Lista de obras - John E Ladbury - Dominio Público Uruguay

(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus

artículo científico publicado en 2014

A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly

scientific article published on 18 April 2019

A Structural Characterization of the Interactions between Titin Z-Repeats and the α-Actinin C-Terminal Domain

artículo científico publicado en 2001

A complex of Shc and Ran-GTPase localises to the cell nucleus

scientific article published on 01 February 2009

A differential scanning calorimetric study of the thermal unfolding of mutant forms of phage T4 lysozyme

artículo científico publicado en 1992

A landscape of driver mutations in melanoma

artículo científico publicado en 2012

A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis. ⬇️

artículo científico publicado en 2015

A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein

artículo científico publicado en 2007

A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans

artículo científico publicado en 2014

A survey of the year 2002 literature on applications of isothermal titration calorimetry

artículo científico publicado en 2003

A survey of the year 2003 literature on applications of isothermal titration calorimetry

artículo científico publicado en 2004

A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin

artículo científico publicado en 2015

Adding calorimetric data to decision making in lead discovery: a hot tip

article

Alternative Modes of Tyrosyl Phosphopeptide Binding to a Src Family SH2 Domain: Implications for Regulation of Tyrosine Kinase Activity†

article

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network

artículo científico publicado en 2016

Application of isothermal titration calorimetry in the biological sciences: things are heating up!

artículo científico publicado en 2004

Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone

article

Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid

artículo científico publicado en 2011

Biophysical characterization of VEGF-aHt DNA aptamer interactions

artículo científico publicado en 2013

CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins

artículo científico publicado en 2013

Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design

artículo científico publicado en 2010

Catalysis and regulation

article

Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems

artículo científico publicado en 2012

Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion ⬇️

artículo científico publicado en 2014

Conformational changes in the AAA ATPase p97-p47 adaptor complex

artículo científico publicado en 2006

Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.

artículo científico publicado en 2006

Corrigendum: Grb2 monomer-dimer equilibrium determines normal versus oncogenic function

artículo científico publicado en 2015

Counting the calories to stay in the groove.

artículo científico publicado en 1995

Crystal Structure and Binding Properties of the CD2 and CD244 (2B4)-binding Protein, CD48

artículo científico publicado en 2006

DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans

artículo científico publicado en 2020

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function

artículo científico publicado en 2009

Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX

artículo científico publicado en 2014

Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors

artículo científico publicado en 2005

Editorial

Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex

artículo científico publicado en 2009

Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling

artículo científico publicado en 2011

Erythropoietin Stimulates Tumor Growth via EphB4.

artículo científico publicado en 2015

Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator

artículo científico publicado en 2001

Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma ⬇️

artículo científico publicado en 2015

Extent of enthalpy-entropy compensation in protein-ligand interactions.

artículo científico publicado en 2011

Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

artículo científico publicado en 2008

Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation

article

FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia

artículo científico publicado en 2018

Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase.

artículo científico publicado en 2006

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

artículo científico publicado en 2013

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer ⬇️

artículo científico publicado en 2016

Grb2 monomer-dimer equilibrium determines normal versus oncogenic function ⬇️

artículo científico publicado en 2015

H-NS forms a superhelical protein scaffold for DNA condensation

artículo científico publicado en 2010

H-NS is a part of a thermally controlled mechanism for bacterial gene regulation.

artículo científico publicado en 2005

H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein

artículo científico publicado en 2002

H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing ⬇️

article

HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer ⬇️

artículo científico publicado en 2014

Heat capacity effects of water molecules and ions at a protein-DNA interface

artículo científico publicado en 2004

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

artículo científico publicado en 1994

Histone deacetylase inhibitors induce medulloblastoma cell death independent of HDACs recruited in REST repression complexes

artículo científico publicado en 2020

INTERACTION OF PORPHYRIN WITH G-QUADRUPLEX STRUCTURES

scientific article published on 01 January 2005

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

artículo científico publicado en 1997

Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.

artículo científico publicado en 2003

Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation

artículo científico publicado en 2007

Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2).

artículo científico publicado en 2008

Inhibition of basal FGF receptor signaling by dimeric Grb2

artículo científico publicado en 2012

Inhibitors to the Src SH2 domain: a lesson in structure--thermodynamic correlation in drug design.

artículo científico publicado en 2001

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli ⬇️

artículo científico publicado en 2013

Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat

artículo científico publicado en 2002

Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria

artículo científico publicado en 2009

Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6.

artículo científico publicado en 2000

Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction

artículo científico publicado en 2007

Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains

artículo científico publicado en 2002

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

artículo científico publicado en 2012

Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.

artículo científico publicado en 2004

Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.

artículo científico publicado en 2008

NMR Assignment of the Apo and Peptide-bound SH2 Domain from the Rous Sarcoma Viral Protein Src

article

Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43. ⬇️

artículo científico publicado en 2016

Noise in cellular signaling pathways: causes and effects

artículo científico publicado en 2012

Non-covalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity ⬇️

artículo científico publicado en 2016

Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications

artículo científico publicado en 2009

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

artículo científico publicado en 2015

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

artículo científico publicado en 2015

Partial filling multiple injection affinity capillary electrophoresis (PFMIACE) to estimate binding constants of receptors to ligands

artículo científico publicado en 2006

Partial-filling affinity capillary electrophoresis techniques to probe the binding of glycopeptide antibiotics to D-Ala-D-Ala terminus peptides.

artículo científico publicado en 2006

Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression ⬇️

artículo científico publicado en 2013

Phosphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells. ⬇️

artículo científico publicado en 2017

Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity

artículo científico publicado en 2014

Potent and selective inhibition of SH3 domains with dirhodium metalloinhibitors

artículo científico publicado en 2015

Probing cocaine-antibody interactions in buffer and human serum

artículo científico publicado en 2012

RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef

artículo científico publicado en 1998

Redox-State-Dependent Complex Formation between Pseudoazurin and Nitrite Reductase

article

Reversal of halophilicity in a protein-DNA interaction by limited mutation strategy

artículo científico publicado en 2002

Rigid-body Ligand Recognition Drives Cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Receptor Triggering

artículo científico publicado en 2011

SLP-76 sterile α motif (SAM) and individual H5 α helix mediate oligomer formation for microclusters and T-cell activation ⬇️

artículo científico publicado en 2013

Solvation and the hidden thermodynamics of a zinc finger probed by nonstandard repair of a protein crevice

artículo científico publicado en 2004

Specific binding of hoechst 33258 to the d(CGCAAATTTGCG)2 duplex: calorimetric and spectroscopic studies ⬇️

artículo científico publicado el 15 de agosto de 1997

Specificity and interactions of the protein OppA: partitioning solvent binding effects using mass spectrometry 1 1Edited by P. E. Wright

article

Specificity is complex and time consuming: mutual exclusivity in tyrosine kinase-mediated signaling

artículo científico publicado en 2003

Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position.

artículo científico publicado en 1993

StpA protein from Escherichia coli condenses supercoiled DNA in preference to linear DNA and protects it from digestion by DNase I and EcoKI. ⬇️

artículo científico publicado en 2005

Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II

artículo científico publicado en 2016

Structural-thermodynamic relationships of interactions in the N-terminal ATP-binding domain of Hsp90.

artículo científico publicado en 2009

Structure and Interactions of the Human Programmed Cell Death 1 Receptor

artículo científico publicado en 2013

Structure, dynamics, and binding thermodynamics of the v-Src SH2 domain: implications for drug design

artículo científico publicado en 2008

Substitution of Charged Residues into the Hydrophobic Core of Escherichia coli Thioredoxin Results in a Change in Heat Capacity of the Native Protein

artículo científico publicado en 1995

Survey of the year 2004: literature on applications of isothermal titration calorimetry

artículo científico publicado en 2006

Survey of the year 2005: literature on applications of isothermal titration calorimetry

artículo científico publicado en 2007

T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes

scientific article published on 25 March 2010

T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26

artículo científico publicado en 2015

T-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation

artículo científico publicado en 2010

Targeting the Shc-EGFR interaction with indomethacin inhibits MAP kinase pathway signalling

artículo científico publicado en 2019

Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity

artículo científico publicado en 2015

Temporally regulated assembly of a dynamic signaling complex associated with the activated TCR

scientific article published on 01 September 2000

The Thermodynamics of Protein–Ligand Interaction and Solvation: Insights for Ligand Design

article

The absence of inorganic salt is required for the crystallization of the complete oligomerization domain of Salmonella typhimurium histone-like nucleoid-structuring protein

artículo científico publicado en 2010

The binding stoichiometry of CIN85 SH3 domain A and cbl-b

artículo científico publicado en 2008

The extended interface: measuring non-local effects in biomolecular interactions

artículo científico publicado en 2004

The hidden thermodynamics of a zinc finger

artículo científico publicado en 2002

The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases

artículo científico publicado en 2001

The role of water in sequence-independent ligand binding by an oligopeptide transporter protein

artículo científico publicado en 1996

The thermodynamics of formation of a three-strand, DNA three-way junction complex.

artículo científico publicado en 1994

The toolbox is open, but who should pay for the job?

artículo científico publicado en 2014

Thermodynamic effects of reduction of the active-site disulfide of Escherichia coli thioredoxin explored by differential scanning calorimetry.

artículo científico publicado en 1994

Tpl2 is required for VEGF-A-stimulated signal transduction and endothelial cell function.

artículo científico publicado en 2019

Turning Up the Heat On Rational Drug Design

artículo científico publicado en 1994

Two EGF molecules contribute additively to stabilization of the EGFR dimer

artículo científico publicado en 1997

Why zinc fingers prefer zinc: ligand-field symmetry and the hidden thermodynamics of metal ion selectivity

artículo científico publicado en 2004

Lista de obras de John E Ladbury

(19)F NMR reveals multiple conformations at the dimer interface of the nonstructural protein 1 effector domain from influenza A virus

A Secreted RNA Binding Protein Forms RNA-Stabilizing Granules in the Honeybee Royal Jelly

A Structural Characterization of the Interactions between Titin Z-Repeats and the α-Actinin C-Terminal Domain

A complex of Shc and Ran-GTPase localises to the cell nucleus

A differential scanning calorimetric study of the thermal unfolding of mutant forms of phage T4 lysozyme

A landscape of driver mutations in melanoma

A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis. ⬇️

A phosphorylation-dependent gating mechanism controls the SH2 domain interactions of the Shc adaptor protein

A requirement for ERK-dependent Dicer phosphorylation in coordinating oocyte-to-embryo transition in C. elegans

A survey of the year 2002 literature on applications of isothermal titration calorimetry

A survey of the year 2003 literature on applications of isothermal titration calorimetry

A variable DNA recognition site organization establishes the LiaR-mediated cell envelope stress response of enterococci to daptomycin

Adding calorimetric data to decision making in lead discovery: a hot tip

Alternative Modes of Tyrosyl Phosphopeptide Binding to a Src Family SH2 Domain: Implications for Regulation of Tyrosine Kinase Activity†

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network

Application of isothermal titration calorimetry in the biological sciences: things are heating up!

Backbone resonance assignments of the 25kD N-terminal ATPase domain from the Hsp90 chaperone

Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid

Biophysical characterization of VEGF-aHt DNA aptamer interactions

CD25 and CD69 induction by α4β1 outside-in signalling requires TCR early signalling complex proteins

Calorimetry as a tool for understanding biomolecular interactions and an aid to drug design

Catalysis and regulation

Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems

Competition between Grb2 and Plcγ1 for FGFR2 regulates basal phospholipase activity and invasion ⬇️

Conformational changes in the AAA ATPase p97-p47 adaptor complex

Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90.

Corrigendum: Grb2 monomer-dimer equilibrium determines normal versus oncogenic function

Counting the calories to stay in the groove.

Crystal Structure and Binding Properties of the CD2 and CD244 (2B4)-binding Protein, CD48

DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans

Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function

Discovery and characterization of novel selective inhibitors of carbonic anhydrase IX

Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors

Editorial

Effects of full-length borealin on the composition and protein-protein interaction activity of a binary chromosomal passenger complex

Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling

Erythropoietin Stimulates Tumor Growth via EphB4.

Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator

Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma ⬇️

Extent of enthalpy-entropy compensation in protein-ligand interactions.

Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation

FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia

Global effects of the energetics of coenzyme binding: NADPH controls the protein interaction properties of human cytochrome P450 reductase.

Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer ⬇️

Grb2 monomer-dimer equilibrium determines normal versus oncogenic function ⬇️

H-NS forms a superhelical protein scaffold for DNA condensation

H-NS is a part of a thermally controlled mechanism for bacterial gene regulation.

H-NS oligomerization domain structure reveals the mechanism for high order self-association of the intact protein

H-NS uses an autoinhibitory conformational switch for environment-controlled gene silencing ⬇️

HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer ⬇️

Heat capacity effects of water molecules and ions at a protein-DNA interface

Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation

Histone deacetylase inhibitors induce medulloblastoma cell death independent of HDACs recruited in REST repression complexes

INTERACTION OF PORPHYRIN WITH G-QUADRUPLEX STRUCTURES

Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.

Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation

Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2).

Inhibition of basal FGF receptor signaling by dimeric Grb2

Inhibitors to the Src SH2 domain: a lesson in structure--thermodynamic correlation in drug design.

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli ⬇️

Interactions defining the specificity between fungal xylanases and the xylanase-inhibiting protein XIP-I from wheat

Investigation of the self-association and hetero-association interactions of H-NS and StpA from Enterobacteria

Localization and characterization of the hyaluronan-binding site on the link module from human TSG-6.

Measurement of the formation of complexes in tyrosine kinase-mediated signal transduction

Metal-dependent folding and stability of nuclear hormone receptor DNA-binding domains

Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions

Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.

Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax.

NMR Assignment of the Apo and Peptide-bound SH2 Domain from the Rous Sarcoma Viral Protein Src

Native and engineered tropism of vectors derived from a rare species D adenovirus serotype 43. ⬇️

Noise in cellular signaling pathways: causes and effects

Non-covalent forces tune the electron transfer complex between ferredoxin and sulfite reductase to optimize enzymatic activity ⬇️

Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications

Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response

Partial filling multiple injection affinity capillary electrophoresis (PFMIACE) to estimate binding constants of receptors to ligands