Lista de obras - Michael J Rogers - Dominio Público Uruguay

A class III semaphorin (Sema3e) inhibits mouse osteoblast migration and decreases osteoclast formation in vitro.

artículo científico publicado en 2012

A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo

artículo científico publicado en 2007

A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton

artículo científico publicado en 2015

A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells.

artículo científico publicado en 2010

Actin polymerization modulates CD44 surface expression, MMP-9 activation, and osteoclast function.

artículo científico publicado en 2007

Activation of γδ T cells by bisphosphonates.

artículo científico publicado en 2010

Antagonistic effects of different classes of bisphosphonates in osteoclasts and macrophages in vitro.

artículo científico publicado en 2003

Biochemical and molecular mechanisms of action of bisphosphonates.

artículo científico publicado en 2010

Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-tRNA synthetase enzymes

scientific article published on 01 July 1996

Bisphosphonates--mechanisms of action in multiple myeloma

artículo científico publicado en 2000

Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages.

artículo científico publicado en 2010

Bone Turnover Markers and Prostate Cancer: Not Just a Measure of Bone Disease?

artículo científico publicado en 2014

Bone remodelling at a glance

artículo científico publicado en 2011

CMT3 alters mitochondrial function in murine osteoclast lineage cells.

artículo científico publicado en 2007

Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro ⬇️

artículo científico publicado el 1 de abril de 2012

Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.

artículo científico publicado en 1997

Contrasting effects of alendronate and clodronate on RAW 264 macrophages: the role of a bisphosphonate metabolite

scientific article published on 01 May 1999

Defective Protein Prenylation in a Spectrum of Patients With Mevalonate Kinase Deficiency

scientific article published on 14 August 2019

Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency

artículo científico publicado en 2017

Effects of tiludronate and ibandronate on the secretion of proinflammatory cytokines and nitric oxide from macrophages in vitro.

artículo científico publicado en 1998

Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo

artículo científico publicado en 2010

From molds and macrophages to mevalonate: a decade of progress in understanding the molecular mode of action of bisphosphonates.

artículo científico publicado en 2004

From vesicle to cytosol.

artículo científico publicado en 2018

Functional interaction between sequestosome-1/p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts

artículo científico publicado en 2010

Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite.

artículo científico publicado en 2002

Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages.

artículo científico publicado en 1998

Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations

artículo científico publicado en 2008

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

artículo científico publicado en 2001

Identification of adenine nucleotide-containing metabolites of bisphosphonate drugs using ion-pair liquid chromatography–electrospray mass spectrometry ⬇️

artículo científico publicado el 19 de diciembre de 1997

Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function.

artículo científico publicado en 2011

Incorporation of bisphosphonates into adenine nucleotides by amoebae of the cellular slime mould Dictyostelium discoideum.

artículo científico publicado en 1994

Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo.

artículo científico publicado en 2012

Inhibition of growth of Dictyostelium discoideum amoebae by bisphosphonate drugs is dependent on cellular uptake

artículo científico publicado en 1997

Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.

artículo científico publicado en 2006

Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mold Dictyostelium discoideum

artículo científico publicado en 1994

Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans

artículo científico publicado en 2007

Isolation and purification of rabbit osteoclasts.

artículo científico publicado en 2012

Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes

scientific article published on 21 February 2019

Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo

artículo científico publicado en 2008

Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy.

artículo científico publicado en 2008

Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells.

artículo científico publicado en 2007

Metabolism of halogenated bisphosphonates by the cellular slime mould dictyostelium discoideum

artículo científico publicado en 1992

Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases.

artículo científico publicado en 2016

Molecular mechanisms of action of bisphosphonates.

artículo científico publicado en 1999

Molecular mechanisms of action of bisphosphonates: current status.

artículo científico publicado en 2006

New Insights Into the Molecular Mechanisms of Action of Bisphosphonates ⬇️

artículo científico publicado el 1 de enero de 2003

Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity.

artículo científico publicado en 2001

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

artículo científico publicado en 1998

Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.

artículo científico publicado en 2007

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche.

artículo científico publicado en 2015

Osteoclasts on bone and dentin in vitro: mechanism of trail formation and comparison of resorption behavior

artículo científico publicado en 2013

Osteoglycin, a novel coordinator of bone and glucose homeostasis.

artículo científico publicado en 2018

Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP.

artículo científico publicado en 2008

Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.

artículo científico publicado en 2008

Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

artículo científico publicado en 2000

Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer

artículo científico publicado en 2014

Signal peptide mutations in RANK prevent downstream activation of NF-κB.

artículo científico publicado en 2011

Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro.

artículo científico publicado en 2003

Statins: lower lipids and better bones?

artículo científico publicado en 2000

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

artículo científico publicado en 2008

Synthesis and characterization of novel fluorescent nitrogen-containing bisphosphonate imaging probes for bone active drugs.

artículo científico publicado en 2011

Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.

artículo científico publicado en 2010

The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling

artículo científico publicado en 2012

The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts

artículo científico publicado en 2009

The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.

artículo científico publicado en 2010

The matricellular protein CYR61 inhibits osteoclastogenesis by a mechanism independent of alphavbeta3 and alphavbeta5.

artículo científico publicado en 2007

The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice.

artículo científico publicado en 2012

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

artículo científico publicado en 2006

The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma

scientific article published on 01 October 2000

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo

artículo científico publicado en 2009

Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells

artículo científico publicado en 2013

Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells.

artículo científico publicado en 2008

Lista de obras de Michael J Rogers

A class III semaphorin (Sema3e) inhibits mouse osteoblast migration and decreases osteoclast formation in vitro.

A comparison between the effects of hydrophobic and hydrophilic statins on osteoclast function in vitro and ovariectomy-induced bone loss in vivo

A highly sensitive prenylation assay reveals in vivo effects of bisphosphonate drug on the Rab prenylome of macrophages outside the skeleton

A role for L-alpha-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells.

Actin polymerization modulates CD44 surface expression, MMP-9 activation, and osteoclast function.

Activation of γδ T cells by bisphosphonates.

Antagonistic effects of different classes of bisphosphonates in osteoclasts and macrophages in vitro.

Biochemical and molecular mechanisms of action of bisphosphonates.

Bisphosphonates are incorporated into adenine nucleotides by human aminoacyl-tRNA synthetase enzymes

Bisphosphonates--mechanisms of action in multiple myeloma

Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages.

Bone Turnover Markers and Prostate Cancer: Not Just a Measure of Bone Disease?

Bone remodelling at a glance

CMT3 alters mitochondrial function in murine osteoclast lineage cells.

Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro ⬇️

Clodronate and liposome-encapsulated clodronate are metabolized to a toxic ATP analog, adenosine 5'-(beta, gamma-dichloromethylene) triphosphate, by mammalian cells in vitro.

Contrasting effects of alendronate and clodronate on RAW 264 macrophages: the role of a bisphosphonate metabolite

Defective Protein Prenylation in a Spectrum of Patients With Mevalonate Kinase Deficiency

Defective protein prenylation is a diagnostic biomarker of mevalonate kinase deficiency

Effects of tiludronate and ibandronate on the secretion of proinflammatory cytokines and nitric oxide from macrophages in vitro.

Fluorescent risedronate analogues reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo

From molds and macrophages to mevalonate: a decade of progress in understanding the molecular mode of action of bisphosphonates.

From vesicle to cytosol.

Functional interaction between sequestosome-1/p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts

Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite.

Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages.

Human osteoclast-poor osteopetrosis with hypogammaglobulinemia due to TNFRSF11A (RANK) mutations

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

Identification of adenine nucleotide-containing metabolites of bisphosphonate drugs using ion-pair liquid chromatography–electrospray mass spectrometry ⬇️

Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function.

Incorporation of bisphosphonates into adenine nucleotides by amoebae of the cellular slime mould Dictyostelium discoideum.

Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo.

Inhibition of growth of Dictyostelium discoideum amoebae by bisphosphonate drugs is dependent on cellular uptake

Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.

Inhibitory effects of bisphosphonates on growth of amoebae of the cellular slime mold Dictyostelium discoideum

Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans

Isolation and purification of rabbit osteoclasts.

Lack of protein prenylation promotes NLRP3 inflammasome assembly in human monocytes

Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo

Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy.

Mechanisms of osteopontin and CD44 as metastatic principles in prostate cancer cells.

Metabolism of halogenated bisphosphonates by the cellular slime mould dictyostelium discoideum

Mevalonate kinase deficiency leads to decreased prenylation of Rab GTPases.

Molecular mechanisms of action of bisphosphonates.

Molecular mechanisms of action of bisphosphonates: current status.

New Insights Into the Molecular Mechanisms of Action of Bisphosphonates ⬇️

Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity.

Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras.

Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL.

Osteoclasts control reactivation of dormant myeloma cells by remodelling the endosteal niche.

Osteoclasts on bone and dentin in vitro: mechanism of trail formation and comparison of resorption behavior

Osteoglycin, a novel coordinator of bone and glucose homeostasis.

Peripheral blood monocytes are responsible for gammadelta T cell activation induced by zoledronic acid through accumulation of IPP/DMAPP.

Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranylgeranyl transferase.

Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298.

Real-time intravital imaging establishes tumor-associated macrophages as the extraskeletal target of bisphosphonate action in cancer

Signal peptide mutations in RANK prevent downstream activation of NF-κB.

Statins prevent bisphosphonate-induced gamma,delta-T-cell proliferation and activation in vitro.

Statins: lower lipids and better bones?

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

Synthesis and characterization of novel fluorescent nitrogen-containing bisphosphonate imaging probes for bone active drugs.

Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.

The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling

The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts

The bisphosphonate zoledronic acid has antimyeloma activity in vivo by inhibition of protein prenylation.

The matricellular protein CYR61 inhibits osteoclastogenesis by a mechanism independent of alphavbeta3 and alphavbeta5.

The mesenchymal stem cell marker CD248 (endosialin) is a negative regulator of bone formation in mice.

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

The potent bisphosphonate ibandronate does not induce myeloma cell apoptosis in a murine model of established multiple myeloma

The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo

Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells

Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells.