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Lista de obras de Mette M. Rosenkilde

2-Oleoyl glycerol is a GPR119 agonist and signals GLP-1 release in humans

artículo científico publicado en 2011

A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus.

artículo científico publicado en 1997

A highly conserved glycine within linker I and the extreme C terminus of G protein alpha subunits interact cooperatively in switching G protein-coupled receptor-to-effector specificity

artículo científico publicado en 2004

AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor

artículo científico publicado en 2005

Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI

artículo científico publicado en 2006

Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74

artículo científico publicado en 1999

Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach

artículo científico publicado en 2011

An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

artículo científico publicado en 2020

Arrestin-independent constitutive endocytosis of GPR125/ADGRA3

scientific article published on 29 October 2019

Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28.

artículo científico publicado en 2016

Autocrine CCL19 blocks dendritic cell migration toward weak gradients of CCL21.

artículo científico publicado en 2016

Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7

scientific article published on 13 September 2019

Biased agonism and allosteric modulation of G protein-coupled receptor 183 - a 7TM receptor also known as Epstein-Barr virus-induced gene 2.

artículo científico publicado en 2017

Biased and constitutive signaling in the CC-chemokine receptor CCR5 by manipulating the interface between transmembrane helices 6 and 7.

artículo científico publicado en 2013

Biased and g protein-independent signaling of chemokine receptors

artículo científico publicado en 2014

Biased signaling of G protein-coupled receptors - From a chemokine receptor CCR7 perspective

artículo científico publicado en 2017

Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119.

artículo científico publicado en 2016

Biased small-molecule ligands for selective inhibition of HIV-1 cell entry via CCR5.

artículo científico publicado en 2016

Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.

artículo científico publicado en 2018

CCL19 with CCL21-tail displays enhanced glycosaminoglycan binding with retained chemotactic potency in dendritic cells

artículo científico publicado en 2018

CD4-Chemokine receptor hybrids in human immunodeficiency virus type 1 infection.

artículo científico publicado en 1999

Cell transformation mediated by the Epstein-Barr virus G protein-coupled receptor BILF1 is dependent on constitutive signaling.

artículo científico publicado en 2010

Chapter 8. Activation mechanisms of chemokine receptors

artículo científico publicado en 2009

Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production

artículo científico publicado en 2017

Comparing olive oil and C4-dietary oil, a prodrug for the GPR119 agonist, 2-oleoyl glycerol, less energy intake of the latter is needed to stimulate incretin hormone secretion in overweight subjects with type 2 diabetes

artículo científico publicado en 2018

Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V.

artículo científico

Corrigendum: Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

artículo científico publicado en 2017

Design, synthesis, and biological evaluation of scaffold-based tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4).

artículo científico publicado en 2014

Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis

artículo científico publicado en 2014

Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes

scientific article published on 12 September 2019

Development of potent and proteolytically stable human neuromedin U receptor agonists.

artículo científico publicado en 2017

Differential CCR7 Targeting in Dendritic Cells by Three Naturally Occurring CC-Chemokines

artículo científico publicado en 2016

Discovery and Characterization of Biased Allosteric Agonists of the Chemokine Receptor CXCR3

article

Discovery and mapping of an intracellular antagonist binding site at the chemokine receptor CCR2.

artículo científico publicado en 2014

Distinct Roles of Extracellular Domains in the Epstein-Barr Virus-Encoded BILF1 Receptor for Signaling and Major Histocompatibility Complex Class I Downregulation

artículo científico publicado en 2019

Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants.

artículo científico publicado en 2010

Dual treatment with a fixed ratio of glucagon and insulin increases the therapeutic window of insulin in diabetic rats.

artículo científico publicado en 2018

EBI2 overexpression in mice leads to B1 B-cell expansion and chronic lymphocytic leukemia-like B-cell malignancies

artículo científico publicado en 2016

EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors

scientific article published on January 2011

EBV, the human host, and the 7TM receptors: defense or offense?

artículo científico publicado en 2014

Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial

artículo científico publicado en 2017

Enhanced agonist residence time, internalization rate and signalling of the GIP receptor variant [E354Q] facilitate receptor desensitization and long-term impairment of the GIP system

scientific article published on 12 July 2019

Epstein-Barr virus-encoded BILF1 is a constitutively active G protein-coupled receptor

artículo científico publicado en 2005

Evaluation of the incretin effect in humans using GIP and GLP-1 receptor antagonists

scientific article published on 03 November 2019

Exendin-4, but not dipeptidyl peptidase IV inhibition, increases small intestinal mass in GK rats

artículo científico publicado en 2007

Extracellular disulfide bridges serve different purposes in two homologous chemokine receptors, CCR1 and CCR5.

artículo científico publicado en 2013

Functional analysis of the murine cytomegalovirus chemokine receptor homologue M33: ablation of constitutive signaling is associated with an attenuated phenotype in vivo

artículo científico publicado en 2007

G Protein-Coupled Receptors in the Sweet Spot: Glycosylation and other Post-translational Modifications

scientific article published on 17 March 2020

GIP's effect on bone metabolism is reduced by the selective GIP receptor antagonist GIP(3-30)NH2

scientific article published on 14 October 2019

GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release.

artículo científico publicado en 2017

GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study

artículo científico publicado en 2017

GIP-(3–42) does not antagonize insulinotropic effects of GIP at physiological concentrations

artículo científico publicado en 2006

GLP-1 Val8: A Biased GLP-1R Agonist with Altered Binding Kinetics and Impaired Release of Pancreatic Hormones in Rats

artículo científico publicado en 2021

GLP-2 and GIP exert separate effects on bone turnover: A randomized, placebo-controlled, crossover study in healthy young men

scientific article published on 15 May 2019

GPR119 as a fat sensor

artículo científico publicado en 2012

GPR183 Is Dispensable for B1 Cell Accumulation and Function, but Affects B2 Cell Abundance, in the Omentum and Peritoneal Cavity

artículo científico publicado en 2022

Gating function of isoleucine-116 in TM-3 (position III:16/3.40) for the activity state of the CC-chemokine receptor 5 (CCR5).

artículo científico publicado en 2014

GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors

artículo científico publicado en 2006

Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice

artículo científico publicado en 2012

Glucose and amino acid metabolism in mice depend mutually on glucagon and insulin receptor signaling

scientific article published on 26 February 2019

Glucose-dependent insulinotropic polypeptide (GIP) receptor antagonists as anti-diabetic agents

artículo científico publicado en 2018

Glucose-dependent insulinotropic polypeptide augments glucagon responses to hypoglycemia in type 1 diabetes

artículo científico publicado en 2014

Glucose-lowering effects and mechanisms of the bile acid-sequestering resin sevelamer

artículo científico publicado en 2018

High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3.

artículo científico publicado en 2005

High content screening for G protein-coupled receptors using cell-based protein translocation assays

artículo científico publicado en 2005

Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1.

artículo científico publicado en 2011

How receptor mutagenesis may confirm or confuse receptor classification.

artículo científico publicado en 1997

Human GIP(3-30)NH2 inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors

artículo científico publicado en 2018

Identification and characterization of small molecule modulators of the Epstein-Barr virus-induced gene 2 (EBI2) receptor

scientific journal article

Identification and functional comparison of seven-transmembrane G-protein-coupled BILF1 receptors in recently discovered nonhuman primate lymphocryptoviruses

artículo científico publicado en 2014

Identification of a novel site within G protein alpha subunits important for specificity of receptor-G protein interaction

artículo científico publicado en 2004

Identification of common mechanisms by which human and mouse cytomegalovirus seven-transmembrane receptor homologues contribute to in vivo phenotypes in a mouse model

artículo científico publicado en 2013

In vivo and in vitro degradation of peptide YY3-36 to inactive peptide YY3-34 in humans

artículo científico publicado en 2016

Increased Body Weight and Fat Mass After Subchronic GIP Receptor Antagonist, but Not GLP-2 Receptor Antagonist, Administration in Rats

scientific article published on 06 August 2019

Influence of chain length on the activity of tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4).

artículo científico publicado en 2016

Inhibition of HIV fusion by small molecule agonists through efficacy-engineering of CXCR4.

artículo científico publicado en 2018

Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist

artículo científico publicado en 2004

Interaction of chemokines with their receptors--from initial chemokine binding to receptor activating steps

artículo científico publicado en 2014

International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors

artículo científico publicado en 2013

Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3

artículo científico publicado en 2007

Ligand binding and micro-switches in 7TM receptor structures

scientific article published on 16 April 2009

Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist

artículo científico publicado en 2011

Ligand-selective small molecule modulators of the constitutively active vGPCR US28

scientific article published on 31 May 2018

Maintenance of improvements in fitness and fatness 1 year after a 3-month lifestyle intervention in overweight men

artículo científico publicado en 2016

Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor

artículo científico publicado en 2003

Microbiological exploitation of the chemokine system

artículo científico publicado en 2003

Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor

artículo científico publicado en 2007

Modulation in Selectivity and Allosteric Properties of Small-Molecule Ligands for CC-Chemokine Receptors

Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5).

artículo científico publicado en 2016

Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)

scientific journal article

Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8

artículo científico publicado en 2007

Molecular interactions of full-length and truncated GIP peptides with the GIP receptor - A comprehensive review

artículo científico publicado en 2019

Molecular mechanism of 7TM receptor activation--a global toggle switch model

artículo científico publicado en 2006

Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor

artículo científico publicado en 2003

Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor

artículo científico publicado en 2007

Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity

artículo científico publicado en 2006

Molecular requirements for inhibition of the chemokine receptor CCR8--probe-dependent allosteric interactions.

artículo científico publicado en 2012

Multistep continuous-flow synthesis in medicinal chemistry: discovery and preliminary structure-activity relationships of CCR8 ligands

artículo científico publicado en 2013

Mutational analysis of CCL20 reveals flexibility of N-terminal amino acid composition and length

scientific article published on 01 August 2018

Mutations along transmembrane segment II of the NK-1 receptor affect substance P competition with non-peptide antagonists but not substance P binding.

artículo científico publicado en 1994

Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry

artículo científico publicado en 2003

N-terminally and C-terminally truncated forms of glucose-dependent insulinotropic polypeptide are high-affinity competitive antagonists of the human GIP receptor

artículo científico publicado en 2015

Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor

artículo científico publicado en 1998

Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo.

artículo científico publicado en 2016

Neuromedin U Does Not Act as a Decretin in Rats

artículo científico publicado en 2018

Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells.

artículo científico publicado en 2017

Oleoyl-lysophosphatidylinositol enhances glucagon-like peptide-1 secretion from enteroendocrine L-cells through GPR119

artículo científico publicado en 2018

Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor.

artículo científico publicado en 2016

Oxyntomodulin: Actions and role in diabetes

artículo científico publicado en 2018

Oxysterol-EBI2 signaling in immune regulation and viral infection

artículo científico publicado en 2014

Paracrine crosstalk between intestinal L- and D-cells controls secretion of glucagon-like peptide-1 in mice

artículo científico publicado en 2019

Partial functional complementation between human and mouse cytomegalovirus chemokine receptor homologues

artículo científico publicado en 2011

Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation and Anti-HIV-1 Activity

article

Perspective: Implications of Ligand-Receptor Binding Kinetics for Therapeutic Targeting of G Protein-Coupled Receptors

scientific article published on 18 March 2020

Pharmacokinetics of high-dose intravenous melatonin in humans.

artículo científico publicado en 2015

Pharmacokinetics of oral and intravenous melatonin in healthy volunteers

artículo científico publicado en 2016

Phorbol esters and SDF-1 induce rapid endocytosis and down modulation of the chemokine receptor CXCR4.

artículo científico publicado en 1997

Physiology of the Incretin Hormones, GIP and GLP-1-Regulation of Release and Posttranslational Modifications

artículo científico publicado en 2019

Porcine glucagon-like peptide-2: structure, signaling, metabolism and effects

artículo científico publicado en 2007

Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding

scientific article published on 17 June 2008

Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor

artículo científico publicado en 2000

Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.

artículo científico publicado en 1997

Probing Biased Signaling in Chemokine Receptors

artículo científico publicado en 2015

Probing the Molecular Interactions between CXC Chemokine Receptor 4 (CXCR4) and an Arginine-Based Tripeptidomimetic Antagonist (KRH-1636)

scientific article published on 02 October 2015

Progress toward rationally designed small-molecule peptide and peptidomimetic CXCR4 antagonists

artículo científico

Prohormone convertase 1/3 is essential for processing of the glucose-dependent insulinotropic polypeptide precursor

artículo científico publicado en 2006

Protein engineering of the chemokine CCL20 prevents psoriasiform dermatitis in an IL-23-dependent murine model.

artículo científico publicado en 2017

Rat cytomegalovirus-encoded γ-chemokine vXCL1 is a highly adapted, species-specific agonist for rat XCR1-positive dendritic cells

scientific article published on 18 November 2019

Rational design of conformationally constrained cyclopentapeptide antagonists for C-x-C chemokine receptor 4 (CXCR4)

artículo científico publicado en 2012

Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

artículo científico publicado en 2015

Recent advances of GIP and future horizons

scientific article published on 12 December 2019

Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2.

artículo científico publicado en 2012

Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding

artículo científico publicado en 2016

Selective Allosteric Modulation of N-Terminally Cleaved, but Not Full Length CCL3 in CCR1

artículo científico publicado en 2019

Selective recognition of the membrane-bound CX3C chemokine, fractalkine, by the human cytomegalovirus-encoded broad-spectrum receptor US28

scientific article published on 01 December 1998

Separate and Combined Glucometabolic Effects of Endogenous Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide 1 in Healthy Individuals

artículo científico publicado en 2019

Signaling via G proteins mediates tumorigenic effects of GPR87.

artículo científico publicado en 2016

Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74.

artículo científico publicado en 2004

Small molecule antagonism of oxysterol-induced Epstein-Barr virus induced gene 2 (EBI2) activation

artículo científico publicado en 2013

Species-specific action of (Pro3)GIP - a full agonist at human GIP receptors, but a partial agonist and competitive antagonist at rat and mouse GIP receptors

artículo científico publicado en 2015

Structural Diversity in Conserved Regions Like the DRY-Motif among Viral 7TM Receptors-A Consequence of Evolutionary Pressure?

artículo científico

Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21

scientific article published on 26 March 2020

Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist

scientific journal article

Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors

artículo científico publicado en 2008

Structure-activity relationship studies of the aromatic positions in cyclopentapeptide CXCR4 antagonists

artículo científico publicado en 2013

Structure-activity relationships and identification of optmized CC-chemokine receptor CCR1, 5, and 8 metal-ion chelators

artículo científico publicado en 2013

Structure-based discovery of novel US28 small molecule ligands with different modes of action

artículo científico publicado en 2016

Structure-function guided modeling of chemokine-GPCR specificity for the chemokine XCL1 and its receptor XCR1

artículo científico publicado en 2019

Sustained effect of glucagon on body weight and blood glucose: Assessed by continuous glucose monitoring in diabetic rats.

artículo científico publicado en 2018

Sweet Taste Receptor Activation in the Gut Is of Limited Importance for Glucose-Stimulated GLP-1 and GIP Secretion

artículo científico publicado en 2017

Targeting herpesvirus reliance of the chemokine system

artículo científico publicado en 2006

Targeting the latent cytomegalovirus reservoir with an antiviral fusion toxin protein.

artículo científico publicado en 2017

The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins

artículo científico publicado en 2004

The E92K melanocortin 1 receptor mutant induces cAMP production and arrestin recruitment but not ERK activity indicating biased constitutive signaling

artículo científico publicado en 2011

The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling

scientific article published on 31 March 2020

The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor

artículo científico publicado en 2017

The anorexic hormone Peptide YY3-36 is rapidly metabolized to inactive Peptide YY3-34 in vivo

artículo científico publicado en 2015

The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis

artículo científico publicado en 2003

The chemokine system -- a major regulator of angiogenesis in health and disease

artículo científico publicado en 2004

The frequency of cytomegalovirus non-ELR UL146 genotypes in neonates with congenital CMV disease is comparable to strains in the background population

artículo científico publicado en 2021

The future of antiviral immunotoxins

artículo científico

The glucagon-like peptide 2 receptor is expressed in enteric neurons and not in the epithelium of the intestine

scientific article published on 06 March 2015

The impact of short-chain fatty acids on GLP-1 and PYY secretion from the isolated perfused rat colon

scientific article published on 01 March 2018

The minor binding pocket: a major player in 7TM receptor activation

artículo científico publicado en 2010

The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist

artículo científico publicado en 2022

Transfer of liraglutide from blood to cerebrospinal fluid is minimal in patients with type 2 diabetes

artículo científico publicado en 2015

Transgenic rescue of adipocyte glucose-dependent insulinotropic polypeptide receptor expression restores high fat diet-induced body weight gain

artículo científico publicado en 2011

Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes

artículo científico publicado en 2017

Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity.

artículo científico publicado en 2001

Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration.

artículo científico publicado en 2017

Vasopressin receptors V1a and V2 are not osmosensors

artículo científico publicado en 2015

Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy.

artículo científico publicado en 2018

Virally encoded chemokines and chemokine receptors in the role of viral infections

artículo científico publicado en 2003

Virus-encoded chemokine receptors--putative novel antiviral drug targets

artículo científico publicado en 2005

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