Lista de obras - Pere Clapés - Dominio Público Uruguay

Aldol addition of dihydroxyacetone to N-Cbz-3-aminopropanal catalyzed by two aldolases variants in microreactors.

artículo científico publicado en 2013

Aldol additions of dihydroxyacetone phosphate to N-Cbz-amino aldehydes catalyzed by L-fuculose-1-phosphate aldolase in emulsion systems: inversion of stereoselectivity as a function of the acceptor aldehyde

artículo científico publicado en 2005

Aldolase-Catalyzed Asymmetric Synthesis of N-Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes

artículo científico publicado en 2019

Aldolase-catalyzed synthesis of conformationally constrained iminocyclitols: preparation of polyhydroxylated benzopyrrolizidines and cyclohexapyrrolizidines

artículo científico publicado en 2014

Application of empirical design methodologies to the study of the influence of reaction conditions and N-alpha-protecting group structure on the enzymatic X-Phe-Leu-NH(2) dipeptide synthesis in buffer/dimethylformamide solvents systems.

artículo científico publicado en 1992

Assessment of primary eye and skin irritants by in vitro cytotoxicity and phototoxicity models: an in vitro approach of new arginine-based surfactant-induced irritation.

artículo científico publicado en 2004

Assessment of the potential irritation and photoirritation of novel amino acid-based surfactants by in vitro methods as alternative to the animal tests.

artículo científico publicado en 2004

Asymmetric assembly of aldose carbohydrates from formaldehyde and glycolaldehyde by tandem biocatalytic aldol reactions

artículo científico publicado en 2015

Asymmetric self- and cross-aldol reactions of glycolaldehyde catalyzed by D-fructose-6-phosphate aldolase.

artículo científico publicado en 2009

Biocatalytic Aldol Addition of Simple Aliphatic Nucleophiles to Hydroxyaldehydes

article

Biocatalytic Construction of Quaternary Centers by Aldol Addition of 3,3-Disubstituted 2-Oxoacid Derivatives to Aldehydes

artículo científico publicado en 2020

Biocatalyzed Synthesis and Structural Characterization of Monoglucuronides of Hydroxytyrosol, Tyrosol, Homovanillic Alcohol, and 3-(4′-Hydroxyphenyl)propanol

artículo científico publicado en 2006

Breaking the Dogma of Aldolase Specificity: Simple Aliphatic Ketones and Aldehydes are Nucleophiles for Fructose-6-phosphate Aldolase

artículo científico publicado en 2017

Carbon-carbon bond-forming enzymes for the synthesis of non-natural amino acids.

artículo científico publicado en 2012

Casuarine stereoisomers from achiral substrates: chemoenzymatic synthesis and inhibitory properties

artículo científico publicado en 2014

Chemo-enzymatic synthesis and glycosidase inhibitory properties of DAB and LAB derivatives

artículo científico publicado en 2013

Chemo-enzymatic synthesis of arginine-based gemini surfactants

artículo científico publicado en 2000

Chemoenzymatic Synthesis and Inhibitory Activities of Hyacinthacines A1 and A2 Stereoisomers

artículo científico publicado en 2007

Chemoenzymatic synthesis and antimicrobial and haemolytic activities of amphiphilic bis(phenylacetylarginine) derivatives

scientific article published on 01 October 2006

Chemoenzymatic synthesis, structural study and biological activity of novel indolizidine and quinolizidine iminocyclitols.

artículo científico publicado en 2012

Comparative study of the antimicrobial activity of bis(Nalpha-caproyl-L-arginine)-1,3-propanediamine dihydrochloride and chlorhexidine dihydrochloride against Staphylococcus aureus and Escherichia coli.

artículo científico publicado en 2006

Complete Switch of Reaction Specificity of an Aldolase by Directed Evolution In Vitro: Synthesis of Generic Aliphatic Aldol Products

artículo científico publicado en 2018

Cover Picture: Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase YfaU from E. Coli (Angew. Chem. Int. Ed. 14/2018)

D-Fagomine lowers postprandial blood glucose and modulates bacterial adhesion

artículo científico publicado en 2011

D-fructose-6-phosphate aldolase in organic synthesis: cascade chemical-enzymatic preparation of sugar-related polyhydroxylated compounds

artículo científico publicado en 2009

Determination of the β-glycosylate fraction of contaminants of emerging concern in lettuce (Lactuca sativa L.) grown under controlled conditions

artículo científico publicado en 2018

Dihydroxyacetone phosphate aldolase catalyzed synthesis of structurally diverse polyhydroxylated pyrrolidine derivatives and evaluation of their glycosidase inhibitory properties.

artículo científico publicado en 2009

Disentangling Complex Mixtures of Compounds with Near-Identical1H and13C NMR Spectra using Pure Shift NMR Spectroscopy

scientific article published on 27 March 2015

Effect of (D)-fagomine on excreted Enterobacteria and weight gain in rats fed a high-fat high-sucrose diet

artículo científico publicado en 2013

Engineered L-serine hydroxymethyltransferase from Streptococcus thermophilus for the synthesis of α,α-dialkyl-α-amino acids

artículo científico publicado en 2015

Engineering the donor selectivity of D-fructose-6-phosphate aldolase for biocatalytic asymmetric cross-aldol additions of glycolaldehyde.

artículo científico publicado en 2014

Enzymatic condensation of cholecystokinin CCK-8 (4-6) and CCK-8 (7-8) peptide fragments in organic media

artículo científico publicado en 1997

Enzymatic peptide synthesis in low water content systems: Preparative enzymatic synthesis of [Leu]- and [Met]-enkephalin derivatives ⬇️

artículo científico publicado el 1 de marzo de 1995

Enzymatic peptide synthesis in organic media: a comparative study of water-miscible and water-immiscible solvent systems

artículo científico publicado en 1990

Enzymatic synthesis of X-Phe-Leu-NH2 in low water content systems: influence of the N-alpha protecting group and the reaction medium composition

scientific article published on 01 July 1993

Enzymatic synthesis of a CCK-8 tripeptide fragment in organic media

scientific article published on 01 June 1996

Enzymatic synthesis of arginine-based cationic surfactants

scientific article published on 01 May 1999

Expedient synthesis of C-aryl carbohydrates by consecutive biocatalytic benzoin and aldol reactions.

artículo científico publicado en 2015

Fructose-6-phosphate Aldolase in Organic Synthesis: Preparation ofd-Fagomine,N-Alkylated Derivatives, and Preliminary Biological Assays

artículo científico publicado en 2006

Highly efficient aldol additions of DHA and DHAP to N-Cbz-amino aldehydes catalyzed by l-rhamnulose-1-phosphate and l-fuculose-1-phosphate aldolases in aqueous borate buffer

artículo científico publicado en 2011

Influence of N-amino protecting group on aldolase-catalyzed aldol additions of dihydroxyacetone phosphate to amino aldehydes

artículo científico publicado en 2006

Influence of solvent and water activity on kinetically controlled peptide synthesis

scientific article published on 01 July 1992

Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts

artículo científico publicado en 2015

Inhibitory properties of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) derivatives acting on glycogen metabolising enzymes.

artículo científico publicado en 2016

Integrated Process for the Enzymatic Synthesis of the Octapeptide PhAcCCK-8

artículo científico publicado en 2002

Interaction of antioxidant biobased epicatechin conjugates with biomembrane models

scientific article published on 27 March 2007

Intramolecular Benzoin Reaction Catalyzed by Benzaldehyde Lyase from Pseudomonas Fluorescens Biovar I.

artículo científico publicado en 2017

Kinetically controlled enzyme-catalyzed synthesis of kyotorphin. An optimization study

artículo científico publicado en 1987

Low potential ocular irritation of arginine-based gemini surfactants and their mixtures with nonionic and zwitterionic surfactants.

artículo científico publicado en 2003

Mathematical model for aldol addition catalyzed by two D-fructose-6-phosphate aldolases variants overexpressed in E. coli.

artículo científico publicado en 2013

Neoglycopeptide synthesis and purification in multi-gram scale: preparation of O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-N alpha-fluoren-9-yl-methoxycarbonyl-hydroxyproline and its use in the pilot-scale synthesis of the potent analgesic gl

scientific article published on 01 March 1997

Novel chemoenzymatic strategy for the synthesis of enantiomerically pure secondary alcohols with sterically similar substituents

artículo científico publicado en 2003

Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase YfaU from E. Coli

artículo científico publicado en 2018

Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase YfaU from E. Coli

Nucleophile Promiscuity of Natural and Engineered Aldolases.

artículo científico publicado en 2018

Purification of non-toxic, biodegradable arginine-based gemini surfactants, bis(Args), by ion exchange chromatography.

artículo científico publicado en 2001

Qualitative and quantitative analysis of new alkyl amide arginine surfactants by high-performance liquid chromatography and capillary electrophoresis

scientific article published on 01 August 1999

Reaction medium engineering in enzymatic peptide fragment condensation: synthesis of eledoisin and LH-RH

artículo científico publicado en 1998

Redesign of the Phosphate Binding Site of L-Rhamnulose- 1-Phosphate Aldolase towards a Dihydroxyacetone Dependent Aldolase

artículo científico publicado en 2011

Redesigning the active site of transaldolase TalB from Escherichia coli: new variants with improved affinity towards nonphosphorylated substrates

artículo científico publicado en 2010

Sequential Biocatalytic Aldol Reactions in Multistep Asymmetric Synthesis: Pipecolic Acid, Piperidine and Pyrrolidine (Homo)Iminocyclitol Derivatives from Achiral Building Blocks

artículo científico publicado en 2014

Serine hydroxymethyl transferase from Streptococcus thermophilus and L-threonine aldolase from Escherichia coli as stereocomplementary biocatalysts for the synthesis of beta-hydroxy-alpha,omega-diamino acid derivatives

artículo científico publicado en 2008

Solid-Phase Synthesis of Glycopeptide Amides under Mild Conditions: Morphiceptin Analogues

scholarly article by Eduard Bardají et al published March 1990 in Angewandte Chemie International Edition

Stereoselective aldol additions catalyzed by dihydroxyacetone phosphate-dependent aldolases in emulsion systems: preparation and structural characterization of linear and cyclic iminopolyols from aminoaldehydes

artículo científico publicado en 2003

Structure-guided minimalist redesign of the L-fuculose-1-phosphate aldolase active site: expedient synthesis of novel polyhydroxylated pyrrolizidines and their inhibitory properties against glycosidases and intestinal disaccharidases

artículo científico publicado en 2010

Structure-guided redesign of D-fructose-6-phosphate aldolase from E. coli: remarkable activity and selectivity towards acceptor substrates by two-point mutation.

artículo científico publicado en 2011

The effect of molecular shape on the thermotropic liquid crystal behavior of monolauroylated amino acid glyceride conjugates

artículo científico publicado en 2005

Thermostability Engineering of a Class II Pyruvate Aldolase from <i>Escherichia coli</i> by <i>in Vivo</i> Folding Interference

artículo científico publicado en 2021

Lista de obras de Pere Clapés

Aldol addition of dihydroxyacetone to N-Cbz-3-aminopropanal catalyzed by two aldolases variants in microreactors.

Aldol additions of dihydroxyacetone phosphate to N-Cbz-amino aldehydes catalyzed by L-fuculose-1-phosphate aldolase in emulsion systems: inversion of stereoselectivity as a function of the acceptor aldehyde

Aldolase-Catalyzed Asymmetric Synthesis of N-Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes

Aldolase-catalyzed synthesis of conformationally constrained iminocyclitols: preparation of polyhydroxylated benzopyrrolizidines and cyclohexapyrrolizidines

Application of empirical design methodologies to the study of the influence of reaction conditions and N-alpha-protecting group structure on the enzymatic X-Phe-Leu-NH(2) dipeptide synthesis in buffer/dimethylformamide solvents systems.

Assessment of primary eye and skin irritants by in vitro cytotoxicity and phototoxicity models: an in vitro approach of new arginine-based surfactant-induced irritation.

Assessment of the potential irritation and photoirritation of novel amino acid-based surfactants by in vitro methods as alternative to the animal tests.

Asymmetric assembly of aldose carbohydrates from formaldehyde and glycolaldehyde by tandem biocatalytic aldol reactions

Asymmetric self- and cross-aldol reactions of glycolaldehyde catalyzed by D-fructose-6-phosphate aldolase.

Biocatalytic Aldol Addition of Simple Aliphatic Nucleophiles to Hydroxyaldehydes

Biocatalytic Construction of Quaternary Centers by Aldol Addition of 3,3-Disubstituted 2-Oxoacid Derivatives to Aldehydes

Biocatalyzed Synthesis and Structural Characterization of Monoglucuronides of Hydroxytyrosol, Tyrosol, Homovanillic Alcohol, and 3-(4′-Hydroxyphenyl)propanol

Breaking the Dogma of Aldolase Specificity: Simple Aliphatic Ketones and Aldehydes are Nucleophiles for Fructose-6-phosphate Aldolase

Carbon-carbon bond-forming enzymes for the synthesis of non-natural amino acids.

Casuarine stereoisomers from achiral substrates: chemoenzymatic synthesis and inhibitory properties

Chemo-enzymatic synthesis and glycosidase inhibitory properties of DAB and LAB derivatives

Chemo-enzymatic synthesis of arginine-based gemini surfactants

Chemoenzymatic Synthesis and Inhibitory Activities of Hyacinthacines A1 and A2 Stereoisomers

Chemoenzymatic synthesis and antimicrobial and haemolytic activities of amphiphilic bis(phenylacetylarginine) derivatives

Chemoenzymatic synthesis, structural study and biological activity of novel indolizidine and quinolizidine iminocyclitols.

Comparative study of the antimicrobial activity of bis(Nalpha-caproyl-L-arginine)-1,3-propanediamine dihydrochloride and chlorhexidine dihydrochloride against Staphylococcus aureus and Escherichia coli.

Complete Switch of Reaction Specificity of an Aldolase by Directed Evolution In Vitro: Synthesis of Generic Aliphatic Aldol Products

Cover Picture: Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase YfaU from E. Coli (Angew. Chem. Int. Ed. 14/2018)

D-Fagomine lowers postprandial blood glucose and modulates bacterial adhesion

D-fructose-6-phosphate aldolase in organic synthesis: cascade chemical-enzymatic preparation of sugar-related polyhydroxylated compounds

Determination of the β-glycosylate fraction of contaminants of emerging concern in lettuce (Lactuca sativa L.) grown under controlled conditions

Dihydroxyacetone phosphate aldolase catalyzed synthesis of structurally diverse polyhydroxylated pyrrolidine derivatives and evaluation of their glycosidase inhibitory properties.

Disentangling Complex Mixtures of Compounds with Near-Identical1H and13C NMR Spectra using Pure Shift NMR Spectroscopy

Effect of (D)-fagomine on excreted Enterobacteria and weight gain in rats fed a high-fat high-sucrose diet

Engineered L-serine hydroxymethyltransferase from Streptococcus thermophilus for the synthesis of α,α-dialkyl-α-amino acids

Engineering the donor selectivity of D-fructose-6-phosphate aldolase for biocatalytic asymmetric cross-aldol additions of glycolaldehyde.

Enzymatic condensation of cholecystokinin CCK-8 (4-6) and CCK-8 (7-8) peptide fragments in organic media

Enzymatic peptide synthesis in low water content systems: Preparative enzymatic synthesis of [Leu]- and [Met]-enkephalin derivatives ⬇️

Enzymatic peptide synthesis in organic media: a comparative study of water-miscible and water-immiscible solvent systems

Enzymatic synthesis of X-Phe-Leu-NH2 in low water content systems: influence of the N-alpha protecting group and the reaction medium composition

Enzymatic synthesis of a CCK-8 tripeptide fragment in organic media

Enzymatic synthesis of arginine-based cationic surfactants

Expedient synthesis of C-aryl carbohydrates by consecutive biocatalytic benzoin and aldol reactions.

Fructose-6-phosphate Aldolase in Organic Synthesis: Preparation ofd-Fagomine,N-Alkylated Derivatives, and Preliminary Biological Assays

Highly efficient aldol additions of DHA and DHAP to N-Cbz-amino aldehydes catalyzed by l-rhamnulose-1-phosphate and l-fuculose-1-phosphate aldolases in aqueous borate buffer

Influence of N-amino protecting group on aldolase-catalyzed aldol additions of dihydroxyacetone phosphate to amino aldehydes

Influence of solvent and water activity on kinetically controlled peptide synthesis

Inhibitor versus chaperone behaviour of d-fagomine, DAB and LAB sp(2)-iminosugar conjugates against glycosidases: A structure-activity relationship study in Gaucher fibroblasts

Inhibitory properties of 1,4-dideoxy-1,4-imino-d-arabinitol (DAB) derivatives acting on glycogen metabolising enzymes.

Integrated Process for the Enzymatic Synthesis of the Octapeptide PhAcCCK-8

Interaction of antioxidant biobased epicatechin conjugates with biomembrane models

Intramolecular Benzoin Reaction Catalyzed by Benzaldehyde Lyase from Pseudomonas Fluorescens Biovar I.

Kinetically controlled enzyme-catalyzed synthesis of kyotorphin. An optimization study

Low potential ocular irritation of arginine-based gemini surfactants and their mixtures with nonionic and zwitterionic surfactants.

Mathematical model for aldol addition catalyzed by two D-fructose-6-phosphate aldolases variants overexpressed in E. coli.

Neoglycopeptide synthesis and purification in multi-gram scale: preparation of O-(2,3,4,6-tetra-O-acetyl-beta-D-galactopyranosyl)-N alpha-fluoren-9-yl-methoxycarbonyl-hydroxyproline and its use in the pilot-scale synthesis of the potent analgesic gl

Novel chemoenzymatic strategy for the synthesis of enantiomerically pure secondary alcohols with sterically similar substituents

Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase YfaU from E. Coli

Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase YfaU from E. Coli

Nucleophile Promiscuity of Natural and Engineered Aldolases.

Purification of non-toxic, biodegradable arginine-based gemini surfactants, bis(Args), by ion exchange chromatography.

Qualitative and quantitative analysis of new alkyl amide arginine surfactants by high-performance liquid chromatography and capillary electrophoresis

Reaction medium engineering in enzymatic peptide fragment condensation: synthesis of eledoisin and LH-RH

Redesign of the Phosphate Binding Site of L-Rhamnulose- 1-Phosphate Aldolase towards a Dihydroxyacetone Dependent Aldolase

Redesigning the active site of transaldolase TalB from Escherichia coli: new variants with improved affinity towards nonphosphorylated substrates

Sequential Biocatalytic Aldol Reactions in Multistep Asymmetric Synthesis: Pipecolic Acid, Piperidine and Pyrrolidine (Homo)Iminocyclitol Derivatives from Achiral Building Blocks

Serine hydroxymethyl transferase from Streptococcus thermophilus and L-threonine aldolase from Escherichia coli as stereocomplementary biocatalysts for the synthesis of beta-hydroxy-alpha,omega-diamino acid derivatives

Solid-Phase Synthesis of Glycopeptide Amides under Mild Conditions: Morphiceptin Analogues

Stereoselective aldol additions catalyzed by dihydroxyacetone phosphate-dependent aldolases in emulsion systems: preparation and structural characterization of linear and cyclic iminopolyols from aminoaldehydes

Structure-guided minimalist redesign of the L-fuculose-1-phosphate aldolase active site: expedient synthesis of novel polyhydroxylated pyrrolizidines and their inhibitory properties against glycosidases and intestinal disaccharidases

Structure-guided redesign of D-fructose-6-phosphate aldolase from E. coli: remarkable activity and selectivity towards acceptor substrates by two-point mutation.

The effect of molecular shape on the thermotropic liquid crystal behavior of monolauroylated amino acid glyceride conjugates

Thermostability Engineering of a Class II Pyruvate Aldolase from <i>Escherichia coli</i> by <i>in Vivo</i> Folding Interference

Titelbild: Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase YfaU from E. Coli (Angew. Chem. 14/2018)