Lista de obras - Philip D Gregory - Dominio Público Uruguay

A TALE nuclease architecture for efficient genome editing

artículo científico publicado en 2011

A Transient Histone Hyperacetylation Signal Marks Nucleosomes for Remodeling at the PHO8 Promoter In Vivo

artículo científico publicado en 2001

A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart.

artículo científico publicado en 2012

A southern blot protocol to detect chimeric nuclease-mediated gene repair.

artículo científico publicado en 2014

Absence of WASp Enhances Hematopoietic and Megakaryocytic Differentiation in a Human Embryonic Stem Cell Model

artículo científico publicado en 2015

An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease.

artículo científico publicado en 2010

An improved zinc-finger nuclease architecture for highly specific genome editing

artículo científico publicado en 2007

An unbiased genome-wide analysis of zinc-finger nuclease specificity

artículo científico publicado en 2011

Biotechnologies and therapeutics: chromatin as a target.

artículo científico publicado en 2002

CRISPR technology for gene therapy

artículo científico publicado en 2014

Chromatin structure of two genomic sites for targeted transgene integration in induced pluripotent stem cells and hematopoietic stem cells.

artículo científico publicado en 2012

Chromosomal translocations induced at specified loci in human stem cells.

scholarly article

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.

artículo científico publicado en 2015

Clinical scale zinc finger nuclease (ZFN)-driven gene-editing of PD-1 in tumor infiltrating lymphocytes (TIL) for the potential treatment of metastatic melanoma.

artículo científico publicado en 2014

Comparison of Zinc Finger Nucleases Versus CRISPR-Specific Nucleases for Genome Editing of the Wiskott-Aldrich Syndrome Locus

artículo científico publicado en 2017

Controlling gene expression in Drosophila using engineered zinc finger protein transcription factors.

artículo científico publicado en 2006

Controlling long-range genomic interactions to reprogram the β-globin locus.

artículo científico publicado en 2013

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells

artículo científico publicado en 2015

DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation

artículo científico publicado en 2011

Dissection of splicing regulation at an endogenous locus by zinc-finger nuclease-mediated gene editing

artículo científico publicado en 2011

Distinct factors control histone variant H3.3 localization at specific genomic regions

artículo científico publicado en 2010

Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

artículo científico publicado en 2014

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

artículo científico publicado en 2012

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases ⬇️

artículo científico publicado el 5 de julio de 2011

Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases

artículo científico publicado en 2011

Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases. ⬇️

artículo científico publicado en 2011

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

artículo científico publicado en 2009

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases

artículo científico publicado en 2011

Enhanced protein production by engineered zinc finger proteins.

artículo científico publicado en 2007

Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

artículo científico publicado en 2011

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

artículo científico publicado en 2008

Functional footprinting of regulatory DNA.

artículo científico publicado en 2015

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

artículo científico publicado en 2010

Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

artículo científico publicado en 2007

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

artículo científico publicado en 2014

Gene regulation in planta by plant-derived engineered zinc finger protein transcription factors.

artículo científico publicado en 2005

Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathy.

artículo científico publicado en 2006

Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo.

artículo científico publicado en 2002

Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases.

artículo científico publicado en 2010

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

artículo científico publicado en 2011

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

artículo científico publicado en 2014

Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application

artículo científico publicado en 2016

Genetic engineering of human pluripotent cells using TALE nucleases

artículo científico publicado en 2011

Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.

artículo científico publicado en 2018

Genome editing with engineered zinc finger nucleases

artículo científico publicado en 2010

Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases

artículo científico publicado en 2013

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

artículo científico publicado en 2008

Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies.

artículo científico publicado en 2010

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

artículo científico publicado en 2005

Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery.

artículo científico publicado en 2015

Histone deimination antagonizes arginine methylation

artículo científico publicado en 2004

Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors.

artículo científico publicado en 2015

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

artículo científico publicado en 2010

Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells

artículo científico publicado en 2014

Improved specificity of TALE-based genome editing using an expanded RVD repertoire

artículo científico publicado en 2015

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

artículo científico publicado en 2015

In vivo genome editing restores haemostasis in a mouse model of haemophilia

artículo científico publicado en 2011

Isogenic human cell lines for drug discovery: regulation of target gene expression by engineered zinc-finger protein transcription factors.

artículo científico publicado en 2005

Knockout rats generated by embryo microinjection of TALENs.

artículo científico publicado en 2011

Knockout rats via embryo microinjection of zinc-finger nucleases

artículo científico publicado en 2009

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction

artículo científico publicado en 2013

Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

artículo científico publicado en 2016

Mapping chromatin structure in yeast

artículo científico publicado en 1999

NA-Seq: a discovery tool for the analysis of chromatin structure and dynamics during differentiation

artículo científico publicado en 2009

Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus

artículo científico publicado en 2016

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

artículo científico publicado en 2009

Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells

artículo científico publicado en 2016

Prostaglandin E2 Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells

artículo científico publicado en 2017

Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells ⬇️

artículo científico publicado el 6 de febrero de 2011

Reactivation of developmentally silenced globin genes by forced chromatin looping.

artículo científico publicado en 2014

Regulation of endogenous gene expression using small molecule-controlled engineered zinc-finger protein transcription factors.

artículo científico publicado en 2007

Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors

artículo científico publicado en 2003

Restriction nucleases as probes for chromatin structure.

artículo científico publicado en 1999

Robust ZFN-mediated genome editing in adult hemophilic mice.

artículo científico publicado en 2013

Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.

scientific article published on 25 October 2013

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases

artículo científico publicado en 2012

Site-specific integration and tailoring of cassette design for sustainable gene transfer.

artículo científico publicado en 2011

Studies of the repressor (BlaI) of beta-lactamase synthesis in Staphylococcus aureus

artículo científico publicado en 1997

Tandem duplication in ermC translational attenuator of the macrolide-lincosamide-streptogramin B resistance plasmid pSES6 from Staphylococcus equorum.

artículo científico publicado en 1996

Targeted correction and restored function of the CFTR gene in cystic fibrosis induced pluripotent stem cells.

artículo científico publicado en 2015

Targeted gene addition in human CD34(+) hematopoietic cells for correction of X-linked chronic granulomatous disease

artículo científico publicado en 2016

Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme

artículo científico publicado en 2012

Targeted gene addition to human mesenchymal stromal cells as a cell-based plasma-soluble protein delivery platform.

artículo científico publicado en 2010

Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases.

artículo científico publicado en 2008

Targeted gene therapy and cell reprogramming in Fanconi anemia

artículo científico publicado en 2014

Targeted genome editing across species using ZFNs and TALENs

artículo científico publicado en 2011

Targeted genome editing in human repopulating haematopoietic stem cells

artículo científico publicado en 2014

Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors.

artículo científico publicado en 2003

Targeted transgene integration in plant cells using designed zinc finger nucleases

artículo científico publicado en 2009

Toward eliminating HLA class I expression to generate universal cells from allogeneic donors

artículo científico publicado en 2013

Trait stacking via targeted genome editing.

artículo científico publicado en 2013

Transcription and chromatin converge: lessons from yeast genetics.

artículo científico publicado en 2001

Transcriptional activation ofBrassica napusβ-ketoacyl-ACP synthase II with an engineered zinc finger protein transcription factor

artículo científico publicado en 2012

Transient cold shock enhances zinc-finger nuclease-mediated gene disruption.

artículo científico publicado en 2010

Zinc-finger Nuclease Editing of Human cxcr4 Promotes HIV-1 CD4+ T Cell Resistance and Enrichment ⬇️

artículo científico publicado el 24 de enero de 2012

Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity.

artículo científico publicado en 2003

Lista de obras de Philip D Gregory

A TALE nuclease architecture for efficient genome editing

A Transient Histone Hyperacetylation Signal Marks Nucleosomes for Remodeling at the PHO8 Promoter In Vivo

A designed zinc-finger transcriptional repressor of phospholamban improves function of the failing heart.

A southern blot protocol to detect chimeric nuclease-mediated gene repair.

Absence of WASp Enhances Hematopoietic and Megakaryocytic Differentiation in a Human Embryonic Stem Cell Model

An engineered zinc finger protein activator of the endogenous glial cell line-derived neurotrophic factor gene provides functional neuroprotection in a rat model of Parkinson's disease.

An improved zinc-finger nuclease architecture for highly specific genome editing

An unbiased genome-wide analysis of zinc-finger nuclease specificity

Biotechnologies and therapeutics: chromatin as a target.

CRISPR technology for gene therapy

Chromatin structure of two genomic sites for targeted transgene integration in induced pluripotent stem cells and hematopoietic stem cells.

Chromosomal translocations induced at specified loci in human stem cells.

Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.

Clinical scale zinc finger nuclease (ZFN)-driven gene-editing of PD-1 in tumor infiltrating lymphocytes (TIL) for the potential treatment of metastatic melanoma.

Comparison of Zinc Finger Nucleases Versus CRISPR-Specific Nucleases for Genome Editing of the Wiskott-Aldrich Syndrome Locus

Controlling gene expression in Drosophila using engineered zinc finger protein transcription factors.

Controlling long-range genomic interactions to reprogram the β-globin locus.

Correction of the sickle cell disease mutation in human hematopoietic stem/progenitor cells

DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation

Dissection of splicing regulation at an endogenous locus by zinc-finger nuclease-mediated gene editing

Distinct factors control histone variant H3.3 localization at specific genomic regions

Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

Editing T cell specificity towards leukemia by zinc finger nucleases and lentiviral gene transfer

Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases ⬇️

Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases

Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases. ⬇️

Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases

Enhanced protein production by engineered zinc finger proteins.

Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

Functional footprinting of regulatory DNA.

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV

Gene regulation in planta by plant-derived engineered zinc finger protein transcription factors.

Gene transfer of an engineered transcription factor promoting expression of VEGF-A protects against experimental diabetic neuropathy.

Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo.

Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases.

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

Genetic and molecular identification of three human TPP1 functions in telomerase action: recruitment, activation, and homeostasis set point regulation

Genetic editing of HLA expression in hematopoietic stem cells to broaden their human application

Genetic engineering of human pluripotent cells using TALE nucleases

Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.

Genome editing with engineered zinc finger nucleases

Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies.

Highly efficient endogenous human gene correction using designed zinc-finger nucleases

Highly efficient homology-driven genome editing in human T cells by combining zinc-finger nuclease mRNA and AAV6 donor delivery.

Histone deimination antagonizes arginine methylation

Homology-driven genome editing in hematopoietic stem and progenitor cells using ZFN mRNA and AAV6 donors.

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

Human intestinal tissue with adult stem cell properties derived from pluripotent stem cells

Improved specificity of TALE-based genome editing using an expanded RVD repertoire

In vivo genome editing of the albumin locus as a platform for protein replacement therapy

In vivo genome editing restores haemostasis in a mouse model of haemophilia

Isogenic human cell lines for drug discovery: regulation of target gene expression by engineered zinc-finger protein transcription factors.

Knockout rats generated by embryo microinjection of TALENs.

Knockout rats via embryo microinjection of zinc-finger nucleases

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction

Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

Mapping chromatin structure in yeast

NA-Seq: a discovery tool for the analysis of chromatin structure and dynamics during differentiation

Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

Preclinical development and qualification of ZFN-mediated CCR5 disruption in human hematopoietic stem/progenitor cells

Prostaglandin E2 Increases Lentiviral Vector Transduction Efficiency of Adult Human Hematopoietic Stem and Progenitor Cells

Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells ⬇️

Reactivation of developmentally silenced globin genes by forced chromatin looping.

Regulation of endogenous gene expression using small molecule-controlled engineered zinc-finger protein transcription factors.

Repression of vascular endothelial growth factor A in glioblastoma cells using engineered zinc finger transcription factors

Restriction nucleases as probes for chromatin structure.

Robust ZFN-mediated genome editing in adult hemophilic mice.

Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection.

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases

Site-specific integration and tailoring of cassette design for sustainable gene transfer.

Studies of the repressor (BlaI) of beta-lactamase synthesis in Staphylococcus aureus

Tandem duplication in ermC translational attenuator of the macrolide-lincosamide-streptogramin B resistance plasmid pSES6 from Staphylococcus equorum.