Lista de obras - Fabio Zuccotto - Dominio Público Uruguay

2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase

artículo científico publicado en 2003

A novel multiple-stage antimalarial agent that inhibits protein synthesis

artículo científico publicado en 2015

A platform for target prediction of phenotypic screening hit molecules

artículo científico publicado en 2019

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

article published in the Proceedings of the National Academy of Sciences of the United States of America

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

artículo científico publicado en 2016

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

scientific article published in Nature

DNA-binding mechanism of the Escherichia coli Ada O(6)-alkylguanine-DNA alkyltransferase

artículo científico publicado en 2000

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR

artículo científico publicado en 1999

Dihydrofolate reductase: a potential drug target in trypanosomes and leishmania.

artículo científico publicado en 1998

Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy

artículo científico publicado en 2015

Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90)

artículo científico publicado en 2013

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

artículo científico publicado en 2016

Exhaustive sampling of the fragment space associated to a molecule leading to the generation of conserved fragments

artículo científico publicado en 2017

Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors

artículo científico publicado en 2014

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

artículo científico publicado en 2018

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease

artículo científico publicado en 2021

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

artículo científico publicado en 2019

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

artículo científico publicado en 2019

Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

artículo científico publicado en 2021

NMS-E973, a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases

artículo científico publicado en 2013

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

artículo científico publicado en 2001

On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

artículo científico publicado en 2018

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future

artículo científico publicado en 2018

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

scholarly article by Victoriano Corpas-Lopez et al published 12 November 2018 in ACS Infectious Diseases

Pharmacophore features distributions in different classes of compounds.

artículo científico publicado en 2003

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

scientific article published on 08 April 2019

Prediction of Drug Penetration in Tuberculosis Lesions

artículo científico publicado en 2016

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.

artículo científico publicado en 2018

Structure-based optimization of potent PDK1 inhibitors

artículo científico publicado en 2010

The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani

scientific article published on 30 January 2020

The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.

artículo científico publicado en 1999

Lista de obras de Fabio Zuccotto

2,4-Diaminopyrimidines as inhibitors of Leishmanial and Trypanosomal dihydrofolate reductase

A novel multiple-stage antimalarial agent that inhibits protein synthesis

A platform for target prediction of phenotypic screening hit molecules

Clinical and veterinary trypanocidal benzoxaboroles target CPSF3

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

DNA-binding mechanism of the Escherichia coli Ada O(6)-alkylguanine-DNA alkyltransferase

Design and synthesis of lipophilic phosphoramidate d4T-MP prodrugs expressing high potency against HIV in cell culture: structural determinants for in vitro activity and QSAR

Dihydrofolate reductase: a potential drug target in trypanosomes and leishmania.

Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy

Discovery of NMS-E973 as novel, selective and potent inhibitor of heat shock protein 90 (Hsp90)

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

Exhaustive sampling of the fragment space associated to a molecule leading to the generation of conserved fragments

Fragment-based hit discovery and structure-based optimization of aminotriazoloquinazolines as novel Hsp90 inhibitors

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

Identification of a Proteasome-Targeting Arylsulfonamide with Potential for the Treatment of Chagas' Disease

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial

NMS-E973, a novel synthetic inhibitor of Hsp90 with activity against multiple models of drug resistance to targeted agents, including intracranial metastases

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

Pharmacokinetics of β-Lactam Antibiotics: Clues from the Past To Help Discover Long-Acting Oral Drugs in the Future

Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani

Pharmacophore features distributions in different classes of compounds.

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Prediction of Drug Penetration in Tuberculosis Lesions

Screening of a Novel Fragment Library with Functional Complexity against Mycobacterium tuberculosis InhA.

Structure-based optimization of potent PDK1 inhibitors

The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani

The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.