Lista de obras - Timothy J. Stalker - Dominio Público Uruguay

A Human Vascular Injury-on-a-Chip Model of Hemostasis

artículo científico publicado en 2020

A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.

artículo científico publicado en 2011

A novel role for calpains in the endothelial dysfunction of hyperglycemia

artículo científico publicado en 2003

A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets.

artículo científico publicado en 2014

A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment.

artículo científico publicado en 2014

A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity

artículo científico publicado en 2014

A systems approach to hemostasis: 4. How hemostatic thrombi limit the loss of plasma-borne molecules from the microvasculature.

artículo científico publicado en 2016

Boundary events: contact-dependent and contact-facilitated signaling between platelets

artículo científico publicado en 2004

Contact-dependent signaling events that promote thrombus formation

artículo científico publicado en 2006

Coordination of platelet agonist signaling during the hemostatic response in vivo

artículo científico publicado en 2017

Correction for Wang et al., Loss of PIP5KIβ demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.

artículo científico publicado en 2009

Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models

artículo científico publicado en 2014

Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D.

artículo científico publicado en 2010

Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis

artículo científico publicado en 2009

Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets.

artículo científico publicado en 2005

GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets

artículo científico publicado en 2020

Harnessing the platelet signaling network to produce an optimal hemostatic response.

artículo científico

Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation

artículo científico publicado en 2007

Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network

artículo científico publicado en 2013

Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury

artículo científico publicado en 2012

Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.

artículo científico publicado en 2004

Interrelationships between structure and function during the hemostatic response to injury

artículo científico publicado en 2019

Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes

artículo científico publicado en 2003

JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets.

artículo científico publicado en 2012

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

artículo científico publicado en 2014

Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation

artículo científico publicado en 2008

Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo

artículo científico publicado en 2002

Microcirculation as a target for the anti-inflammatory properties of statins.

artículo científico publicado en 2002

Minding the gaps to promote thrombus growth and stability

artículo científico publicado en 2005

Minding the gaps--and the junctions, too.

artículo científico publicado en 2012

Mouse laser injury models: variations on a theme

scientific article published on 16 April 2020

Mouse models of platelet function in vivo

artículo científico publicado en 2020

Novel therapeutic targets at the platelet vascular interface.

artículo científico publicado en 2008

Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease

artículo científico publicado en 2011

Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine.

artículo científico publicado en 2017

Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

artículo científico publicado en 2017

Platelet signaling

artículo científico publicado en 2012

Platelets and hemostasis: a new perspective on an old subject

artículo científico publicado en 2016

Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion

scientific journal article

Platelet‐targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse ⬇️

artículo científico publicado el 1 de noviembre de 2012

RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury

artículo científico publicado en 2010

RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists

artículo científico publicado en 2018

Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury

artículo científico publicado en 2007

Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis

artículo científico publicado en 2017

Shaping the platelet response to vascular injury

artículo científico publicado en 2014

Simulation of intrathrombus fluid and solute transport using in vivo clot structures with single platelet resolution.

artículo científico publicado en 2013

Spatiotemporal regulation of coagulation and platelet activation during the hemostatic response in vivo

artículo científico

The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes

artículo científico publicado en 2005

The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis

artículo científico publicado en 2017

Use of electron microscopy to study platelets and thrombi

scientific article published on 18 May 2020

Lista de obras de Timothy J. Stalker

A Human Vascular Injury-on-a-Chip Model of Hemostasis

A newly identified complex of spinophilin and the tyrosine phosphatase, SHP-1, modulates platelet activation by regulating G protein-dependent signaling.

A novel role for calpains in the endothelial dysfunction of hyperglycemia

A systems approach to hemostasis: 1. The interdependence of thrombus architecture and agonist movements in the gaps between platelets.

A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment.

A systems approach to hemostasis: 3. Thrombus consolidation regulates intrathrombus solute transport and local thrombin activity

A systems approach to hemostasis: 4. How hemostatic thrombi limit the loss of plasma-borne molecules from the microvasculature.

Boundary events: contact-dependent and contact-facilitated signaling between platelets

Contact-dependent signaling events that promote thrombus formation

Coordination of platelet agonist signaling during the hemostatic response in vivo

Correction for Wang et al., Loss of PIP5KIβ demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.

Defective release of α granule and lysosome contents from platelets in mouse Hermansky-Pudlak syndrome models

Diminished contact-dependent reinforcement of Syk activation underlies impaired thrombus growth in mice lacking Semaphorin 4D.

Disruption of SEMA4D ameliorates platelet hypersensitivity in dyslipidemia and confers protection against the development of atherosclerosis

Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets.

GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets

Harnessing the platelet signaling network to produce an optimal hemostatic response.

Hematopoietic lineage cell specific protein 1 (HS1) is a functionally important signaling molecule in platelet activation

Hierarchical organization in the hemostatic response and its relationship to the platelet-signaling network

Inhibition of Rho-kinase attenuates endothelial-leukocyte interaction during ischemia-reperfusion injury

Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection.

Interrelationships between structure and function during the hemostatic response to injury

Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes

JAM-A protects from thrombosis by suppressing integrin αIIbβ3-dependent outside-in signaling in platelets.

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice

Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation

Mechanisms of amelioration of glucose-induced endothelial dysfunction following inhibition of protein kinase C in vivo

Microcirculation as a target for the anti-inflammatory properties of statins.

Minding the gaps to promote thrombus growth and stability

Minding the gaps--and the junctions, too.

Mouse laser injury models: variations on a theme

Mouse models of platelet function in vivo

Novel therapeutic targets at the platelet vascular interface.

Occlusive thrombi arise in mammals but not birds in response to arterial injury: evolutionary insight into human cardiovascular disease

Peptides derived from MARCKS block coagulation complex assembly on phosphatidylserine.

Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

Platelet signaling

Platelets and hemostasis: a new perspective on an old subject

Platelets lacking PIP5KIγ have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion

Platelet‐targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse ⬇️

RGS/Gi2alpha interactions modulate platelet accumulation and thrombus formation at sites of vascular injury

RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists

Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury

Regulation of Platelet Activation and Coagulation and Its Role in Vascular Injury and Arterial Thrombosis

Shaping the platelet response to vascular injury

Simulation of intrathrombus fluid and solute transport using in vivo clot structures with single platelet resolution.

Spatiotemporal regulation of coagulation and platelet activation during the hemostatic response in vivo

The calcium-dependent protease calpain causes endothelial dysfunction in type 2 diabetes

The small molecule MERTK inhibitor UNC2025 decreases platelet activation and prevents thrombosis

Use of electron microscopy to study platelets and thrombi