Lista de obras - Jinping Gan - Dominio Público Uruguay

Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone.

artículo científico publicado en 2017

Biliary excretion of pravastatin and taurocholate in rats with bile salt export pump (Bsep) impairment.

artículo científico publicado en 2016

Bioactivation of substituted thiophenes including α-chlorothiophene-containing compounds in human liver microsomes

artículo científico publicado en 2011

CYP3A4-mediated ester cleavage as the major metabolic pathway of the oral taxane 3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183).

artículo científico publicado en 2009

Characterization of efflux transporters involved in distribution and disposition of apixaban.

artículo científico publicado en 2013

Clinical significance of CYP2C19 polymorphisms on the metabolism and pharmacokinetics of 11β-hydroxysteroid dehydrogenase type-1 inhibitor BMS-823778.

artículo científico publicado en 2017

Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

artículo científico publicado en 2017

Cytochrome P450 11A1 Bioactivation of a Kinase Inhibitor in Rats: Use of Radioprofiling, Modulation of Metabolism, and Adrenocortical Cell Lines to Evaluate Adrenal Toxicity ⬇️

artículo científico publicado el 2 de marzo de 2012

Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.

artículo científico publicado en 2017

Discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone as a potent and selective I(Kur) inhibitor

artículo científico publicado en 2012

Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity

artículo científico publicado en 2015

Drug safety is a barrier to the discovery and development of new androgen receptor antagonists.

artículo científico publicado en 2010

Drug-Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization.

artículo científico publicado en 2016

High-resolution mass spectrometry-based background subtraction for identifying protein modifications in a complex biological system: detection of acetaminophen-bound microsomal proteins including argininosuccinate synthetase.

artículo científico publicado en 2015

Identification of the oxidative and conjugative enzymes involved in the biotransformation of brivanib

artículo científico publicado en 2011

In vitro assessment of cytochrome P450 inhibition and induction potential of tanespimycin and its major metabolite, 17-amino-17-demethoxygeldanamycin

artículo científico publicado en 2011

In vitro screening of 50 highly prescribed drugs for thiol adduct formation--comparison of potential for drug-induced toxicity and extent of adduct formation.

artículo científico publicado en 2009

Integration of Physiologically-Based Pharmacokinetic Modeling into Early Clinical Development: An Investigation of the Pharmacokinetic Nonlinearity

artículo científico publicado en 2015

In vitro model systems to investigate bile salt export pump (BSEP) activity and drug interactions: A review

artículo científico

Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2).

artículo científico publicado en 2011

LC-MS/MS bioanalysis of plasma 1, 14-tetradecanedioic acid and 1, 16-hexadecanedioic acid as candidate biomarkers for organic anion-transporting polypeptide mediated drug-drug interactions

scientific article published on 14 September 2018

Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry

scientific article published on 04 December 2019

Mechanism-based inhibition of human cytochrome P4503A4 by domperidone

artículo científico publicado en 2010

Metabolic chiral inversion of brivanib and its relevance to safety and pharmacology

artículo científico publicado en 2012

Metabolism and disposition of [14C]brivanib alaninate after oral administration to rats, monkeys, and humans

artículo científico publicado en 2011

Metabolism, excretion, and pharmacokinetics of oral brivanib in patients with advanced or metastatic solid tumors.

artículo científico publicado en 2010

Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization

artículo científico publicado en 2020

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.

artículo científico publicado en 2017

Non-cytochrome P450-mediated bioactivation and its toxicological relevance.

artículo científico publicado en 2016

Phase I dose-escalation study of the novel antiandrogen BMS-641988 in patients with castration-resistant prostate cancer

artículo científico publicado en 2011

Quantitation of repaglinide and metabolites in mouse whole-body thin tissue sections using droplet-based liquid microjunction surface sampling-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.

artículo científico publicado en 2015

Quantitative analysis of polyethylene glycol (PEG) and PEGylated proteins in animal tissues by LC-MS/MS coupled with in-source CID

artículo científico publicado en 2014

Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism

artículo científico publicado en 2010

Strategy for the Quantitation of a Protein Conjugate via Hybrid Immunocapture-Liquid Chromatography with Sequential HRMS and SRM-Based LC-MS/MS Analyses.

artículo científico publicado en 2017

Synthesis and Biological Evaluation of a Novel (18)F-labeled Adnectin as a PET Radioligand for Imaging PD-L1 Expression.

artículo científico publicado en 2017

Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists

scientific article published on 02 November 2012

Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT(2C) receptor agonists.

artículo científico publicado en 2013

Tissue distribution and tumor uptake of folate receptor-targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration

artículo científico publicado en 2016

Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents

artículo científico publicado en 2009

Ultrasensitive quantitative LC-MS/MS of an inhibitor of apoptosis protein's antagonist in plasma using protein target affinity extraction.

artículo científico publicado en 2016

Lista de obras de Jinping Gan

Bile Salt Homeostasis in Normal and Bsep Gene Knockout Rats with Single and Repeated Doses of Troglitazone.

Biliary excretion of pravastatin and taurocholate in rats with bile salt export pump (Bsep) impairment.

Bioactivation of substituted thiophenes including α-chlorothiophene-containing compounds in human liver microsomes

CYP3A4-mediated ester cleavage as the major metabolic pathway of the oral taxane 3'-tert-butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel (BMS-275183).

Characterization of efflux transporters involved in distribution and disposition of apixaban.

Clinical significance of CYP2C19 polymorphisms on the metabolism and pharmacokinetics of 11β-hydroxysteroid dehydrogenase type-1 inhibitor BMS-823778.

Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects

Cytochrome P450 11A1 Bioactivation of a Kinase Inhibitor in Rats: Use of Radioprofiling, Modulation of Metabolism, and Adrenocortical Cell Lines to Evaluate Adrenal Toxicity ⬇️

Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.

Discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone as a potent and selective I(Kur) inhibitor

Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity

Drug safety is a barrier to the discovery and development of new androgen receptor antagonists.

Drug-Protein Adducts: Chemistry, Mechanisms of Toxicity, and Methods of Characterization.

High-resolution mass spectrometry-based background subtraction for identifying protein modifications in a complex biological system: detection of acetaminophen-bound microsomal proteins including argininosuccinate synthetase.

Identification of the oxidative and conjugative enzymes involved in the biotransformation of brivanib

In vitro assessment of cytochrome P450 inhibition and induction potential of tanespimycin and its major metabolite, 17-amino-17-demethoxygeldanamycin

In vitro screening of 50 highly prescribed drugs for thiol adduct formation--comparison of potential for drug-induced toxicity and extent of adduct formation.

Integration of Physiologically-Based Pharmacokinetic Modeling into Early Clinical Development: An Investigation of the Pharmacokinetic Nonlinearity

In vitro model systems to investigate bile salt export pump (BSEP) activity and drug interactions: A review

Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2).

LC-MS/MS bioanalysis of plasma 1, 14-tetradecanedioic acid and 1, 16-hexadecanedioic acid as candidate biomarkers for organic anion-transporting polypeptide mediated drug-drug interactions

Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry

Mechanism-based inhibition of human cytochrome P4503A4 by domperidone

Metabolic chiral inversion of brivanib and its relevance to safety and pharmacology

Metabolism and disposition of [14C]brivanib alaninate after oral administration to rats, monkeys, and humans

Metabolism, excretion, and pharmacokinetics of oral brivanib in patients with advanced or metastatic solid tumors.

Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.

Non-cytochrome P450-mediated bioactivation and its toxicological relevance.

Phase I dose-escalation study of the novel antiandrogen BMS-641988 in patients with castration-resistant prostate cancer

Quantitation of repaglinide and metabolites in mouse whole-body thin tissue sections using droplet-based liquid microjunction surface sampling-high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.

Quantitative analysis of polyethylene glycol (PEG) and PEGylated proteins in animal tissues by LC-MS/MS coupled with in-source CID

Repaglinide-gemfibrozil drug interaction: inhibition of repaglinide glucuronidation as a potential additional contributing mechanism

Strategy for the Quantitation of a Protein Conjugate via Hybrid Immunocapture-Liquid Chromatography with Sequential HRMS and SRM-Based LC-MS/MS Analyses.

Synthesis and Biological Evaluation of a Novel (18)F-labeled Adnectin as a PET Radioligand for Imaging PD-L1 Expression.

Synthesis and SAR of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones as 5-HT2C receptor agonists

Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT(2C) receptor agonists.

Tissue distribution and tumor uptake of folate receptor-targeted epothilone folate conjugate, BMS-753493, in CD2F1 mice after systemic administration

Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents

Ultrasensitive quantitative LC-MS/MS of an inhibitor of apoptosis protein's antagonist in plasma using protein target affinity extraction.