Lista de obras -

Activated protein C in sepsis: the promise of nonanticoagulant activated protein C.

artículo científico publicado en 2008

Activated protein C signals through the thrombin receptor PAR1 in endothelial cells

artículo científico publicado en 2003

Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII.

artículo científico publicado en 2006

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

artículo científico publicado en 2002

Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.

artículo científico publicado en 2013

Alternatively spliced tissue factor is not sufficient for embryonic development

artículo científico publicado en 2014

Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner.

artículo científico publicado en 2013

Angiotensin II Infusion Leads to Aortic Dissection in LRP8 Deficient Mice

scientific article published on 12 July 2020

Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients

scientific article published on 07 September 2020

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice

artículo científico publicado en 2015

Coagulation signaling and cancer immunotherapy

artículo científico publicado en 2020

Complete abolishment of coagulant activity in monomeric disulfide-deficient tissue factor

artículo científico publicado en 2011

Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development.

artículo científico publicado en 2010

Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

artículo científico publicado en 2016

Cross-talk of integrin alpha3beta1 and tissue factor in cell migration

artículo científico publicado en 2004

Differential role of tissue factor pathway inhibitors 1 and 2 in melanoma vasculogenic mimicry ⬇️

artículo científico publicado el 1 de septiembre de 2003

Disulfide isomerization switches tissue factor from coagulation to cell signaling

artículo científico publicado en 2006

EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice.

artículo científico publicado en 2015

Emerging insights in tissue factor-dependent signaling events.

artículo científico publicado en 2006

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

artículo científico publicado en 2009

Endothelial GLP-1 (Glucagon-Like Peptide-1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice With Experimental Arterial Hypertension

scientific article published on 21 November 2019

Endothelial protein C receptor function in murine and human breast cancer development

artículo científico publicado en 2013

Engineering of a membrane-triggered activity switch in coagulation factor VIIa

artículo científico publicado en 2017

Engineering of substrate selectivity for tissue factor.factor VIIa complex signaling through protease-activated receptor 2.

artículo científico publicado en 2010

Evidence for activation of tissue factor by an allosteric disulfide bond

artículo científico publicado en 2006

Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1.

artículo científico publicado en 2008

Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2.

artículo científico publicado en 2017

Hematopoietic tissue factor-protease-activated receptor 2 signaling promotes hepatic inflammation and contributes to pathways of gluconeogenesis and steatosis in obese mice

artículo científico publicado en 2014

Hepatocyte nuclear factor-4-independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting selective histone acetyltransferases

artículo científico publicado en 2009

Identification of the coagulation factor VIIa integrin binding site required for pro-angiogenic PAR2 signaling

artículo científico publicado en 2017

Infrared fluorescence for vascular barrier breach in vivo--a novel method for quantitation of albumin efflux.

artículo científico publicado en 2012

Inhibition of tissue factor signaling suppresses tumor growth

artículo científico publicado en 2007

LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis

scientific article published on 29 August 2019

Molecular dynamics simulations and functional characterization of the interactions of the PAR2 ectodomain with factor VIIa ⬇️

artículo científico publicado en 2009

Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality

scientific article published on 05 September 2019

Nonproteolytic properties of murine alternatively spliced tissue factor: implications for integrin-mediated signaling in murine models

artículo científico publicado en 2012

Nox2+ Myeloid cells drive vascular inflammation and endothelial dysfunction in heart failure after myocardial infarction via angiotensin II receptor type 1

artículo científico publicado en 2020

Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor.

artículo científico publicado en 2013

P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice

artículo científico publicado en 2011

PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

artículo científico publicado en 2015

Paraoxonase-2 regulates coagulation activation through endothelial tissue factor

artículo científico publicado en 2018

Plasmin-induced migration of endothelial cells. A potential target for the anti-angiogenic action of angiostatin

artículo científico publicado en 2002

Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1).

artículo científico publicado en 2004

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension

artículo científico publicado en 2017

Podocyte Integrin-β 3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy

scientific article published on 24 July 2020

Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids

artículo científico publicado en 2020

Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice

artículo científico publicado en 2008

Protease-activated receptor 2 signaling in inflammation

artículo científico

Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain

artículo científico publicado en 2004

Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling

artículo científico publicado en 2005

Regulation of angiogenesis by tissue factor cytoplasmic domain signaling

artículo científico publicado en 2004

Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling

artículo científico publicado en 2016

Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia.

artículo científico publicado en 2007

Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation

artículo científico publicado en 2003

Rivaroxaban Effects Illustrate the Underestimated Importance of Activated Platelets in Thrombin Generation Assessed by Calibrated Automated Thrombography

artículo científico publicado en 2019

Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis

artículo científico publicado en 2007

Role of zymogenicity-determining residues of coagulation factor VII/VIIa in cofactor interaction and macromolecular substrate recognition

artículo científico publicado en 2002

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.

artículo científico publicado en 2017

Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity.

artículo científico publicado en 2018

Targeting clotting proteins in cancer therapy - progress and challenges

artículo científico publicado en 2016

The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.

artículo científico publicado en 2010

The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis

artículo científico publicado en 2003

Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome).

artículo científico publicado en 2015

Thiol pathways in the regulation of tissue factor prothrombotic activity ⬇️

artículo científico publicado el 1 de septiembre de 2011

Thrombin generation and the pathogenesis of cancer

artículo científico publicado en 2006

Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression.

artículo científico publicado en 2016

Tissue Factor Coagulant Activity is Regulated by the Plasma Membrane Microenvironment

artículo científico publicado en 2018

Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking

artículo científico publicado en 2017

Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling

artículo científico publicado en 2012

Tissue factor and protease-activated receptor signaling in cancer

artículo científico publicado en 2008

Tissue factor as a mediator of coagulation and signaling in cancer and chronic inflammation

artículo científico publicado en 2018

Tissue factor associates with survival and regulates tumour progression in osteosarcoma.

artículo científico publicado en 2016

Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity.

artículo científico publicado en 2007

Tissue factor in cancer progression and angiogenesis

artículo científico publicado en 2010

Tissue factor mutated at the allosteric Cys186-Cys209 disulfide bond is severely impaired in decrypted procoagulant activity

artículo científico publicado en 2010

Tissue factor proangiogenic signaling in cancer progression

artículo científico publicado en 2012

Tissue factor-protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation.

artículo científico publicado en 2011

Lista de obras de

Activated protein C in sepsis: the promise of nonanticoagulant activated protein C.

Activated protein C signals through the thrombin receptor PAR1 in endothelial cells

Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor VII.

Activation of endothelial cell protease activated receptor 1 by the protein C pathway

Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma.

Alternatively spliced tissue factor is not sufficient for embryonic development

Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner.

Angiotensin II Infusion Leads to Aortic Dissection in LRP8 Deficient Mice

Characterization of Thrombin Generation Curve Shape in Presence of Platelets from Acute Venous Thromboembolism Patients

Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice

Coagulation signaling and cancer immunotherapy

Complete abolishment of coagulant activity in monomeric disulfide-deficient tissue factor

Cooperation of tissue factor cytoplasmic domain and PAR2 signaling in breast cancer development.

Corrigendum: PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

Cross-talk of integrin alpha3beta1 and tissue factor in cell migration

Differential role of tissue factor pathway inhibitors 1 and 2 in melanoma vasculogenic mimicry ⬇️

Disulfide isomerization switches tissue factor from coagulation to cell signaling

EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice.

Emerging insights in tissue factor-dependent signaling events.

Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality

Endothelial GLP-1 (Glucagon-Like Peptide-1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice With Experimental Arterial Hypertension

Endothelial protein C receptor function in murine and human breast cancer development

Engineering of a membrane-triggered activity switch in coagulation factor VIIa

Engineering of substrate selectivity for tissue factor.factor VIIa complex signaling through protease-activated receptor 2.

Evidence for activation of tissue factor by an allosteric disulfide bond

Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1.

Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2.

Hematopoietic tissue factor-protease-activated receptor 2 signaling promotes hepatic inflammation and contributes to pathways of gluconeogenesis and steatosis in obese mice

Hepatocyte nuclear factor-4-independent synthesis of coagulation factor VII in breast cancer cells and its inhibition by targeting selective histone acetyltransferases

Identification of the coagulation factor VIIa integrin binding site required for pro-angiogenic PAR2 signaling

Infrared fluorescence for vascular barrier breach in vivo--a novel method for quantitation of albumin efflux.

Inhibition of tissue factor signaling suppresses tumor growth

LIM-only protein FHL2 attenuates vascular tissue factor activity, inhibits thrombus formation in mice and FHL2 genetic variation associates with human venous thrombosis

Molecular dynamics simulations and functional characterization of the interactions of the PAR2 ectodomain with factor VIIa ⬇️

Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality

Nonproteolytic properties of murine alternatively spliced tissue factor: implications for integrin-mediated signaling in murine models

Nox2+ Myeloid cells drive vascular inflammation and endothelial dysfunction in heart failure after myocardial infarction via angiotensin II receptor type 1

Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor.

P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice

PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

Paraoxonase-2 regulates coagulation activation through endothelial tissue factor

Plasmin-induced migration of endothelial cells. A potential target for the anti-angiogenic action of angiostatin

Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1).

Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension

Podocyte Integrin-β 3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy

Procoagulant activities of skeletal muscle and cardiac myosins require both myosin protein and myosin-associated anionic phospholipids

Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice

Protease-activated receptor 2 signaling in inflammation

Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain

Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling

Regulation of angiogenesis by tissue factor cytoplasmic domain signaling

Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling

Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia.

Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation

Rivaroxaban Effects Illustrate the Underestimated Importance of Activated Platelets in Thrombin Generation Assessed by Calibrated Automated Thrombography

Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis

Role of zymogenicity-determining residues of coagulation factor VII/VIIa in cofactor interaction and macromolecular substrate recognition

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.

Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity.

Targeting clotting proteins in cancer therapy - progress and challenges

The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors.

The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis

Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome).

Thiol pathways in the regulation of tissue factor prothrombotic activity ⬇️

Thrombin generation and the pathogenesis of cancer

Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression.

Tissue Factor Coagulant Activity is Regulated by the Plasma Membrane Microenvironment

Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking

Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodelling

Tissue factor and protease-activated receptor signaling in cancer

Tissue factor as a mediator of coagulation and signaling in cancer and chronic inflammation

Tissue factor associates with survival and regulates tumour progression in osteosarcoma.

Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity.

Tissue factor in cancer progression and angiogenesis

Tissue factor mutated at the allosteric Cys186-Cys209 disulfide bond is severely impaired in decrypted procoagulant activity

Tissue factor proangiogenic signaling in cancer progression

Tissue factor-protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation.