Lista de obras - J Ryan - Dominio Público Uruguay

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

artículo científico publicado en 2020

BCL2 suppresses PARP1 function and nonapoptotic cell death.

artículo científico publicado en 2012

BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics

scientific article published on 22 July 2019

BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics.

artículo científico publicado en 2015

BH3 profiling in whole cells by fluorimeter or FACS ⬇️

artículo científico publicado el 20 de abril de 2013

BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals

artículo científico publicado en 2008

Bcl-xL controls a switch between cell death modes during mitotic arrest

artículo científico publicado en 2014

Bcl-xL controls a switch between cell death modes during mitotic arrest.

artículo científico publicado en 2014

Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells

artículo científico publicado en 2017

Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines

artículo científico publicado en 2016

Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.

artículo científico publicado en 2014

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

artículo científico publicado en 2015

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

artículo científico publicado en 2017

Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia.

artículo científico publicado en 2016

Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.

artículo científico publicado en 2010

High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.

artículo científico publicado en 2013

High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors

artículo científico publicado en 2020

Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation.

artículo científico publicado en 2014

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

artículo científico publicado en 2019

Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199

artículo científico publicado en 2014

Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

artículo científico publicado en 2021

Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer

scientific article published on 28 August 2019

Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.

artículo científico publicado en 2014

Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling

artículo científico publicado en 2019

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy ⬇️

artículo científico publicado el 27 de octubre de 2011

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains.

artículo científico publicado en 2016

Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

artículo científico publicado en 2012

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

artículo científico publicado en 2017

The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance

artículo científico

iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry

artículo científico publicado en 2016

Lista de obras de J Ryan

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division

BCL2 suppresses PARP1 function and nonapoptotic cell death.

BH3 profiling discriminates on-target small molecule BH3 mimetics from putative mimetics

BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics.

BH3 profiling in whole cells by fluorimeter or FACS ⬇️

BIM and other BCL-2 family proteins exhibit cross-species conservation of function between zebrafish and mammals

Bcl-xL controls a switch between cell death modes during mitotic arrest

Bcl-xL controls a switch between cell death modes during mitotic arrest.

Complementary dynamic BH3 profiles predict co-operativity between the multi-kinase inhibitor TG02 and the BH3 mimetic ABT-199 in acute myeloid leukaemia cells

Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines

Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1

Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia.

Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.

High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.

High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors

Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation.

MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer

Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199

Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration

Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer

Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.

Prediction of venetoclax activity in precursor B-ALL by functional assessment of apoptosis signaling

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy ⬇️

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains.

Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis

The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance

iBH3: simple, fixable BH3 profiling to determine apoptotic priming in primary tissue by flow cytometry