Lista de obras - Shaun P Jackson - Dominio Público Uruguay

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

artículo científico publicado en 2016

A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis

artículo científico publicado en 2006

A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex

artículo científico publicado en 2008

A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow

artículo científico publicado en 2012

A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists

artículo científico publicado en 2006

A multimode-TIRFM and microfluidic technique to examine platelet adhesion dynamics

artículo científico publicado en 2013

A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance.

artículo científico publicado en 2011

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

scientific article published on 01 June 2009

An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation

scientific article published on 25 March 2019

An investigation on platelet transport during thrombus formation at micro-scale stenosis

artículo científico publicado en 2013

Antiplatelet therapy: in search of the 'magic bullet'.

artículo científico publicado en 2003

Antithrombotic phosphoinositide 3-kinase β inhibitors in humans: a 'shear' delight!

artículo científico publicado en 2012

Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis

artículo científico publicado en 2018

Application of a strain rate gradient microfluidic device to von Willebrand's disease screening

artículo científico publicado en 2017

Are Erk, Btk, and PECAM-1 major players in GPIb signaling? The challenge of unraveling signaling events downstream of platelet GPIb

artículo científico publicado en 2007

Arterial thrombosis—insidious, unpredictable and deadly ⬇️

artículo científico publicado el 7 de noviembre de 2011

Autoregulation of von Willebrand factor function by a disulfide bond switch.

artículo científico publicado en 2018

Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function

artículo científico publicado en 2012

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

artículo científico publicado en 2011

Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clots

artículo científico publicado en 1997

Calpain regulation of cytoskeletal signaling complexes in von Willebrand factor-stimulated platelets. Distinct roles for glycoprotein Ib-V-IX and glycoprotein IIb-IIIa (integrin alphaIIbbeta3) in von Willebrand factor-induced signal transduction

artículo científico publicado en 1997

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

artículo científico publicado en 2012

Class I phosphoinositide 3-kinases.

artículo científico publicado en 2003

Collagen surfaces to measure thrombus formation under flow: possibilities for standardization

scientific article published on 01 April 2011

Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets.

artículo científico publicado en 2018

Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization

artículo científico publicado en 2006

Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading

scientific article published on 04 June 2007

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

artículo científico publicado en 2017

Differentiating haemostasis from thrombosis for therapeutic benefit

artículo científico publicado en 2013

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922).

artículo científico publicado en 2016

Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow.

artículo científico publicado en 2001

Distinct substrate specificities and functional roles for the 78- and 76-kDa forms of mu-calpain in human platelets

artículo científico publicado en 1997

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice

artículo científico publicado en 2014

Dual Biomembrane Force Probe enables single-cell mechanical analysis of signal crosstalk between multiple molecular species.

artículo científico publicado en 2017

Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity.

artículo científico publicado en 2007

Dynamics of platelet thrombus formation.

artículo científico publicado en 2009

Endogenous fibrinolysis facilitates clot retraction in vivo

artículo científico publicado en 2017

Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular injury

artículo científico publicado en 2009

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

artículo científico publicado en 2007

Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target

artículo científico publicado en 2011

Ferric chloride thrombosis model: unraveling the vascular effects of a highly corrosive oxidant

artículo científico publicado en 2015

Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.

artículo científico publicado en 2010

Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPib/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shear

artículo científico publicado en 1999

High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction

artículo científico publicado en 2010

Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation

artículo científico publicado en 2006

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.

artículo científico publicado en 2008

Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets

artículo científico publicado en 2007

Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha.

artículo científico publicado en 2005

Imaging signaling processes in platelets.

artículo científico publicado en 2006

Improved analogs and novel delivery systems for somatostatin octapeptides.

artículo científico publicado en 1996

Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform

artículo científico publicado en 2007

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

artículo científico publicado en 2018

Is thrombin the problem or (dis)solution?

artículo científico publicado en 2009

Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor.

artículo científico publicado en 2006

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263).

artículo científico publicado en 2013

Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics.

artículo científico publicado en 2018

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

artículo científico publicado en 2015

Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticles

artículo científico publicado en 2018

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia.

artículo científico publicado en 2017

New insights into the haemostatic function of platelets.

artículo científico publicado en 2009

Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.

artículo científico publicado en 2009

Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction

artículo científico publicado en 2011

PI 3-kinase p110beta: a new target for antithrombotic therapy

scientific journal article

PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis

article

PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading.

artículo científico publicado en 2010

Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels

artículo científico publicado en 2012

Pathophysiological Levels of Soluble P-Selectin Mediate Adhesion of Leukocytes to the Endothelium Through Mac-1 Activation

artículo científico publicado en 2008

Phenotype changes resulting in high-affinity binding of von Willebrand factor to recombinant glycoprotein Ib-IX: analysis of the platelet-type von Willebrand disease mutations.

artículo científico publicado en 2001

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

artículo científico publicado en 2011

Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.

artículo científico publicado en 2009

Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway.

artículo científico publicado en 2010

Platelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeleton

scientific journal article

Procoagulant platelets: are they necrotic?

artículo científico publicado en 2010

Purification and characterisation of a snake venom phospholipase A2: A potent inhibitor of platelet aggregation

scientific article published on 01 June 1993

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

artículo científico publicado en 2014

Raised Plasma Soluble P-Selectin in Peripheral Arterial Occlusive Disease Enhances Leukocyte Adhesion

artículo científico publicado en 2005

Rapid assembly and profiling of an anticoagulant sulfoprotein library

artículo científico publicado en 2019

RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear.

artículo científico publicado en 2002

Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets

artículo científico publicado en 2009

SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets.

artículo científico publicado en 2004

SR-BI and fatty platelets

scientific article published on 01 September 2010

Safety and efficacy of targeting platelet proteinase-activated receptors in combination with existing anti-platelet drugs as antithrombotics in mice

artículo científico publicado en 2012

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

artículo científico publicado en 2005

Shear induces a unique series of morphological changes in translocating platelets: effects of morphology on translocation dynamics

artículo científico publicado en 2005

Shear-dependent tether formation during platelet translocation on von Willebrand factor

artículo científico publicado en 2002

Signaling role for phospholipase C gamma 2 in platelet glycoprotein Ib alpha calcium flux and cytoskeletal reorganization. Involvement of a pathway distinct from FcR gamma chain and Fc gamma RIIA.

artículo científico publicado en 2003

Specific function of phosphoinositide 3-kinase beta in the control of DNA replication

scholarly article

Structural and hydrodynamic simulation of an acute stenosis-dependent thrombosis model in mice

artículo científico publicado en 2011

Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib/IX and integrin alpha IIbbeta 3. Studies in human platelets ans transfected Chinese hamster ovary cells

scientific article published on 01 December 2000

Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110alpha inhibitors.

artículo científico publicado en 2007

Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration.

artículo científico publicado en 2008

The bioactive phospholipid, lysophosphatidylcholine, induces cellular effects via G-protein-dependent activation of adenylyl cyclase.

artículo científico publicado en 1996

The catalytic class I(A) PI3K isoforms play divergent roles in breast cancer cell migration.

artículo científico publicado en 2010

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.

artículo científico publicado en 2015

The clot thickens--oxidized lipids and thrombosis

The contribution of thrombin-induced platelet activation to thrombus growth is diminished under pathological blood shear conditions

artículo científico publicado en 2011

The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis.

artículo científico publicado en 2006

The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerization and cytoskeletal reorganization in rolling platelets and glycoprotein Ib/V/IX-transfected cells.

artículo científico publicado en 1999

Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency

scientific article published on 03 January 2006

Thrombin-dependent intravascular leukocyte trafficking regulated by fibrin and the platelet receptors GPIb and PAR4.

artículo científico publicado en 2015

Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms

scientific article published on 14 January 2019

Thromboinflammatory Functions of Platelets in Ischemia-Reperfusion Injury and Its Dysregulation in Diabetes

artículo científico publicado en 2018

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.

artículo científico publicado en 2009

Type I phosphoinositide 3-kinases: potential antithrombotic targets?

artículo científico publicado en 2006

Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse.

artículo científico publicado en 2016

Lista de obras de Shaun P Jackson

14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function

A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis

A functional 14-3-3zeta-independent association of PI3-kinase with glycoprotein Ib alpha, the major ligand-binding subunit of the platelet glycoprotein Ib-IX-V complex

A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow

A mechanistic model for paradoxical platelet activation by ligand-mimetic alphaIIb beta3 (GPIIb/IIIa) antagonists

A multimode-TIRFM and microfluidic technique to examine platelet adhesion dynamics

A sensitized RNA interference screen identifies a novel role for the PI3K p110γ isoform in medulloblastoma cell proliferation and chemoresistance.

A shear gradient–dependent platelet aggregation mechanism drives thrombus formation

An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation

An investigation on platelet transport during thrombus formation at micro-scale stenosis

Antiplatelet therapy: in search of the 'magic bullet'.

Antithrombotic phosphoinositide 3-kinase β inhibitors in humans: a 'shear' delight!

Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis

Application of a strain rate gradient microfluidic device to von Willebrand's disease screening

Are Erk, Btk, and PECAM-1 major players in GPIb signaling? The challenge of unraveling signaling events downstream of platelet GPIb

Arterial thrombosis—insidious, unpredictable and deadly ⬇️

Autoregulation of von Willebrand factor function by a disulfide bond switch.

Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Calpain cleavage of focal adhesion proteins regulates the cytoskeletal attachment of integrin alphaIIbbeta3 (platelet glycoprotein IIb/IIIa) and the cellular retraction of fibrin clots

Calpain regulation of cytoskeletal signaling complexes in von Willebrand factor-stimulated platelets. Distinct roles for glycoprotein Ib-V-IX and glycoprotein IIb-IIIa (integrin alphaIIbbeta3) in von Willebrand factor-induced signal transduction

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

Class I phosphoinositide 3-kinases.

Collagen surfaces to measure thrombus formation under flow: possibilities for standardization

Compression force sensing regulates integrin αIIbβ3 adhesive function on diabetic platelets.

Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization

Conversion of platelets from a proaggregatory to a proinflammatory adhesive phenotype: role of PAF in spatially regulating neutrophil adhesion and spreading

Corrigendum: 14-3-3ζ regulates the mitochondrial respiratory reserve linked to platelet phosphatidylserine exposure and procoagulant function.

Differentiating haemostasis from thrombosis for therapeutic benefit

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922).

Distinct glycoprotein Ib/V/IX and integrin alpha IIbbeta 3-dependent calcium signals cooperatively regulate platelet adhesion under flow.

Distinct substrate specificities and functional roles for the 78- and 76-kDa forms of mu-calpain in human platelets

Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice

Dual Biomembrane Force Probe enables single-cell mechanical analysis of signal crosstalk between multiple molecular species.

Dual P2Y 12 receptor signaling in thrombin-stimulated platelets--involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity.

Dynamics of platelet thrombus formation.

Endogenous fibrinolysis facilitates clot retraction in vivo

Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular injury

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling.

Evidence of platelet activation at medically used hypothermia and mechanistic data indicating ADP as a key mediator and therapeutic target

Ferric chloride thrombosis model: unraveling the vascular effects of a highly corrosive oxidant

Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene.

Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPib/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shear

High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction

Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation

Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth.

Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin alpha IIb beta 3 adhesive function in platelets

Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha.

Imaging signaling processes in platelets.

Improved analogs and novel delivery systems for somatostatin octapeptides.

Insulin-like growth factor-1 regulates platelet activation through PI3-Kalpha isoform

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

Is thrombin the problem or (dis)solution?

Leucine-rich repeats 2-4 (Leu60-Glu128) of platelet glycoprotein Ibalpha regulate shear-dependent cell adhesion to von Willebrand factor.

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263).

Mosquito-Derived Anophelin Sulfoproteins Are Potent Antithrombotics.

MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents

Multi-photon near-infrared emission saturation nanoscopy using upconversion nanoparticles

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia.

New insights into the haemostatic function of platelets.

Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.

Novel role of platelets in mediating inflammatory responses and ventricular rupture or remodeling following myocardial infarction

PI 3-kinase p110beta: a new target for antithrombotic therapy

PI(3)Kγ has an important context-dependent role in neutrophil chemokinesis

PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading.

Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels

Pathophysiological Levels of Soluble P-Selectin Mediate Adhesion of Leukocytes to the Endothelium Through Mac-1 Activation

Phenotype changes resulting in high-affinity binding of von Willebrand factor to recombinant glycoprotein Ib-IX: analysis of the platelet-type von Willebrand disease mutations.

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

Phosphoinositide 3-kinase p110 beta regulates integrin alpha IIb beta 3 avidity and the cellular transmission of contractile forces.

Platelet recruitment to the inflamed glomerulus occurs via an alphaIIbbeta3/GPVI-dependent pathway.

Platelets and the injured vessel wall-- "rolling into action": focus on glycoprotein Ib/V/IX and the platelet cytoskeleton

Procoagulant platelets: are they necrotic?

Purification and characterisation of a snake venom phospholipase A2: A potent inhibitor of platelet aggregation

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

Raised Plasma Soluble P-Selectin in Peripheral Arterial Occlusive Disease Enhances Leukocyte Adhesion

Rapid assembly and profiling of an anticoagulant sulfoprotein library

RhoA sustains integrin alpha IIbbeta 3 adhesion contacts under high shear.

Role of phosphoinositide 3-kinase beta in glycoprotein VI-mediated Akt activation in platelets