Lista de obras - Pablo Pelegrín - Dominio Público Uruguay

2-methoxyestradiol in the pathophysiology of endometriosis: focus on angiogenesis and therapeutic potential

artículo científico

3D chitosan scaffolds impair NLRP3 inflammasome response in macrophages

scientific article published on 17 April 2019

A fish cell surface receptor defined by a mAb mediates leukocyte aggregation and deactivation

artículo científico publicado en 2001

A genetically encoded IL-1β bioluminescence resonance energy transfer sensor to monitor inflammasome activity

artículo científico publicado en 2012

A role for acidophilic granulocytes in the testis of the gilthead seabream (Sparus aurata L., Teleostei).

artículo científico publicado en 2003

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.

artículo científico publicado en 2015

ATP modulates acute inflammation in vivo through dual oxidase 1-derived H2O2 production and NF-κB activation.

artículo científico publicado en 2014

Acidophilic granulocytes of the marine fish gilthead seabream (Sparus aurata L.) produce interleukin-1beta following infection with Vibrio anguillarum

artículo científico publicado en 2004

Amino Acid Residues in the P2X7 Receptor that Mediate Differential Sensitivity to ATP and BzATP

scientific article published on 10 October 2006

Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling

artículo científico publicado en 2014

Author Correction: Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization

artículo científico publicado en 2020

Brief Report: Late-Onset Cryopyrin-Associated Periodic Syndrome Due to Myeloid-Restricted Somatic NLRP3 Mosaicism

artículo científico publicado en 2016

C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation

artículo científico publicado en 2010

CD14 release induced by P2X7 receptor restrict inflammation and increases survival during sepsis

artículo científico publicado en 2020

Cell volume regulation modulates NLRP3 inflammasome activation

artículo científico publicado en 2012

Characterisation of gilthead seabream acidophilic granulocytes by a monoclonal antibody unequivocally points to their involvement in fish phagocytic response

artículo científico publicado en 2002

Current status of inflammasome blockers as anti-inflammatory drugs ⬇️

artículo científico publicado el 22 de mayo de 2012

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease.

artículo científico publicado en 2017

Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates

artículo científico publicado en 2009

Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization

scientific article published on 08 April 2019

Early innate immune response and redistribution of inflammatory cells in the bony fish gilthead seabream experimentally infected with Vibrio anguillarum

artículo científico publicado en 2005

Editorial overview: Purinergic P2X receptors in innate immunity and inflammation

scientific article published on 12 June 2019

Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding.

artículo científico publicado en 2008

Identification of Thr283 as a key determinant of P2X7 receptor function

artículo científico publicado en 2006

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

artículo científico publicado en 2016

Interleukin-1beta isolated from a marine fish reveals up-regulated expression in macrophages following activation with lipopolysaccharide and lymphokines.

artículo científico publicado en 2001

Intestinal secretory and absorptive function in Trichinella spiralis mouse model of postinfective gut dysfunction: role of bile acids

artículo científico publicado en 2007

Involvement of P2X7 receptor in neuronal degeneration triggered by traumatic injury.

artículo científico publicado en 2016

Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death.

artículo científico publicado en 2016

Ion Channels in Inflammatory Processes: What Is Known and What Is Next?

artículo científico publicado en 2016

Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation.

artículo científico publicado en 2016

M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b

artículo científico publicado en 2016

MCC950 closes the active conformation of NLRP3 to an inactive state

scientific article published on 13 May 2019

Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process

artículo científico publicado en 2016

Many ways to dilate the P2X7 receptor pore ⬇️

artículo científico publicado el 1 de julio de 2011

Measuring IL-1β Processing by Bioluminescence Sensors I: Using a Bioluminescence Resonance Energy Transfer Biosensor

artículo científico publicado en 2016

Measuring NLR Oligomerization III: Detection of NLRP3 Complex by Bioluminescence Resonance Energy Transfer

artículo científico publicado en 2016

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.

artículo científico publicado en 2016

Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis: New Therapeutic Approaches for Bisphosphonates ⬇️

artículo científico publicado el 8 de julio de 2012

Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish

artículo científico publicado en 2007

Molecular cloning and expression analysis of tumor necrosis factor alpha from a marine fish reveal its constitutive expression and ubiquitous nature

artículo científico publicado en 2002

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

artículo científico publicado en 2018

Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins

artículo científico publicado en 2016

Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules ⬇️

artículo científico publicado el 28 de diciembre de 2010

P2X(7) receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness

artículo científico publicado en 2011

P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases

artículo científico publicado en 2010

P2X7 Receptor-Dependent Intestinal Afferent Hypersensitivity in a Mouse Model of Postinfectious Irritable Bowel Syndrome

scientific article published on 22 June 2011

P2X7 receptor activation impairs exogenous MHC class I oligopeptides presentation in antigen presenting cells

artículo científico publicado en 2013

P2X7 receptor antagonism in the treatment of cancers ⬇️

artículo científico publicado el 27 de mayo de 2011

P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis.

artículo científico publicado en 2019

P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release

artículo científico publicado en 2012

P2X7 receptors mediate resistance to toxin-induced cell lysis

artículo científico publicado en 2014

Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway

artículo científico publicado en 2006

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

artículo científico publicado en 2006

Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc

artículo científico publicado en 2009

Pharmacological characterization of pannexin-1 currents expressed in mammalian cells

artículo científico publicado en 2008

Phylogeny of cytokines: molecular cloning and expression analysis of sea bass Dicentrarchus labrax interleukin-1β

article

Production and mechanism of secretion of interleukin-1beta from the marine fish gilthead seabream

artículo científico publicado en 2004

Purinergic receptors and the inflammatory response mediated by lipids

article

Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages

artículo científico publicado en 2015

Reprogramming macrophages by plasmin

artículo científico publicado en 2017

Response to Boyle et al

artículo científico publicado en 2013

SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer

artículo científico publicado en 2016

Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4

artículo científico publicado en 2019

Signaling Through Purinergic Receptor P2Y2 Enhances Macrophage IL-1β Production ⬇️

artículo científico

Targeting interleukin-1 signaling in chronic inflammation: focus on P2X(7) receptor and Pannexin-1.

artículo científico publicado en 2008

The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases.

artículo científico publicado en 2017

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

artículo científico publicado en 2014

The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release

artículo científico publicado en 2009

The gasdermins, a protein family executing cell death and inflammation

artículo científico publicado en 2019

The inflammasome pathway in stable COPD and acute exacerbations

artículo científico publicado en 2016

The participation of plasma membrane hemichannels to purinergic signaling

artículo científico publicado en 2013

The tumor necrosis factor alpha of the bony fish seabream exhibits the in vivo proinflammatory and proliferative activities of its mammalian counterparts, yet it functions in a species-specific manner.

artículo científico publicado en 2004

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives ⬇️

artículo científico publicado en 2014

WDR90 is a new component of the NLRC4 inflammasome involved in Salmonella Typhimurium resistance

scientific article published on 02 July 2019

El receptor P2X7 se asocia a distintas rutas de liberación de IL-1beta en macrófagos de ratón

Artículo científico

Lista de obras de Pablo Pelegrín

2-methoxyestradiol in the pathophysiology of endometriosis: focus on angiogenesis and therapeutic potential

3D chitosan scaffolds impair NLRP3 inflammasome response in macrophages

A fish cell surface receptor defined by a mAb mediates leukocyte aggregation and deactivation

A genetically encoded IL-1β bioluminescence resonance energy transfer sensor to monitor inflammasome activity

A role for acidophilic granulocytes in the testis of the gilthead seabream (Sparus aurata L., Teleostei).

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3.

ATP modulates acute inflammation in vivo through dual oxidase 1-derived H2O2 production and NF-κB activation.

Acidophilic granulocytes of the marine fish gilthead seabream (Sparus aurata L.) produce interleukin-1beta following infection with Vibrio anguillarum

Amino Acid Residues in the P2X7 Receptor that Mediate Differential Sensitivity to ATP and BzATP

Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling

Author Correction: Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization

Brief Report: Late-Onset Cryopyrin-Associated Periodic Syndrome Due to Myeloid-Restricted Somatic NLRP3 Mosaicism

C-terminal calmodulin-binding motif differentially controls human and rat P2X7 receptor current facilitation

CD14 release induced by P2X7 receptor restrict inflammation and increases survival during sepsis

Cell volume regulation modulates NLRP3 inflammasome activation

Characterisation of gilthead seabream acidophilic granulocytes by a monoclonal antibody unequivocally points to their involvement in fish phagocytic response

Current status of inflammasome blockers as anti-inflammatory drugs ⬇️

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease.

Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1beta release through pyrophosphates

Early endosome autoantigen 1 regulates IL-1β release upon caspase-1 activation independently of gasdermin D membrane permeabilization

Early innate immune response and redistribution of inflammatory cells in the bony fish gilthead seabream experimentally infected with Vibrio anguillarum

Editorial overview: Purinergic P2X receptors in innate immunity and inflammation

Facilitation of P2X7 receptor currents and membrane blebbing via constitutive and dynamic calmodulin binding.

Identification of Thr283 as a key determinant of P2X7 receptor function

Inflammasome-dependent IL-1β release depends upon membrane permeabilisation

Interleukin-1beta isolated from a marine fish reveals up-regulated expression in macrophages following activation with lipopolysaccharide and lymphokines.

Intestinal secretory and absorptive function in Trichinella spiralis mouse model of postinfective gut dysfunction: role of bile acids

Involvement of P2X7 receptor in neuronal degeneration triggered by traumatic injury.

Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death.

Ion Channels in Inflammatory Processes: What Is Known and What Is Next?

Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation.

M1 and M2 Functional Imprinting of Primary Microglia: Role of P2X7 Activation and miR-125b

MCC950 closes the active conformation of NLRP3 to an inactive state

Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process

Many ways to dilate the P2X7 receptor pore ⬇️

Measuring IL-1β Processing by Bioluminescence Sensors I: Using a Bioluminescence Resonance Energy Transfer Biosensor

Measuring NLR Oligomerization III: Detection of NLRP3 Complex by Bioluminescence Resonance Energy Transfer

Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.

Modulating P2X7 Receptor Signaling during Rheumatoid Arthritis: New Therapeutic Approaches for Bisphosphonates ⬇️

Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish

Molecular cloning and expression analysis of tumor necrosis factor alpha from a marine fish reveal its constitutive expression and ubiquitous nature

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

Neutrophils mediate Salmonella Typhimurium clearance through the GBP4 inflammasome-dependent production of prostaglandins

Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules ⬇️

P2X(7) receptor activation enhances SK3 channels- and cystein cathepsin-dependent cancer cells invasiveness

P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases

P2X7 Receptor-Dependent Intestinal Afferent Hypersensitivity in a Mouse Model of Postinfectious Irritable Bowel Syndrome

P2X7 receptor activation impairs exogenous MHC class I oligopeptides presentation in antigen presenting cells

P2X7 receptor antagonism in the treatment of cancers ⬇️

P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis.

P2X7 receptor-stimulation causes fever via PGE2 and IL-1β release

P2X7 receptors mediate resistance to toxin-induced cell lysis

Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway

Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

Pannexin-1-dependent caspase-1 activation and secretion of IL-1beta is regulated by zinc

Pharmacological characterization of pannexin-1 currents expressed in mammalian cells

Phylogeny of cytokines: molecular cloning and expression analysis of sea bass Dicentrarchus labrax interleukin-1β

Production and mechanism of secretion of interleukin-1beta from the marine fish gilthead seabream

Purinergic receptors and the inflammatory response mediated by lipids

Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages

Reprogramming macrophages by plasmin

Response to Boyle et al

SCN4B acts as a metastasis-suppressor gene preventing hyperactivation of cell migration in breast cancer

Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4

Signaling Through Purinergic Receptor P2Y2 Enhances Macrophage IL-1β Production ⬇️

Targeting interleukin-1 signaling in chronic inflammation: focus on P2X(7) receptor and Pannexin-1.

The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases.

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

The P2X(7) receptor-pannexin connection to dye uptake and IL-1beta release

The gasdermins, a protein family executing cell death and inflammation

The inflammasome pathway in stable COPD and acute exacerbations

The participation of plasma membrane hemichannels to purinergic signaling

The tumor necrosis factor alpha of the bony fish seabream exhibits the in vivo proinflammatory and proliferative activities of its mammalian counterparts, yet it functions in a species-specific manner.

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives ⬇️

WDR90 is a new component of the NLRC4 inflammasome involved in Salmonella Typhimurium resistance

El receptor P2X7 se asocia a distintas rutas de liberación de IL-1beta en macrófagos de ratón