenosyl-L-methionine and its related metabolites on Hypersil ODS and Supelcosil LC-ABZ stationary phases

scientific article published on 01 April 1993

Analytical and semi-preparative separation of diastereomeric lipid amino acid conjugates

artículo científico publicado en 1994

Application of drug efficiency index in drug discovery: a strategy towards low therapeutic dose.

artículo científico publicado en 2011

Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution.

artículo científico publicado en 2004

Binding measurements of indolocarbazole derivatives to immobilised human serum albumin by high-performance liquid chromatography

scientific article published on 01 February 1996

Chromatographic Hydrophobicity Index by Fast-Gradient RP-HPLC:  A High-Throughput Alternative to log P/log D

artículo científico publicado en 1997

Chromatographic separation and molecular modelling of triazines with respect to their inhibition of the growth of L1210/R71 cells

artículo científico publicado en 1992

Detection of the principal synthetic route indicative impurity in lamotrigine

artículo científico publicado en 1999

Direct Measurement of Intracellular Compound Concentration by RapidFire Mass Spectrometry Offers Insights into Cell Permeability.

artículo científico publicado en 2015

Displacement chromatography of oligomycins

scientific article published on 01 January 1987

Estimating Unbound Volume of Distribution and Tissue Binding by In Vitro HPLC-Based Human Serum Albumin and Immobilised Artificial Membrane-Binding Measurements ⬇️

artículo científico publicado el 1 de octubre de 2010

Estimation of Volume of Distribution in Humans from High Throughput HPLC-Based Measurements of Human Serum Albumin Binding and Immobilized Artificial Membrane Partitioning

artículo científico publicado en 2006

Fast gradient HPLC method to determine compounds binding to human serum albumin. Relationships with octanol/water and immobilized artificial membrane lipophilicity.

artículo científico publicado en 2003

Fast liquid chromatographic method to determine compounds binding to human serum albumin

artículo científico publicado en 2003

Improving the passive permeability of macrocyclic peptides: Balancing permeability with other physicochemical properties

artículo científico publicado en 2014

In vitro measurement of drug efficiency index to aid early lead optimization

artículo científico publicado en 2012

Interrogating the relationship between rat in vivo tissue distribution and drug property data for >200 structurally unrelated molecules.

artículo científico publicado en 2015

Lipophilicity and pKa estimates from gradient high-performance liquid chromatography

artículo científico publicado en 2002

Microwave extraction. A novel sample preparation method for chromatography

artículo científico publicado en 1986

Modeling cellular pharmacokinetics of 14- and 15-membered macrolides with physicochemical properties.

artículo científico publicado en 2011

Nitric oxide effects on polyamine pathways in cultured hepatocytes.

artículo científico publicado en 1994

Physicochemical profile of macrolides and their comparison with small molecules.

artículo científico publicado en 2011

Predictive approaches to increase absorption of compounds during lead optimisation ⬇️

artículo científico publicado el 19 de julio de 2013

Rapid method for the estimation of octanol/water partition coefficient (log P(oct)) from gradient RP-HPLC retention and a hydrogen bond acidity term (zetaalpha(2)(H)).

artículo científico publicado en 2001

Relationships between the chromatographic retention data and the effects of nucleoside derivatives in highly metastatic 3LL cells

artículo científico publicado el 1 de julio de 1992

Supreme activity of gramicidin S against resistant, persistent and biofilm cells of staphylococci and enterococci

scientific article published on 29 November 2019

Synthesis and biological activity of heteroaryl 3-(1,1-dioxo-2H-(1,2,4)-benzothiadizin-3-yl)-4-hydroxy-2(1H)-quinolinone derivatives as hepatitis C virus NS5B polymerase inhibitors.

artículo científico publicado en 2009

The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits

artículo científico publicado en 2015

Two-dimensional high-performance liquid chromatographic method for assaying S-adenosyl-L-methionine and its related metabolites in tissues

scientific article published on 01 September 1993

[Development of methods for the chromatographic analysis of Hevizos]

artículo científico publicado en 1993

[Gas chromatographic determination of the water-octanol partition constant]

scientific article published on 01 September 1983

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