Lista de obras - Shin-ichi Tsunoda - Dominio Público Uruguay

A Novel Bispecific Antibody against Human CD3 and Ephrin Receptor A10 for Breast Cancer Therapy

artículo científico publicado en 2015

A gapmer antisense oligonucleotide targeting SRRM4 is a novel therapeutic medicine for lung cancer

scientific article published on 20 May 2019

Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials

scientific article published on 22 September 2010

Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.

artículo científico publicado en 2015

Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes.

artículo científico publicado en 2011

Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure

artículo científico publicado en 2012

Amorphous silica nanoparticles enhance cross-presentation in murine dendritic cells

artículo científico publicado en 2012

Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection

artículo científico publicado en 2012

Annexin A4 is a possible biomarker for cisplatin susceptibility of malignant mesothelioma cells ⬇️

artículo científico publicado el 4 de abril de 2012

Anti-inflammatory effects of a novel TNFR1-selective antagonistic TNF mutant on established murine collagen-induced arthritis

artículo científico publicado en 2011

Antibody-based therapy targeting tumor vascular endothelial cells suppresses solid tumor growth in rats

scientific article published on 01 July 1997

Application of bioactive mutant TNF alpha to a mucosal vaccine adjuvant

artículo científico publicado en 2010

Arsenic trioxide inhibits human t cell-lymphotropic virus-1-induced syncytiums by down-regulating gp46.

artículo científico publicado en 2009

Asian dust particles induce macrophage inflammatory responses via mitogen-activated protein kinase activation and reactive oxygen species production.

artículo científico publicado en 2014

Bioconjugation of laminin peptide YIGSR with poly(styrene co-maleic acid) increases its antimetastatic effect on lung metastasis of B16-BL6 melanoma cells

artículo científico publicado en 1999

Bioconjugation of tumor necrosis factor-alpha with the copolymer of divinyl ether and maleic anhydride increasing its antitumor potency

scientific article published on 01 October 1997

Carbon Nanomaterials: Efficacy and Safety for Nanomedicine.

artículo científico publicado en 2012

Cell array coupled with laser scanning cytometry allows easy analysis of changes in cyclin expression during the cell cycle. An application of cell array system.

artículo científico publicado en 2002

Comparative study on transduction and toxicity of protein transduction domains.

artículo científico publicado en 2008

Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist

artículo científico publicado en 2008

Creation of TNFR1-selective antagonist and its therapeutic effects

artículo científico publicado en 2010

Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy

artículo científico publicado en 2010

Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor.

artículo científico publicado en 2010

Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using a phage display system

artículo científico publicado en 2009

Creation of novel cell-penetrating peptides for intracellular drug delivery using systematic phage display technology originated from Tat transduction domain

artículo científico publicado en 2007

Crystallization and preliminary X-ray analysis of the tumour necrosis factor alpha-tumour necrosis factor receptor type 2 complex

artículo científico publicado en 2009

Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice

artículo científico publicado en 2015

Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy.

artículo científico publicado en 2004

Development of a novel DDS for site-specific PEGylated proteins

artículo científico publicado en 2011

Development of an antibody proteomics system using a phage antibody library for efficient screening of biomarker proteins ⬇️

artículo científico publicado el 8 de octubre de 2010

Distribution and histologic effects of intravenously administered amorphous nanosilica particles in the testes of mice

artículo científico publicado en 2012

Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in murine macrophages.

artículo científico publicado en 2011

Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages.

artículo científico publicado en 2011

Eph receptor A10 has a potential as a target for a prostate cancer therapy.

artículo científico publicado en 2014

Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers

artículo científico publicado en 2014

Evaluation of silica nanoparticle binding to major human blood proteins.

artículo científico publicado en 2014

Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients.

artículo científico publicado en 2013

Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists

artículo científico publicado en 2009

Fine tuning of receptor-selectivity for tumor necrosis factor-α using a phage display system with one-step competitive panning.

artículo científico publicado en 2011

Generation and characterization of a bispecific diabody targeting both EPH receptor A10 and CD3.

artículo científico publicado en 2014

Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2.

artículo científico publicado en 2009

Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles

artículo científico publicado en 2012

Histological analysis of 70-nm silica particles-induced chronic toxicity in mice.

artículo científico publicado en 2009

Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors

artículo científico publicado en 2015

Identification of new candidates as mucosal vaccine adjuvant in TNF family cytokines

artículo científico publicado en 2011

In vitro remodeling of tumor vascular endothelial cells using conditioned medium from various tumor cells and their sensitivity to TNF-alpha

artículo científico publicado en 2000

Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.

artículo científico publicado en 2010

Intestinal absorption and biological effects of orally administered amorphous silica particles.

artículo científico publicado en 2014

Intranasal exposure to amorphous nanosilica particles could activate intrinsic coagulation cascade and platelets in mice

artículo científico publicado en 2013

LIGHT protein suppresses tumor growth by augmentation of immune response.

artículo científico publicado en 2009

Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung ⬇️

artículo científico publicado el 25 de enero de 2011

Liver-specific microRNAs as biomarkers of nanomaterial-induced liver damage

artículo científico publicado en 2013

Lysine-deficient lymphotoxin-α mutant for site-specific PEGylation ⬇️

artículo científico publicado el 25 de agosto de 2011

Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies obtained from immune-phage antibody libraries against HIV-1 Nef and Vif.

artículo científico publicado en 2011

Molecular design of conjugated tumor necrosis factor-alpha: synthesis and characteristics of polyvinyl pyrrolidone modified tumor necrosis factor-alpha

artículo científico publicado en 1999

Molecular design of polyvinylpyrrolidone-conjugated interleukin-6 for enhancement of in vivo thrombopoietic activity in mice

artículo científico publicado en 2000

Mutants of lymphotoxin-α with augmented cytotoxic activity via TNFR1 for use in cancer therapy.

artículo científico publicado en 2012

Novel protein engineering strategy for creating highly receptor-selective mutant TNFs

artículo científico publicado en 2009

Organelle-targeted delivery of biological macromolecules using the protein transduction domain: potential applications for Peptide aptamer delivery into the nucleus.

artículo científico publicado en 2008

Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation.

artículo científico publicado en 2010

Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice.

artículo científico publicado en 2011

Promotion of optimized protein therapy by bioconjugation as a polymeric DDS.

artículo científico publicado en 2006

Quality enhancement of the non-immune phage scFv library to isolate effective antibodies

artículo científico publicado en 2006

Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody.

artículo científico publicado en 2013

Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction

artículo científico publicado en 2006

Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants

artículo científico publicado en 2007

Selective enhancer of tumor vascular permeability for optimization of cancer chemotherapy.

artículo científico publicado en 2004

Silica and titanium dioxide nanoparticles cause pregnancy complications in mice

artículo científico publicado en 2011

Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity

scientific article published on 26 March 2008

Size and surface modification of amorphous silica particles determine their effects on the activity of human CYP3A4 in vitro.

artículo científico publicado en 2014

Solution of the structure of the TNF-TNFR2 complex

artículo científico publicado en 2010

Structure-activity relationship of T-cell receptors based on alanine scanning

scientific article published on 31 October 2011

Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant

artículo científico publicado en 2009

Surface modification of amorphous nanosilica particles suppresses nanosilica-induced cytotoxicity, ROS generation, and DNA damage in various mammalian cells

artículo científico publicado en 2012

Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application ⬇️

artículo científico publicado el 22 de enero de 2011

TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant

artículo científico publicado en 2009

The targeting of anionized polyvinylpyrrolidone to the renal system.

artículo científico publicado en 2004

The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models

artículo científico publicado en 2008

The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF

artículo científico publicado en 2009

The use of PVP as a polymeric carrier to improve the plasma half-life of drugs.

artículo científico publicado en 2004

The use of a mutant TNF-alpha as a vaccine adjuvant for the induction of mucosal immune responses

artículo científico publicado en 2009

Therapeutic effect of PEGylated TNFR1-selective antagonistic mutant TNF in experimental autoimmune encephalomyelitis mice

Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B.

artículo científico publicado en 2010

Tumor vascular targeting using a tumor-tissue endothelium-specific monoclonal antibody as an effective strategy for cancer chemotherapy

artículo científico publicado en 1999

[Antibody engineering for next-generation biodrug development]

scientific article published on 01 January 2013

[Application of nanomaterials for drug innovation and their risks]

artículo científico publicado en 2008

[Development of a technology platform for novel drug discovery aimed at regulating biological function]

scientific article published on 01 January 2010

[Transdermal penetration and biodistribution of nanomaterials and their acute toxicity in vivo]

artículo científico publicado en 2011

Lista de obras de Shin-ichi Tsunoda

A Novel Bispecific Antibody against Human CD3 and Ephrin Receptor A10 for Breast Cancer Therapy

A gapmer antisense oligonucleotide targeting SRRM4 is a novel therapeutic medicine for lung cancer

Acute phase proteins as biomarkers for predicting the exposure and toxicity of nanomaterials

Aminopeptidase P3, a new member of the TNF-TNFR2 signaling complex, induces phosphorylation of JNK1 and JNK2.

Amorphous nanosilica induce endocytosis-dependent ROS generation and DNA damage in human keratinocytes.

Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure

Amorphous silica nanoparticles enhance cross-presentation in murine dendritic cells

Amorphous silica nanoparticles size-dependently aggravate atopic dermatitis-like skin lesions following an intradermal injection

Annexin A4 is a possible biomarker for cisplatin susceptibility of malignant mesothelioma cells ⬇️

Anti-inflammatory effects of a novel TNFR1-selective antagonistic TNF mutant on established murine collagen-induced arthritis

Antibody-based therapy targeting tumor vascular endothelial cells suppresses solid tumor growth in rats

Application of bioactive mutant TNF alpha to a mucosal vaccine adjuvant

Arsenic trioxide inhibits human t cell-lymphotropic virus-1-induced syncytiums by down-regulating gp46.

Asian dust particles induce macrophage inflammatory responses via mitogen-activated protein kinase activation and reactive oxygen species production.

Bioconjugation of laminin peptide YIGSR with poly(styrene co-maleic acid) increases its antimetastatic effect on lung metastasis of B16-BL6 melanoma cells

Bioconjugation of tumor necrosis factor-alpha with the copolymer of divinyl ether and maleic anhydride increasing its antitumor potency

Carbon Nanomaterials: Efficacy and Safety for Nanomedicine.

Cell array coupled with laser scanning cytometry allows easy analysis of changes in cyclin expression during the cell cycle. An application of cell array system.

Comparative study on transduction and toxicity of protein transduction domains.

Creation and X-ray structure analysis of the tumor necrosis factor receptor-1-selective mutant of a tumor necrosis factor-alpha antagonist

Creation of TNFR1-selective antagonist and its therapeutic effects

Creation of a LIGHT mutant with the capacity to evade the decoy receptor for cancer therapy

Creation of a lysine-deficient LIGHT mutant with the capacity for site-specific PEGylation and low affinity for a decoy receptor.

Creation of lysine-deficient mutant lymphotoxin-alpha with receptor selectivity by using a phage display system

Creation of novel cell-penetrating peptides for intracellular drug delivery using systematic phage display technology originated from Tat transduction domain

Crystallization and preliminary X-ray analysis of the tumour necrosis factor alpha-tumour necrosis factor receptor type 2 complex

Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice

Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy.

Development of a novel DDS for site-specific PEGylated proteins

Development of an antibody proteomics system using a phage antibody library for efficient screening of biomarker proteins ⬇️

Distribution and histologic effects of intravenously administered amorphous nanosilica particles in the testes of mice

Effect of amorphous silica nanoparticles on in vitro RANKL-induced osteoclast differentiation in murine macrophages.

Effect of surface properties of silica nanoparticles on their cytotoxicity and cellular distribution in murine macrophages.

Eph receptor A10 has a potential as a target for a prostate cancer therapy.

Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers

Evaluation of silica nanoparticle binding to major human blood proteins.

Expression of Eph receptor A10 is correlated with lymph node metastasis and stage progression in breast cancer patients.

Fast binding kinetics and conserved 3D structure underlie the antagonistic activity of mutant TNF: useful information for designing artificial proteo-antagonists

Fine tuning of receptor-selectivity for tumor necrosis factor-α using a phage display system with one-step competitive panning.

Generation and characterization of a bispecific diabody targeting both EPH receptor A10 and CD3.

Generation of mouse macrophages expressing membrane-bound TNF variants with selectivity for TNFR1 or TNFR2.

Hemopexin as biomarkers for analyzing the biological responses associated with exposure to silica nanoparticles

Histological analysis of 70-nm silica particles-induced chronic toxicity in mice.

Identification and evaluation of metastasis-related proteins, oxysterol binding protein-like 5 and calumenin, in lung tumors

Identification of new candidates as mucosal vaccine adjuvant in TNF family cytokines

In vitro remodeling of tumor vascular endothelial cells using conditioned medium from various tumor cells and their sensitivity to TNF-alpha

Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.

Intestinal absorption and biological effects of orally administered amorphous silica particles.

Intranasal exposure to amorphous nanosilica particles could activate intrinsic coagulation cascade and platelets in mice

LIGHT protein suppresses tumor growth by augmentation of immune response.

Limited expression of reticulocalbin-1 in lymphatic endothelial cells in lung tumor but not in normal lung ⬇️

Liver-specific microRNAs as biomarkers of nanomaterial-induced liver damage

Lysine-deficient lymphotoxin-α mutant for site-specific PEGylation ⬇️

Modifying the antigen-immunization schedule improves the variety of monoclonal antibodies obtained from immune-phage antibody libraries against HIV-1 Nef and Vif.

Molecular design of conjugated tumor necrosis factor-alpha: synthesis and characteristics of polyvinyl pyrrolidone modified tumor necrosis factor-alpha

Molecular design of polyvinylpyrrolidone-conjugated interleukin-6 for enhancement of in vivo thrombopoietic activity in mice

Mutants of lymphotoxin-α with augmented cytotoxic activity via TNFR1 for use in cancer therapy.

Novel protein engineering strategy for creating highly receptor-selective mutant TNFs

Organelle-targeted delivery of biological macromolecules using the protein transduction domain: potential applications for Peptide aptamer delivery into the nucleus.

Potential adjuvant effect of intranasal urban aerosols in mice through induction of dendritic cell maturation.

Promotion of allergic immune responses by intranasally-administrated nanosilica particles in mice.

Promotion of optimized protein therapy by bioconjugation as a polymeric DDS.

Quality enhancement of the non-immune phage scFv library to isolate effective antibodies

Robo4 is an effective tumor endothelial marker for antibody-drug conjugates based on the rapid isolation of the anti-Robo4 cell-internalizing antibody.

Role of Tyr306 in the C-terminal fragment of Clostridium perfringens enterotoxin for modulation of tight junction

Role of amino acid residue 90 in bioactivity and receptor binding capacity of tumor necrosis factor mutants

Selective enhancer of tumor vascular permeability for optimization of cancer chemotherapy.

Silica and titanium dioxide nanoparticles cause pregnancy complications in mice

Simple and highly sensitive assay system for TNFR2-mediated soluble- and transmembrane-TNF activity

Size and surface modification of amorphous silica particles determine their effects on the activity of human CYP3A4 in vitro.

Solution of the structure of the TNF-TNFR2 complex

Structure-activity relationship of T-cell receptors based on alanine scanning

Structure-function relationship of tumor necrosis factor (TNF) and its receptor interaction based on 3D structural analysis of a fully active TNFR1-selective TNF mutant

Surface modification of amorphous nanosilica particles suppresses nanosilica-induced cytotoxicity, ROS generation, and DNA damage in various mammalian cells

Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application ⬇️

TNF superfamily member, TL1A, is a potential mucosal vaccine adjuvant

The targeting of anionized polyvinylpyrrolidone to the renal system.

The therapeutic effect of TNFR1-selective antagonistic mutant TNF-alpha in murine hepatitis models

The treatment of established murine collagen-induced arthritis with a TNFR1-selective antagonistic mutant TNF