Lista de obras - Steven A Johnsen - Dominio Público Uruguay

A Subset of Histone H2B Genes Produces Polyadenylated mRNAs under a Variety of Cellular Conditions ⬇️

artículo científico publicado el 22 de mayo de 2013

A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.

artículo científico publicado en 2018

ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells

scientific article published on 19 June 2019

Aberrant NFATc1 signaling counteracts TGFβ-mediated growth arrest and apoptosis induction in pancreatic cancer progression

artículo científico publicado en 2019

Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex

artículo científico publicado en 2010

Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice

artículo científico publicado en 2009

BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells.

artículo científico publicado en 2018

BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire.

artículo científico publicado en 2016

BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells

artículo científico publicado en 2016

Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription

artículo científico publicado en 2014

CDK4 inhibition diminishes p53 activation by MDM2 antagonists

scholarly article by Anusha Sriraman et al published 11 September 2018 in Cell Death and Disease

CDK9 and H2B monoubiquitination: a well-choreographed dance.

artículo científico publicado en 2012

CHD1 loss negatively influences metastasis-free survival in R0-resected prostate cancer patients and promotes spontaneous metastasis in vivo

scientific article published on 07 January 2021

CHD1 regulates cell fate determination by activation of differentiation-induced genes

artículo científico publicado en 2017

Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.

artículo científico publicado en 2017

Combined treatment with CBP and BET inhibitors reverses inadvertent activation of detrimental super enhancer programs in DIPG cells

scientific article published on 21 August 2020

Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity.

artículo científico publicado en 2017

Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites

article

DeltaNp63-dependent super enhancers define molecular identity in pancreatic cancer by an interconnected transcription factor network.

artículo científico publicado en 2018

Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue.

artículo científico publicado en 2004

EZH2 regulates pancreatic cancer subtype identity and tumor progression via transcriptional repression of GATA6

scientific article published on 09 September 2020

Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer

artículo científico publicado en 2014

Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?

artículo científico publicado en 2017

Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer

scientific article published on 09 August 2019

Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer

artículo científico publicado en 2022

Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta.

artículo científico publicado en 2003

Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B.

artículo científico publicado en 2011

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer

artículo científico publicado en 2017

Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling ⬇️

artículo científico publicado el 31 de julio de 2013

H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription.

artículo científico publicado en 2015

HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models.

artículo científico publicado en 2015

Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation

artículo científico publicado en 2016

Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner.

artículo científico publicado en 2017

Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer.

artículo científico publicado en 2014

Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing

artículo científico publicado en 2009

Interfering with the dynamics of estrogen receptor-regulated transcription

scientific article published on 01 January 2006

Krüppel-like Transcription Factor KLF10 Suppresses TGFβ-Induced Epithelial-to-Mesenchymal Transition via a Negative Feedback Mechanism

artículo científico publicado en 2017

Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness

artículo científico publicado en 2016

Loss of RNF40 decreases NF-κB activity in colorectal cancer cells and reduces colitis burden in mice

article

Loss of causes DNA repair defects and enhances prostate cancer therapeutic responsiveness

artículo científico publicado en 2018

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

artículo científico publicado en 2016

Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines.

artículo científico publicado en 2003

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

artículo científico publicado en 2015

NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy

scholarly article

No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3.

artículo científico publicado en 2016

Novel role of Tieg1 in muscle metabolism and mitochondrial oxidative capacities

scientific article published on 19 October 2019

Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy

artículo científico publicado en 2015

Perturbing Enhancer Activity in Cancer Therapy.

artículo científico publicado en 2019

Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function ⬇️

artículo científico publicado el 1 de junio de 2012

RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease

artículo científico publicado en 2021

RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk

artículo científico publicado en 2020

RNF40 regulates gene expression in an epigenetic context-dependent manner.

artículo científico publicado en 2017

Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens.

artículo científico publicado en 2005

Relevance of Sp Binding Site Polymorphism in WWOX for Treatment Outcome in Pancreatic Cancer.

artículo científico publicado en 2016

Role of TIEG1 in biological processes and disease states.

artículo científico publicado en 2007

SIRT2 directs the replication stress response through CDK9 deacetylation.

artículo científico publicado en 2013

STIM1 Mediates Calcium-Dependent Epigenetic Reprogramming in Pancreatic Cancer

artículo científico publicado en 2021

SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.

artículo científico publicado en 2014

Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation

artículo científico publicado en 2015

Super enhancers - new analyses and perspectives on the low hanging fruit

artículo científico publicado en 2017

Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2.

artículo científico publicado en 2015

Synthesis, characterization, and biological evaluation of new tetrazole-based platinum(II) and palladium(II) chlorido complexes — Potent cisplatin analogues and their trans isomers ⬇️

artículo científico publicado el 13 de diciembre de 2012

TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.

artículo científico publicado en 2002

Targeted therapy of epigenomic regulatory mechanisms controlling the epithelial to mesenchymal transition during tumor progression.

artículo científico publicado en 2014

The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair.

artículo científico publicado en 2011

The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming

artículo científico publicado en 2020

The enigmatic role of H2Bub1 in cancer ⬇️

artículo científico publicado el 13 de abril de 2012

The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene.

artículo científico publicado en 2008

The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells

artículo científico publicado en 2012

The histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis

artículo científico publicado en 2020

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

artículo científico publicado en 2008

The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness

artículo científico publicado en 2019

The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones.

artículo científico publicado en 2005

The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner

artículo científico publicado en 2017

Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene.

artículo científico publicado en 2002

Twist1 induces distinct cell states depending on TGFBR1-activation

artículo científico publicado en 2016

USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity

artículo científico publicado en 2019

USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response

artículo científico publicado en 2021

USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer

scientific article published on 04 December 2019

Usp22 deficiency impairs intestinal epithelial lineage specification in vivo

artículo científico publicado en 2015

Lista de obras de Steven A Johnsen

A Subset of Histone H2B Genes Produces Polyadenylated mRNAs under a Variety of Cellular Conditions ⬇️

A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart.

ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells

Aberrant NFATc1 signaling counteracts TGFβ-mediated growth arrest and apoptosis induction in pancreatic cancer progression

Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex

Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice

BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells.

BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire.

BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells

Bromodomain protein BRD4 is required for estrogen receptor-dependent enhancer activation and gene transcription

CDK4 inhibition diminishes p53 activation by MDM2 antagonists

CDK9 and H2B monoubiquitination: a well-choreographed dance.

CHD1 loss negatively influences metastasis-free survival in R0-resected prostate cancer patients and promotes spontaneous metastasis in vivo

CHD1 regulates cell fate determination by activation of differentiation-induced genes

Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.

Combined treatment with CBP and BET inhibitors reverses inadvertent activation of detrimental super enhancer programs in DIPG cells

Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity.

Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites

DeltaNp63-dependent super enhancers define molecular identity in pancreatic cancer by an interconnected transcription factor network.

Differential gene expression of TGF beta inducible early gene (TIEG), Smad7, Smad2 and Bard1 in normal and malignant breast tissue.

EZH2 regulates pancreatic cancer subtype identity and tumor progression via transcriptional repression of GATA6

Epigenetic plasticity: a central regulator of epithelial-to-mesenchymal transition in cancer

Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?

Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer

Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer

Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta.

Estrogen-dependent gene transcription in human breast cancer cells relies upon proteasome-dependent monoubiquitination of histone H2B.

Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer

Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling ⬇️

H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription.

HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models.

Histone Chaperone SSRP1 is Essential for Wnt Signaling Pathway Activity During Osteoblast Differentiation

Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner.

Identification of a DNA methylation signature to predict disease-free survival in locally advanced rectal cancer.

Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing

Interfering with the dynamics of estrogen receptor-regulated transcription

Krüppel-like Transcription Factor KLF10 Suppresses TGFβ-Induced Epithelial-to-Mesenchymal Transition via a Negative Feedback Mechanism

Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness

Loss of RNF40 decreases NF-κB activity in colorectal cancer cells and reduces colitis burden in mice

Loss of causes DNA repair defects and enhances prostate cancer therapeutic responsiveness

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

Mutual antagonism of estrogen receptors alpha and beta and their preferred interactions with steroid receptor coactivators in human osteoblastic cell lines.

NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.

NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy

No Significant Cytotoxic Effect of the EZH2 Inhibitor Tazemetostat (EPZ-6438) on Pediatric Glioma Cells with Wildtype Histone 3 or Mutated Histone 3.3.

Novel role of Tieg1 in muscle metabolism and mitochondrial oxidative capacities

Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy

Perturbing Enhancer Activity in Cancer Therapy.

Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function ⬇️

RNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease

RNF40 exerts stage-dependent functions in differentiating osteoblasts and is essential for bone cell crosstalk

RNF40 regulates gene expression in an epigenetic context-dependent manner.

Regulation of osteoblastic phenotype and gene expression by hop-derived phytoestrogens.

Relevance of Sp Binding Site Polymorphism in WWOX for Treatment Outcome in Pancreatic Cancer.

Role of TIEG1 in biological processes and disease states.

SIRT2 directs the replication stress response through CDK9 deacetylation.

STIM1 Mediates Calcium-Dependent Epigenetic Reprogramming in Pancreatic Cancer

SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.

Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation

Super enhancers - new analyses and perspectives on the low hanging fruit

Suppression of early hematogenous dissemination of human breast cancer cells to bone marrow by retinoic Acid-induced 2.

Synthesis, characterization, and biological evaluation of new tetrazole-based platinum(II) and palladium(II) chlorido complexes — Potent cisplatin analogues and their trans isomers ⬇️

TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses.

Targeted therapy of epigenomic regulatory mechanisms controlling the epithelial to mesenchymal transition during tumor progression.

The H2B ubiquitin ligase RNF40 cooperates with SUPT16H to induce dynamic changes in chromatin structure during DNA double-strand break repair.

The H2B ubiquitin-protein ligase RNF40 is required for somatic cell reprogramming

The enigmatic role of H2Bub1 in cancer ⬇️

The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene.

The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells

The histone H2B ubiquitin ligase RNF40 is required for HER2-driven mammary tumorigenesis

The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression

The histone methyltransferase DOT1L is required for proper DNA damage response, DNA repair, and modulates chemotherapy responsiveness

The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones.

The β-catenin/CBP-antagonist ICG-001 inhibits pediatric glioma tumorigenicity in a Wnt-independent manner

Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene.

Twist1 induces distinct cell states depending on TGFBR1-activation

USP22 exerts tumor-suppressive functions in colorectal cancer by decreasing mTOR activity

USP22 promotes HER2-driven mammary carcinoma aggressiveness by suppressing the unfolded protein response

USP22-dependent HSP90AB1 expression promotes resistance to HSP90 inhibition in mammary and colorectal cancer