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Lista de obras de Natalia Trayanova

"Beauty is a light in the heart": the transformative potential of optogenetics for clinical applications in cardiovascular medicine.

artículo científico publicado en 2014

A New MRI-Based Model of Heart Function with Coupled Hemodynamics and Application to Normal and Diseased Canine Left Ventricles

artículo científico publicado en 2015

A comprehensive multiscale framework for simulating optogenetics in the heart.

artículo científico publicado en 2013

A comprehensive stroke risk assessment by combining atrial computational fluid dynamics simulations and functional patient data

A computational approach to understanding the cardiac electromechanical activation sequence in the normal and failing heart, with translation to the clinical practice of CRT

artículo científico publicado en 2012

A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms

artículo científico publicado en 2011

A feasibility study of arrhythmia risk prediction in patients with myocardial infarction and preserved ejection fraction.

artículo científico publicado en 2016

A novel rule-based algorithm for assigning myocardial fiber orientation to computational heart models.

artículo científico publicado en 2012

Accuracy of prediction of infarct-related arrhythmic circuits from image-based models reconstructed from low and high resolution MRI.

artículo científico publicado en 2015

Action potential dynamics explain arrhythmic vulnerability in human heart failure: a clinical and modeling study implicating abnormal calcium handling

artículo científico publicado en 2008

Action potential morphology heterogeneity in the atrium and its effect on atrial reentry: a two-dimensional and quasi-three-dimensional study.

artículo científico publicado en 2006

Advances in modeling ventricular arrhythmias: from mechanisms to the clinic.

artículo científico

Arrhythmia dynamics in computational models of the atria following virtual ablation of re-entrant drivers

artículo científico publicado en 2018

Arrhythmia risk stratification based on QT interval instability: an intracardiac electrocardiogram study.

artículo científico publicado en 2013

Association of regional myocardial conduction velocity with the distribution of hypoattenuation on contrast-enhanced perfusion computed tomography in patients with postinfarct ventricular tachycardia

scientific article published on 26 October 2018

Atrial defibrillation voltage: falling to a new low ⬇️

artículo científico publicado el 29 de octubre de 2010

Automatically generated, anatomically accurate meshes for cardiac electrophysiology problems.

artículo científico publicado en 2009

Cardiac Optogenetics: 2018

artículo científico publicado en 2018

Cardiac electromechanical models: from cell to organ.

artículo científico

Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling.

artículo científico publicado en 2013

Characterization of the relationship between preshock state and virtual electrode polarization-induced propagated graded responses resulting in arrhythmia induction.

artículo científico publicado en 2006

Comparative analysis of three different modalities for characterization of the seismocardiogram.

artículo científico publicado en 2009

Comparing Reentrant Drivers Predicted by Image-Based Computational Modeling and Mapped by Electrocardiographic Imaging in Persistent Atrial Fibrillation.

artículo científico publicado en 2018

Comparison of the effects of continuous and pulsatile left ventricular-assist devices on ventricular unloading using a cardiac electromechanics model.

artículo científico publicado en 2011

Computational Identification of Ventricular Arrhythmia Risk in Pediatric Myocarditis

scientific article published on 06 March 2019

Computational analysis of the effect of mitral and aortic regurgitation on the function of ventricular assist devices using 3D cardiac electromechanical model.

artículo científico publicado en 2017

Computational analysis of the effect of valvular regurgitation on ventricular mechanics using a 3D electromechanics model.

artículo científico publicado en 2015

Computational cardiology: how computer simulations could be used to develop new therapies and advance existing ones

artículo científico publicado en 2012

Computational medicine: translating models to clinical care

artículo científico publicado en 2012

Computational modeling of cardiac optogenetics: Methodology overview & review of findings from simulations

artículo científico publicado en 2015

Computational models in cardiology

artículo científico publicado en 2019

Computational models of heart disease.

artículo científico publicado en 2014

Computational prediction of the effects of the intra-aortic balloon pump on heart failure with valvular regurgitation using a 3D cardiac electromechanical model

artículo científico publicado en 2017

Computational rabbit models to investigate the initiation, perpetuation, and termination of ventricular arrhythmia.

artículo científico publicado en 2016

Computationally guided personalized targeted ablation of persistent atrial fibrillation

scientific article published on 19 August 2019

Correction: Virtual Electrophysiological Study of Atrial Fibrillation in Fibrotic Remodeling.

artículo científico publicado en 2016

Defibrillation of the heart: insights into mechanisms from modelling studies.

artículo científico publicado en 2006

Defibrillation success with high frequency electric fields is related to degree and location of conduction block.

artículo científico publicado en 2013

Disrupted calcium release as a mechanism for atrial alternans associated with human atrial fibrillation

artículo científico publicado en 2014

Distribution of electromechanical delay in the heart: insights from a three-dimensional electromechanical model.

artículo científico publicado en 2010

EFFECT OF KCNQ1 G229D MUTATION ON CARDIAC PUMPING EFFICACY AND REENTRANT DYNAMICS IN VENTRICLES: COMPUTATIONAL STUDY.

artículo científico publicado en 2018

Early somatic mosaicism is a rare cause of long-QT syndrome

scientific article published on 28 September 2016

Effects of mechano-electric feedback on scroll wave stability in human ventricular fibrillation

artículo científico publicado en 2013

Effects of regional mitochondrial depolarization on electrical propagation: implications for arrhythmogenesis.

artículo científico publicado en 2014

Efficient preloading of the ventricles by a properly timed atrial contraction underlies stroke work improvement in the acute response to cardiac resynchronization therapy

artículo científico publicado en 2013

Electromechanical models of the ventricles

artículo científico publicado en 2011

Estimation of local orientations in fibrous structures with applications to the Purkinje system.

artículo científico publicado en 2011

Evaluating intramural virtual electrodes in the myocardial wedge preparation: simulations of experimental conditions.

artículo científico publicado en 2007

Exploring susceptibility to atrial and ventricular arrhythmias resulting from remodeling of the passive electrical properties in the heart: a simulation approach

artículo científico publicado en 2014

Field of view of mapping catheters quantified by electrogram associations with radius of myocardial attenuation on contrast-enhanced cardiac computed tomography

artículo científico publicado en 2018

From genetics to smart watches: developments in precision cardiology

artículo científico publicado en 2019

Harnessing the Power of Integrated Mitochondrial Biology and Physiology: A Special Report on the NHLBI Mitochondria in Heart Diseases Initiative

artículo científico publicado en 2015

How computer simulations of the human heart can improve anti-arrhythmia therapy

artículo científico publicado en 2015

How personalized heart modeling can help treatment of lethal arrhythmias: A focus on ventricular tachycardia ablation strategies in post-infarction patients

scientific article published on 09 January 2020

Image-based Reconstruction of 3D Myocardial Infarct Geometry for Patient Specific Applications.

artículo científico publicado en 2015

Image-based estimation of ventricular fiber orientations for patient-specific simulations.

artículo científico publicado en 2011

Image-based estimation of ventricular fiber orientations for personalized modeling of cardiac electrophysiology.

artículo científico publicado en 2012

Image-based left ventricular shape analysis for sudden cardiac death risk stratification

artículo científico publicado en 2014

Image-based models of cardiac structure in health and disease.

artículo científico publicado en 2010

Image-based models of cardiac structure with applications in arrhythmia and defibrillation studies.

artículo científico publicado en 2009

Image-based reconstruction of three-dimensional myocardial infarct geometry for patient-specific modeling of cardiac electrophysiology

artículo científico publicado en 2015

Imaging-Based Simulations for Predicting Sudden Death and Guiding Ventricular Tachycardia Ablation

artículo científico publicado en 2017

In the Spotlight: Cardiovascular Engineering

scientific article published on 01 January 2008

In the spotlight: Cardiovascular engineering

artículo científico publicado en 2012

In the spotlight: cardiovascular engineering

artículo científico publicado en 2011

In the spotlight: cardiovascular engineering.

artículo científico publicado en 2010

Increased thin filament activation enhances alternans in human chronic atrial fibrillation

artículo científico publicado en 2018

Influence of LVAD function on mechanical unloading and electromechanical delay: a simulation study

artículo científico publicado en 2017

Initiation of a High-Frequency Jet Ventilation Strategy for Catheter Ablation for Atrial Fibrillation: Safety and Outcomes Data

scientific article published on 01 November 2018

Integrative computational models of cardiac arrhythmias -- simulating the structurally realistic heart.

artículo científico publicado en 2009

Intermittent drivers anchoring to structural heterogeneities as a major pathophysiological mechanism of human persistent atrial fibrillation.

artículo científico publicado en 2016

Light-based Approaches to Cardiac Arrhythmia Research: From Basic Science to Translational Applications

artículo científico publicado en 2016

Maintenance of ventricular fibrillation in heterogeneous ventricle

artículo científico publicado en 2006

Mapping of cardiac electrical activation with electromechanical wave imaging: an in silico-in vivo reciprocity study.

artículo científico publicado en 2010

Mathematical approaches to understanding and imaging atrial fibrillation: significance for mechanisms and management

artículo científico publicado en 2014

Mathematical simulations of ligand-gated and cell-type specific effects on the action potential of human atrium.

artículo científico publicado en 2008

Mechanisms Underlying Isovolumic Contraction and Ejection Peaks in Seismocardiogram Morphology.

artículo científico publicado en 2012

Mechanisms linking electrical alternans and clinical ventricular arrhythmia in human heart failure.

artículo científico publicado en 2016

Mechanisms of arrhythmogenesis related to calcium-driven alternans in a model of human atrial fibrillation.

artículo científico publicado en 2016

Mechanisms of human atrial fibrillation initiation: clinical and computational studies of repolarization restitution and activation latency.

artículo científico publicado en 2012

Mechanisms of mechanically induced spontaneous arrhythmias in acute regional ischemia.

artículo científico publicado en 2009

Mechanistic enquiry into the effect of increased pacing rate on the upper limit of vulnerability.

artículo científico publicado en 2006

Mechanistic insight into prolonged electromechanical delay in dyssynchronous heart failure: a computational study

scientific article published on 09 August 2013

Mechanistic investigation into the arrhythmogenic role of transmural heterogeneities in regional ischaemia phase 1A.

artículo científico publicado en 2007

Methodology for image-based reconstruction of ventricular geometry for patient-specific modeling of cardiac electrophysiology.

artículo científico publicado en 2014

Microdomain-Specific Modulation of L-Type Calcium Channels Leads to Triggered Ventricular Arrhythmia in Heart Failure.

artículo científico publicado en 2016

Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.

artículo científico publicado en 2011

Modeling the aging heart: from local respiratory defects to global rhythm disturbances.

artículo científico publicado en 2015

Modelling methodology of atrial fibrosis affects rotor dynamics and electrograms

artículo científico publicado en 2016

Models of cardiac electromechanics based on individual hearts imaging data: image-based electromechanical models of the heart

artículo científico publicado en 2010

Models of stretch-activated ventricular arrhythmias.

artículo científico publicado en 2010

Modulation of shock-end virtual electrode polarisation as a direct result of 3D fluorescent photon scattering.

artículo científico publicado en 2006

Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention

artículo científico publicado en 2016

Myocardial Infarct Segmentation From Magnetic Resonance Images for Personalized Modeling of Cardiac Electrophysiology

artículo científico publicado en 2015

Myocardial infarct segmentation and reconstruction from 2D late-gadolinium enhanced magnetic resonance images

scientific article published on 01 January 2014

Myocardial ischemia lowers precordial thump efficacy: an inquiry into mechanisms using three-dimensional simulations.

artículo científico publicado en 2006

Myofiber Architecture of the Human Atria as Revealed by Submillimeter Diffusion Tensor Imaging.

artículo científico publicado en 2016

Myofilament protein dynamics modulate EAD formation in human hypertrophic cardiomyopathy

artículo científico publicado en 2017

New insights into defibrillation of the heart from realistic simulation studies.

artículo científico publicado en 2014

New insights on the cardiac safety factor: Unraveling the relationship between conduction velocity and robustness of propagation

scientific article published on 22 January 2019

Opsin spectral sensitivity determines the effectiveness of optogenetic termination of ventricular fibrillation in the human heart: a simulation study.

artículo científico publicado en 2016

Optimal contrast-enhanced MRI image thresholding for accurate prediction of ventricular tachycardia using ex-vivo high resolution models

scientific article published on 03 October 2018

Optimizing cardiac resynchronization therapy to minimize ATP consumption heterogeneity throughout the left ventricle: a simulation analysis using a canine heart failure model.

artículo científico publicado en 2014

Optogenetic defibrillation terminates ventricular arrhythmia in mouse hearts and human simulations.

artículo científico publicado en 2016

Optogenetics-enabled assessment of viral gene and cell therapy for restoration of cardiac excitability.

artículo científico publicado en 2015

Optogenetics-enabled dynamic modulation of action potential duration in atrial tissue: feasibility of a novel therapeutic approach.

artículo científico publicado en 2014

Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern

artículo científico publicado en 2016

Personalized virtual-heart technology for guiding the ablation of infarct-related ventricular tachycardia

artículo científico publicado en 2018

Photon scattering effects in optical mapping of propagation and arrhythmogenesis in the heart

artículo científico publicado en 2007

Placement of implantable cardioverter-defibrillators in paediatric and congenital heart defect patients: a pipeline for model generation and simulation prediction of optimal configurations.

artículo científico publicado en 2013

Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.

artículo científico publicado en 2017

Precisely parameterized experimental and computational models of tissue organization

artículo científico publicado en 2016

Quantifying the uncertainty in model parameters using Gaussian process-based Markov chain Monte Carlo in cardiac electrophysiology

artículo científico publicado en 2018

Rate-dependent force, intracellular calcium, and action potential voltage alternans are modulated by sarcomere length and heart failure induced-remodeling of thin filament regulation in human heart failure: A myocyte modeling study.

artículo científico publicado en 2015

Reentry in survived subepicardium coupled to depolarized and inexcitable midmyocardium: insights into arrhythmogenesis in ischemia phase 1B

artículo científico publicado en 2008

Regional cooling facilitates termination of spiral-wave reentry through unpinning of rotors in rabbit hearts.

artículo científico publicado en 2011

Relationship Between Fibrosis Detected on Late Gadolinium-Enhanced Cardiac Magnetic Resonance and Re-Entrant Activity Assessed With Electrocardiographic Imaging in Human Persistent Atrial Fibrillation.

artículo científico publicado en 2017

Reversible cardiac conduction block and defibrillation with high-frequency electric field.

artículo científico publicado en 2011

Role of 3-Dimensional Architecture of Scar and Surviving Tissue in Ventricular Tachycardia: Insights From High-Resolution Ex Vivo Porcine Models

artículo científico publicado en 2018

Role of cellular uncoupling in arrhythmogenesis in ischemia phase 1B.

artículo científico publicado en 2006

See the light: can optogenetics restore healthy heartbeats? And, if it can, is it really worth the effort?

artículo científico

Sensitivity of reentrant driver localization to electrophysiological parameter variability in image-based computational models of persistent atrial fibrillation sustained by a fibrotic substrate.

artículo científico publicado en 2017

Sodium current reduction unmasks a structure-dependent substrate for arrhythmogenesis in the normal ventricles

artículo científico publicado en 2014

Spatially Adaptive Multi-Scale Optimization for Local Parameter Estimation in Cardiac Electrophysiology

artículo científico publicado en 2017

Submillimeter diffusion tensor imaging and late gadolinium enhancement cardiovascular magnetic resonance of chronic myocardial infarction

scientific article published on 11 January 2017

Susceptibility to arrhythmia in the infarcted heart depends on myofibroblast density.

artículo científico publicado en 2011

Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.

artículo científico publicado en 2008

Tachycardia in post-infarction hearts: insights from 3D image-based ventricular models.

artículo científico publicado en 2013

Terminating ventricular tachyarrhythmias using far-field low-voltage stimuli: mechanisms and delivery protocols

artículo científico publicado en 2013

Termination of re-entrant atrial tachycardia via optogenetic stimulation with optimized spatial targeting: insights from computational models

artículo científico publicado en 2017

The Fibrotic Substrate in Persistent Atrial Fibrillation Patients: Comparison Between Predictions From Computational Modeling and Measurements From Focal Impulse and Rotor Mapping

scientific article published on 29 August 2018

The role of fibroblasts in complex fractionated electrograms during persistent/permanent atrial fibrillation: implications for electrogram-based catheter ablation.

artículo científico publicado en 2011

The role of mechanoelectric feedback in vulnerability to electric shock.

artículo científico publicado en 2008

The role of personalized atrial modeling in understanding atrial fibrillation mechanisms and improving treatment

scientific article published on 31 January 2019

Three-dimensional mechanisms of increased vulnerability to electric shocks in myocardial infarction: altered virtual electrode polarizations and conduction delay in the peri-infarct zone.

artículo científico publicado en 2012

Towards personalized computational modelling of the fibrotic substrate for atrial arrhythmia.

artículo científico publicado en 2016

Transmural electrophysiological heterogeneities in action potential duration increase the upper limit of vulnerability

artículo científico publicado en 2006

Tropomyosin dynamics during cardiac muscle contraction as governed by a multi-well energy landscape

artículo científico publicado en 2018

Tunnel propagation of postshock activations as a hypothesis for fibrillation induction and isoelectric window.

artículo científico publicado en 2008

Universal atrial coordinates applied to visualisation, registration and construction of patient specific meshes.

artículo científico publicado en 2019

Unstable QT interval dynamics precedes ventricular tachycardia onset in patients with acute myocardial infarction: a novel approach to detect instability in QT interval dynamics from clinical ECG.

artículo científico publicado en 2011

Using personalized computer models to custom-tailor ablation procedures for atrial fibrillation patients: are we there yet?

artículo científico publicado en 2017

Verification of cardiac mechanics software: benchmark problems and solutions for testing active and passive material behaviour ⬇️

artículo científico publicado en 2015

Virtual 3D heart models to aid pacemaker implantation in children.

artículo científico publicado en 2014

Virtual electrophysiological study as a tool for evaluating efficacy of MRI techniques in predicting adverse arrhythmic events in ischemic patients

artículo científico publicado en 2018

Virtual electrophysiological study of atrial fibrillation in fibrotic remodeling

artículo científico publicado en 2015

Vulnerability to electric shocks in the regionally-ischemic ventricles

article

β-adrenergic stimulation augments transmural dispersion of repolarization via modulation of delayed rectifier currents IKs and IKr in the human ventricle

artículo científico publicado en 2017

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