Lista de obras - Jean-Noel Freund - Dominio Público Uruguay

A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53

artículo científico publicado en 2018

Activity of the rat lactase gene promoter in transfected human colon cancer cells

scientific article published on 01 November 1995

Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin

artículo científico publicado en 2009

Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells

artículo científico publicado en 2006

Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage.

artículo científico publicado en 2014

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype ⬇️

artículo científico publicado el 9 de diciembre de 2010

CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula

scientific article published on 02 August 2010

Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos

scientific journal article

Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer

scientific article published on 31 March 2008

Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and β-Catenin Activity in Colon Cancer Cells ⬇️

artículo científico publicado el 24 de diciembre de 2011

Cdx2 determines the fate of postnatal intestinal endoderm

scientific journal article

Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells.

artículo científico publicado en 2011

Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate

artículo científico publicado en 2014

Cellular and molecular partners involved in gut morphogenesis and differentiation ⬇️

artículo científico publicado el 29 de junio de 1998

Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells

artículo científico publicado en 1997

Chromatin de-condensation by switching substrate elasticity

artículo científico publicado en 2018

Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice

artículo científico publicado en 2014

Comparative expression of the mRNA for three intestinal hydrolases during postnatal development in the rat

artículo científico publicado en 1990

Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone

artículo científico publicado en 2011

Contribution of soft substrates to malignancy and tumor suppression during colon cancer cell division

artículo científico publicado en 2013

Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha

artículo científico publicado en 2004

Dietary control of the lactase mRNA distribution along the rat small intestine

artículo científico publicado en 1992

Different expression of the mRNA detected by the cDNA for fetal rat lactase in the jejunum and colon

artículo científico publicado en 1990

Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors.

artículo científico publicado en 2007

Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2

artículo científico publicado en 2003

Directing nuclear deformation on micropillared surfaces by substrate geometry and cytoskeleton organization.

artículo científico publicado en 2013

Discrepancy between the intestinal lactase enzymatic activity and mRNA accumulation in sucklings and adults. Effect of starvation and thyroxine treatment.

artículo científico publicado en 1989

Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells.

artículo científico publicado en 2016

Do co-translated product(s) of lactase-phlorizin hydrolase accumulate in the rat intestine?

artículo científico publicado el 1 de noviembre de 1992

Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.

artículo científico publicado en 2003

Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras

artículo científico publicado en 1999

Endoderm- and mesenchyme-dependent commitment of the differentiated epithelial cell types in the developing intestine of rat.

artículo científico publicado en 2003

Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome

artículo científico publicado en 2016

Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi

artículo científico publicado en 2012

Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2.

artículo científico publicado en 2009

Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities.

artículo científico

Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability

scientific article published on 30 May 2006

Functional diversity and interactions between the repeat domains of rat intestinal lactase ⬇️

artículo científico publicado el 1 de octubre de 1997

Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein

artículo científico publicado en 2006

Functional interference between thyroid hormone receptor alpha (TRalpha) and natural truncated TRDeltaalpha isoforms in the control of intestine development.

artículo científico publicado en 2001

Gastric intestinal metaplasia revisited: function and regulation of CDX2.

artículo científico

Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant.

artículo científico publicado en 2013

Gradient expression of Cdx along the rat intestine throughout postnatal development

artículo científico publicado el 14 de diciembre de 1992

Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration.

artículo científico publicado en 2017

Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer.

artículo científico publicado en 2004

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies

artículo científico publicado en 2007

Identification of homologues of the mammalian intestinal lactase gene in non-mammals (birds and molluscs).

artículo científico publicado en 1997

Identity and intestinal pathologies: the Cdx2 homeotic gene

artículo científico publicado en 2012

Immunohistochemical expression of CDX2, β-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer ⬇️

artículo científico publicado el 2 de septiembre de 2010

Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2 ⬇️

artículo científico publicado el 8 de octubre de 2012

Intestinal epithelial-mesenchymal cell interactions.

artículo científico publicado en 1998

Involvement of T3Ralpha- and beta-receptor subtypes in mediation of T3 functions during postnatal murine intestinal development

artículo científico publicado en 1999

Key Role of the Cdx2 Homeobox Gene in Extracellular Matrix–mediated Intestinal Cell Differentiation ⬇️

artículo científico publicado el 15 de diciembre de 1997

Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines.

artículo científico publicado en 2008

Lactase expression is controlled differently in the jejunum and ileum during development in rats

artículo científico publicado en 1991

Lactase is unchanged in suckling mice fed with lactose-free milk

artículo científico publicado en 1998

Laminin isoforms: biological roles and effects on the intracellular distribution of nuclear proteins in intestinal epithelial cells.

artículo científico publicado en 2004

Mesenchyme-mediated effects of retinoic acid during rat intestinal development

artículo científico publicado en 1997

Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase ⬇️

artículo científico publicado el 14 de febrero de 2013

Multiple levels of control of the stage- and region-specific expression of rat intestinal lactase

artículo científico publicado en 1993

Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice

artículo científico publicado en 2007

NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon

artículo científico publicado en 2010

Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.

artículo científico publicado en 2005

Precancerous lesions upon sporadic activation of beta-catenin in mice.

artículo científico publicado en 2007

Production of low-lactose milk by ectopic expression of intestinal lactase in the mouse mammary gland

scientific article published on 01 February 1999

Promotion of intestinal carcinogenesis by dietary methionine

artículo científico publicado en 1999

Rat lactase activity and mRNA expression in relation to the thyroid and corticoid status

artículo científico publicado en 1991

Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer

artículo científico publicado en 2012

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

artículo científico publicado en 2004

Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs

artículo científico publicado en 2019

Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival.

artículo científico publicado en 2007

Subepithelial fibroblast cell lines from different levels of gut axis display regional characteristics.

artículo científico publicado en 1998

TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3.

artículo científico publicado en 2014

Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease

artículo científico publicado en 2010

Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia

artículo científico publicado en 2021

The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development.

artículo científico publicado en 2003

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms.

artículo científico publicado en 2018

The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms

artículo científico publicado en 2020

The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity.

artículo científico publicado en 2011

The gene for intestinal sucrase-isomaltase as member of a gene family

artículo científico publicado en 1989

The homeobox gene Cdx1 belongs to the p53-p21(WAF)-Bcl-2 network in intestinal epithelial cells

artículo científico publicado en 2002

The human mucin MUC4 is transcriptionally regulated by caudal-related homeobox, hepatocyte nuclear factors, forkhead box A, and GATA endodermal transcription factors in epithelial cancer cells.

artículo científico publicado en 2007

The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells

artículo científico publicado en 2007

The rat LPH gene 5' region: comparative structure with the human gene

artículo científico publicado el 1 de enero de 1992

The tumor suppressor Apc controls planar cell polarities central to gut homeostasis.

artículo científico publicado en 2012

The tumor suppressor CDX2 opposes pro-metastatic biomechanical modifications of colon cancer cells through organization of the actin cytoskeleton.

artículo científico publicado en 2016

Transcriptional regulation of the intestinal nuclear bile acid farnesoid X receptor (FXR) by the caudal-related homeobox 2 (CDX2).

artículo científico publicado en 2014

Type IV collagen mRNA accumulates in the mesenchymal compartment at early stages of murine developing intestine.

artículo científico publicado en 1990

Ultrastructural study of intestinal lactase gene expression

scientific article published on 01 January 1995

Understanding epithelial homeostasis in the intestine: An old battlefield of ideas, recent breakthroughs and remaining controversies

artículo científico publicado en 2013

Verification of the lactase site of rat lactase-phlorizin hydrolase by site-directed mutagenesis

artículo científico publicado en 1995

Wnt/(beta)-catenin signaling regulates the expression of the homeobox gene Cdx1 in embryonic intestine.

artículo científico publicado en 2000

Lista de obras de Jean-Noel Freund

A redox ruthenium compound directly targets PHD2 and inhibits the HIF1 pathway to reduce tumor angiogenesis independently of p53

Activity of the rat lactase gene promoter in transfected human colon cancer cells

Anchoring secreted proteins in endoplasmic reticulum by plant oleosin: the example of vitamin B12 cellular sequestration by transcobalamin

Bile acids induce ectopic expression of intestinal guanylyl cyclase C Through nuclear factor-kappaB and Cdx2 in human esophageal cells

Broader expression of the mouse platelet factor 4-cre transgene beyond the megakaryocyte lineage.

CDX2 autoregulation in human intestinal metaplasia of the stomach: impact on the stability of the phenotype ⬇️

CDX2 in congenital gut gastric-type heteroplasia and intestinal-type Meckel diverticula

Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos

Cdx1, a dispensable homeobox gene for gut development with limited effect in intestinal cancer

Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and β-Catenin Activity in Colon Cancer Cells ⬇️

Cdx2 determines the fate of postnatal intestinal endoderm

Cdx2 homeoprotein inhibits non-homologous end joining in colon cancer but not in leukemia cells.

Cell guidance into quiescent state through chromatin remodeling induced by elastic modulus of substrate

Cellular and molecular partners involved in gut morphogenesis and differentiation ⬇️

Changing intestinal connective tissue interactions alters homeobox gene expression in epithelial cells

Chromatin de-condensation by switching substrate elasticity

Combined NADPH oxidase 1 and interleukin 10 deficiency induces chronic endoplasmic reticulum stress and causes ulcerative colitis-like disease in mice

Comparative expression of the mRNA for three intestinal hydrolases during postnatal development in the rat

Concerted involvement of Cdx/Hox genes and Wnt signaling in morphogenesis of the caudal neural tube and cloacal derivatives from the posterior growth zone

Contribution of soft substrates to malignancy and tumor suppression during colon cancer cell division

Control of differentiation-induced calbindin-D9k gene expression in Caco-2 cells by cdx-2 and HNF-1alpha

Dietary control of the lactase mRNA distribution along the rat small intestine

Different expression of the mRNA detected by the cDNA for fetal rat lactase in the jejunum and colon

Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors.

Differential regulation of the glucose-6-phosphatase TATA box by intestine-specific homeodomain proteins CDX1 and CDX2

Directing nuclear deformation on micropillared surfaces by substrate geometry and cytoskeleton organization.

Discrepancy between the intestinal lactase enzymatic activity and mRNA accumulation in sucklings and adults. Effect of starvation and thyroxine treatment.

Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells.

Do co-translated product(s) of lactase-phlorizin hydrolase accumulate in the rat intestine?

Down-regulation of the tumor suppressor PTEN by the tumor necrosis factor-alpha/nuclear factor-kappaB (NF-kappaB)-inducing kinase/NF-kappaB pathway is linked to a default IkappaB-alpha autoregulatory loop.

Downregulation of the colon tumour-suppressor homeobox gene Cdx-2 by oncogenic ras

Endoderm- and mesenchyme-dependent commitment of the differentiated epithelial cell types in the developing intestine of rat.

Enhanced Ghrelin Levels and Hypothalamic Orexigenic AgRP and NPY Neuropeptide Expression in Models of Jejuno-Colonic Short Bowel Syndrome

Enteropathogenic e.coli sustains iodoacetamide-induced ulcerative colitis-like colitis in rats: modulation of IL-1β, IL-6, TNF-α, COX-2, and apoptosisi

Expression and localisation of insulin receptor substrate 2 in normal intestine and colorectal tumours. Regulation by intestine-specific transcription factor CDX2.

Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities.

Frequent rearrangements and amplification of the CDX2 homeobox gene in human sporadic colorectal cancers with chromosomal instability

Functional diversity and interactions between the repeat domains of rat intestinal lactase ⬇️

Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein

Functional interference between thyroid hormone receptor alpha (TRalpha) and natural truncated TRDeltaalpha isoforms in the control of intestine development.

Gastric intestinal metaplasia revisited: function and regulation of CDX2.

Gastric intrinsic factor deficiency with combined GIF heterozygous mutations and FUT2 secretor variant.

Gradient expression of Cdx along the rat intestine throughout postnatal development

Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration.

Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer.

Identification and characterization of human Mex-3 proteins, a novel family of evolutionarily conserved RNA-binding proteins differentially localized to processing bodies

Identification of homologues of the mammalian intestinal lactase gene in non-mammals (birds and molluscs).

Identity and intestinal pathologies: the Cdx2 homeotic gene

Immunohistochemical expression of CDX2, β-catenin, and TP53 in inflammatory bowel disease-associated colorectal cancer ⬇️

Increasing the oxygen load by treatment with myo-inositol trispyrophosphate reduces growth of colon cancer and modulates the intestine homeobox gene Cdx2 ⬇️

Intestinal epithelial-mesenchymal cell interactions.

Involvement of T3Ralpha- and beta-receptor subtypes in mediation of T3 functions during postnatal murine intestinal development

Key Role of the Cdx2 Homeobox Gene in Extracellular Matrix–mediated Intestinal Cell Differentiation ⬇️

Key elements of the BMP/SMAD pathway co-localize with CDX2 in intestinal metaplasia and regulate CDX2 expression in human gastric cell lines.

Lactase expression is controlled differently in the jejunum and ileum during development in rats

Lactase is unchanged in suckling mice fed with lactose-free milk

Laminin isoforms: biological roles and effects on the intracellular distribution of nuclear proteins in intestinal epithelial cells.

Mesenchyme-mediated effects of retinoic acid during rat intestinal development

Molecular and cellular effects of vitamin B12 in brain, myocardium and liver through its role as co-factor of methionine synthase ⬇️

Multiple levels of control of the stage- and region-specific expression of rat intestinal lactase

Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice

NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon

Phosphorylation of the homeotic tumor suppressor Cdx2 mediates its ubiquitin-dependent proteasome degradation.

Precancerous lesions upon sporadic activation of beta-catenin in mice.

Production of low-lactose milk by ectopic expression of intestinal lactase in the mouse mammary gland

Promotion of intestinal carcinogenesis by dietary methionine

Rat lactase activity and mRNA expression in relation to the thyroid and corticoid status

Regulation of the tumor suppressor homeogene Cdx2 by HNF4α in intestinal cancer

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

Severe head dysgenesis resulting from imbalance between anterior and posterior ontogenetic programs

Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival.

Subepithelial fibroblast cell lines from different levels of gut axis display regional characteristics.

TAF4 inactivation reveals the 3 dimensional growth promoting activities of collagen 6A3.

Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease

Temporal multiomic modeling reveals a B-cell receptor proliferative program in chronic lymphocytic leukemia

The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development.

The Cdx2 homeobox gene suppresses intestinal tumorigenesis through non-cell-autonomous mechanisms.

The atypical cadherin MUCDHL antagonizes colon cancer formation and inhibits oncogenic signaling through multiple mechanisms

The control of chromosome segregation during mitosis in epithelial cells by substrate elasticity.