Lista de obras - Pedro A. Lazo - Dominio Público Uruguay

A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection.

artículo científico publicado en 2008

Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation

artículo científico publicado en 2005

Accessibility of DNA-epoxycellulose to sequence-specific DNA-binding proteins.

artículo científico publicado en 1984

Activation of multiple genes by provirus integration in the Mlvi-4 locus in T-cell lymphomas induced by Moloney murine leukemia virus ⬇️

artículo científico publicado el 1 de mayo de 1990

Alteration of the VRK1-p53 autoregulatory loop in human lung carcinomas

artículo científico publicado en 2007

Amino acids and glucose utilization by different metabolic pathways in ascites-tumour cells

scientific article published on 01 June 1981

Amplification of the integrated viral transforming genes of human papillomavirus 18 and its 5'-flanking cellular sequence located near the myc protooncogene in HeLa cells.

artículo científico publicado en 1989

Apoptosis protection and survival signal by the CD53 tetraspanin antigen

artículo científico publicado en 2003

Brain hexokinase has two spatially discrete sites for binding of glucose-6-phosphate

artículo científico publicado en 1980

Carcinogenesis by human papillomaviruses

artículo científico publicado en 1993

Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1

artículo científico publicado en 1999

Complex genomic rearrangement within the 12q15 multiple aberration region induced by integrated human papillomavirus 18 in a cervical carcinoma cell line.

artículo científico publicado en 1997

Deletion in human chromosome region 12q13-15 by integration of human papillomavirus DNA in a cervical carcinoma cell line.

artículo científico publicado en 1995

Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2 ⬇️

artículo científico publicado el 4 de agosto de 2011

Discrimination of biclonal B-cell chronic lymphoproliferative neoplasias by tetraspanin antigen expression

scientific article published on 01 September 2005

Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway

artículo científico publicado en 2011

Energetics of tumour cells: enzymic basis of aerobic glycolysis

scientific article published on 01 October 1980

Expression of a new isoform of the tumor susceptibility TSG101 protein lacking a leucine zipper domain in Burkitt lymphoma cell lines

artículo científico publicado en 1999

Expression of aberrant functional and nonfunctional transcripts of the FHIT gene in Burkitt's lymphomas.

artículo científico publicado en 1999

Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis

artículo científico publicado en 2015

Genetic alterations by human papillomaviruses in oncogenesis ⬇️

artículo científico publicado el 30 de marzo de 1992

Genetic changes in carcinoma of the colon

artículo científico publicado el 26 de septiembre de 1992

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

HindIII RFLP in the human CD53 gene on 1p13

artículo científico publicado en 1994

Human JC polyomavirus in normal colorectal mucosa, hyperplastic polyps, sporadic adenomas, and adenocarcinomas in Portugal.

artículo científico publicado en 2013

Human TSG101 does not replace Saccharomyces cerevisiae VPS23 role in the quality control of plasma membrane proteins ⬇️

artículo científico publicado el 25 de abril de 2003

Human VRK1 is an early response gene and its loss causes a block in cell cycle progression

artículo científico publicado en 2008

Human VRK2 (Vaccinia-related Kinase 2) Modulates Tumor Cell Invasion by Hyperactivation of NFAT1 and Expression of Cyclooxygenase-2 ⬇️

artículo científico publicado el 26 de octubre de 2012

Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression

artículo científico publicado en 2013

Human gene therapy: trends and current problems

artículo científico publicado en 1996

Human papillomavirus DNA in cervical lesions from Morocco and its implications for cancer control.

artículo científico publicado en 2003

Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK

artículo científico publicado en 2004

Identification of a dominant epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations

artículo científico publicado en 2007

Identification of an AMP-activatable pyruvate dehydrogenase isozyme in embryos and tumors

scientific article published on 01 November 1980

Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells.

artículo científico publicado en 1997

Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?

artículo científico publicado en 2018

Induction of DNA synthesis by ligation of the CD53 tetraspanin antigen in primary cultures of mesangial cells.

artículo científico publicado en 2003

Interference with p53 functions in human viral infections, a target for novel antiviral strategies?

artículo científico publicado en 2011

Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis

artículo científico publicado en 2000

Is Centrosomal Protein 70, a Centrosomal Protein with New Roles in Breast Cancer Dissemination and Metastasis, a Facilitator of Epithelial-Mesenchymal Transition?

artículo científico publicado en 2017

JC virus in the pathogenesis of colorectal cancer, an etiological agent or another component in a multistep process?

artículo científico publicado en 2010

Ligation of CD53/OX44, a tetraspan antigen, induces homotypic adhesion mediated by specific cell-cell interactions

scientific article published on 01 June 1997

Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas ⬇️

artículo científico publicado el 1 de enero de 1990

Loss of the TSG101 leucine zipper domain in aggressive non-Hodgkin's lymphomas

artículo científico publicado en 2000

Mitochondrial membrane-bound hexokinase of ascites tumor cells. Functional implications of lysine residues studied by modification with imidoesters

scientific article published on 01 June 1982

Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein

artículo científico publicado en 2008

Novel Dominant KCNQ2 Exon 7 Partial In-Frame Duplication in a Complex Epileptic and Neurodevelopmental Delay Syndrome

artículo científico publicado en 2020

Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase

artículo científico publicado en 2019

Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation

artículo científico publicado en 2016

Papillomavirus integration: prognostic marker in cervical cancer?

scientific article published on 01 May 1997

Pathogenesis of viral infections

artículo científico publicado en 1985

Pathogenic convergence of CNVs in genes functionally associated to a severe neuromotor developmental delay syndrome

artículo científico publicado en 2021

Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy

artículo científico publicado en 2024

Pattern of expression of tetraspanin antigen genes in Burkitt lymphoma cell lines.

artículo científico publicado en 1998

Physiological activation of human neutrophils down-regulates CD53 cell surface antigen ⬇️

artículo científico publicado el 1 de junio de 1998

Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation

artículo científico publicado en 2009

Recombination between two integrated proviruses, one of which was inserted near c-myc in a retrovirus-induced rat thymoma: implications for tumor progression.

artículo científico publicado en 1988

Recurrent integration of papillomavirus DNA within the human 12q14-15 uterine breakpoint region in genital carcinomas.

artículo científico publicado en 1998

Reverting p53 activation after recovery of cellular stress to resume with cell cycle progression

artículo científico publicado en 2017

Roles of VRK1 as a new player in the control of biological processes required for cell division.

artículo científico publicado en 2011

Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals ⬇️

artículo científico publicado el 13 de marzo de 2013

Shuttle vectors to study somatic mutagenesis and regulation of gene expression in the immune system

artículo científico publicado en 1985

Specific inactivation of animal hexokinases by xylose in vitro, in situ and in vivo

artículo científico publicado el 1 de febrero de 1979

Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications

artículo científico publicado en 2011

Tetraspan transmembrane antigen levels in Burkitt lymphoma cell lines

scientific article published on 01 May 1998

Tetraspanin proteins as organisers of membrane microdomains and signalling complexes.

artículo científico publicado en 2003

The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53

artículo científico publicado en 2008

The Mlvi-1 locus involved in the induction of rat T-cell lymphomas and the pvt-1/Mis-1 locus are identical.

artículo científico publicado en 1989

The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer

artículo científico publicado en 2009

The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

artículo científico publicado en 2000

The human zinc-finger protein-7 gene is located 90 kb 3' of MYC and is not expressed in Burkitt lymphoma cell lines.

artículo científico publicado en 1994

The spinal muscular atrophy with pontocerebellar hypoplasia gene VRK1 regulates neuronal migration through an amyloid-β precursor protein-dependent mechanism.

artículo científico publicado en 2015

The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines

artículo científico publicado en 2006

The vaccinia virus B1R kinase induces p53 downregulation by an Mdm2-dependent mechanism

artículo científico publicado en 2004

Tumour induction of host leucine starvation

scientific article published on 01 December 1981

VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy

artículo científico publicado en 2020

VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage

artículo científico publicado en 2020

VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.

artículo científico publicado en 2018

VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage

artículo científico publicado en 2015

VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes

artículo científico publicado en 2019

VRK1 interacts with p53 forming a basal complex that is activated by UV-induced DNA damage

artículo científico publicado en 2014

VRK1 phosphorylates and protects NBS1 from ubiquitination and proteasomal degradation in response to DNA damage

scientific journal article

VRK1 regulates Cajal body dynamics and protects coilin from proteasomal degradation in cell cycle

artículo científico publicado en 2015

VRK1 signaling pathway in the context of the proliferation phenotype in head and neck squamous cell carcinoma.

artículo científico publicado en 2006

VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling

artículo científico publicado en 2012

VRK2 identifies a subgroup of primary high-grade astrocytomas with a better prognosis

artículo científico publicado en 2013

VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer

artículo científico publicado en 2010

Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling

artículo científico publicado en 2006

Vaccinia-related kinase 1 (VRK1) confers resistance to DNA-damaging agents in human breast cancer by affecting DNA damage response

artículo científico publicado en 2014

Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage

artículo científico publicado en 2012

Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1

artículo científico publicado en 2007

Variant translocations in two Burkitt's lymphoma cell lines are located in the MLV14 locus.

artículo científico publicado en 1992

c-Jun phosphorylation by the human vaccinia-related kinase 1 (VRK1) and its cooperation with the N-terminal kinase of c-Jun (JNK)

artículo científico publicado en 2004

p53 downregulates its activating vaccinia-related kinase 1, forming a new autoregulatory loop

artículo científico publicado en 2006

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

Lista de obras de Pedro A. Lazo

A central role for CK1 in catalyzing phosphorylation of the p53 transactivation domain at serine 20 after HHV-6B viral infection.

Aberrant expression of tetraspanin molecules in B-cell chronic lymphoproliferative disorders and its correlation with normal B-cell maturation

Accessibility of DNA-epoxycellulose to sequence-specific DNA-binding proteins.

Activation of multiple genes by provirus integration in the Mlvi-4 locus in T-cell lymphomas induced by Moloney murine leukemia virus ⬇️

Alteration of the VRK1-p53 autoregulatory loop in human lung carcinomas

Amino acids and glucose utilization by different metabolic pathways in ascites-tumour cells

Amplification of the integrated viral transforming genes of human papillomavirus 18 and its 5'-flanking cellular sequence located near the myc protooncogene in HeLa cells.

Apoptosis protection and survival signal by the CD53 tetraspanin antigen

Brain hexokinase has two spatially discrete sites for binding of glucose-6-phosphate

Carcinogenesis by human papillomaviruses

Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1

Complex genomic rearrangement within the 12q15 multiple aberration region induced by integrated human papillomavirus 18 in a cervical carcinoma cell line.

Deletion in human chromosome region 12q13-15 by integration of human papillomavirus DNA in a cervical carcinoma cell line.

Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2 ⬇️

Discrimination of biclonal B-cell chronic lymphoproliferative neoplasias by tetraspanin antigen expression

Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway

Energetics of tumour cells: enzymic basis of aerobic glycolysis

Expression of a new isoform of the tumor susceptibility TSG101 protein lacking a leucine zipper domain in Burkitt lymphoma cell lines

Expression of aberrant functional and nonfunctional transcripts of the FHIT gene in Burkitt's lymphomas.

Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis

Genetic alterations by human papillomaviruses in oncogenesis ⬇️

Genetic changes in carcinoma of the colon

Guidelines for the use and interpretation of assays for monitoring autophagy

HindIII RFLP in the human CD53 gene on 1p13

Human JC polyomavirus in normal colorectal mucosa, hyperplastic polyps, sporadic adenomas, and adenocarcinomas in Portugal.

Human TSG101 does not replace Saccharomyces cerevisiae VPS23 role in the quality control of plasma membrane proteins ⬇️

Human VRK1 is an early response gene and its loss causes a block in cell cycle progression

Human VRK2 (Vaccinia-related Kinase 2) Modulates Tumor Cell Invasion by Hyperactivation of NFAT1 and Expression of Cyclooxygenase-2 ⬇️

Human VRK2 modulates apoptosis by interaction with Bcl-xL and regulation of BAX gene expression

Human gene therapy: trends and current problems

Human papillomavirus DNA in cervical lesions from Morocco and its implications for cancer control.

Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK

Identification of a dominant epitope in human vaccinia-related kinase 1 (VRK1) and detection of different intracellular subpopulations

Identification of an AMP-activatable pyruvate dehydrogenase isozyme in embryos and tumors

Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells.

Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?

Induction of DNA synthesis by ligation of the CD53 tetraspanin antigen in primary cultures of mesangial cells.

Interference with p53 functions in human viral infections, a target for novel antiviral strategies?

Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis

Is Centrosomal Protein 70, a Centrosomal Protein with New Roles in Breast Cancer Dissemination and Metastasis, a Facilitator of Epithelial-Mesenchymal Transition?

JC virus in the pathogenesis of colorectal cancer, an etiological agent or another component in a multistep process?

Ligation of CD53/OX44, a tetraspan antigen, induces homotypic adhesion mediated by specific cell-cell interactions

Long-distance activation of the Myc protooncogene by provirus insertion in Mlvi-1 or Mlvi-4 in rat T-cell lymphomas ⬇️

Loss of the TSG101 leucine zipper domain in aggressive non-Hodgkin's lymphomas

Mitochondrial membrane-bound hexokinase of ascites tumor cells. Functional implications of lysine residues studied by modification with imidoesters

Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein

Novel Dominant KCNQ2 Exon 7 Partial In-Frame Duplication in a Complex Epileptic and Neurodevelopmental Delay Syndrome

Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase

Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation

Papillomavirus integration: prognostic marker in cervical cancer?

Pathogenesis of viral infections

Pathogenic convergence of CNVs in genes functionally associated to a severe neuromotor developmental delay syndrome

Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy

Pattern of expression of tetraspanin antigen genes in Burkitt lymphoma cell lines.

Physiological activation of human neutrophils down-regulates CD53 cell surface antigen ⬇️

Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation

Recombination between two integrated proviruses, one of which was inserted near c-myc in a retrovirus-induced rat thymoma: implications for tumor progression.

Recurrent integration of papillomavirus DNA within the human 12q14-15 uterine breakpoint region in genital carcinomas.

Reverting p53 activation after recovery of cellular stress to resume with cell cycle progression

Roles of VRK1 as a new player in the control of biological processes required for cell division.

Sensitivity of the kinase activity of human vaccinia-related kinase proteins to toxic metals ⬇️

Shuttle vectors to study somatic mutagenesis and regulation of gene expression in the immune system

Specific inactivation of animal hexokinases by xylose in vitro, in situ and in vivo

Substrate profiling of human vaccinia-related kinases identifies coilin, a Cajal body nuclear protein, as a phosphorylation target with neurological implications

Tetraspan transmembrane antigen levels in Burkitt lymphoma cell lines

Tetraspanin proteins as organisers of membrane microdomains and signalling complexes.

The C/H3 domain of p300 is required to protect VRK1 and VRK2 from their downregulation induced by p53

The Mlvi-1 locus involved in the induction of rat T-cell lymphomas and the pvt-1/Mis-1 locus are identical.

The SRY-HMG box gene, SOX4, is a target of gene amplification at chromosome 6p in lung cancer

The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

The human zinc-finger protein-7 gene is located 90 kb 3' of MYC and is not expressed in Burkitt lymphoma cell lines.

The spinal muscular atrophy with pontocerebellar hypoplasia gene VRK1 regulates neuronal migration through an amyloid-β precursor protein-dependent mechanism.

The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines

The vaccinia virus B1R kinase induces p53 downregulation by an Mdm2-dependent mechanism

Tumour induction of host leucine starvation

VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy

VRK1 Phosphorylates Tip60/KAT5 and Is Required for H4K16 Acetylation in Response to DNA Damage

VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis.

VRK1 chromatin kinase phosphorylates H2AX and is required for foci formation induced by DNA damage