Lista de obras - Francesco Leonetti - Dominio Público Uruguay

1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships

artículo científico publicado en 2008

2-D and 3-D modeling of imidazoline receptor ligands: insights into pharmacophore

scientific article published on 01 May 1997

An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors

artículo científico publicado en 2008

Attenuation of autoimmune disease in Fas-deficient mice by treatment with a cytotoxic benzodiazepine.

artículo científico publicado en 2003

BCR-ABL Inhibitors in Chronic Myeloid Leukemia: Process Chemistry and Biochemical Profile ⬇️

artículo científico publicado el 1 de enero de 2011

Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to

artículo científico publicado en 2020

Binding of Tracizolines to the Imidazoline Receptor: Role of Lipophilicity in Quantitative Structure-Activity Relationship Modelsa

artículo científico publicado en 1999

Computational methods for the design of potent aromatase inhibitors

artículo científico publicado en 2013

Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.

artículo científico publicado en 2001

Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9

article by Orazio Nicolotti et al published December 2012 in European Journal of Medicinal Chemistry

Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase

artículo científico publicado en 2012

Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors.

artículo científico publicado en 2004

Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors

artículo científico publicado en 2010

Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase

artículo científico publicado en 2011

Discovery of a Novel Class of Potent Coumarin Monoamine Oxidase B Inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one Methanesulfonate (NW-1772) as a Highly Potent, Selective, R

article

Discovery of a Potent and Selective Hetero-Bivalent AChE Inhibitor via Bioisosteric Replacement

scholarly article by Orazio Nicolotti et al published 14 March 2011 in Molecular Informatics

Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase

scholarly article by Angela Stefanachi et al published January 2015 in European Journal of Medicinal Chemistry

Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.

artículo científico publicado en 2002

Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways

artículo científico publicado en 2015

Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors

artículo científico publicado en 2008

Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity

artículo científico publicado en 2011

Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs

scientific article published on 01 December 2000

Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations

artículo científico publicado en 2011

Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides.

artículo científico publicado en 2017

Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models.

artículo científico publicado en 1998

Local boundedness for solutions of a class of nonlinear elliptic systems

artículo científico publicado en 2022

Multitarget-directed tricyclic pyridazinones as G protein-coupled receptor ligands and cholinesterase inhibitors

artículo científico publicado en 2015

No Lavrentiev gap for some double phase integrals

artículo científico publicado en 2022

Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein

artículo científico publicado en 2011

Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

artículo científico publicado en 2000

Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model

artículo científico publicado en 2010

Screening of matrix metalloproteinases available from the protein data bank: insights into biological functions, domain organization, and zinc binding groups

artículo científico publicado en 2007

Solid phase synthesis of a molecular library of pyrimidines, pyrazoles, and isoxazoles with biological potential

article published in 2010

Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase

artículo científico publicado en 2007

Strategies of multi-objective optimization in drug discovery and development

artículo científico publicado en 2011

Structural insights into monoamine oxidase inhibitory potency and selectivity of 7-substituted coumarins from ligand- and target-based approaches

artículo científico publicado en 2006

Structure activity studies of a novel cytotoxic benzodiazepine.

artículo científico publicado en 2003

Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities

artículo científico publicado en 2006

Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams

Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding

artículo científico publicado en 2014

Lista de obras de Francesco Leonetti

1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships

2-D and 3-D modeling of imidazoline receptor ligands: insights into pharmacophore

An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors

Attenuation of autoimmune disease in Fas-deficient mice by treatment with a cytotoxic benzodiazepine.

BCR-ABL Inhibitors in Chronic Myeloid Leukemia: Process Chemistry and Biochemical Profile ⬇️

Bcr-Abl Allosteric Inhibitors: Where We Are and Where We Are Going to

Binding of Tracizolines to the Imidazoline Receptor: Role of Lipophilicity in Quantitative Structure-Activity Relationship Modelsa

Computational methods for the design of potent aromatase inhibitors

Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.

Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9

Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase

Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors.

Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors

Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase

Discovery of a Novel Class of Potent Coumarin Monoamine Oxidase B Inhibitors: Development and Biopharmacological Profiling of 7-[(3-Chlorobenzyl)oxy]-4-[(methylamino)methyl]-2H-chromen-2-one Methanesulfonate (NW-1772) as a Highly Potent, Selective, R

Discovery of a Potent and Selective Hetero-Bivalent AChE Inhibitor via Bioisosteric Replacement

Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4′-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase

Expedient solid-phase synthesis of fluorogenic protease substrates using the 7-amino-4-carbamoylmethylcoumarin (ACC) fluorophore.

Galloyl benzamide-based compounds modulating tumour necrosis factor α-stimulated c-Jun N-terminal kinase and p38 mitogen-activated protein kinase signalling pathways

Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors

Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity

Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs

Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations

Investigating Structural Requirements for the Antiproliferative Activity of Biphenyl Nicotinamides.

Ligand binding to I2 imidazoline receptor: the role of lipophilicity in quantitative structure-activity relationship models.

Local boundedness for solutions of a class of nonlinear elliptic systems

Multitarget-directed tricyclic pyridazinones as G protein-coupled receptor ligands and cholinesterase inhibitors

No Lavrentiev gap for some double phase integrals

Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein

Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

Screening of benzamidine-based thrombin inhibitors via a linear interaction energy in continuum electrostatics model

Screening of matrix metalloproteinases available from the protein data bank: insights into biological functions, domain organization, and zinc binding groups

Solid phase synthesis of a molecular library of pyrimidines, pyrazoles, and isoxazoles with biological potential

Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase

Strategies of multi-objective optimization in drug discovery and development

Structural insights into monoamine oxidase inhibitory potency and selectivity of 7-substituted coumarins from ligand- and target-based approaches

Structure activity studies of a novel cytotoxic benzodiazepine.

Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities

Toward a fragment-based approach to MMPs inhibitors: an expedite and efficient synthesis of N-hydroxylactams

Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding