Lista de obras - Hervé Le Hir - Dominio Público Uruguay

5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly

artículo científico publicado en 2002

5'-End RET splicing: absence of variants in normal tissues and intron retention in pheochromocytomas.

artículo científico publicado en 2002

A UPF3-mediated regulatory switch that maintains RNA surveillance

artículo científico publicado en 2009

A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner

artículo científico publicado en 2018

A mechanistic study of helicases with magnetic traps

artículo científico publicado en 2017

A novel rat tyrosine hydroxylase mRNA species generated by alternative splicing.

artículo científico publicado en 1996

Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module

artículo científico publicado en 2004

Biochemical characterization of the RNA helicase UPF1 involved in nonsense-mediated mRNA decay.

artículo científico publicado en 2012

CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex

artículo científico publicado en 2012

CLIP-seq to discover transcriptome-wide imprinting of RNA binding proteins in living cells.

artículo científico publicado en 2015

Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain

artículo científico publicado en 2013

DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway

artículo científico publicado en 2003

Erratum to: Insights into the design and interpretation of iCLIP experiments.

artículo científico publicado en 2017

Exon Junction Complexes can have distinct functional flavours to regulate specific splicing events.

artículo científico publicado en 2018

Expression of GFRalpha1 receptor splicing variants with different biochemical properties is modulated during kidney development

scientific journal article

HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition

artículo científico publicado en 2018

How introns influence and enhance eukaryotic gene expression

artículo científico publicado en 2003

Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly

artículo científico publicado en 2012

Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities

artículo científico publicado en 2015

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies

artículo científico publicado en 2007

Insights into the design and interpretation of iCLIP experiments

artículo científico publicado en 2017

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex

artículo científico publicado en 2010

Mechanism of ATP turnover inhibition in the EJC

artículo científico publicado en 2009

Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2

artículo científico publicado en 2011

Monitored eCLIP: high accuracy mapping of RNA-protein interactions

Mutations in the Spliceosome Component CWC27 Cause Retinal Degeneration with or without Additional Developmental Anomalies ⬇️

artículo científico publicado en 2017

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

artículo científico publicado en 2007

Nonsense-mediated mRNA decay inhibition by HTLV-1 Tax protein.

artículo científico publicado en 2014

Nonsense-mediated mRNA decay involves two distinct Upf1-bound complexes

artículo científico publicado en 2018

Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions

artículo científico publicado en 2000

Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators

artículo científico publicado en 2012

Relative expression of the RET9 and RET51 isoforms in human pheochromocytomas

scientific article published on 01 May 2000

Splicing enhances translation in mammalian cells: an additional function of the exon junction complex

artículo científico publicado en 2004

Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA

artículo científico publicado en 2006

The exon junction complex as a node of post-transcriptional networks

artículo científico

The exon junction complex differentially marks spliced junctions ⬇️

artículo científico publicado el 5 de septiembre de 2010

The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity

artículo científico publicado en 2005

The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

artículo científico publicado en 2001

The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly.

artículo científico publicado en 2007

The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1.

artículo científico publicado en 2012

The protein Mago provides a link between splicing and mRNA localization.

artículo científico publicado en 2001

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains

artículo científico publicado en 2012

Transcriptome-wide modulation of splicing by the exon junction complex

artículo científico publicado en 2014

UPF1-like helicase grip on nucleic acids dictates processivity

artículo científico publicado en 2018

Lista de obras de Hervé Le Hir

5' exon interactions within the human spliceosome establish a framework for exon junction complex structure and assembly

5'-End RET splicing: absence of variants in normal tissues and intron retention in pheochromocytomas.

A UPF3-mediated regulatory switch that maintains RNA surveillance

A conserved structural element in the RNA helicase UPF1 regulates its catalytic activity in an isoform-specific manner

A mechanistic study of helicases with magnetic traps

A novel rat tyrosine hydroxylase mRNA species generated by alternative splicing.

Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module

Biochemical characterization of the RNA helicase UPF1 involved in nonsense-mediated mRNA decay.

CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex

CLIP-seq to discover transcriptome-wide imprinting of RNA binding proteins in living cells.

Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domain

DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway

Erratum to: Insights into the design and interpretation of iCLIP experiments.

Exon Junction Complexes can have distinct functional flavours to regulate specific splicing events.

Expression of GFRalpha1 receptor splicing variants with different biochemical properties is modulated during kidney development

HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition

How introns influence and enhance eukaryotic gene expression

Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly

Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies

Insights into the design and interpretation of iCLIP experiments

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex

Mechanism of ATP turnover inhibition in the EJC

Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2

Monitored eCLIP: high accuracy mapping of RNA-protein interactions

Mutations in the Spliceosome Component CWC27 Cause Retinal Degeneration with or without Additional Developmental Anomalies ⬇️

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity

Nonsense-mediated mRNA decay inhibition by HTLV-1 Tax protein.

Nonsense-mediated mRNA decay involves two distinct Upf1-bound complexes

Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions

Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulators

Relative expression of the RET9 and RET51 isoforms in human pheochromocytomas

Splicing enhances translation in mammalian cells: an additional function of the exon junction complex

Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA

The exon junction complex as a node of post-transcriptional networks

The exon junction complex differentially marks spliced junctions ⬇️

The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity

The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay

The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly.

The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1.

The protein Mago provides a link between splicing and mRNA localization.

Tight intramolecular regulation of the human Upf1 helicase by its N- and C-terminal domains

Transcriptome-wide modulation of splicing by the exon junction complex

UPF1-like helicase grip on nucleic acids dictates processivity