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Lista de obras de Fiona Watt

(More) women in science

scholarly article by Fiona Watt published in March 2018

2009 winner: Ravi Desai

artículo científico publicado en 2010

?1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum

scholarly article by Wai Jing Kee published in July 2000

A Novel Automated High-Content Analysis Workflow Capturing Cell Population Dynamics from Induced Pluripotent Stem Cell Live Imaging Data

artículo científico publicado en 2016

A blueprint for translational regenerative medicine

scientific article published on 01 December 2020

A central role for alpha beta T cells in the pathogenesis of murine lupus

scientific article published on 01 June 1999

A crucial role of beta 1 integrins for keratinocyte migration in vitro and during cutaneous wound repair

artículo científico publicado en 2002

A framework for advancing our understanding of cancer-associated fibroblasts

scientific article published on 24 January 2020

A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells

artículo científico publicado en 2017

A high-content platform to characterise human induced pluripotent stem cell lines

artículo científico publicado en 2015

A model for in vitro studies of epidermal homeostasis: proliferation and involucrin synthesis by cultured human keratinocytes during recovery after stripping off the suprabasal layers

artículo científico publicado en 1988

A new technology for revealing the flow profile in integrated lab-on-a-chip

artículo científico publicado en 2012

A protein phosphatase network controls temporal and spatial dynamics of differentiation commitment in human epidermis

A protein phosphatase network controls the temporal and spatial dynamics of differentiation commitment in human epidermis

artículo científico publicado en 2017

A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis

artículo científico publicado en 2001

A stem cell gene expression profile of human squamous cell carcinomas

artículo científico publicado en 2008

A tumor-associated beta 1 integrin mutation that abrogates epithelial differentiation control

artículo científico publicado en 2003

A year in the life of eLife ⬇️

artículo científico publicado el 15 de octubre de 2013

Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis

artículo científico publicado en 1992

Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions

artículo científico publicado en 2010

Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.

artículo científico publicado en 2007

Adhesion of human epidermal keratinocytes to laminin

artículo científico publicado en 1994

Adult epidermal Notch activity induces dermal accumulation of T cells and neural crest derivatives through upregulation of jagged 1

artículo científico publicado en 2010

Advancing research

artículo científico publicado en 2014

Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure

artículo científico publicado en 2016

Altered expression of CD44 isoforms in squamous-cell carcinomas and cell lines derived from them

artículo científico publicado en 1996

An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

artículo científico publicado en 2022

An activating beta1 integrin mutation increases the conversion of benign to malignant skin tumors.

artículo científico publicado en 2009

An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis.

artículo científico publicado en 2018

An unusual strain of human keratinocytes which do not stratify or undergo terminal differentiation in culture

artículo científico publicado en 1988

Analysis of cultured keratinocytes from a transgenic mouse model of psoriasis: effects of suprabasal integrin expression on keratinocyte adhesion, proliferation and terminal differentiation

artículo científico publicado en 1999

Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis

artículo científico publicado en 1997

Apoptosis in mesenchymal stromal cells induces in vivo recipient-mediated immunomodulation.

artículo científico publicado en 2017

Assaying proliferation and differentiation capacity of stem cells using disaggregated adult mouse epidermis

Asymmetric stem-cell divisions define the architecture of human oesophageal epithelium

artículo científico publicado en 2000

Autoantibodies to posttranslationally modified type II collagen as potential biomarkers for rheumatoid arthritis

artículo científico publicado en 2013

Autophagy mediates the mitotic senescence transition

artículo científico publicado en 2009

BLIMP1 is required for postnatal epidermal homeostasis but does not define a sebaceous gland progenitor under steady-state conditions

artículo científico publicado en 2014

Balancing work and life: a conversation with Fiona Watt. Interview by Majlinda Lako and Susan Daher

artículo científico publicado en 2009

Bench to bedside: Current advances in regenerative medicine

artículo científico publicado en 2018

Best Paper Award 2003.

artículo científico publicado en 2004

Beta-catenin and Hedgehog signal strength can specify number and location of hair follicles in adult epidermis without recruitment of bulge stem cells

artículo científico publicado en 2005

Biochemical specificity of Xenopus notochord

artículo científico publicado en 1985

Biosynthesis of EGF receptor, transferrin receptor and colligin by cultured human keratinocytes and the effect of retinoic acid

artículo científico publicado en 1985

CD44 is the major peanut lectin-binding glycoprotein of human epidermal keratinocytes and plays a role in intercellular adhesion

artículo científico publicado en 1995

CIRM and UKRMP: Different Ways to Invest in Regenerative Medicine.

artículo científico publicado en 2016

Calcium-induced changes in cytoskeleton and motility of cultured human keratinocytes

artículo científico publicado en 1987

Calcium-induced changes in distribution and solubility of cadherins, integrins and their associated cytoplasmic proteins in human keratinocytes.

artículo científico publicado en 1995

Calcium-induced intercellular adhesion of keratinocytes does not involve accumulation of beta 1 integrins at cell-cell contacts and does not involve changes in the levels or phosphorylation of catenins

artículo científico publicado en 1998

Calcium-induced reorganization of desmosomal components in cultured human keratinocytes

artículo científico publicado en 1984

Carboxylate microsphere-induced cellular toxicity in human lung fibroblasts

article

Cell Biology of Tissues and Tumors ⬇️

artículo científico publicado el 15 de noviembre de 2010

Cell adhesion. Fibronectin and integrin knockouts come unstuck

artículo científico publicado en 1994

Cell culture models of differentiation

artículo científico publicado en 1991

Cell shape controls terminal differentiation of human epidermal keratinocytes

artículo científico publicado en 1988

Cell-extracellular matrix interactions in normal and diseased skin

scientific article published on April 2011

Changes in cell-surface carbohydrate during terminal differentiation of human epidermal keratinocytes

artículo científico publicado en 1992

Changes in expression of members of the fos and jun families and myc network during terminal differentiation of human keratinocytes

artículo científico publicado en 1995

Changes in keratinocyte adhesion during terminal differentiation: reduction in fibronectin binding precedes alpha 5 beta 1 integrin loss from the cell surface

artículo científico publicado en 1990

Changes in the abundance and distribution of actin and associated proteins during terminal differentiation of human epidermal keratinocytes.

artículo científico publicado en 1991

Changes in the distribution of actin-associated proteins during epidermal wound healing

artículo científico publicado en 1993

Changes in the expression of alpha v integrins in oral squamous cell carcinomas

artículo científico publicado en 1997

Changes in type I keratin expression associated with HPV16 transformation of human epidermal keratinocytes

artículo científico publicado en 1992

Characterisation of eight monoclonal antibodies to involucrin

artículo científico publicado en 1992

Characterisation of the peanut lectin-binding glycoproteins of human epidermal keratinocytes

artículo científico publicado en 1990

Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin

artículo científico publicado en 2008

Chromosomal localisation of the human envoplakin gene (EVPL) to the region of the tylosis oesophageal cancer gene (TOCG) on 17q25.

artículo científico publicado en 1996

Clinically-relevant vulnerabilities of deep machine learning systems for skin cancer diagnosis

scientific article published on 12 September 2020

Clonal growth of dermal papilla cells in hydrogels reveals intrinsic differences between Sox2-positive and -negative cells in vitro and in vivo

artículo científico publicado en 2011

Common genetic variation drives molecular heterogeneity in human iPSCs

artículo científico publicado en 2017

Common genetic variation drives molecular heterogeneity in human iPSCs

Comparison of integrin expression and terminal differentiation capacity in cell lines derived from oral squamous cell carcinomas

artículo científico publicado en 1993

Comparison of integrin, cadherin, and catenin expression in squamous cell carcinomas of the oral cavity

artículo científico publicado en 1998

Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

artículo científico publicado en 2016

Contribution of GATA6 to homeostasis of the human upper pilosebaceous unit and acne pathogenesis

artículo científico publicado en 2020

Contribution of stem cells and differentiated cells to epidermal tumours

artículo científico publicado en 2003

Correction: Rac1 Deletion Causes Thymic Atrophy.

artículo científico publicado en 2011

Correlation between hyperproliferation and suprabasal integrin expression in human epidermis reconstituted in culture

artículo científico publicado en 1997

Corrigendum: Common genetic variation drives molecular heterogeneity in human iPSCs

artículo científico publicado en 2017

Cutting edge: amelioration of kidney disease in a transgenic mouse model of lupus nephritis by administration of the caspase inhibitor carbobenzoxy-valyl-alanyl-aspartyl-(beta-o-methyl)-fluoromethylketone

artículo científico publicado en 2001

DNA amplification is rare in normal human cells

scientific article published on March 1990

Decoupling geometrical and chemical cues directing epidermal stem cell fate on polymer brush-based cell micro-patterns.

artículo científico publicado en 2013

Decreased expression of fibronectin and the alpha 5 beta 1 integrin during terminal differentiation of human keratinocytes

artículo científico publicado en 1991

Defining Adult Stem Cells by Function, Not by Phenotype.

artículo científico publicado en 2018

Defining dermal adipose tissue

artículo científico publicado en 2014

Delta regulates keratinocyte spreading and motility independently of differentiation

artículo científico publicado en 2001

Delta-like 1-mediated cis-inhibition of Jagged1/2 signalling inhibits differentiation of human epidermal cells in culture

artículo científico publicado en 2019

Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth

artículo científico publicado en 2017

Dermal fibroblast-derived growth factors restore the ability of beta(1) integrin-deficient embryonal stem cells to differentiate into keratinocytes.

artículo científico publicado en 2001

Designer skin: lineage commitment in postnatal epidermis

artículo científico publicado en 2002

Different consequences of beta1 integrin deletion in neonatal and adult mouse epidermis reveal a context-dependent role of integrins in regulating proliferation, differentiation, and intercellular communication

artículo científico publicado en 2005

Differential sensitivity of epidermal cell subpopulations to beta-catenin-induced ectopic hair follicle formation

artículo científico publicado en 2010

Differentiation of Embryonal Stem Cells into Keratinocytes: Comparison of Wild-Type and β1Integrin-Deficient Cells

article by Claudia Bagutti et al published October 1996 in Developmental Biology

Distinct fibroblast lineages determine dermal architecture in skin development and repair.

artículo científico publicado en 2013

Diverse epigenetic strategies interact to control epidermal differentiation

artículo científico publicado en 2012

Diverse mechanisms for endogenous regeneration and repair in mammalian organs

artículo científico publicado en 2018

Dose and context dependent effects of Myc on epidermal stem cell proliferation and differentiation

artículo científico publicado en 2010

Downregulation of keratin 76 expression during oral carcinogenesis of human, hamster and mouse.

artículo científico publicado en 2013

Dual role of inactivating Lef1 mutations in epidermis: tumor promotion and specification of tumor type

artículo científico publicado en 2007

Dynamic culture substrates that mimic the topography of the epidermal-dermal junction

article

Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for beta-catenin and Notch signalling

artículo científico publicado en 2008

ERK MAPK activation bursts and propagation in adult and embryonic mouse skin

Effect of growth environment on spatial expression of involucrin by human epidermal keratinocytes

artículo científico publicado en 1987

Efficient differentiation of embryonic stem cells into mesodermal precursors by BMP, retinoic acid and Notch signalling

artículo científico publicado en 2012

Elaine Fuchs

artículo científico publicado en 2004

Employing core regulatory circuits to define cell identity

Engineered Microenvironments to Direct Epidermal Stem Cell Behavior at Single-Cell Resolution

artículo científico publicado en 2016

Envoplakin and Periplakin are Components of the Paraneoplastic Pemphigus Antigen Complex

scientific article published on 01 December 1998

Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin

artículo científico publicado en 1996

Envoplakin, a possible candidate gene for focal NEPPK/esophageal cancer (TOC): the integration of genetic and physical maps of the TOC region on 17q25.

artículo científico publicado en 1999

Epidermal Cadm1 Expression Promotes Autoimmune Alopecia via Enhanced T Cell Adhesion and Cytotoxicity

artículo científico publicado en 2011

Epidermal Deletion of Rac1 Causes Stem Cell Depletion, Irrespective of whether Deletion Occurs during Embryogenesis or Adulthood

Epidermal Notch signalling: differentiation, cancer and adhesion

artículo científico publicado en 2008

Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells

Epidermal Wnt signalling regulates transcriptome heterogeneity and proliferative fate in neighbouring cells.

artículo científico publicado en 2018

Epidermal Wnt/β-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors

artículo científico publicado en 2014

Epidermal barrier defects link atopic dermatitis with altered skin cancer susceptibility

artículo científico publicado en 2014

Epidermal label-retaining cells: background and recent applications

artículo científico publicado en 2004

Epidermal stem cell diversity and quiescence

artículo científico publicado en 2009

Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation

artículo científico publicado en 2007

Epidermal stem cells are retained in vivo throughout skin aging ⬇️

artículo científico publicado en 2008

Epidermal stem cells as targets for gene transfer

artículo científico publicado en 2000

Epidermal stem cells in culture

artículo científico publicado en 1988

Epidermal stem cells: an update

artículo científico publicado en 2006

Epidermal stem cells: markers, patterning and the control of stem cell fate ⬇️

artículo científico publicado el 29 de junio de 1998

Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages

artículo científico publicado en 2016

Epithelial cell differentiation pathways in the human prostate: identification of intermediate phenotypes by keratin expression

artículo científico publicado en 2001

Epithelial stem cells, wound healing and cancer ⬇️

artículo científico publicado el 24 de febrero de 2012

Erratum: Extracellular-matrix tethering regulates stem-cell fate

artículo científico publicado en 2012

Erratum: MYC in mammalian epidermis: how can an oncogene stimulate differentiation? (Erratum)

scholarly article published in Nature Reviews Cancer

Evidence against a major role for integrins in calcium-dependent intercellular adhesion of epidermal keratinocytes

article

Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment

artículo científico publicado en 2003

Evidence that apoptosis and terminal differentiation of epidermal keratinocytes are distinct processes

article

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation

artículo científico publicado en 1994

Exons 5-15 of kazrin are dispensable for murine epidermal morphogenesis and homeostasis

artículo científico publicado en 2012

Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale

artículo científico publicado en 2010

Expression and function of the keratinocyte integrins

scientific article published on 01 January 1993

Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

Expression of E-cadherin, P-cadherin and involucrin by normal and neoplastic keratinocytes in culture

artículo científico publicado en 1991

Expression of Notch pathway genes in mammalian epidermis and modulation by β-Catenin

article

Expression of a Chimeric Antigen Receptor Specific for Donor HLA Class I Enhances the Potency of Human Regulatory T Cells in Preventing Human Skin Transplant Rejection.

artículo científico publicado en 2016

Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions

artículo científico publicado en 2004

Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes

artículo científico publicado en 2000

Extracellular-matrix tethering regulates stem-cell fate

artículo científico publicado en 2012

FRMD4A upregulation in human squamous cell carcinoma promotes tumor growth and metastasis and is associated with poor prognosis

artículo científico publicado en 2012

Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation

artículo científico publicado en 2015

Fibroblast heterogeneity: implications for human disease

artículo científico publicado en 2018

Fibroblast state switching orchestrates dermal maturation and wound healing

artículo científico publicado en 2018

Fibroblast state switching orchestrates dermal maturation and wound healing

Fibronectin inhibits the terminal differentiation of human keratinocytes

artículo científico publicado en 1989

Fibrotic enzymes modulate wound-induced skin tumorigenesis

artículo científico publicado en 2021

Fiona Watt

artículo científico publicado en 2003

Fran Balkwill

artículo científico publicado en 2005

Functional down-regulation of alpha 5 beta 1 integrin in keratinocytes is reversible but commitment to terminal differentiation is not.

artículo científico publicado en 1993

Functional significance of CD9 association with beta 1 integrins in human epidermal keratinocytes

artículo científico publicado en 1996

Galectin-6 is a novel skin anti-microbial peptide that is modulated by the skin barrier and microbiome

artículo científico publicado en 2016

Gene targeting of envoplakin, a cytoskeletal linker protein and precursor of the epidermal cornified envelope

artículo científico publicado en 2001

Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02

artículo científico publicado en 2019

Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes

artículo científico publicado en 2013

Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer

artículo científico publicado en 2009

Genomic landscape and clonal architecture of mouse oral squamous cell carcinomas dictate tumour ecology

artículo científico publicado en 2020

HAN11 binds mDia1 and controls GLI1 transcriptional activity

artículo científico publicado en 2006

Hair Follicle Epidermal Stem Cells Define a Niche for Tactile Sensation

Hair follicle dermal papilla cells at a glance

artículo científico publicado en 2011

Hair follicle epidermal stem cells define a niche for tactile sensation

artículo científico publicado en 2018

Heterogeneity within Stratified Epithelial Stem Cell Populations Maintains the Oral Mucosa in Response to Physiological Stress

scientific article published on 01 December 2019

Heterogeneous expression of keratin, involucrin, and extracellular matrix among subpopulations of a poorly differentiated human cervical carcinoma: possible relationships to patterns of invasion

artículo científico publicado en 1989

High-throughput micro-patterning platform reveals Nodal-dependent dissection of peri-gastrulation-associated versus pre-neurulation associated fate patterning

High-throughput micropatterning platform reveals Nodal-dependent bisection of peri-gastrulation-associated versus preneurulation-associated fate patterning

scientific article published on 21 October 2019

High-throughput stem-cell niches

Homeostasis, regeneration and tumour formation in the mammalian epidermis

Human Skin Aging Is Associated with Reduced Expression of the Stem Cell Markers β1 Integrin and MCSP

Human epidermal stem cell differentiation is modulated by specific lipid subspecies

scientific article published on 25 August 2020

Human sebaceous tumors harbor inactivating mutations in LEF1.

artículo científico publicado en 2006

IMMUNOMODULATORY ROLE OF KERATIN 76 IN ORAL AND GASTRIC CANCER

scholarly article published 21 April 2018

Identification of Novel Keratinocyte Differentiation Modulating Compounds by High-Throughput Screening

Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs

artículo científico publicado en 2005

Identification of an 80kD protein associated with the alpha 3 beta 1 integrin as a proteolytic fragment of the alpha 3 subunit: studies with human keratinocytes

artículo científico publicado en 1995

Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse

scientific journal article

Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors

Identifying extrinsic versus intrinsic drivers of variation in cell behaviour in human iPS cell lines from healthy donors

Immunoelectron microscopic analysis of cornified cell envelope formation in normal and psoriatic epidermis

article

Immunolocalization of keratan sulphate in the human embryonic cornea and other human foetal organs

artículo científico publicado en 1986

Immunomodulatory role of Keratin 76 in oral and gastric cancer

scientific article published in Nature Communications

Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility

artículo científico publicado en 2016

Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis

artículo científico publicado en 2003

Influence of beta1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: alpha3beta1, but not alpha2beta1, suppresses malignant conversion

artículo científico publicado en 2001

Influence of cell shape and adhesiveness on stratification and terminal differentiation of human keratinocytes in culture

artículo científico publicado en 1987

Influence of cytochalasin d-induced changes in cell shape on proteoglycan synthesis by cultured articular chondrocytes

artículo científico publicado en 1988

Inhibition of β-catenin signalling in dermal fibroblasts enhances hair follicle regeneration during wound healing

artículo científico publicado en 2016

Innate sensing of microbial products promotes wound-induced skin cancer

artículo científico publicado en 2015

Integrative genomic and functional analysis of human oral squamous cell carcinoma cell lines reveals synergistic effects of FAT1 and CASP8 inactivation

scientific article published on 28 September 2016

Integrin expression and function in HPV 16-immortalised human keratinocytes in the presence or absence of v-Ha-ras. Comparison with cervical intraepithelial neoplasia

artículo científico publicado en 1994

Integrin expression by human epidermal keratinocytes can be modulated by interferon-gamma, transforming growth factor-beta, tumor necrosis factor-alpha, and culture on a dermal equivalent

artículo científico publicado en 1995

Integrin expression during human epidermal development in vivo and in vitro

artículo científico publicado en 1991

Integrin expression in normal, hyperplastic, dysplastic, and malignant oral epithelium

artículo científico publicado en 1993

Integrin special issue

artículo científico publicado en 2009

Interaction of periplakin and envoplakin with intermediate filaments

artículo científico publicado en 2002

Involucrin and Other Markers of Keratinocyte Terminal Differentiation ⬇️

artículo científico publicado el 1 de julio de 1983

Involucrin synthesis is correlated with cell size in human epidermal cultures

artículo científico publicado en 1981

JCS Prize. 2006 winner: Satomi Matsuoka.

artículo científico publicado en 2007

JCS in 2010 - Ringing in the Changes

scientific article published on 01 January 2010

Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis

artículo científico

Julia Polak

artículo científico publicado en 2004

Kalinin, epiligrin and GB3 antigen: kalinepiligrinin-3?

artículo científico publicado en 1992

Kazrin regulates keratinocyte cytoskeletal networks, intercellular junctions and differentiation

scientific article published on 07 October 2008

Kazrin, a novel periplakin-interacting protein associated with desmosomes and the keratinocyte plasma membrane

artículo científico publicado en 2004

KazrinA is required for axial elongation and epidermal integrity in Xenopus tropicalis

artículo científico publicado en 2008

KazrinE is a desmosome-associated liprin that colocalises with acetylated microtubules

artículo científico publicado en 2009

Keratinocyte culture club

artículo científico publicado en 1982

Keratinocyte cultures: an experimental model for studying how proliferation and terminal differentiation are co-ordinated in the epidermis

article

Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway

artículo científico publicado en 2003

LRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development.

artículo científico publicado en 2013

Lack of intrinsic polarity in the ligand-binding ability of keratinocyte beta1 integrins

artículo científico publicado en 1998

Lack of keratan sulphate in the human notochord

artículo científico publicado en 1988

Launching eLife, Part 1 ⬇️

artículo científico publicado el 15 de octubre de 2012

Launching eLife, Part 2.

artículo científico publicado en 2012

Lineage Tracing ⬇️

artículo científico publicado el 20 de enero de 2012

Loss of alpha 6 and beta 4 integrin subunits coincides with loss of basement membrane components in oral squamous cell carcinomas

artículo científico publicado en 1993

Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.

artículo científico publicado en 2018

Lrig1 controls intestinal stem-cell homeostasis by negative regulation of ErbB signalling

artículo científico publicado en 2012

Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis

artículo científico publicado en 2009

Lrig1 marks a population of gastric epithelial cells capable of long-term tissue maintenance and growth in vitro

artículo científico publicado en 2018

MYC in mammalian epidermis: how can an oncogene stimulate differentiation?

artículo científico publicado en 2008

Macrophage Infiltration and Alternative Activation during Wound Healing Promote MEK1-Induced Skin Carcinogenesis

artículo científico publicado en 2016

Mammalian skin cell biology: at the interface between laboratory and clinic

artículo científico publicado en 2014

Manipulation of stem cell proliferation and lineage commitment: visualisation of label-retaining cells in wholemounts of mouse epidermis

artículo científico publicado en 2003

Map clusters of diseases to tackle multimorbidity

artículo científico publicado en 2020

Markers of epidermal stem cell subpopulations in adult mammalian skin

artículo científico publicado en 2014

Measurement of the rate of epidermal terminal differentiation: expression of involucrin by S-phase keratinocytes in culture and in psoriatic plaques

artículo científico publicado en 1987

Mechanisms, Hallmarks, and Implications of Stem Cell Quiescence

artículo científico publicado en 2019

Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier

artículo científico publicado en 2007

Micro-scaled topographies direct differentiation of human epidermal stem cells

artículo científico publicado en 2018

Microtubule organizing centres in cells in culture and in hybrids derived from them

DPhil Thesis of Fiona Watt

Microtubule-organizing centres in binucleate cells and homosynkaryons

artículo científico publicado en 1980

Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis

artículo científico publicado en 2012

Mimicking the topography of the epidermal-dermal interface with elastomer substrates.

artículo científico publicado en 2015

Mitogens induce calcium transients in both dividing and terminally differentiating keratinocytes ⬇️

artículo científico publicado el 1 de junio de 1991

Modulating the stem cell niche for tissue regeneration

artículo científico publicado en 2014

Monodisperse collagen-gelatin beads as potential platforms for 3D cell culturing

scientific article published on 29 August 2013

Mutant Lef1 controls Gata6 in sebaceous gland development and cancer

scientific article published on 18 March 2019

Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1

artículo científico publicado en 2006

Myosin 10 is involved in murine pigmentation.

artículo científico publicado en 2018

NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis

artículo científico publicado en 2019

Nanog maintains pluripotency of mouse embryonic stem cells by inhibiting NFkappaB and cooperating with Stat3.

artículo científico publicado en 2008

Necl2 regulates epidermal adhesion and wound repair

scientific article published on October 2009

New roles for integrins in squamous-cell carcinoma

artículo científico publicado en 2006

Non-profit publishing: open access and the end of copyright transfer

artículo científico publicado en 2004

Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen.

artículo científico publicado en 2014

Onset of expression of peanut lectin-binding glycoproteins is correlated with stratification of keratinocytes during human epidermal development in vivo and in vitro

artículo científico publicado en 1989

Optimised retroviral infection of human epidermal keratinocytes: long-term expression of transduced integrin gene following grafting on to SCID mice

artículo científico publicado en 1998

Out of Eden: stem cells and their niches

artículo científico publicado en 2000

PA-FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation

artículo científico publicado en 2000

PI3-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation

artículo científico publicado en 2009

Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial ⬇️

artículo científico publicado en 2015

Paraneoplastic Pemphigus Sera React Strongly with Multiple Epitopes on the Various Regions of Envoplakin and Periplakin, Except for the C-Terminal Homologous Domain of Periplakin

article published in 2001

Patterning of human epidermal stem cells on undulating elastomer substrates reflects differences in cell stiffness

artículo científico publicado en 2019

Patterns of junctional communication in animal tissues

scientific article published on 01 January 1987

Patterns of junctional communication in skin: studies on cultured keratinocytes

artículo científico publicado en 1987

Pelota Regulates Epidermal Differentiation by Modulating BMP and PI3K/AKT Signaling Pathways

artículo científico publicado en 2016

Pentapeptide inhibitor of epidermal mitosis: production and responsiveness in cultures of normal, transformed and neoplastic human keratinocytes

artículo científico publicado en 1989

Poised cell circuits in human skin are activated in disease ⬇️

artículo científico publicado en 2020

Polyclonal origin and hair induction ability of dermal papillae in neonatal and adult mouse back skin

artículo científico publicado en 2012

Production of scatter factor by ndk, a strain of epithelial cells, and inhibition of scatter factor activity by suramin

artículo científico publicado en 1991

Professor Sir Henry Harris (1925-2014).

artículo científico publicado en 2015

Proliferation and terminal differentiation of human epidermal keratinocytes in culture

article

Proliferative heterogeneity in the human prostate: evidence for epithelial stem cells

artículo científico publicado en 2000

Prolonged expression of differentiated phenotype by chondrocytes cultured at low density on a composite substrate of collagen and agarose that restricts cell spreading

artículo científico publicado en 1988

Rac1 deletion causes thymic atrophy

artículo científico publicado en 2011

Recognizing the importance of new tools and resources for research

artículo científico publicado en 2015

Regulation by vitamin A of envelope cross-linking in cultured keratinocytes derived from different human epithelia

artículo científico publicado en 1982

Regulation of ERK basal and pulsatile activity control proliferation and exit from the stem cell compartment in mammalian epidermis

scientific article published on 10 July 2020

Regulation of cell surface beta 1 integrin levels during keratinocyte terminal differentiation

artículo científico publicado en 1995

Regulation of development and differentiation by the extracellular matrix

artículo científico publicado en 1993

Regulation of interleukin-1alpha expression by integrins and epidermal growth factor receptor in keratinocytes from a mouse model of inflammatory skin disease

artículo científico publicado en 2003

Regulation of keratinocyte shape, migration and wound epithelialization by IGF-1- and EGF-dependent signalling pathways

artículo científico publicado en 2003

Regulation of keratinocyte terminal differentiation by integrin-extracellular matrix interactions

artículo científico publicado en 1993

Repeal and Replace: Adipocyte Regeneration in Wound Repair

artículo científico publicado en 2017

Reply to Chi et al.

artículo científico publicado en 2016

Reprogramming adult dermis to a neonatal state through epidermal activation of β-catenin

artículo científico publicado en 2011

Restoration of alpha v beta 5 integrin expression in neoplastic keratinocytes results in increased capacity for terminal differentiation and suppression of anchorage-independent growth.

artículo científico publicado en 1996

Rewiring of an epithelial differentiation factor, miR-203, to inhibit human squamous cell carcinoma metastasis

artículo científico publicado en 2014

Role of LIM kinases in normal and psoriatic human epidermis

artículo científico publicado en 2006

Role of beta-catenin in epidermal stem cell expansion, lineage selection, and cancer

artículo científico publicado en 2008

Role of integrins in mouse eyelid development: studies in normal embryos and embryos in which there is a failure of eyelid fusion

article

Role of integrins in regulating epidermal adhesion, growth and differentiation

artículo científico publicado en 2002

Role of melanoma chondroitin sulphate proteoglycan in patterning stem cells in human interfollicular epidermis

artículo científico publicado en 2003

Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis

scientific journal article

Role of the extracellular matrix in regulating stem cell fate

artículo científico publicado en 2013

Scalable topographies to support proliferation and Oct4 expression by human induced pluripotent stem cells.

artículo científico publicado en 2016

Selective migration of terminally differentiating cells from the basal layer of cultured human epidermis

artículo científico publicado en 1984

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression

artículo científico publicado en 1993

Sequence variation in the I-like domain of the beta1 integrin subunit in human oral squamous cell carcinomas

artículo científico publicado en 2004

Seven actionable strategies for advancing women in science, engineering, and medicine

artículo científico publicado en 2015

Shape-Induced Terminal Differentiation of Human Epidermal Stem Cells Requires p38 and Is Regulated by Histone Acetylation ⬇️

artículo científico publicado el 2 de noviembre de 2011

Sic transit gloria: farewell to the epidermal transit amplifying cell?

article by Fiona Watt, Philip H. Jones and Benjamin D. Simons published in 2007

Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro

artículo científico publicado en 1999

Sin3a is essential for the genome integrity and viability of pluripotent cells

artículo científico publicado en 2011

Single-cell electroporation using proton beam fabricated biochips

artículo científico publicado en 2012

Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a regulator of stem cell quiescence

artículo científico publicado en 2006

Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells

artículo científico publicado en 2013

Skin Cell Heterogeneity in Development, Wound Healing, and Cancer

article

Sox2 modulates the function of two distinct cell lineages in mouse skin

artículo científico publicado en 2013

Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis

artículo científico publicado en 2009

Spatial and single-cell transcriptional profiling identifies functionally distinct human dermal fibroblast subpopulations.

artículo científico publicado en 2018

Spatial constraints govern competition of mutant clones in human epidermis.

artículo científico publicado en 2017

Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells

artículo científico publicado en 2013

Stem cell depletion through epidermal deletion of Rac1.

artículo científico publicado en 2005

Stem cell fate and patterning in mammalian epidermis

artículo científico publicado en 2001

Stem cell heterogeneity and plasticity in epithelia

artículo científico

Stem cell patterning and fate in human epidermis

artículo científico publicado en 1995

Stem cells are dispensable for lung homeostasis but restore airways after injury

scholarly article

Stem cells: on the front line

artículo científico publicado en 2011

Stem cells: the generation and maintenance of cellular diversity

artículo científico publicado en 1989

Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters.

artículo científico publicado en 2000

Stratification and terminal differentiation of cultured epidermal cells

artículo científico publicado en 1982

Structure and regulation of the envoplakin gene

artículo científico publicado en 2000

Studies with cultured human epidermal keratinocytes: Potential relevance to corneal wound healing

Subcellular distribution of envoplakin and periplakin: insights into their role as precursors of the epidermal cornified envelope

artículo científico publicado en 2000

Subpopulations of chondrocytes from different zones of pig articular cartilage. Isolation, growth and proteoglycan synthesis in culture

artículo científico publicado en 1990

Suprabasal alpha 5 beta1 integrin expression stimulates formation of epidermal squamous cell carcinomas without disrupting TGFbeta signaling or inducing spindle cell tumors

artículo científico publicado en 2005

Suprabasal alpha6beta4 integrin expression in epidermis results in enhanced tumourigenesis and disruption of TGFbeta signalling

artículo científico publicado en 2003

Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis

artículo científico publicado en 1995

Switch from alphavbeta5 to alphavbeta6 integrin expression protects squamous cell carcinomas from anoikis

artículo científico publicado en 2004

Syntenin mediates Delta1-induced cohesiveness of epidermal stem cells in culture

artículo científico publicado en 2007

Terminal differentiation of epidermal keratinocytes

artículo científico publicado en 1989

The 5' noncoding region of the mouse involucrin gene: comparison with the human gene and genes encoding other cornified envelope precursors

artículo científico publicado en 1995

The Androgen Receptor Antagonizes Wnt/β-Catenin Signaling in Epidermal Stem Cells

artículo científico publicado en 2015

The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development

artículo científico publicado en 2000

The Human Cell Atlas

artículo científico publicado en 2017

The Human Cell Atlas

The Human Cell Atlas White Paper ⬇️

artículo científico publicado en 2018

The RNA Methyltransferase Misu (NSun2) Mediates Myc-Induced Proliferation and Is Upregulated in Tumors

The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors

artículo científico publicado en 2006

The RNA-methyltransferase Misu (NSun2) poises epidermal stem cells to differentiate

artículo científico publicado en 2011

The adaptive immune response to cardiac injury-the true roadblock to effective regenerative therapies?

artículo científico publicado en 2017

The basement membrane of hair follicle stem cells is a muscle cell niche

artículo científico publicado en 2011

The cell-surface marker MTS24 identifies a novel population of follicular keratinocytes with characteristics of progenitor cells

artículo científico publicado en 2006

The distribution of actin cables and microtubules in hybrids between malignant and non-malignant cells, and in tumours derived from them

artículo científico publicado en 1978

The eLife approach to peer review ⬇️

artículo científico publicado el 30 de abril de 2013

The epidermal keratinocyte

artículo científico

The epidermal stem cell compartment: variation in expression levels of E-cadherin and catenins within the basal layer of human epidermis

artículo científico publicado en 1997

The interfollicular epidermis of adult mouse tail comprises two distinct cell lineages that are differentially regulated by Wnt, Edaradd, and Lrig1.

artículo científico publicado en 2013

The peanut lectin-binding glycoproteins of human epidermal keratinocytes

artículo científico publicado en 1988

The plakin family: versatile organizers of cytoskeletal architecture ⬇️

artículo científico publicado el 1 de junio de 1997

The reward of great collaborations

The role of keratins in modulating carcinogenesis via communication with cells of the immune system

artículo científico publicado en 2019

The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis

artículo científico publicado en 1999

The stem cell compartment in human interfollicular epidermis

artículo científico publicado en 2002

The therapeutic potential of stem cells

artículo científico publicado en 2010

The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis

artículo científico publicado en 2008

The vitamin D receptor is required for mouse hair cycle progression but not for maintenance of the epidermal stem cell compartment

artículo científico publicado en 2008

The α2 and α5 integrin genes: identification of transcription factors that regulate promoter activity in epidermal keratinocytes

article

Topo II alpha reporter mice reveal proliferative regions in the epidermis and small intestine

artículo científico publicado en 2005

Towards gene therapy for haemophilia B using primary human keratinocytes

artículo científico publicado en 1993

Transcriptional and post-translational regulation of beta 1 integrin expression during keratinocyte terminal differentiation ⬇️

artículo científico publicado el 25 de julio de 1992

Transfection of beta 4 integrin subunit into a neoplastic keratinocyte line fails to restore terminal differentiation capacity or influence proliferation

artículo científico publicado en 1996

Transgenic Mice Expressing IFN-γ in the Epidermis Have Eczema, Hair Hypopigmentation, and Hair Loss

article

Transgenic mice expressing IFN-gamma in the epidermis are a model of inflammatory skin disease and systemic lupus erythematosus.

artículo científico publicado en 2005

Transient activation of FOXN1 in keratinocytes induces a transcriptional programme that promotes terminal differentiation: contrasting roles of FOXN1 and Akt.

artículo científico publicado en 2004

Transient activation of beta-catenin signalling in adult mouse epidermis is sufficient to induce new hair follicles but continuous activation is required to maintain hair follicle tumours

artículo científico publicado en 2004

Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate

artículo científico publicado en 2010

Two strains of human keratinocytes transfected with HPV16 DNA: comparison with the normal parental cells

artículo científico publicado en 1991

Two subpopulations of differentiated chondrocytes identified with a monoclonal antibody to keratan sulfate

artículo científico publicado en 1985

Type XVII collagen coordinates proliferation in the interfollicular epidermis

artículo científico publicado en 2017

UK funders learn from COVID-19 'white-water ride'

artículo científico publicado en 2020

Understanding allergy and cancer risk: what are the barriers?

Understanding allergy and cancer risk: what are the barriers?

Understanding fibroblast heterogeneity in the skin

artículo científico publicado en 2014

Unexpected Hedgehog-Wnt interactions in epithelial differentiation

artículo científico publicado en 2004

Upregulation of CD26 expression in epithelial cells and stromal cells during wound-induced skin tumour formation.

artículo científico publicado en 2011

What does it take to recruit and retain senior women faculty? ⬇️

artículo científico publicado el 5 de marzo de 2013

What is AI? Applications of artificial intelligence to dermatology

scientific article published on 20 January 2020

What is the point of large-scale collections of human induced pluripotent stem cells?

artículo científico publicado en 2013

Women in cell biology: getting to the top

Women in cell biology: how personal lives shape careers

article published in 2006

Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties

artículo científico publicado en 2017

Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity

artículo científico publicado en 2010

Zena Werb [interview by Fiona M Watt].

artículo científico publicado en 2004

beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion

artículo científico publicado en 1999

beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms

artículo científico

beta1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum

artículo científico publicado en 2000

c-MYC-induced sebaceous gland differentiation is controlled by an androgen receptor/p53 axis

artículo científico publicado en 2013

c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny

artículo científico publicado en 2001

c-Myc promotes differentiation of human epidermal stem cells

artículo científico publicado en 1997

eLife and early career researchers

artículo científico publicado en 2013

p19ARF-independent induction of p53 and cell cycle arrest by Raf in murine keratinocytes

artículo científico publicado en 2001

β-Catenin Stabilization in Skin Fibroblasts Causes Fibrotic Lesions by Preventing Adipocyte Differentiation of the Reticular Dermis

artículo científico publicado en 2016

β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition

artículo científico publicado en 2012

Amparo Cano

artículo científico

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