Lista de obras - Piet Herdewijn - Dominio Público Uruguay

(D)- and (L)-cyclohexenyl-G, a new class of antiviral agents: synthesis, conformational analysis, molecular modeling, and biological activity

artículo científico publicado en 2001

1,2,4-Triazole Derivatives Inhibiting the Human Immunodeficiency Virus Type 1 (HIV-1) in vitro

article

1,2;3,4-Di-O-isopropylidene-l-galactose synthesis from its d-enantiomer

1,5-Anhydro-2-Deoxy-D-Altritol Oligonucleotides as Conformationally Restricted Analogues of Rna

1-(2,3-Dideoxy-erythro-beta-D-hexopyranosyl)cytosine: an example of the conformational and stacking properties of pyranosyl pyrimidine nucleosides. A crystallographic and computational approach

artículo científico publicado el 1 de febrero de 1992

1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase

artículo científico publicado en 2002

1′, 5′ -Anhydrohexitol Oligonucleotides: Synthesis, Base Pairing and Recognition by Regular Oligodeoxyribonucleotides and Oligoribonucleotides

1′,5′-Anhydro-l-ribo-hexitol Adenine Nucleic Acids (α-l-HNA-A): Synthesis and Chiral Selection Properties in the Mirror Image World

artículo científico publicado en 2015

1′,5′-Anhydrohexitol Oligonucleotides: Hybridisation and Strand Displacement with Oligoribonucleotides, Interaction with RNase H and HIV Reverse Transcriptase

article

2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.

artículo científico publicado en 1990

2'-Deoxyribonucleoside phosphoramidate triphosphate analogues as alternative substrates for E. coli polymerase III.

artículo científico publicado en 2012

2'-O-hydroxyalkoxymethylribonucleosides and their incorporation into oligoribonucleotides

artículo científico publicado en 2007

2-Hydroxyethoxyethylated Bases as Acyclic Analogues of 1,5-Anhydrohexitol Nucleoside Derivatives

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

artículo científico publicado en 2003

3-Phosphono-L-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase.

artículo científico publicado en 2010

3′-Amidated 3′-Deoxyxylofuranose Analogues of N 6-−Cyclopentyladenosines: a New Class of Non-Xanthine Antagonists at the Adenosine A1 Receptor

3′-Deoxy-3′-hydroxymethyl-aldopentopyranosyl nucleoside synthesis. Part I

5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists

artículo científico publicado en 2002

5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity

artículo científico publicado en 1990

5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication

artículo científico publicado en 1991

5-(Thien-2-yl)-2′-deoxyuridine: A New and Potent Inhibitor of Herpes Simplex Virus Type 1 Replication

5-Hydroxytryptophan as a building block in oligopeptides using Fmoc/tBu SPPS

5-Substituted pyrimidine 1,5-anhydrohexitols: Conformational analysis and interaction with viral thymidine kinase

artículo científico publicado en 1999

9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo

artículo científico publicado en 1991

A Methyl Group Controls Conformational Equilibrium in Human Mitochondrial tRNALys

artículo científico publicado en 2007

A Novel and Enantioselective Approach to the Synthesis of Cyclohexane Carbocyclic Nucleosides Starting from (-)-Carvone

A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics ⬇️

artículo científico publicado en 2013

A Potential Prebiotic Route to Adenine from Hypoxanthine

scholarly article by Irene M. Lagoja published in July 2005

A Single Amino Acid Substitution in Therminator DNA Polymerase Increases Incorporation Efficiency of Deoxyxylonucleotides

artículo científico publicado en 2018

A Straightforward Stereoselective Synthesis of d- and l-5-Hydroxy-4-hydroxymethyl-2-cyclohexenylguanine ⬇️

artículo científico publicado el 14 de diciembre de 2001

A Versatile NMR Technique for the Identification of Phosphorylation Sites in Oligosaccharides

A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro

artículo científico publicado en 2010

A highly enantio-selective hexitol nucleic acid template for nonenzymatic oligoguanylate synthesis.

artículo científico publicado en 1999

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

artículo científico publicado en 2009

A novel and convenient strategy for the synthesis of phthalazines from an aryne precursor

A novel helper phage for HaloTag-mediated co-display of enzyme and substrate on phage

artículo científico publicado en 2015

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase

artículo científico publicado en 2006

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.

artículo científico publicado en 2009

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

artículo científico publicado en 2010

A short and convenient strategy for the synthesis of pyridazines via Diaza–Wittig reaction

A short and straightforward approach towards 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines

A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides

artículo científico publicado en 2003

A simplified and standardized polymerase chain reaction format for the diagnosis of leishmaniasis

artículo científico publicado en 2008

A synthetic substrate of DNA polymerase deviating from the bases, sugar, and leaving group of canonical deoxynucleoside triphosphates

artículo científico publicado en 2013

Access to a New Type of Homo-C-Nucleosides with a “Split” 8-Deazapurine via a 1,3-Dipolar Cycloaddition Reaction

Achiral, acyclic nucleic acids: synthesis and biophysical studies of a possible prebiotic polymer

Acyclic oligonucleotides: possibilities and limitations

Additions and Corrections - Resolution of Aristeromycin Enantiomers

article

Affinity modification of EcoRII DNA methyltransferase by the dialdehyde-substituted DNA duplexes: mapping the enzyme region that interacts with DNA.

artículo científico publicado en 2002

Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria.

artículo científico publicado en 2011

Alpha-homo-DNA and RNA form a parallel oriented non-A, non-B-type double helical structure.

artículo científico publicado en 2001

Amidate Prodrugs of Cyclic 9-()-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine with Potent Anti-Herpesvirus Activity

Amidate Prodrugs of Deoxythreosyl Nucleoside Phosphonates as Dual Inhibitors of HIV and HBV Replication

artículo científico publicado en 2016

Amino Acid Phosphoramidate Nucleotides as Alternative Substrates for HIV-1 Reverse Transcriptase

article

Amino acids derived from ornithine

Aminoacyl-tRNA synthetase inhibitors as potent and synergistic immunosuppressants

artículo científico publicado en 2008

An acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleoside

artículo científico publicado en 1995

An easy and fast method for the evaluation of Staphylococcus epidermidis type I signal peptidase inhibitors

artículo científico publicado en 2009

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

artículo científico publicado en 2009

Anti-Hiv-1 Activity of 2',3'-Dideoxinucleoside Analogues : Structure-Activity Relationship

article

Anti-norovirus activity of C7-modified 4-amino-pyrrolo[2,1-f][1,2,4]triazine C-nucleosides

scientific article published on 07 March 2020

Antibacterial 5'-O-(N-dipeptidyl)-sulfamoyladenosines.

artículo científico publicado en 2008

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

artículo científico publicado en 2017

Antimalarial antisense activity of hexitol nucleic acids

artículo científico publicado en 1999

Antisense oligonucleotides

scientific article published on 01 January 1996

Application of the Mitsunobu-Type Condensation Reaction to the Synthesis of Phosphonate Derivatives of Cyclohexenyl and Cyclohexanyl Nucleosides

Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication

artículo científico publicado en 2015

Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds.

artículo científico publicado en 2017

Base pairing involving artificial bases in vitro and in vivo.

artículo científico publicado en 2015

Base pairing properties of D- and L-cyclohexene nucleic acids (CeNA).

artículo científico publicado en 2003

Base-Modified Nucleic Acids as a Powerful Tool for Synthetic Biology and Biotechnology

artículo científico publicado en 2017

Base−Base Interactions in the Minor Groove of Double-Stranded DNA

Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity

artículo científico publicado en 2016

Binary genetic cassettes for selecting XNA-templated DNA synthesis in vivo

artículo científico publicado en 2013

Biological activity of hexitol nucleic acids targeted at Ha-ras and intracellular adhesion molecule-1 mRNA

artículo científico publicado en 2000

Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf

artículo científico publicado en 2009

Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.

artículo científico publicado en 1987

Branched-chain nucleosides: Synthesis of 3′-deoxy-3′-C- hydroxymethyl-α-l-lyxopyranosyl thymine and 3′-deoxy- 3′-C-hydroxymethyl-α-l-threofuranosyl thymine

Carbohydrate chiral-pool approach to four enantiomerically pure 2-naphthylmethyl 3-hydroxy-2-methylbutanoates

article published in 2008

Carbohydrate-based approach to four enantiomerically pure 2-naphthylmethyl 3-hydroxy-2-methylbutanoates

Catalysts from synthetic genetic polymers

artículo científico publicado en 2015

Characterization and sequence confirmation of unnatural amino acid containing peptide libraries using electrospray ionization mass spectrometry

artículo científico publicado en 2002

Characterization of modification sites during peptide synthesis using liquid secondary ion/collision-induced dissociation mass spectrometry and a computer program

scholarly article by Jef Rozenski et al published November 1994 in Journal of Mass Spectrometry

Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties

artículo científico publicado en 1997

Characterization of the posttranscriptional modifications in Legionella pneumophila small-subunit ribosomal RNA.

artículo científico publicado en 2008

ChemInform Abstract: Oligonucleotides Containing Disaccharide Nucleosides

ChemInform Abstract: Selection of New Sequence-Selective Unnatural Peptides Binding to Double-Stranded Deoxyribonucleic Acids (dsDNA) by Means of a Gel-Retardation Experiment for Library Analysis

Chemical Etiology of Nucleic Acids: Aminopropyl Nucleic Acids (APNAs)

artículo científico publicado en 2007

Chemical Morphing of DNA Containing Four Noncanonical Bases

article published in 2016

Chemical Morphing of DNA Containing Four Noncanonical Bases.

artículo científico publicado en 2016

Chemical Synthesis of 13C and 15N Labeled Nucleosides

Chemical evolution of a bacterium's genome.

artículo científico publicado en 2011

Chemical fidelity of an RNA polymerase ribozyme

article by James Attwater et al published 2013 in Chemical Science

Chemical incorporation of 1-methyladenosine into oligonucleotides

artículo científico publicado en 2002

Chemical incorporation of 1-methyladenosine, minor tRNA component, into oligonucleotides.

artículo científico publicado en 2003

Chemical incorporation of minor tRNA component O-β-D-ribofuranosyl-(1''-2')-adenosine-5''-phosphate into oligoribonucleotides

Cleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleoside

artículo científico publicado en 2003

Comparative In Vitro Anti-Hepatitis C Virus Activities of a Selected Series of Polymerase, Protease, and Helicase Inhibitors

artículo científico publicado en 2008

Comparative Liquid Chromatographic Stability Study of Thymidine and 1- (2-Deoxy-α-D-Erythro-Pentofuranosyl) Thymine

Comparative structural dynamics of Tyrosyl-tRNA synthetase complexed with different substrates explored by molecular dynamics

artículo científico publicado en 2008

Comparison between the orthorhombic and tetragonal forms of the heptamer sequence d[GCG(xT)GCG]/d(CGCACGC) ⬇️

artículo científico publicado el 26 de agosto de 2010

Comparison of library screening techniques used in the development of dsDNA ligands

artículo científico publicado en 2003

Complete NMR characterization of lychnose from Stellaria media (L.) Vill

article by Mieke Vanhaecke et al published November 2006 in Carbohydrate Research

Complexation of lipofectamine and cholesterol-modified DNA sequences studied by single-molecule fluorescence techniques

artículo científico publicado en 2007

Computational alanine scanning and free energy decomposition for E. coli type I signal peptidase with lipopeptide inhibitor complex

artículo científico publicado en 2007

Conformational and Chiral Selection of Oligonucleotides

artículo científico publicado en 2007

Conformationally restricted carbohydrate-modified nucleic acids and antisense technology

artículo científico publicado en 1999

Conjugation of Oligonucleotides to 3′-Polar Moieties

article

Contribution of dihydrouridine in folding of the D-arm in tRNA

artículo científico publicado en 2015

Cooperative dynamics of a DNA polymerase replicating complex

artículo científico

Correct bond order assignment in a molecular framework using integer linear programming with application to molecules where only non-hydrogen atom coordinates are available

artículo científico publicado en 2005

Correction: Base pairing involving artificial bases and

Corrigendum to “Substrate based peptide aldehyde inhibits bacterial type I signal peptidase” [Bioorg. Med. Chem. Lett. 19 (2009) 2880]

scholarly article published in Bioorganic & Medicinal Chemistry Letters

Corrigendum to “Synthesis of 3′-C-branched 1′,5′-anhydromannitol nucleosides as new antiherpes agents” [Tetrahedron 54 (1998) 2209]

scholarly article published in Tetrahedron

Cover Picture: Polymerase-Catalysed Incorporation of Glucose Nucleotides into a DNA Duplex (Chem. Eur. J. 22/2009)

Crystal structure of double helical hexitol nucleic acids

artículo científico publicado en 2002

Crystallization and preliminary X-ray study of the D-altritol oligonucleotide GTGTACAC.

artículo científico publicado en 2010

Cyclin G-associated kinase (GAK) affinity and antiviral activity studies of a series of 3-C-substituted isothiazolo[4,3-b]pyridines

scientific article published on 28 November 2018

Cyclohexene Nucleic Acids (CeNA): Serum Stable Oligonucleotides that Activate RNase H and Increase Duplex Stability with Complementary RNA

artículo científico publicado en 2000

Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity.

artículo científico publicado en 2001

Cyclohexenyl nucleic acids: conformationally flexible oligonucleotides

artículo científico publicado en 2005

DNA duplexes with reactive dialdehyde groups as novel reagents for cross-linking to restriction- modification enzymes.

artículo científico

DNA-Binding Ligands from Peptide Libraries Containing Unnatural Amino Acids

Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods

artículo científico publicado en 2002

De novo approach to l-anhydrohexitol nucleosides as building blocks for the synthesis of l-hexitol nucleic acids (l-HNA)

Delivery of antisense oligonucleotides using cholesterol-modified sense dendrimers and cationic lipids

artículo científico publicado en 2005

Delta-di-carboxybutyl phosphoramidate of 2'-deoxycytidine-5'-monophosphate as substrate for DNA polymerization by HIV-1 reverse transcriptase

artículo científico publicado en 2009

Dendritic Nucleotides: Interaction with an Aliphatic Acid Monolayer

artículo científico publicado en 2008

Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents

artículo científico publicado en 2005

Design and synthesis of nucleolipids as possible activated precursors for oligomer formation via intramolecular catalysis: stability study and supramolecular organization

artículo científico publicado en 2014

Design of Bioactive Peptides from Naturally Occurring -Conotoxin Structures

artículo científico publicado en 2012

Detection of RNA hybridization by pyrene-labeled probes.

artículo científico publicado en 2009

Development of Synthetic Strategies for the Construction of Pyrido[4,3-d]pyrimidine Libraries – the Discovery of a New Class of PDE-4 Inhibitors

article

Development of Synthetic Strategies for the Construction of Pyrido[4,3-d]pyrimidine Libraries — The Discovery of a New Class of PDE-4 Inhibitors

Diagnostic accuracy of a new Leishmania PCR for clinical visceral leishmaniasis in Nepal and its role in diagnosis of disease

artículo científico publicado en 2008

Difference in conformational diversity between nucleic acids with a six-membered 'sugar' unit and natural 'furanose' nucleic acids

artículo científico publicado en 2003

Dimeric building blocks with N-cyanoguanidine linkage for oligonucleotide synthesis

article

Dipeptides as leaving group in the enzyme-catalyzed DNA synthesis

artículo científico publicado en 2012

Direct observation of two cyclohexenyl (CeNA) ring conformations in duplex DNA ⬇️

artículo científico publicado el 1 de julio de 2010

Disaccharide Nucleosides And Their Enzymatic And Chemical Incorporation Into Oligonucleotides

article

Discovery of 7-N-Piperazinylthiazolo[5,4-d]pyrimidine Analogues as a Novel Class of Immunosuppressive Agents with in Vivo Biological Activity

Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment in Vivo

artículo científico publicado en 2018

Discovery of a new Mycobacterium tuberculosis thymidylate synthase X inhibitor with a unique inhibition profile

artículo científico publicado en 2017

Discovery of a new subclass of α-conotoxins in the venom of Conus australis

artículo científico publicado en 2014

Discovery of an acyclic nucleoside phosphonate that inhibits Mycobacterium Tuberculosis ThyX based on the binding mode of a 5-alkynyl substrate analogue

scholarly article published 2014

Discovery of an acyclic nucleoside phosphonate that inhibits Mycobacterium tuberculosis ThyX based on the binding mode of a 5-alkynyl substrate analogue

artículo científico publicado en 2013

Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

artículo científico publicado en 2004

Discovery of dual death-associated protein related apoptosis inducing protein kinase 1 and 2 inhibitors by a scaffold hopping approach

artículo científico publicado en 2014

Divers Stereoisomers of N-Acetylhydroxyprolinol as Sugar Substitute in Oligonucleotides

article by G. Ceulemans et al published September 1998 in Nucleosides & nucleotides

Double Protection of the Heterocyclic Base of Xanthosine and 2′-Deoxyxanthosine

Easy Synthesis and Different Conformational Behavior of Purine and Pyrimidine .beta.-D-glycero-Pent-2'-enopyranosyl Nucleosides

article by Bogdan Doboszewski et al published December 1995 in Journal of Organic Chemistry

Effect of (E)-5-(2-bromovinyl)uracil on the catabolism and antitumor activity of 5-fluorouracil in rats and leukemic mice.

artículo científico publicado en 1986

Effect of Molecular Crowding on DNA Polymerase Reactions along Unnatural DNA Templates

artículo científico publicado en 2020

Effect of aromatic short-chain analogues of ceramide on axonal growth in hippocampal neurons

artículo científico publicado en 1999

Effects of Six-Membered Carbohydrate Rings on Structure, Stability, and Kinetics of G-Quadruplexes

Efficient transfer of information from hexitol nucleic acids to RNA during nonenzymatic oligomerization.

artículo científico publicado en 1999

Emimycin and its nucleoside derivatives: Synthesis and antiviral activity

artículo científico publicado en 2017

Enantiomeric Selection Properties of β-homoDNA: Enhanced Pairing for Heterochiral Complexes

artículo científico publicado en 2013

Enantioselective Approach to the Synthesis of Cyclohexane Carbocyclic Nucleosides

Enantioselective Synthesis and Conformational Analysis of Cyclohexene Carbocyclic Nucleosides

Enantioselective Synthesis and Conformational Study of Cyclohexene Carbocyclic Nucleosides

Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate

scientific article published on 22 October 2020

Enzymatic Incorporation in DNA of 1,5-Anhydrohexitol Nucleotides†

artículo científico publicado en 2000

Enzymatic Incorporation of Modified Purine Nucleotides in DNA.

artículo científico publicado en 2017

Enzymatic Synthesis of Phosphonomethyl Oligonucleotides by Therminator Polymerase

scholarly article by Marleen Renders et al published 26 March 2007 in Angewandte Chemie International Edition

Enzymatic Synthesis of Phosphonomethyl Oligonucleotides by Therminator Polymerase

Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism

artículo científico publicado en 2003

Enzymatic polymerization of phosphonate nucleosides.

artículo científico publicado en 2008

Enzymatic resolution and base pairing properties of D- and L-cyclohexenyl nucleic acids (CeNA).

artículo científico publicado en 2005

Enzymatically catalyzed DNA synthesis using L-Asp-dGMP, L-Asp-dCMP, and L-Asp-dTMP.

artículo científico publicado en 2008

Evaluation of Capillary HPLC/Mass Spectrometry as an Alternative Analysis Method for Gel Electrophoresis of Oligonucleotides

article published in 2004

Evaluation of anhydrohexitol nucleic acid, cyclohexenyl nucleic acid and d-altritol nucleic acid-modified 2'-O-methyl RNA mixmer antisense oligonucleotides for exon skipping in vitro

artículo científico publicado en 2016

Evaluation of the Kinetics of Hydrolysis of Diamino Analogues of 2′- Or 3′-Deoxyadenosine and of 9-(2-Deoxy-β-D-threo−Pentofuranosyl)adenine or 9-(3-Dexoy-β-D-threo−Pentofuranosyl)adenine By Liquid Chromatography

Evaluation of the Kinetics of Hydrolysis of Monoamino Analogues of 2′- or 3′-Deoxyadenosine and of 9-(2-Deoxy-β-D-Threo-pentofuranosyl)Adenine or 9-(3-Deoxy-β-D-threo-pentofuranosyl)Adenine by Liquid Chromatography

Evaluation of the cellular uptake of hexitol nucleic acids in HeLa cells

scientific article published on 01 August 2000

Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis

artículo científico publicado en 2009

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs

artículo científico publicado en 2017

Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands

artículo científico publicado en 1998

Facile Synthesis of 3′-C-Branched 1,5-Anhydrohexitol Nucleosides

Facile immobilization of DNA using an enzymatic his-tag mimic.

artículo científico publicado en 2017

Formation of a 2-methyl-branched fatty aldehyde during peroxisomal α-oxidation

artículo científico publicado en 1997

Full Pre-Steady-State Kinetic Analysis of Single Nucleotide Incorporation by DNA Polymerases

scientific article published on 01 September 2019

Further biological and molecular characterization of actinophage VWB.

artículo científico publicado en 1990

Gas chromatographic determination of alkyl lysophospholipids after solid-phase extraction from cell culture media

article

Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain

artículo científico publicado en 2011

Glycosyl Transferase Activity of theEscherichia coliPenicillin-Binding Protein 1b: Specificity Profile for the Substrate†

artículo científico publicado en 2006

HNA and ANA high-affinity arrays for detections of DNA and RNA single-base mismatches

artículo científico publicado en 2008

Helical structure of xylose-DNA.

artículo científico publicado en 2010

Heterocyclic modifications of oligonucleotides and antisense technology.

artículo científico publicado en 2000

Hexitol Nucleic Acids (HNA): Synthesis and Properties

article

Hexitol nucleic acid-containing aptamers are efficient ligands of HIV-1 TAR RNA.

artículo científico publicado en 2005

Highly potent and selective inhibition of bovine viral diarrhea virus replication by γ-carboline derivatives

artículo científico publicado en 2010

Homo-N-nucleosides: Incorporation into oligonucleotides and antiviral activity

artículo científico publicado en 1996

How does hydroxyl introduction influence the double helical structure: the stabilization of an altritol nucleic acid:ribonucleic acid duplex

artículo científico publicado en 2012

Hybridization between “Six-Membered” Nucleic Acids: RNA as a Universal Information System

scientific article published on 01 December 2001

Hybridization specificity, enzymatic activity and biological (Ha-ras) activity of oligonucleotides containing 2,4-dideoxy-beta-D-erythro-hexopyranosyl nucleosides

artículo científico publicado en 1993

Hydrolysis of aspartic acid phosphoramidate nucleotides: a comparative quantum chemical study

artículo científico publicado en 2009

Hydroxy fatty acids for the delivery of dideoxynucleosides as anti-HIV agents

artículo científico publicado en 2013

IDENTIFICATION OF THE EXOPOLYSACCHARIDE AMYLOVORAN BY NMR[1]

Identification of a novel resistance mutation for benzimidazole inhibitors of the HCV RNA-dependent RNA polymerase

artículo científico publicado en 2011

Identification of a peptide inhibitor against glycosomal phosphoglycerate kinase of Trypanosoma brucei by a synthetic peptide library approach.

artículo científico publicado en 1995

Imidazo[4,5-c]pyridines inhibit the in vitro replication of the classical swine fever virus and target the viral polymerase.

artículo científico publicado en 2007

Imidazopyridine- and purine-thioacetamide derivatives: potent inhibitors of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1).

artículo científico publicado en 2014

Iminodiacetic-phosphoramidates as metabolic prototypes for diversifying nucleic acid polymerization in vivo

artículo científico publicado en 2010

Iminodipropionic acid as the leaving group for DNA polymerization by HIV-1 reverse transcriptase.

artículo científico publicado en 2011

Improved hybridisation potential of oligonucleotides comprising O-methylated anhydrohexitol nucleoside congeners

artículo científico publicado en 2001

In Search of Acyclic Analogues as Universal Nucleosides in Degenerate Probes

In vitro NCp7 enhancement of ribozyme-mediated cleavage of full-length human IL-6 mRNA.

artículo científico publicado en 1995

In vitro disposition profiling of heterocyclic compounds

artículo científico publicado en 2015

Incorporation of 5-hydroxytryptophan in oligopeptides

Incorporation of Amino Acids with Long-Chain Terminal Olefins into Proteins.

artículo científico publicado en 2016

Incorporation of a disaccharide nucleoside into the backbone of double-stranded DNA: crystallization and preliminary X-ray diffraction

artículo científico publicado en 2005

Incorporation of hexose nucleoside analogues into oligonucleotides: synthesis, base-pairing properties and enzymatic stability ⬇️

artículo científico publicado el 25 de septiembre de 1992

Increased uptake of antisense oligonucleotides by delivery as double stranded complexes

artículo científico publicado en 2004

Influence of Fluorination of the Sugar Moiety on the Anti-HIV-1 Activity of 2',3'-Dideoxynucleosides

article

Influence of Threose Nucleoside Units on the Catalytic Activity of a Hammerhead Ribozyme

scholarly article by Veerle Kempeneers published in January 2004

Influence of the incorporation of a cyclohexenyl nucleic acid (CeNA) residue onto the sequence d(CGCGAATTCGCG)

artículo científico publicado en 2008

Influence of the linkage between leaving group and nucleoside on substrate efficiency for incorporation in DNA catalyzed by reverse transcriptase

artículo científico publicado en 2010

Influence of the nucleobase and anchimeric assistance of the carboxyl acid groups in the hydrolysis of amino acid nucleoside phosphoramidates

artículo científico publicado en 2011

Inhibition of MDR1 expression with altritol-modified siRNAs

artículo científico publicado en 2007

Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides

artículo científico publicado en 2004

Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs.

artículo científico publicado en 2010

Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives

artículo científico publicado en 2007

Insight into ligand selectivity in HCV NS5B polymerase: molecular dynamics simulations, free energy decomposition and docking

artículo científico publicado en 2009

Intracellular metabolism and mechanism of anti-retrovirus action of 9-(2-phosphonylmethoxyethyl)adenine, a potent anti-human immunodeficiency virus compound

artículo científico publicado en 1991

Invading Escherichia coli Genetics with a Xenobiotic Nucleic Acid Carrying an Acyclic Phosphonate Backbone (ZNA)

scientific article published on 28 June 2019

Investigation of The Kinetics of Degradation of Hexopyranosylated Cytosine Nucleosides Using Liquid Chromatography

Investigation of the DNA-dependent cyclohexenyl nucleic acid polymerization and the cyclohexenyl nucleic acid-dependent DNA polymerization

artículo científico publicado en 2005

Investigations on Sarcosine and Isonipecotic Acid Containing Peptide Nucleic Acids

Iron/Copper Co-Catalyzed Cross-Coupling Reaction for the Synthesis of 6-Substituted 7-Deazapurines and the Corresponding Nucleosides

artículo científico publicado en 2019

Isoguanine and 5-methyl-isocytosine bases, in vitro and in vivo

artículo científico publicado en 2015

Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster

artículo científico publicado en 2010

Isothiazolo[4,3-b]pyridines as inhibitors of cyclin G associated kinase : synthesis, structure-activity relationship studies and antiviral activity.

artículo científico

L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation

artículo científico publicado en 2016

Lead Optimization ofN6-Cyclopentyl-3′-amido-3′-deoxyxylofuranosyladenines as Adenosine A1Receptor Antagonists

Lipophilic nalmefene prodrugs to achieve a one-month sustained release.

artículo científico publicado en 2016

Liquid chromatographic separation of hexopyranosylated cytosine nucleosides from their degradation products

artículo científico publicado en 1997

Liquid chromatographic study of the stability of 5-halogeno-2′-deoxyuridines

artículo científico publicado en 1993

Mapping of T7 RNA polymerase active site with novel reagents - oligonucleotides with reactive dialdehyde groups

article

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, a selective anti-human immunodeficiency virus agent

artículo científico publicado en 1989

Mechanism of cytostatic action of novel 5-(thien-2-yl)- and 5-(furan-2-yl)-substituted pyrimidine nucleoside analogues against tumor cells transfected by the thymidine kinase gene of herpes simplex virus.

artículo científico publicado en 1994

Metabolic Recruitment and Directed Evolution of Nucleoside Triphosphate Uptake in Escherichia coli.

artículo científico publicado en 2018

Methylated Hexitol Nucleic Acids, Towards Congeners with Improved Antisense Potential

artículo científico publicado en 2003

Methylated Nucleobases: Synthesis and Evaluation for Base Pairing In Vitro and In Vivo

artículo científico publicado en 2018

Mixed oligonucleotide analogues with an acyclic carbohydrate moiety and a N-cyanoguanidine functionality

scientific article published in 1994

Modified oligonucleotides containing 1-beta-D-galactopyranosylthymine: synthesis and substrate properties

artículo científico publicado en 2002

Modulation of BACE1 Activity by Chemically Modified Aptamers

artículo científico publicado en 2018

Molecular Dynamics of double stranded Xylo Nucleic Acid (XyloNA).

artículo científico publicado en 2017

Molecular analysis of archived blood slides reveals an atypical human Trypanosoma infection

artículo científico publicado en 2008

Molecular dipstick test for diagnosis of sleeping sickness.

artículo científico

Molecular simulation of cyclohexanyl nucleic acid (CNA) duplexes with CNA, DNA and RNA and CNA triloop and tetraloop hairpin structures

artículo científico publicado en 2016

Molecular-Dynamics Studies of Single-Stranded Hexitol, Altritol, Mannitol, and Ribose Nucleic Acids (HNA, MNA, ANA, and RNA, Resp.) and of the Stability of HNA⋅RNA, ANA⋅RNA, and MNA⋅RNA Duplexes

article

Mutations in the chikungunya virus non-structural proteins cause resistance to favipiravir (T-705), a broad-spectrum antiviral

artículo científico publicado en 2014

Mycobacterium tuberculosis Thymidine Monophosphate Kinase Inhibitors: Biological Evaluation and Conformational Analysis of 2′- and 3′-Modified Thymidine Analogues

scholarly article by Philippe Van Rompaey et al published August 2003 in European Journal of Organic Chemistry

N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action

artículo científico publicado en 2003

N8-Glycosylated 8-Azapurine and Methylated Purine Nucleobases: Synthesis and Study of Base Pairing Properties

artículo científico publicado en 2019

NMR study on the interaction of the conserved CREX 'stem-loop' in the Hepatitis E virus genome with a naphthyridine-based ligand

artículo científico publicado en 2015

NMR-based conformational analysis of 2',6-disubstituted uridines and antiviral evaluation of new phosphoramidate prodrugs

artículo científico publicado en 2015

Nanostructures from Synthetic Genetic Polymers

artículo científico publicado en 2016

Neoglycoproteins as carriers for antiviral drugs: synthesis and analysis of protein-drug conjugates

article

New dsDNA binding unnatural oligopeptides with pyrimidine selectivity

artículo científico publicado en 2002

New dsDNA-Binding Hybrid Molecules Combining an Unnatural Peptide and an Intercalating Moiety

scholarly article by Patrick Chaltin et al published March 2003 in Helvetica Chimica Acta

Nonenzymatic Template-Directed Reactions on Altritol Oligomers, Preorganized Analogues of Oligonucleotides

Nonenzymatic synthesis of RNA and DNA oligomers on hexitol nucleic acid templates: the importance of the A structure

artículo científico publicado en 1999

Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides

artículo científico publicado en 2000

Novel nucleoside strategies for anti-HIV and anti-HSV therapy

artículo científico publicado el 1 de julio de 1992

Nucleic acids with a six-membered 'carbohydrate' mimic in the backbone

scientific article published on January 2010

Nucleic acids with a six-membered carbohydrate mimic and RNA interference

article published in 2007

Nucleolipids as potential organogelators

artículo científico publicado en 2007

Nucleoside Phosphate-Conjugates Come of Age: Catalytic Transformation, Polymerase Recognition and Antiviral Properties

artículo científico publicado en 2015

Nucleosides with Transposed Base or 4'-Hydroxymethyl Moieties and Their Corresponding Oligonucleotides

artículo científico publicado en 2015

Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors ⬇️

artículo científico publicado en 2004

Nucleotides. Part XXXI. Modified Oligomeric 2?-5? A Analogues: Synthesis of 2?-5? oligonucleotides with 9-(3?-azido-3?-deoxy-?-D-xylofuranosyl)adenine and 9-(3?-amino-3?-deoxy-?-D-xylofuranosyl)adenine as modified nucleosides

scholarly article by Piet Herdewijn et al published 13 December 1989 in Helvetica Chimica Acta

Nucleotides. Part XXXIVSynthesis of Modified Oligomeric 2?-5?A Analogues: Potential Antiviral Agents

scholarly article by Piet Herdewijn et al published 30 January 1991 in Helvetica Chimica Acta

Nucleotides. Part. XXXII. Synthesis of 2?-5? Connected oligonucleotides. Prodrugs for antiviral and antitumoral nucleosides

scholarly article by Piet Herdewijn et al published 13 December 1989 in Helvetica Chimica Acta

Oligodeoxynucleotides Containing 2′-Deoxy-1-methyladenosine andDimroth Rearrangement

article

Oligodeoxynucleotides containing N1-methyl-2'-deoxyadenosine and N6-methyl-2'-deoxyadenosine

artículo científico publicado en 2009

Oligonucleotide Analogues with 4-Hydroxy-N-Acetylprolinol as Sugar Substitute

article by Griet Ceulemans et al published December 1997 in Chemistry—A European Journal

Oligonucleotide promoted peptide bond formation using a tRNA mimicking approach

artículo científico publicado en 2017

Oligonucleotides Composed of 2‘-Deoxy-1‘,5‘-anhydro-d-mannitol Nucleosides with a Purine Base Moiety

article published in 1998

Oligonucleotides Containing Disaccharide Nucleosides

scholarly article by Ekaterina V. Efimtseva et al published 15 August 2001 in Helvetica Chimica Acta

Oligonucleotides Containing Disaccharide Nucleosides: Synthesis, Physicochemical, and Substrate Properties

artículo científico publicado en 2003

Oligonucleotides containing a ribo-configured cyclohexanyl nucleoside: probing the role of sugar conformation in base pairing selectivity

artículo científico publicado en 2015

Oligonucleotides with 1,5-anhydrohexitol nucleoside building blocks: crystallization and preliminary X-ray studies of h(GTGTACAC)

Oligonucleotides with 2,6-Diaminopurine Base Replacing for Adenine: Synthesis and Properties

Oligonucleotides with 3-hydroxy-N-acetylprolinol as sugar substitute

article by Griet Ceulemans et al published November 1997 in Tetrahedron

Oligonucleotides with Reactive Dialdehyde Groups as Novel Affinity Reagents

Oligonucleotides with cyclohexene-nucleoside building blocks: crystallization and preliminary X-ray studies of a left-handed sequence GTGTACAC.

artículo científico publicado en 2005

On the Enzymatic Formation of Metal Base Pairs with Thiolated and pKa -Perturbed Nucleotides

scientific article published on 01 October 2019

On the enzymatic incorporation of an imidazole nucleotide into DNA.

artículo científico publicado en 2017

One-Step Synthesis of Hypoxanthine from Glycinamide and Diformylurea

scholarly article by Irene M. Lagoja published in January 2004

Optimization of Isothiazolo[4,3- b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity

artículo científico publicado en 2018

Organophosphorus-catalyzed diaza-Wittig reaction: application to the synthesis of pyridazines

scientific article published on 01 September 2014

Overcoming the membrane barrier: Recruitment of γ-glutamyl transferase for intracellular release of metabolic cargo from peptide vectors

artículo científico publicado en 2016

Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity

artículo científico publicado en 2012

Peptide Analogues of DNA Consisting of l-α-Amino-γ-thymine Butyric Acid and l-Valine Subunits

Peroxisomal beta-oxidation of 2-methyl-branched acyl-CoA esters: stereospecific recognition of the 2S-methyl compounds by trihydroxycoprostanoyl-CoA oxidase and pristanoyl-CoA oxidase

scientific journal article

Phenolic profiling of caffeic acid O-methyltransferase-deficient poplar reveals novel benzodioxane oligolignols

artículo científico publicado en 2004

Phospho-carboxylic anhydride of a homologated nucleoside leads to primer degradation in the presence of a polymerase

scholarly article by Dhuldeo Kachare published in June 2014

Phosphodiester substrates for incorporation of nucleotides in DNA using HIV-1 reverse transcriptase.

artículo científico publicado en 2009

Phosphonates Derivatives of 2',3'-Dideoxy-2',3'-didehydro-pentopyranosyl Nucleosides

Phosphonomethyl Oligonucleotides as Backbone-Modified Artificial Genetic Polymers.

artículo científico publicado en 2018

Phosphoramidite building blocks for efficient incorporation of 2′-O-aminoethoxy(and propoxy)methyl nucleosides into oligonucleotides

Phosphorus Pentachloride Promoted gem-Dichlorination of 2′- and 3′-Deoxynucleosides

artículo científico publicado en 2018

Poly(2-acrylamido-2-methyl-1-propanamide) (PAMPA): A Neutral, Water-Soluble Synthetic Polymer with Double-Stranded Helix Conformation

article

Polymerase-catalysed incorporation of glucose nucleotides into a DNA duplex

artículo científico publicado en 2009

Polymerase-catalyzed synthesis of DNA from phosphoramidate conjugates of deoxynucleotides and amino acids

artículo científico publicado en 2007

Polymerase-dependent DNA synthesis from phosphoramidate-activated nucleotides

artículo científico publicado en 2011

Positive cooperativity between acceptor and donor sites of the peptidoglycan glycosyltransferase

artículo científico publicado en 2014

Post-transcriptional modification mapping in the Clostridium acetobutylicum 16S rRNA by mass spectrometry and reverse transcriptase assays

artículo científico publicado en 2007

Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine.

artículo científico publicado en 1986

Potentiating effect of ribavirin on the anti-retrovirus activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside in vitro and in vivo

artículo científico publicado en 1989

Practical method for the parallel synthesis of 2′-amido-2′-deoxyadenosines

Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing

artículo científico publicado en 2011

Preparation of 6-deuteriopenicillins

Preparation of Guanine and Diaminopurine from Biuret. Part III

scholarly article by Irene M. Lagoja published in April 2007

Probing ambiguous base-pairs by genetic transformation with XNA templates.

artículo científico publicado en 2014

Probing the MVAI methyltransferase region that interacts with DNA: affinity labeling with the dialdehyde-containing DNA duplexes.

artículo científico publicado en 2000

Properties of Oligonucleotides with Six Membered Carbohydrate Mimics and a 1,4-Relationship Between the Base Moiety and the Hydroxymethyl Group

article

Protection of 1-methyladenosine and its chemical incorporation into oligonucleotides

Protection of 2,6-Diaminopurine 2′-Deoxyriboside

Protection of the Lactam Function of 2′-Deoxyinosine with A 2-(4-Nitrophenyl)-Ethyl Moiety

Pseudouridine detection improvement by derivatization with methyl vinyl sulfone and capillary HPLC-mass spectrometry

artículo científico publicado en 2005

RNA as a target for drug design, the example of Tat-TAR interaction.

artículo científico publicado en 2002

RNase H mediated cleavage of RNA by cyclohexene nucleic acid (CeNA).

artículo científico publicado en 2001

Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

scientific article published on 21 November 2018

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

artículo científico publicado en 1988

Rational design of a bacterial import system for new-to-nature molecules

artículo científico publicado en 2024

Reaction of adenine nucleosides, tosylated in the carbohydrate moiety, with lithium triethylborohydride

Reactivity of Amino Acid Nucleoside Phosphoramidates: A Mechanistic Quantum Chemical Study

Recognition of HNA and 1,5-anhydrohexitol nucleotides by DNA metabolizing enzymes

artículo científico publicado en 2002

Recognition of threosyl nucleotides by DNA and RNA polymerases

artículo científico publicado en 2003

Redesigning the leaving group in nucleic acid polymerization

artículo científico

Regioselective 2′-O-debenzoylation of 2',3'-di-O-benzoyl threose nucleosides

Regioselective cross-coupling reactions and nucleophilic aromatic substitutions on a 5,7-dichloropyrido[4,3-d]pyrimidine scaffold

Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid.

artículo científico publicado en 2005

Replication of hexitol oligonucleotides as a prelude to the propagation of a third type of nucleic acid in vivo

artículo científico publicado en 2003

Replicative Capability of Anhydrohexitol Analogues of Nucleotides

Reverse transcriptase incorporation of 1,5-anhydrohexitol nucleotides

artículo científico publicado en 2001

Ribavirin antagonizes inhibitory effects of pyrimidine 2',3'-dideoxynucleosides but enhances inhibitory effects of purine 2',3'-dideoxynucleosides on replication of human immunodeficiency virus in vitro

artículo científico publicado en 1987

Ribavirin derivatives with a hexitol moiety: synthesis and antiviral evaluation

artículo científico publicado en 2003

Ribosylation of Pyrimidine 2′-Deoxynucleosides

SYNTHESIS OFN6-ALKYLATED ADENOSINE DERIVATIVES

Scalable Synthesis, In Vitro cccDNA Reduction, and In Vivo Antihepatitis B Virus Activity of a Phosphonomethoxydeoxythreosyl Adenine Prodrug

artículo científico publicado en 2020

Screening of a synthetic pentapeptide library composed of d-amino acids against fructose-1,6-biphosphate aldolase

Selection of New Sequence-Selective Unnatural Peptides Binding to Double-Stranded Deoxyribonucleic Acids (dsDNA) by Means of a Gel-Retardation Experiment for Library Analysis

scholarly article by Patrick Chaltin et al published August 2002 in Helvetica Chimica Acta

Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents

artículo científico publicado en 2015

Selective antiherpetic activity of carbocyclic analogues of (E)-5-(2-halogenovinyl)-2′-deoxyuridines: Dependence on specific phosphorylation by viral thymidine kinase

artículo científico publicado en 1985

Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness.

artículo científico publicado en 1994

Self-complementary sequence context in mature miRNAs

artículo científico publicado en 2010

Silica Gel Functionalised with Different Spacers as Solid Support for Oligonucleotide Synthesis

article published in 1988

Simple approach to 1-O-protected (R)- and (S)-glycerols from l- and d-arabinose for glycerol nucleic acids (GNA) monomers research

Simple approach to the synthesis of 3-fluoro pyrazolo[1,5-a]pyrimidine analogues

article by Hassen Bel Abed et al published May 2013 in Tetrahedron Letters

Solid Phase Synthesis of 2′, 5′-Oligoadenylates Containing 3′-Fluorinated Ribose

Solution Structure and Conformational Dynamics of Deoxyxylonucleic Acids (dXNA): An Orthogonal Nucleic Acid Candidate

article

Solution Structure of a Hexitol Nucleic Acid Duplex with Four Consecutive T⋅T Base Pairs

article

Solution structure of a HNA-RNA hybrid

artículo científico publicado en 2000

Some 6-aza-5-substituted-2'-deoxyuridines show potent and selective inhibition of herpes simplex virus type 1 thymidine kinase

artículo científico publicado en 1998

Some Examples of the Use of Trifluoromethane Sulfonic Anhydride in Nucleic Acid Chemistry

Stereocontrolled Synthesis of Ara-Type Cyclohexenyl Nucleosides

Stereocontrolled synthesis of phosphonate derivatives of tetrahydro- and dihydro-2H-pyranyl nucleosides: The selectivity of the Ferrier rearrangement

Stereoelectronic properties of five anti-HSV-1 2'-deoxynucleosides analogues with heterocyclic substituents in the 5-position: a comparison with BVDU.

artículo científico publicado en 1994

Stereoselective synthesis of (−)-ara-cyclohexenyl-adenine

Stereospecific synthesis of a pentopyranosyl analogue of d4T monophosphate

artículo científico publicado en 1994

Straightforward Synthesis of Labeled and Unlabeled Pyrimidine d4Ns via 2′,3′-Diyne seco Analogues through Olefin Metathesis Reactions

article published in 2003

Strategies in the Design of Antiviral Drugs

Strategy for the synthesis of pyridazine heterocycles and their derivatives

artículo científico publicado en 2013

Structural Characterization and Biological Evaluation of Small Interfering RNAs Containing Cyclohexenyl Nucleosides

article

Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution

scientific article published on 08 December 2020

Structural Study of Two 5-Heteroaromatic-2′ deoxyuridines and Their 5-Bromine-heteroaromatic Analogues: Theoretical Conformational Analysis and NMR Experiments

scholarly article by Isabelle Creuven et al published March 1997 in Nucleosides & nucleotides

Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins

artículo científico publicado en 2016

Structural and binding study of modified siRNAs with the Argonaute 2 PAZ domain by NMR spectroscopy

artículo científico publicado en 2011

Structural basis for the role of LYS220 as proton donor for nucleotidyl transfer in HIV-1 reverse transcriptase

article

Structural characterization of N-linked oligosaccharides from cellobiohydrolase I secreted by the filamentous fungus Trichoderma reesei RUTC 30.

artículo científico publicado en 1997

Structural requirements for antiviral activity in nucleosides

Structure Determination of the Top-Loop of the Conserved 3′-Terminal Secondary Structure in the Genome of Flaviviruses

artículo científico publicado en 2010

Structure of the alpha-homo-DNA:RNA duplex and the function of twist and slide to catalogue nucleic acid duplexes

artículo científico publicado en 2007

Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC

artículo científico publicado en 2008

Structure, stability and function of 5-chlorouracil modified A:U and G:U base pairs

artículo científico publicado en 2013

Structure-Activity Relationship Study of a Potent α-Thrombin Binding Aptamer Incorporating Hexitol Nucleotides

artículo científico publicado en 2020

Structure-Function Elucidation of a New -Conotoxin, Lo1a, from Conus longurionis

artículo científico publicado en 2014

Structure-activity relationship of short-chain sphingoid bases as inhibitors of sphingosine kinase

artículo científico publicado en 1999

Structure-activity relationship study of the pyridine moiety of isothiazolo[4,3-b]pyridines as antiviral agents targeting cyclin G-associated kinase

artículo científico publicado en 2019

Structure-activity relationships of bisphosphate nucleotide derivatives as P2Y1 receptor antagonists and partial agonists.

artículo científico publicado en 1999

Studies on Disaccharide Nucleoside Synthesis. Mechanism of the Formation of Trisaccharide Purine Nucleosides

scientific article published on 01 April 1999

Substituted 5-Benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: A New Class of Pestivirus Inhibitors

Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors

artículo científico publicado en 2006

Substrate based peptide aldehyde inhibits bacterial type I signal peptidase

artículo científico publicado en 2009

Substrate-Dependence of Competitive Nucleotide Pyrophosphatase/Phosphodiesterase1 (NPP1) Inhibitors

artículo científico publicado en 2017

Sugar Modified Oligonucleotides

article by K. Augustyns et al published January 1991 in Nucleosides & nucleotides

Sugar and Base-Modified 2',3'-Dideoxynucleosides as Potential Anti-Aids Drugs

article

Sulfonate derived phosphoramidates as active intermediates in the enzymatic primer-extension of DNA.

artículo científico

Syntheses of 5'-Nucleoside Monophosphate Derivatives with Unique Aminal, Hemiaminal, and Hemithioaminal Functionalities: A New Class of 5'-Peptidyl Nucleotides.

artículo científico publicado en 2016

Synthesis and Activity of Oligonucleotides Containing a Biologically Active Nucleoside at the 2′End

Synthesis and Anti-HIV Activity of Dideoxycytidine Analogues Containing a Pyranose Carbohydrate Moiety

article

Synthesis and Antisense Properties of Fluoro Cyclohexenyl Nucleic Acid (F-CeNA), a Nuclease Stable Mimic of 2′-Fluoro RNA

artículo científico publicado en 2012

Synthesis and Antitumor Activity of C-7-Alkynylated and Arylated Pyrrolotriazine C-Ribonucleosides

scientific article published on 09 July 2020

Synthesis and Antiviral Activities of Some New 5-Heteroaromatic Substituted Derivatives of 2'-Deoxyuridine

Synthesis and Antiviral Activity of 1.4-Dioxane, 1.4-Oxathiane and 1,4-Morpholine Nucleoside Analogues

Synthesis and Antiviral Activity of the alpha-Analogues of 1,5-Anhydrohexitol Nucleosides (1,5-Anhydro-2,3-dideoxy-D-ribohexitol Nucleosides).

artículo científico publicado en 1997

Synthesis and Antiviral Evaluation of 3'-Substituted Thymidine Analogues Derived from 3'-Amino-3'-deoxythymidine

Synthesis and Antiviral Evaluation of Ribavirin Congeners Containing a Hexitol Moiety ⬇️

artículo científico publicado el 1 de mayo de 2003

Synthesis and Biological Activity of 3′-Modified 2′-5′ Adenylate Trimers

Synthesis and Biological Activity of the Mono- and Diamino Analogues of 2′-Deoxyadenosine, Cordycepin, 9-(3-Deoxy-α-D-Threo-Pentofuranosyl)-Adenine (A Structural Component of Agrocin 84) and 9-(2-Deoxy-α-D-Threo-Pentofuranosyl)Adenine

Synthesis and Biological Evaluation of Pyrrolo[2,1-f][1,2,4]triazine C-Nucleosides with a Ribose, 2'-Deoxyribose, and 2',3'-Dideoxyribose Sugar Moiety

artículo científico publicado en 2017

Synthesis and Biological Evaluation of a Series of New Cyclohexenyl Nucleosides

Synthesis and Conformation of Pentopyranoside Nucleoside Phosphonates

scientific article published on 14 May 2019

Synthesis and Conformational Analysis of 1,5-Anhydro-2,4-dideoxy-D-mannitol Nucleosides

Synthesis and Conformational Analysis of 2?-Deoxy-2?-(3-methoxybenzamido)adenosine, a rational-designed inhibitor of trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH)

article

Synthesis and Conformational Properties of O-β-D-Ribofuranosyl-(1′′-2′)-guanosine and (Adenosine)-5′′-phosphate

Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines

article

Synthesis and Pairing Properties of Oligonucleotides Containing 3-Hydroxy-4-hydroxymethyl-1-cyclohexanyl Nucleosides

article

Synthesis and Pairing Properties of Oligonucleotides Containing 3-Hydroxy-4-hydroxymethyl-1-cyclohexanyl Nucleosides

Synthesis and Properties of O--D-ribofuranosyl-(1″→2′)-guanosine-5″- O-phosphate and Its Derivatives

scholarly article by Ekaterina V. Efimtseva et al published February 2003 in Helvetica Chimica Acta

Synthesis and Properties of O-β-D-Ribofuranosyl-(1″-2′)-Adenosine-5″-O-Phosphate and Its Derivatives

scholarly article by Andrei A. Rodionov et al published October 2000 in Nucleosides, Nucleotides & Nucleic Acids

Synthesis and Properties of Oligonucleotides Containing 2,4-Dihydroxycyclohexyl Nucleosides

scholarly article by Dorothée Bardiot et al published December 2005 in Helvetica Chimica Acta

Synthesis and Properties of Some 2'-O-d-Ribofuranosyl-nucleosides

Synthesis and Stability of Oligonucleotides Containing Acyclic Achiral Nucleoside Analogues with Two Base Moieties

Synthesis and Structure-Activity Relationship Studies of Benzo[b][1,4]oxazin-3(4H)-one Analogues as Inhibitors of Mycobacterial Thymidylate Synthase X

scientific article published on 20 February 2019

Synthesis and anti-HIV activity of guanine modified fluorinated acyclic nucleoside phosphonates derivatives

article

Synthesis and anti-herpes activity of 5-trifluorovinyl-2′-deoxyuridine

artículo científico publicado en 1992

Synthesis and anti-herpetic activity of phosphoramidate ProTides

artículo científico publicado en 2013

Synthesis and antibacterial evaluation of a novel series of 2-(1,2-dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazoles

artículo científico publicado en 2011

Synthesis and antiherpes virus activity of 1,5-anhydrohexitol nucleosides.

artículo científico publicado en 1993

Synthesis and antiviral activity evaluation of 3'-fluoro-3'-deoxyribonucleosides: broad-spectrum antiviral activity of 3'-fluoro-3'-deoxyadenosine.

artículo científico publicado en 1989

Synthesis and antiviral activity of 2-deoxy-1,5-anhydro-D-mannitol nucleosides containing a pyrimidine base moiety

artículo científico publicado en 1996

Synthesis and antiviral activity of 3'-heterocyclic substituted 3'-deoxythymidines

artículo científico publicado en 1990

Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines

artículo científico publicado en 1991

Synthesis and antiviral activity of 5-thien-2-yl-2'-deoxyuridine analogues.

artículo científico publicado en 1993

Synthesis and antiviral activity of a series of new cyclohexenyl nucleosides

artículo científico publicado en 2003

Synthesis and antiviral activity of acyclic analogues of 1,5-anhydrohexitol nucleosides using Mitsunobu reaction

Synthesis and antiviral activity of acyclic nucleosides with a 3(S),5-dihydroxypentyl or 4(R)-methoxy-3(S),5-dihydroxypentyl side chain

artículo científico publicado en 1992

Synthesis and antiviral activity of phosphonate derivatives of enantiomeric dihydro-2H-pyranyl nucleosides

scientific article published in 1995

Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2'-deoxyuridines and (E)-5-(2-halovinyl)-2'-deoxycytidines.

artículo científico publicado en 1985

Synthesis and antiviral evaluation of 3′-substituted thymidine analogues derived from 3′-amino-3′-deoxythymidine

Synthesis and antiviral evaluation of base-modified deoxythreosyl nucleoside phosphonates

artículo científico publicado en 2017

Synthesis and antiviral evaluation of cyclopentyl nucleoside phosphonates.

artículo científico publicado en 2018

Synthesis and antiviral evaluation of some beta-L-2', 3'-dideoxy-5-chloropyrimidine nucleosides and pronucleotides

artículo científico publicado en 2000

Synthesis and apoptogenic activity of fluorinated ceramide and dihydroceramide analogues.

artículo científico publicado en 1999

Synthesis and base pairing properties of 1',5'-anhydro-L-hexitol nucleic acids (L-HNA).

artículo científico publicado en 2009

Synthesis and biological evaluation of a series of new cyclohexenyl nucleosides

artículo científico publicado en 2003

Synthesis and biological evaluation of ceramide analogues with substituted aromatic rings or an allylic fluoride in the sphingoid moiety

artículo científico publicado en 2000

Synthesis and cleavage experiments of oligonucleotide conjugates with a diimidazole-derived catalytic center

artículo científico publicado en 2002

Synthesis and conformational analysis of 1-[2,4-dideoxy-4-C-hydroxymethyl-alpha-l-lyxopyranosyl]thymine

artículo científico publicado en 2004

Synthesis and conformational analysis of a ribo-type cyclohexenyl nucleoside

artículo científico publicado en 2005

Synthesis and conformational behavior of purine and pyrimidine β-d-threo-hex-3'-enopyranosyl nucleosides

Synthesis and conformational properties of O-beta-D-ribofuranosyl-(1''-2')-guanosine and (adenosine)-5''-phosphate

artículo científico publicado en 2003

Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis

artículo científico publicado en 2011

Synthesis and evaluation of 5-substituted-2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis

scholarly article published 2011

Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.

artículo científico publicado en 2012

Synthesis and evaluation of C-5 modified 2'-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase.

artículo científico publicado en 2015

Synthesis and evaluation of hexitol nucleoside congeners as ambiguous nucleosides

Synthesis and evaluation of novel ligands for the histamine H₄ receptor based on a pyrrolo[2,3-d]pyrimidine scaffold

artículo científico publicado en 2012

Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

artículo científico publicado en 2002

Synthesis and hybridization properties of inverse oligonucleotides.

artículo científico publicado en 1997

Synthesis and in vitro antiviral activities of [(dihydrofuran-2-yl)oxy]methyl-phosphonate nucleosides with 2-substituted adenine as base

artículo científico publicado en 2015

Synthesis and in vitro enzymatic and antiviral evaluation of phosphoramidate d4T derivatives as chain terminators

artículo científico publicado en 2011

Synthesis and in vitro evaluation of 2-amino-4-N-piperazinyl-6-(3,4-dimethoxyphenyl)-pteridines as dual immunosuppressive and anti-inflammatory agents

artículo científico publicado en 2010

Synthesis and physicochemical properties of oligonucleotides with an N-cyanoguanidine function instead of the natural phosphate internucleotide linkage

artículo científico publicado en 1993

Synthesis and properties of aminopropyl nucleic acids

artículo científico publicado en 2005

Synthesis and properties of phosphorylated 3'-O-beta-D-ribofuranosyl-2'-deoxythymidine

artículo científico publicado en 2003

Synthesis and stability of oligonucleotides containing acyclic achiral nucleoside analogues with two base moieties

artículo científico

Synthesis and structure-activity relationship studies of 2-(1,3,4-oxadiazole-2(3H)-thione)-3-amino-5-arylthieno[2,3-b]pyridines as inhibitors of DRAK2.

artículo científico publicado en 2014

Synthesis and structure-activity relationships of 3,5-disubstituted-pyrrolo[2,3- b]pyridines as inhibitors of adaptor associated kinase 1 (AAK1) with antiviral activity

artículo científico publicado en 2019

Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase.

artículo científico publicado en 1995

Synthesis of (E)-3′-Phosphonoalkenyl Modified Nucleoside Phosphonates via a Highly Stereoselective Olefin Cross-Metathesis Reaction

Synthesis of .DELTA.3-1-methylene-1-carbacephems

artículo científico publicado en 1986

Synthesis of 1,5-Anhydro-2-(N6-Cyclopentyladenin-9-Yl)-2-Deoxy-D-Altrohexitol

Synthesis of 1,5-Anhydro-D-Mannitol Nucleosides with a Purine Base Moeety

Synthesis of 1,5-Anhydrohexitol Nucleosides as Mimics of AZT, D4T and DDC

Synthesis of 1,5-anhydrohexitol building blocks for oligonucleotide synthesis

artículo científico publicado en 2003

Synthesis of 2'-N-formamido nucleosides and biological evaluation

artículo científico publicado en 2009

Synthesis of 2'-O-beta-d-Ribofuranosylnucleosides

artículo científico publicado en 2007

Synthesis of 2'-cyclohexenylnucleosides and corresponding CeNA building blocks

artículo científico publicado en 2008

Synthesis of 2,4-dideoxy-.beta.-D-erythro-hexopyranosyl nucleosides

Synthesis of 2?-Deoxy-5-(isothiazol-5-yl)uridine and Its Interaction with the HSV-1 Thymidine Kinase

article

Synthesis of 2′-5′ Adenylate Trimers Containing 3′-Modified β-D-Xylofuranosyl-Adenine Derivatives at the 2′-End

article published in 1987

Synthesis of 2′-Deoxy-2′ -Fluoro-D-Arabinopyranopyranosyl Nucleosides and Their 3′,4′-Seco analogues

Synthesis of 2′-O-α-d-ribofuranosyladenosine, monomeric unit of poly(ADP–ribose)

Synthesis of 3'-Amino-3'-deoxyadenosine Derivatives as Potential Drugs for the Treatment of Malaria

scholarly article by Johanna Soenens et al published 1 May 1995 in Nucleosides, Nucleotides & Nucleic Acids

Synthesis of 3'-Fluoro-3'-Deoxyribonucleosides; Anti-HIV-1 and Cytostatic Properties

article

Synthesis of 3'-o-phosphonoethyl nucleosides with an adenine and a thymine base moiety

artículo científico publicado en 2009

Synthesis of 3′-C-branched 1′,5′-anhydromannitol nucleosides as new antiherpes agents

article published in 1998

Synthesis of 3′-Deoxy-3′-C-Hydroxymethyl-aldopentopyranosyl Nucleosides and their Incorporation in Oligonucleotides. Part II 1

article

Synthesis of 3′-Fluoro-3′-deoxy-N6-cyclopentyladenosine

Synthesis of 3′-O-phosphonomethyl nucleosides with an adenine base moiety

Synthesis of 3′-fluoromethylthio-, 3′-fluoromethylsulfinyl- and 3′-fluoromethylsulfonyl-substituted 3′-deoxythymidine

Synthesis of 5′-O-phosphonomethyl-2′,3′-didehydro-2′,3′-dideoxyuridine by use of P-methoxybenzyl as a N3-protecting group

Synthesis of 6-aryl-2′-deoxyuridine nucleosides via a Liebeskind cross-coupling methodology

Synthesis of 9-(3-azido-2,3-dideoxy-β-D--pentofuranosyl)-2,6-diaminopurine (AzddDAP)

article published in 1989

Synthesis of Alanine and Proline Amino Acids with Amino or Guanidinium Substitution on the Side Chain

Synthesis of D-altritol nucleosides with a 3'-O-tert-butyldimethylsilyl protecting group

artículo científico publicado en 2004

Synthesis of N-methyl-d-ribopyranuronamide nucleosides

artículo científico publicado en 2008

Synthesis of Nicotinamide Adenine Dinucleotide (NAD) Analogues with a Sugar Modified Nicotinamide Moiety

Synthesis of Novel -substituted guanidine linked nucleoside dimers and their incorporation into oligonucleotides

artículo científico publicado en 1993

Synthesis of Nucleosides Fluorinated in the Sugar Moiety. The Application of Diethylaminosulfur Trifluoride to the Synthesis of Fluorinated Nucleosides

article by Piet Herdewijn et al published January 1989 in Nucleosides & nucleotides

Synthesis of Oligoribonucleotides Containing Pyrimidine 2'-O-[(Hydroxyalkoxy)methyl]ribonucleosides

Synthesis of Peptidoglycan Units with UDP at the Anomeric Position

Synthesis of Protected Amino Hexitol Nucleosides as Building Blocks for Oligonucleotide Synthesis

artículo científico publicado en 2018

Synthesis of Pyranose Nucleosides

Synthesis of RNA ContainingO-β-D-Ribofuranosyl-(1″2′)-adenosine-5″-phosphate and 1-Methyladenosine, Minor Components of tRNA

artículo científico publicado en 2005

Synthesis of Thymidine Analogues with a Cyanoimido Substituent

Synthesis of a 2,4,6-trisubstituted 5-cyano-pyrimidine library and evaluation of its immunosuppressive activity in a Mixed Lymphocyte Reaction assay

artículo científico publicado en 2013

Synthesis of a 3'-Fluoro-3'-deoxytetrose Adenine Phosphonate.

artículo científico publicado en 2017

Synthesis of a C-Nucleoside Phosphonate by Base-Promoted Epimerization

artículo científico publicado en 2018

Synthesis of a Nucleobase-Modified ProTide Library

artículo científico publicado en 2016

Synthesis of a Pyridoxine–Peptide Based Delivery System for Nucleotides

Synthesis of a Threosyl‐C‐nucleoside Phosphonate ⬇️

scholarly article

Synthesis of a new branched chain hexopyranosyl nucleoside: 1-[2′,3′-dideoxy-3′-C-(hydroxymethyl)-α-D-erythro-pentopyranosyl]-thymine

Synthesis of altritol nucleoside phosphoramidites for oligonucleotide synthesis

artículo científico publicado en 2007

Synthesis of an Uncharged cAMP-Analogue

Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity

artículo científico publicado en 2014

Synthesis of enantiomeric-pure cyclohexenyl nucleoside building blocks for oligonucleotide synthesis

Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons

artículo científico publicado en 2002

Synthesis of modified peptidoglycan precursor analogues for the inhibition of glycosyltransferase.

artículo científico publicado en 2012

Synthesis of new acyclic nucleoside phosphonates (ANPs) substituted on the 1′ and/or 2′ positions

Synthesis of new biocarrier–nucleotide systems for cellular delivery in bacterial auxotrophic strains

article

Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors

artículo científico publicado en 2010

Synthesis of nucleoside analogues with a 1,5-anhydrohexitol moiety

article published in 1993

Synthesis of oligonucleotides modified in the sugar moiety.

artículo científico publicado en 1991

Synthesis of protected D-altritol nucleosides as building blocks for oligonucleotide synthesis

Synthesis of ribonucleosides by condensation using trimethylsilyl triflate

artículo científico publicado en 2007

Synthesis of the Anticodon HairpintRNAfMet ContainingN-{[9-(β-D-Ribofuranosyl)-9H-purin-6-yl]carbamoyl}-L-threonine (=N6-{{[(1S,2R)-1-Carboxy-2-hydroxypropyl]amino}carbonyl}adenosine, t6A)

scholarly article by Valerie Boudou et al published 19 January 2000 in Helvetica Chimica Acta

Synthesis of the β-2',3'-Unsaturated Pentopyranosyl Nucleosides and Their 3'-Hydroxymethyl Congeners

Synthesis of thymidine from 5-iodo-2′-deoxyuridine

Synthesis of α-L-threose nucleoside phosphonates via regioselective sugar protection

artículo científico publicado en 2013

Synthesis of β configured 2′,3′-unsaturated pentopyranosyl nucleosides

Synthesis, Biological Activity, and Molecular Modeling of Ribose-Modified Deoxyadenosine Bisphosphate Analogues as P2Y1Receptor Ligands

article

Synthesis, and in vitro enzymatic and antiviral evaluation of d4T polyphosphate derivatives as chain terminators

artículo científico publicado en 2012

Synthesis, enzymatic stability and physicochemical properties of oligonucleotides containing a N-cyanoguanidine linkage

Synthesis, immunosuppressive activity and structure-activity relationship study of a new series of 4-N-piperazinyl-thieno[2,3-d]pyrimidine analogues

artículo científico publicado en 2010

Synthesis, solution conformations and hydrolytic stability of 3'-substituted 2'-deoxyribonucleosides ⬇️

artículo científico publicado el 1 de enero de 1991

Synthetic Strategies Towards the Synthesis of 1–(2,4-Dideoxy-4-C-hydroxymethyl-α-L-Lyxopyranosyl)base Nucleosies

Synthetic dsDNA-Binding Peptides Using Natural Compounds as Model

scholarly article by Filip Borgions et al published June 2006 in Helvetica Chimica Acta

Synthetic genetic polymers capable of heredity and evolution

artículo científico publicado en 2012

T. cruzi OligoC-TesT: a simplified and standardized polymerase chain reaction format for diagnosis of Chagas disease

artículo científico publicado en 2009

TNA as a Potential Alternative to Natural Nucleic Acids

artículo científico publicado en 2001

Targeting RNA with Conformationally Restricted Oligonucleotides

Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates-Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues

artículo científico publicado en 2020

The 2',3'-dideoxyriboside of 2,6-diaminopurine and its 2',3'-didehydro derivative inhibit the deamination of 2',3'-dideoxyadenosine, an inhibitor of human immunodeficiency virus (HIV) replication

artículo científico publicado en 1987

The 2',3'-dideoxyriboside of 2,6-diaminopurine selectively inhibits human immunodeficiency virus (HIV) replication in vitro

artículo científico publicado en 1987

The 5-chlorouracil:7-deazaadenine base pair as an alternative to the dT:dA base pair

article

The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

artículo científico publicado en 2007

The N1-(3'-Deoxythymidin-3'-yl)-N2-cyano-N3-(5'-deoxythymidin-5'-yl) Guanidine Dimeric Building Block in Automated DNA Synthesis and Mass Spectrometric Analysis of Its Integrity

article published in 1995

The Network of Replication, Transcription, and Reverse Transcription of a Synthetic Genetic Cassette

artículo científico publicado en 2020

The alpha-L-ribo-isomers of RNA and LNA (locked nucleic acid)

scientific article published on 01 January 2001

The biolabile 2'-O-pivaloyloxymethyl modification in an RNA helix: an NMR solution structure

artículo científico publicado en 2013

The crystal structure of the CeNA:RNA hybrid ce(GCGTAGCG):r(CGCUACGC)

artículo científico publicado en 2011

The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine

artículo científico publicado en 2000

The effect of addition of carbon powder to samples in liquid secondary ion mass spectrometry: Improved ionization of apolar compounds

article

The interplay between antiviral activity, oligonucleotide hybridisation and nucleic acids incorporation studies

artículo científico publicado en 2006

The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target

artículo científico publicado en 2010

The naturally occurring N6-threonyl adenine in anticodon loop of Schizosaccharomyces pombe tRNAi causes formation of a unique U-turn motif

artículo científico publicado en 2006

The synthesis of modified D- and L-anhydrohexitol nucleosides

Theoretical Analysis of a Self-Replicator With Reduced Template Inhibition Based on an Informational Leaving Group

artículo científico publicado en 2016

Thiazolo[3,2-a]benzimidazol-3(2H)-one derivatives: Structure-activity relationships of selective nucleotide pyrophosphatase/phosphodiesterase1 (NPP1) inhibitors

artículo científico publicado en 2016

Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase

artículo científico publicado en 2003

Toward safe genetically modified organisms through the chemical diversification of nucleic acids

artículo científico publicado en 2009

Towardl-Homo-DNA: Stereoselective de Novo Synthesis of β-l-erythro-Hexopyranosyl Nucleosides

scientific article published on 01 October 2010

Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.

artículo científico publicado en 1996

Unexpected Shift to a 4-Imino Tautomer Upon N4-Acylation of 5-Methylcytosin-1-yl Nucleoside Analogues

Use of Cyclohexene Epoxides in the Preparation of Carbocyclic Nucleosides

Use of RNA in drug design

artículo científico

Vitamin-guanosine monophosphate conjugates for in vitro transcription priming

artículo científico publicado en 2020

What Is XNA?

scientific article published on 19 July 2019

Xylonucleic acid: synthesis, structure, and orthogonal pairing properties

artículo científico publicado en 2015

[Structure-activity relation study of anti-herpes associations with a 2'-deoxyuridine basic structure]

scientific article published on 01 January 1995

alpha-L-ribo-configured locked nucleic acid (alpha-L-LNA): synthesis and properties

artículo científico publicado en 2002

d(GCGTAGC), an Equilibrium Between a Hairpin Structure and an Unusual Duplex

α-Homo-DNA and RNA Form a Parallel Oriented Non-A, Non-B-Type Double Helical Structure

γ-Hydroxyethyl piperidine iminosugar and N-alkylated derivatives: a study of their activity as glycosidase inhibitors and as immunosuppressive agents

artículo científico publicado en 2014

Lista de obras de Piet Herdewijn

(D)- and (L)-cyclohexenyl-G, a new class of antiviral agents: synthesis, conformational analysis, molecular modeling, and biological activity

1,2,4-Triazole Derivatives Inhibiting the Human Immunodeficiency Virus Type 1 (HIV-1) in vitro

1,2;3,4-Di-O-isopropylidene-l-galactose synthesis from its d-enantiomer

1,5-Anhydro-2-Deoxy-D-Altritol Oligonucleotides as Conformationally Restricted Analogues of Rna

1-(2,3-Dideoxy-erythro-beta-D-hexopyranosyl)cytosine: an example of the conformational and stacking properties of pyranosyl pyrimidine nucleosides. A crystallographic and computational approach

1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase

1′, 5′ -Anhydrohexitol Oligonucleotides: Synthesis, Base Pairing and Recognition by Regular Oligodeoxyribonucleotides and Oligoribonucleotides

1′,5′-Anhydro-l-ribo-hexitol Adenine Nucleic Acids (α-l-HNA-A): Synthesis and Chiral Selection Properties in the Mirror Image World

1′,5′-Anhydrohexitol Oligonucleotides: Hybridisation and Strand Displacement with Oligoribonucleotides, Interaction with RNase H and HIV Reverse Transcriptase

2'-Azido-2',3'-dideoxythymidine: synthesis and crystal structure of a 2'-substituted dideoxynucleoside.

2'-Deoxyribonucleoside phosphoramidate triphosphate analogues as alternative substrates for E. coli polymerase III.

2'-O-hydroxyalkoxymethylribonucleosides and their incorporation into oligoribonucleotides

2-Hydroxyethoxyethylated Bases as Acyclic Analogues of 1,5-Anhydrohexitol Nucleoside Derivatives

3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase

3-Phosphono-L-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase.

3′-Amidated 3′-Deoxyxylofuranose Analogues of N 6-−Cyclopentyladenosines: a New Class of Non-Xanthine Antagonists at the Adenosine A1 Receptor

3′-Deoxy-3′-hydroxymethyl-aldopentopyranosyl nucleoside synthesis. Part I

5'-Deoxy congeners of 9-(3-amido-3-deoxy-beta-D-xylofuranosyl)-N(6)-cyclopentyladenine: new adenosine A(1) receptor antagonists and inverse agonists

5'-O-phosphonomethyl-2',3'-dideoxynucleosides: synthesis and anti-HIV activity

5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication

5-(Thien-2-yl)-2′-deoxyuridine: A New and Potent Inhibitor of Herpes Simplex Virus Type 1 Replication

5-Hydroxytryptophan as a building block in oligopeptides using Fmoc/tBu SPPS

5-Substituted pyrimidine 1,5-anhydrohexitols: Conformational analysis and interaction with viral thymidine kinase

9-[(2RS)-3-fluoro-2-phosphonylmethoxypropyl] derivatives of purines: a class of highly selective antiretroviral agents in vitro and in vivo

A Methyl Group Controls Conformational Equilibrium in Human Mitochondrial tRNALys

A Novel and Enantioselective Approach to the Synthesis of Cyclohexane Carbocyclic Nucleosides Starting from (-)-Carvone

A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics ⬇️

A Potential Prebiotic Route to Adenine from Hypoxanthine

A Single Amino Acid Substitution in Therminator DNA Polymerase Increases Incorporation Efficiency of Deoxyxylonucleotides

A Straightforward Stereoselective Synthesis of d- and l-5-Hydroxy-4-hydroxymethyl-2-cyclohexenylguanine ⬇️

A Versatile NMR Technique for the Identification of Phosphorylation Sites in Oligosaccharides

A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro

A highly enantio-selective hexitol nucleic acid template for nonenzymatic oligoguanylate synthesis.

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity

A novel and convenient strategy for the synthesis of phthalazines from an aryne precursor

A novel helper phage for HaloTag-mediated co-display of enzyme and substrate on phage

A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase

A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase.

A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects

A short and convenient strategy for the synthesis of pyridazines via Diaza–Wittig reaction

A short and straightforward approach towards 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines

A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides

A simplified and standardized polymerase chain reaction format for the diagnosis of leishmaniasis

A synthetic substrate of DNA polymerase deviating from the bases, sugar, and leaving group of canonical deoxynucleoside triphosphates

Access to a New Type of Homo-C-Nucleosides with a “Split” 8-Deazapurine via a 1,3-Dipolar Cycloaddition Reaction

Achiral, acyclic nucleic acids: synthesis and biophysical studies of a possible prebiotic polymer

Acyclic oligonucleotides: possibilities and limitations

Additions and Corrections - Resolution of Aristeromycin Enantiomers

Affinity modification of EcoRII DNA methyltransferase by the dialdehyde-substituted DNA duplexes: mapping the enzyme region that interacts with DNA.

Ajuga remota Benth.: from ethnopharmacology to phytomedical perspective in the treatment of malaria.

Alpha-homo-DNA and RNA form a parallel oriented non-A, non-B-type double helical structure.

Amidate Prodrugs of Cyclic 9-()-[3-Hydroxy-2-(phosphonomethoxy)propyl]adenine with Potent Anti-Herpesvirus Activity

Amidate Prodrugs of Deoxythreosyl Nucleoside Phosphonates as Dual Inhibitors of HIV and HBV Replication

Amino Acid Phosphoramidate Nucleotides as Alternative Substrates for HIV-1 Reverse Transcriptase

Amino acids derived from ornithine

Aminoacyl-tRNA synthetase inhibitors as potent and synergistic immunosuppressants

An acyclic 5-nitroindazole nucleoside analogue as ambiguous nucleoside

An easy and fast method for the evaluation of Staphylococcus epidermidis type I signal peptidase inhibitors

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

Anti-Hiv-1 Activity of 2',3'-Dideoxinucleoside Analogues : Structure-Activity Relationship

Anti-norovirus activity of C7-modified 4-amino-pyrrolo[2,1-f][1,2,4]triazine C-nucleosides

Antibacterial 5'-O-(N-dipeptidyl)-sulfamoyladenosines.

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

Antimalarial antisense activity of hexitol nucleic acids

Antisense oligonucleotides

Application of the Mitsunobu-Type Condensation Reaction to the Synthesis of Phosphonate Derivatives of Cyclohexenyl and Cyclohexanyl Nucleosides

Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication

Astemizole analogues with reduced hERG inhibition as potent antimalarial compounds.

Base pairing involving artificial bases in vitro and in vivo.

Base pairing properties of D- and L-cyclohexene nucleic acids (CeNA).

Base-Modified Nucleic Acids as a Powerful Tool for Synthetic Biology and Biotechnology

Base−Base Interactions in the Minor Groove of Double-Stranded DNA

Bifunctional aryloxyphosphoramidate prodrugs of 2'-C-Me-uridine: synthesis and anti-HCV activity

Binary genetic cassettes for selecting XNA-templated DNA synthesis in vivo

Biological activity of hexitol nucleic acids targeted at Ha-ras and intracellular adhesion molecule-1 mRNA

Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf

Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.

Branched-chain nucleosides: Synthesis of 3′-deoxy-3′-C- hydroxymethyl-α-l-lyxopyranosyl thymine and 3′-deoxy- 3′-C-hydroxymethyl-α-l-threofuranosyl thymine

Carbohydrate chiral-pool approach to four enantiomerically pure 2-naphthylmethyl 3-hydroxy-2-methylbutanoates