Filtros de búsqueda

Lista de obras de Eline Slagboom

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots

artículo científico publicado en 2015

A characterization of postzygotic mutations identified in monozygotic twins

article published in 2018

A common mineralocorticoid receptor polymorphism (I180V) interacts with life events in relation to perfectionism in eating disorders: a pilot study

scientific article published on 14 September 2014

A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer

artículo científico publicado en 2003

A data-driven methodology reveals novel myofiber clusters in older human muscles

artículo científico publicado en 2020

A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis

artículo científico publicado en 2014

A gene variant near ATM is significantly associated with metformin treatment response in type 2 diabetes: a replication and meta-analysis of five cohorts.

artículo científico publicado en 2012

A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam Study).

artículo científico publicado en 1998

A genome wide association analysis in the GENDER study.

artículo científico publicado en 2009

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

artículo científico publicado en 2011

A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

scientific article published on 02 August 2019

A genome-wide association study of anorexia nervosa

artículo científico publicado en 2014

A genome-wide association study suggests that a locus within the ataxin 2 binding protein 1 gene is associated with hand osteoarthritis: the Treat-OA consortium.

artículo científico publicado en 2009

A genome-wide copy number association study of osteoporotic fractures points to the 6p25.1 locus.

artículo científico publicado en 2013

A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium

artículo científico publicado en 2016

A genome-wide linkage scan reveals CD53 as an important regulator of innate TNF-alpha levels

artículo científico publicado en 2010

A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p.

artículo científico publicado en 2005

A high-quality human reference panel reveals the complexity and distribution of genomic structural variants

scientific article published on 06 October 2016

A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration

artículo científico publicado en 2015

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility

article

A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium

artículo científico publicado en 2010

A meta-analysis of genome-wide association studies identifies multiple longevity genes

scientific article published on 14 August 2019

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip

artículo científico publicado en 2014

A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function

artículo científico publicado en 2013

A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals

scientific article published on 20 August 2019

A metabolomic profile is associated with the risk of incident coronary heart disease

artículo científico publicado en 2014

A mixture model with random-effects components for classifying sibling pairs.

artículo científico publicado en 2011

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

article by Sven J. van der Lee et al published 27 May 2019 in Acta Neuropathologica

A powerful and rapid approach to human genome scanning using small quantities of genomic DNA

artículo científico publicado en 2001

A reference panel of 64,976 haplotypes for genotype imputation

artículo científico publicado en 2016

A whole genome association study of neuroticism using DNA pooling

artículo científico publicado en 2007

A whole-genome scan for 24-hour respiration rate: a major locus at 10q26 influences respiration during sleep

artículo científico publicado en 2004

Abdominal fat accumulation in adults born preterm exposed antenatally to maternal glucocorticoid treatment is dependent on glucocorticoid receptor gene variation

artículo científico publicado en 2011

Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice

artículo científico publicado en 2016

Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population

artículo científico publicado en 2011

Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity

artículo científico publicado en 2017

Activity limitations in the lower extremities in patients with osteoarthritis: the modifying effects of illness perceptions and mental health.

artículo científico publicado en 2006

Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study

artículo científico publicado en 2016

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception.

artículo científico publicado en 2018

Age-related accrual of methylomic variability is linked to fundamental ageing mechanisms

artículo científico publicado en 2016

Aging as accelerated accumulation of somatic variants: whole-genome sequencing of centenarian and middle-aged monozygotic twin pairs

artículo científico publicado en 2013

Allele-sharing statistics using information on family history

artículo científico publicado en 2010

Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive C-reactive protein levels in the GARP study

artículo científico publicado en 2007

Ambulant 24-h glucose rhythms mark calendar and biological age in apparently healthy individuals

artículo científico

Amino acid profiling in urine by capillary zone electrophoresis - mass spectrometry.

artículo científico publicado en 2007

An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial.

artículo científico publicado en 2016

An alternative approach to multiple testing for methylation QTL mapping reduces the proportion of falsely identified CpGs

scientific article published on 04 October 2014

An in vivo study on brain microstructure in biological and chronological ageing

artículo científico publicado en 2015

Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARK-AGE Study

artículo científico publicado en 2016

Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: risk of mortality and fatal cardiovascular disease in an elderly population-based cohort

scientific article published on 01 October 1999

Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data

artículo científico publicado en 2012

Antioxidants linked with physical, cognitive and psychological frailty: Analysis of candidate biomarkers and markers derived from the MARK-AGE study

artículo científico publicado en 2018

Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes?

artículo científico publicado en 2010

ApoE plasma levels and risk of cardiovascular mortality in old age

artículo científico publicado en 2006

Assessment of health status by molecular measures in adults ranging from middle-aged to old: Ready for clinical use?

artículo científico publicado en 2016

Assessment of osteoarthritis candidate genes in a meta-analysis of nine genome-wide association studies

artículo científico publicado en 2014

Assessment of the contribution of APOE gene variants to metabolic phenotypes associated with familial longevity at middle age.

scientific article published on 15 August 2016

Association analysis of insulin-like growth factor-1 axis parameters with survival and functional status in nonagenarians of the Leiden Longevity Study

artículo científico publicado en 2015

Association between leptin, adiponectin and resistin and long-term progression of hand osteoarthritis

artículo científico publicado en 2011

Association between several clinical and radiological determinants with long-term clinical progression and good prognosis of lower limb osteoarthritis

artículo científico publicado en 2011

Association between the rs7903146 Polymorphism in the TCF7L2 Gene and Parameters Derived with Continuous Glucose Monitoring in Individuals without Diabetes.

artículo científico publicado en 2016

Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age.

artículo científico publicado en 2002

Association of a nsSNP in ADAMTS14 to some osteoarthritis phenotypes

scientific article published on 14 September 2008

Association of adiponectin and leptin with relative telomere length in seven independent cohorts including 11,448 participants

artículo científico publicado en 2014

Association of common genetic variants with brain microbleeds: A Genome-wide Association Study

scientific article published on 10 September 2020

Association of handgrip strength with patient-reported outcome measures after total hip and knee arthroplasty

scientific article published on 18 February 2020

Association of liver enzymes and computed tomography markers of liver steatosis with familial longevity

artículo científico publicado en 2014

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults

Association of matrilin-3 polymorphisms with spinal disc degeneration and osteoarthritis of the first carpometacarpal joint of the hand

artículo científico publicado en 2006

Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites

scientific article published on 01 April 2005

Association of the autoimmunity locus 4q27 with juvenile idiopathic arthritis.

artículo científico publicado en 2009

Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip.

artículo científico publicado en 2004

Association of the risk of osteoarthritis with high innate production of interleukin-1beta and low innate production of interleukin-10 ex vivo, upon lipopolysaccharide stimulation

artículo científico publicado en 2005

Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort

artículo científico publicado en 2002

Association study in eating disorders: TPH2 associates with anorexia nervosa and self-induced vomiting.

artículo científico publicado en 2010

Association study of candidate genes for the progression of hand osteoarthritis.

artículo científico publicado en 2013

Association study of the estrogen receptor I gene (ESR1) in anorexia nervosa and eating disorders: no replication found

artículo científico publicado en 2013

Associations between age and gray matter volume in anatomical brain networks in middle-aged to older adults

artículo científico publicado en 2014

Associations between joint effusion in the knee and gene expression levels in the circulation: a meta-analysis.

artículo científico publicado en 2016

Associations of Cytomegalovirus Infection With All-Cause and Cardiovascular Mortality in Multiple Observational Cohort Studies of Older Adults

scientific article published on 10 September 2020

Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

artículo científico publicado en 2020

Author Correction: L1 drives IFN in senescent cells and promotes age-associated inflammation

scientific article published on 01 August 2019

Author Correction: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

scientific article published on 01 May 2019

Autosomal genetic variation is associated with DNA methylation in regions variably escaping X-chromosome inactivation

scientific article published in Nature Communications

Basal cell carcinoma genetic susceptibility increases the rate of skin ageing: a Mendelian randomization study

scientific article published on 05 September 2019

Blood lipids influence DNA methylation in circulating cells

artículo científico publicado en 2016

Blood metabolomic measures associate with present and future glycemic control in type 2 diabetes

Body mass index and alignment and their interaction as risk factors for progression of knees with radiographic signs of osteoarthritis

artículo científico publicado en 2011

Both low circulating insulin-like growth factor-1 and high-density lipoprotein cholesterol are associated with hair loss in middle-aged women.

artículo científico publicado en 2016

Brain tissue volumes in familial longevity: the Leiden Longevity Study

artículo científico publicado en 2012

Butyrylcholinesterase: association with the metabolic syndrome and identification of 2 gene loci affecting activity

artículo científico publicado en 2006

C-reactive protein and glucose regulation in familial longevity

artículo científico publicado en 2011

C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects

artículo científico publicado en 2011

C. elegans DAF-12, Nuclear Hormone Receptors and human longevity and disease at old age.

artículo científico publicado en 2005

CD226(DNAM-1) is associated with susceptibility to juvenile idiopathic arthritis

scientific article published on 23 July 2014

Cerebral Microbleeds and Lacunar Infarcts Are Associated with Walking Speed Independent of Cognitive Performance in Middle-Aged to Older Adults.

artículo científico publicado en 2016

Cerebral small vessel disease genomics and its implications across the lifespan

artículo científico publicado en 2020

Characteristics of de novo structural changes in the human genome

artículo científico publicado en 2015

Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence: commonalities and differences between chromosomes

artículo científico publicado en 2013

Chromosome 4q25, microsomal transfer protein gene, and human longevity: novel data and a meta-analysis of association studies

artículo científico publicado en 2006

Chronic inhibition of the respiratory chain in human fibroblast cultures: differential responses related to subject chronological and biological age.

artículo científico publicado en 2011

Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

artículo científico publicado en 2018

Classification for Longevity Potential: The Use of Novel Biomarkers ⬇️

artículo científico publicado en 2016

Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP study

scientific article published on 17 October 2006

Combined association and linkage analysis applied to the APOE locus

artículo científico publicado en 2004

Combined linkage and association analyses of the 124-bp allele of marker D2S2944 with anxiety, depression, neuroticism and major depression

artículo científico publicado en 2005

Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycemic clamps

artículo científico publicado en 2009

Common CFTR gene variants influence body composition and survival in rural Ghana.

artículo científico publicado en 2009

Common gene variants, mortality and extreme longevity in humans.

artículo científico publicado en 2000

Common paraoxonase gene variants, mortality risk and fatal cardiovascular events in elderly subjects

artículo científico publicado en 2000

Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp

artículo científico publicado en 2012

Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study

artículo científico publicado en 2017

Copy number variation associates with mortality in long-lived individuals: a genome-wide assessment

artículo científico publicado en 2015

Correction to: A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity

scientific article published on 18 January 2020

Correction: Common Variants in the Type 2 Diabetes KCNQ1 Gene Are Associated with Impairments in Insulin Secretion During Hyperglycaemic Glucose Clamp

artículo científico publicado en 2012

Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2016

Correction: The complex genetics of gait speed: genome-wide meta-analysis approach

artículo científico publicado en 2017

Correction: Transcriptional Profiling of Human Familial Longevity Indicates a Role for ASF1A and IL7R.

artículo científico publicado en 2012

Corrigendum: DNA methylation signatures link prenatal famine exposure to growth and metabolism

artículo científico publicado en 2015

Cortical phase changes measured using 7-T MRI in subjects with subjective cognitive impairment, and their association with cognitive function

artículo científico publicado en 2014

Cortisol serum levels in familial longevity and perceived age: the Leiden longevity study.

artículo científico publicado en 2012

DNA Methylation Landscapes of Human Fetal Development

artículo científico publicado en 2015

DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age.

artículo científico publicado en 2016

DNA methods for detecting and analyzing mutations in vivo.

artículo científico publicado en 1987

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood.

artículo científico publicado en 2018

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific

artículo científico publicado en 2009

DNA methylation of IGF2, GNASAS, INSIGF and LEP and being born small for gestational age.

artículo científico publicado en 2011

DNA methylation signatures link prenatal famine exposure to growth and metabolism

artículo científico publicado en 2014

DNA methylation signatures of educational attainment

artículo científico publicado en 2018

DNA modification study of major depressive disorder: beyond locus-by-locus comparisons

artículo científico publicado en 2014

DNA processing, aging, and cancer. The impact of new technology

artículo científico publicado en 1991

Decreased levels of bisecting GlcNAc glycoforms of IgG are associated with human longevity

artículo científico publicado en 2010

Defining the role of common variation in the genomic and biological architecture of adult human height

artículo científico publicado en 2014

Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency

artículo científico publicado en 2013

Design, measurement and processing of region-specific DNA methylation assays: the mass spectrometry-based method EpiTYPER.

artículo científico publicado en 2015

Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project

artículo científico publicado en 2011

Detecting dispersed duplications in high-throughput sequencing data using a database-free approach

artículo científico publicado en 2015

Detection of sequence variability of the collagen type IIalpha 1 3' variable number of tandem repeat

scientific article published on 01 November 2000

Developmental determinants in non-communicable chronic diseases and ageing.

artículo científico publicado en 2015

Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation

artículo científico publicado en 2015

Disease variants alter transcription factor levels and methylation of their binding sites

artículo científico publicado en 2016

Do senescence markers correlate in vitro and in situ within individual human donors?

artículo científico publicado en 2018

Dose-response effects of a Web-based physical activity program on body composition and metabolic health in inactive older adults: additional analyses of a randomized controlled trial.

artículo científico publicado en 2014

Doyle Index is a valuable additional pain measure in osteoarthritis

artículo científico publicado en 2010

Drug-Gene Interactions of Antihypertensive Medications and Risk of Incident Cardiovascular Disease: A Pharmacogenomics Study from the CHARGE Consortium

artículo científico publicado en 2015

Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval

artículo científico publicado en 2013

Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children.

artículo científico publicado en 2013

Dynamic clonal hematopoiesis and functional T-cell immunity in a supercentenarian

artículo científico publicado en 2020

Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.

artículo científico publicado en 2015

Eating disorders: from twin studies to candidate genes and beyond

artículo científico publicado en 2005

Effect of calendar age on physical performance: A comparison of standard clinical measures with instrumented measures in middle-aged to older adults

artículo científico

Effects of a web-based intervention on physical activity and metabolism in older adults: randomized controlled trial.

artículo científico publicado en 2013

Efficacy and toxicity of methotrexate in early rheumatoid arthritis are associated with single-nucleotide polymorphisms in genes coding for folate pathway enzymes.

artículo científico publicado en 2006

Employing biomarkers of healthy ageing for leveraging genetic studies into human longevity

artículo científico publicado en 2016

Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs

artículo científico publicado en 2012

Epigenetic variation in monozygotic twins: a genome-wide analysis of DNA methylation in buccal cells

artículo científico publicado en 2014

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

artículo científico publicado en 2016

Establishing a Twin Register: An Invaluable Resource for (Behavior) Genetic, Epidemiological, Biomarker, and 'Omics' Studies

artículo científico publicado en 2018

Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population.

artículo científico publicado en 2003

Evidence for a role of the genomic region of the gene encoding for the alpha1 chain of type IX collagen (COL9A1) in hip osteoarthritis: A population-based study.

artículo científico publicado en 2005

Evidence for familial aggregation of hand, hip, and spine but not knee osteoarthritis in siblings with multiple joint involvement: the GARP study.

artículo científico publicado en 2004

Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly

artículo científico publicado en 2007

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity

artículo científico publicado en 2012

Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study.

artículo científico publicado en 2006

Exome and whole genome sequencing in aging and longevity.

artículo científico

Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.

artículo científico publicado en 2012

Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study.

artículo científico publicado en 2010

FCRL3 promoter 169 CC homozygosity is associated with susceptibility to rheumatoid arthritis in Dutch Caucasians

artículo científico publicado en 2006

Facial appearance reflects human familial longevity and cardiovascular disease risk in healthy individuals.

artículo científico publicado en 2012

Facing up to the global challenges of ageing

artículo científico publicado en 2018

Factor VII Activating Protease Polymorphism (G534E) Is Associated with Increased Risk for Stroke and Mortality

artículo científico publicado en 2011

Familial Longevity Is Associated With Higher TSH Secretion and Strong TSH-fT3 Relationship.

artículo científico publicado en 2015

Familial Longevity Is Not Associated with Major Differences in the Hypothalamic-Pituitary-Gonadal Axis in Healthy Middle-Aged Men.

artículo científico publicado en 2016

Familial Resemblance for Serum Metabolite Concentrations — Corrigendum

scholarly article published in Twin Research and Human Genetics

Familial longevity is associated with decreased thyroid function

artículo científico publicado en 2010

Familial longevity is characterized by high circadian rhythmicity of serum cholesterol in healthy elderly individuals.

artículo científico publicado en 2016

Familial longevity is marked by better cognitive performance at middle age: the Leiden Longevity Study

artículo científico publicado en 2013

Familial longevity is marked by enhanced insulin sensitivity

artículo científico publicado en 2010

Familial longevity is marked by lower diurnal salivary cortisol levels: the Leiden Longevity Study.

artículo científico publicado en 2012

Familial resemblance for serum metabolite concentrations

artículo científico publicado en 2013

Families in comparison: An individual-level comparison of life-course and family reconstructions between population and vital event registers

artículo científico publicado en 2020

Family based association analyses between the serotonin transporter gene polymorphism (5-HTTLPR) and neuroticism, anxiety and depression

artículo científico publicado en 2007

Fast LC-ESI-MS/MS analysis and influence of sampling conditions for gut metabolites in plasma and serum

scientific article published on 26 August 2019

Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study

artículo científico publicado en 2010

Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C

artículo científico publicado en 2015

Frailty Questionnaire Is Not a Strong Prognostic Factor for Functional Outcomes in Hip or Knee Arthroplasty Patients

artículo científico publicado en 2019

Frailty in end-stage hip or knee osteoarthritis: validation of the Groningen Frailty Indicator (GFI) questionnaire.

artículo científico publicado en 2017

Further Evidence for a QTL Influencing Body Mass Index on Chromosome 7p from a Genome-wide Scan in Dutch Families

article

GWAS for executive function and processing speed suggests involvement of the CADM2 gene.

artículo científico publicado en 2015

GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy

artículo científico publicado en 2014

Gene expression analysis of mTOR pathway: association with human longevity

artículo científico publicado en 2012

Gene set analysis of GWAS data for human longevity highlights the relevance of the insulin/IGF-1 signaling and telomere maintenance pathways

artículo científico publicado en 2011

Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function

artículo científico publicado en 2009

Genes encoding longevity: from model organisms to humans

artículo científico publicado en 2008

Genes expressed in blood link osteoarthritis with apoptotic pathways.

artículo científico publicado en 2013

Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study.

artículo científico publicado en 2014

Genetic Variation in the Interleukin-10 Gene Promoter and Risk of Coronary and Cerebrovascular Events: The PROSPER Study

article

Genetic and environmental influences interact with age and sex in shaping the human methylome.

artículo científico publicado en 2016

Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting

Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study

artículo científico publicado en 2009

Genetic association analysis of LARS2 with type 2 diabetes

artículo científico publicado en 2010

Genetic association analysis of RHOB and TXNDC3 in osteoarthritis

artículo científico publicado en 2007

Genetic determination of telomere size in humans: a twin study of three age groups.

artículo científico publicado en 1994

Genetic influences on disordered eating behaviour are largely independent of body mass index.

artículo científico publicado en 2007

Genetic instability and aging: theories, facts, and future perspectives

artículo científico publicado en 1989

Genetic linkage analysis of 14 candidate gene loci in a family with autosomal dominant osteoarthritis without dysplasia.

artículo científico publicado en 1997

Genetic linkage and association analysis for loneliness in Dutch twin and sibling pairs points to a region on chromosome 12q23-24.

artículo científico publicado en 2005

Genetic polymorphisms of the renin–angiotensin system and complications of insulin‐dependent diabetes mellitus

scientific article published on 01 July 2000

Genetic predictors of fibrin D-dimer levels in healthy adults

artículo científico publicado en 2011

Genetic studies of body mass index yield new insights for obesity biology

artículo científico publicado en 2015

Genetic variants determining survival and fertility in an adverse African environment: a population-based large-scale candidate gene association study.

scientific article published on 27 June 2016

Genetic variants in the glucocorticoid receptor gene (NR3C1) and cardiovascular disease risk. The Leiden 85-plus Study

artículo científico publicado en 2006

Genetic variation at the TPH2 gene influences impulsivity in addition to eating disorders

artículo científico publicado en 2012

Genetic variation in PCAF, a key mediator in epigenetics, is associated with reduced vascular morbidity and mortality: evidence for a new concept from three independent prospective studies

article

Genetic variation in VTCN1 (B7-H4) is associated with course of disease in juvenile idiopathic arthritis.

artículo científico publicado en 2013

Genetic variation in pentraxin (PTX) 3 gene associates with PTX3 production and fertility in women.

artículo científico publicado en 2009

Genetic variation in the interleukin-1 beta-converting enzyme associates with cognitive function. The PROSPER study

artículo científico publicado en 2008

Genetically defined elevated homocysteine levels do not result in widespread changes of DNA methylation in leukocytes

artículo científico publicado en 2017

Genetically determined prospect to become long-lived is associated with less abdominal fat and in particular less abdominal visceral fat in men.

artículo científico

Genetics and Not Shared Environment Explains Familial Resemblance in Adult Metabolomics Data

artículo científico publicado en 2020

Genetics and behavioral medicine: risk factors for cardiovascular disease

artículo científico publicado en 1997

Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging).

artículo científico publicado en 2007

Genetics of human aging. The search for genes contributing to human longevity and diseases of the old.

artículo científico publicado en 2000

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

artículo científico publicado en 2018

Genome of The Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

artículo científico publicado en 2015

Genome-Wide Association Study Reveals First Locus for Anorexia Nervosa and Metabolic Correlations

scholarly article

Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns.

artículo científico publicado en 2018

Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length

scientific article published on 27 February 2020

Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis

artículo científico publicado en 2016

Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation

artículo científico publicado en 2018

Genome-wide association and functional studies identify a role for matrix Gla protein in osteoarthritis of the hand

artículo científico

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

artículo científico publicado en 2014

Genome-wide association scan for five major dimensions of personality

artículo científico publicado en 2010

Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity

artículo científico publicado en 2010

Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

artículo científico publicado en 2014

Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

artículo científico publicado en 2011

Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.

artículo científico publicado en 2019

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

artículo científico publicado en 2015

Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels

artículo científico publicado en 2018

Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region

artículo científico publicado en 2013

Genome-wide association study of smoking initiation and current smoking

artículo científico publicado en 2009

Genome-wide identification of directed gene networks using large-scale population genomics data

scientific article published in Nature Communications

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

artículo científico publicado en 2020

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

artículo científico publicado en 2013

Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands

artículo científico publicado en 2008

Genome-wide linkage scan in affected sibling pairs identifies novel susceptibility region for venous thromboembolism: Genetics In Familial Thrombosis study.

artículo científico publicado en 2013

Genome-wide linkage scan to identify Loci for age at first cigarette in Dutch sibling pairs

artículo científico publicado en 2005

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

artículo científico publicado en 2017

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

artículo científico publicado en 2012

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

artículo científico publicado en 2017

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels

artículo científico publicado en 2016

Genome-wide patterns and properties of de novo mutations in humans

artículo científico publicado en 2015

Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

artículo científico publicado en 2016

Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy

artículo científico publicado en 2012

Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits ⬇️

artículo científico publicado en 2016

Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

artículo científico publicado en 2021

Genomic studies in ageing research: the need to integrate genetic and gene expression approaches

article

Genomics of human longevity.

artículo científico publicado en 2011

Getting personal: Endogenous adenosine receptor signaling in lymphoblastoid cell lines

artículo científico publicado en 2016

Glucocorticoid receptor gene polymorphisms are associated with reduced first-phase glucose-stimulated insulin secretion and disposition index in women, but not in men

article

Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases

artículo científico publicado en 2020

Growth hormone secretion is diminished and tightly controlled in humans enriched for familial longevity

artículo científico publicado en 2016

Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk

scientific article published on 11 April 2019

Hallmark features of immunosenescence are absent in familial longevity

artículo científico publicado en 2010

Handgrip strength at midlife and familial longevity : The Leiden Longevity Study

artículo científico publicado en 2011

Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis

artículo científico publicado en 1999

Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age

article

Hematopoietic capacity and exceptional survival: the Leiden Longevity Study

artículo científico publicado en 2008

Heritabilities of apolipoprotein and lipid levels in three countries

artículo científico publicado en 2002

Heritabilities of radiologic osteoarthritis in peripheral joints and of disc degeneration of the spine

artículo científico publicado en 1999

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

artículo científico publicado en 2020

Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus

scientific article published on 05 March 2007

High Adiposity Is Associated With Higher Nocturnal and Diurnal Glycaemia, but Not With Glycemic Variability in Older Individuals Without Diabetes.

artículo científico publicado en 2018

High Liver Enzyme Concentrations are Associated with Higher Glycemia, but not with Glycemic Variability, in Individuals without Diabetes Mellitus

artículo científico publicado en 2017

High microsatellite and SNP genotyping success rates established in a large number of genomic DNA samples extracted from mouth swabs and genotypes

artículo científico publicado en 2006

High serum glucose levels are associated with a higher perceived age.

artículo científico publicado en 2011

High-yield noninvasive human genomic DNA isolation method for genetic studies in geographically dispersed families and populations

artículo científico publicado en 1995

Historical demography and longevity genetics: Back to the future

artículo científico publicado en 2017

Homocysteine and familial longevity: the Leiden Longevity Study

artículo científico publicado en 2011

Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis

artículo científico publicado en 2017

How to deal with the early GWAS data when imputing and combining different arrays is necessary

artículo científico publicado en 2011

Human Cytokine Response to ex vivo Amyloid-β Stimulation is Mediated by Genetic Factors

article

Human Plasma N-glycosylation as Analyzed by Matrix-Assisted Laser Desorption/Ionization-Fourier Transform Ion Cyclotron Resonance-MS Associates with Markers of Inflammation and Metabolic Health ⬇️

artículo científico publicado en 2016

Human cytokine response to ex vivo amyloid-beta stimulation is mediated by genetic factors.

artículo científico publicado en 2005

Human in vivo longevity is reflected in vitro by differential metabolism as measured by 1H-NMR profiling of cell culture supernatants

article

Human insulin/IGF-1 and familial longevity at middle age.

artículo científico publicado en 2009

Human longevity and 11p15.5: a study in 1321 centenarians

artículo científico publicado en 2009

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies

artículo científico publicado en 2012

Human longevity is characterised by high thyroid stimulating hormone secretion without altered energy metabolism

artículo científico publicado en 2015

Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction

artículo científico publicado en 2011

IL7R gene expression network associates with human healthy ageing

artículo científico publicado en 2015

Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array

artículo científico publicado en 2013

Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis

artículo científico publicado en 2008

Identification of context-dependent expression quantitative trait loci in whole blood

artículo científico publicado en 2016

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study

artículo científico publicado en 2012

Identification of seven loci affecting mean telomere length and their association with disease

artículo científico publicado en 2013

Identifying the genomic determinants of aging and longevity in human population studies: progress and challenges

artículo científico publicado en 2013

IgG glycosylation and DNA methylation are interconnected with smoking

artículo científico publicado en 2017

Impact of genetic variations in the WRN gene on age related pathologies and mortality

scientific article published on 06 January 2006

In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study.

artículo científico publicado en 2014

Incident venous thromboembolic events in the Prospective Study of Pravastatin in the Elderly at Risk (PROSPER).

artículo científico publicado en 2011

Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues

scientific article published on 04 April 2012

Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans

artículo científico publicado en 2011

Influence of candidate genes on attention problems in children: a longitudinal study

artículo científico publicado en 2010

Influence of familial factors on radiologic disease progression over two years in siblings with osteoarthritis at multiple sites: A prospective longitudinal cohort study

artículo científico publicado en 2007

Innate production of tumour necrosis factor alpha and interleukin 10 is associated with radiological progression of knee osteoarthritis

artículo científico publicado en 2007

Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study

artículo científico publicado en 2010

Insulin-like growth factor I gene promoter polymorphism, collagen type II alpha1 (COL2A1) gene, and the prevalence of radiographic osteoarthritis: the Rotterdam Study

artículo científico publicado en 2004

Integrating metabolomics profiling measurements across multiple biobanks.

artículo científico publicado en 2014

Integrating protein-protein interaction networks with gene-gene co-expression networks improves gene signatures for classifying breast cancer metastasis

artículo científico publicado en 2011

Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug-metabolite atlas

scientific article published on 13 January 2020

Interleukin-1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression Study

artículo científico publicado en 2010

Interleukin-1 region meta-analysis with osteoarthritis phenotypes

artículo científico publicado en 2009

Interrelationships Between Pituitary Hormones as Assessed From 24-hour Serum Concentrations in Healthy Older Subjects

artículo científico publicado en 2020

Investigation of the association of the CRTM and CRTL1 genes with radiographically evident osteoarthritis in subjects from the Rotterdam study

artículo científico publicado en 1997

Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches.

artículo científico publicado en 2014

L1 drives IFN in senescent cells and promotes age-associated inflammation

scientific article published on 06 February 2019

LDL cholesterol still a problem in old age? A Mendelian randomization study

Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations

scientific article published on 30 January 2009

Large scale meta-analysis of urinary C-terminal telopeptide, serum cartilage oligomeric protein and matrix metalloprotease degraded type II collagen and their role in prevalence, incidence and progression of osteoarthritis

article

Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand

artículo científico publicado en 2009

Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis

artículo científico publicado en 2010

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT and QRS intervals: CHARGE Pharmacogenomics Working Group.

artículo científico publicado en 2016

Large-scale plasma metabolome analysis reveals alterations in HDL metabolism in migraine

scientific article published on 03 April 2019

Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers

artículo científico publicado en 2014

Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study

artículo científico publicado en 2012

Lifestyle and youthful looks.

artículo científico publicado en 2015

Lifestyle-intervention-induced Reduction of Abdominal Fat is Reflected by a Decreased Circulating Glycerol Level and An Increased HDL Diameter

scientific article published on 09 April 2020

Linkage analysis of smoking initiation and quantity in Dutch sibling pairs

artículo científico publicado en 2004

Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype

artículo científico publicado en 2007

Lipid metabolism in long-lived families: the Leiden Longevity Study

artículo científico publicado en 2010

Lipoprotein particle profiles mark familial and sporadic human longevity

artículo científico publicado en 2006

Literature-based genetic risk scores for coronary heart disease: the Cardiovascular Registry Maastricht (CAREMA) prospective cohort study

artículo científico publicado en 2012

Liver Fat Assessed With CT Relates to MRI Markers of Incipient Brain Injury in Middle-Aged to Elderly Overweight Persons

artículo científico publicado en 2016

Liver X receptor alpha associates with human life span

scientific article published on 01 April 2007

Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.

artículo científico publicado en 2013

Longevity Relatives Count score identifies heritable longevity carriers and suggests case improvement in genetic studies

scientific article published on 30 April 2020

Longevity around the turn of the 20th century: life-long sustained survival advantage for parents of today's nonagenarians. ⬇️

artículo científico publicado en 2018

Longevity defined as top 10% survivors and beyond is transmitted as a quantitative genetic trait

artículo científico publicado en 2019

Longevity defined as top 10% survivors is transmitted as a quantitative genetic trait: results from large three-generation datasets

Longitudinal weight differences, gene expression and blood biomarkers in BMI-discordant identical twins.

artículo científico publicado en 2015

Low computed tomography coronary artery calcium scores in familial longevity: the Leiden Longevity Study

artículo científico publicado en 2014

Low mitochondrial DNA content associates with familial longevity: the Leiden Longevity Study

artículo científico publicado en 2014

Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study

artículo científico publicado en 2009

Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.

artículo científico publicado en 2015

Lower Susceptibility to Cerebral Small Vessel Disease in Human Familial Longevity

article published in 2013

Lower proportion of naïve peripheral CD8+ T cells and an unopposed pro-inflammatory response to human Cytomegalovirus proteins in vitro are associated with longer survival in very elderly people

artículo científico publicado en 2012

Lymphotoxin-alpha C804A polymorphism is a risk factor for stroke. The PROSPER study

artículo científico publicado en 2008

MARK-AGE biomarkers of ageing

artículo científico publicado en 2015

Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA cohort study

artículo científico publicado en 2012

Markers of health and disease and pigmented spots in a middle-aged population

artículo científico publicado en 2015

Maternal and child cytokine relationship in early life is not altered by cytokine gene polymorphisms. ⬇️

artículo científico publicado en 2016

Men Have a Stronger Monocyte-Derived Cytokine Production Response upon Stimulation with the Gram-Negative Stimulus Lipopolysaccharide than Women: A Pooled Analysis Including 15 Study Populations

artículo científico publicado en 2019

Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors.

artículo científico publicado en 2006

Messenger RNA levels and methylation patterns of GAPDH and beta-actin genes in rat liver, spleen and brain in relation to aging

artículo científico publicado en 1990

Meta-analyses of genes modulating intracellular T3 bio-availability reveal a possible role for the DIO3 gene in osteoarthritis susceptibility

artículo científico publicado en 2010

Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes

artículo científico publicado en 2012

Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance

artículo científico publicado en 2014

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

artículo científico publicado en 2016

Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism

artículo científico publicado en 2015

Meta-analysis of four new genome scans for lipid parameters and analysis of positional candidates in positive linkage regions

artículo científico publicado en 2005

Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22

artículo científico publicado en 2010

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

artículo científico publicado en 2016

Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect

artículo científico publicado en 2013

Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging

artículo científico publicado en 2013

Metabolic Age Based on the BBMRI-NL 1H-NMR Metabolomics Repository as Biomarker of Age-related Disease

artículo científico publicado en 2020

Metabolic effects of a 13-weeks lifestyle intervention in older adults: The Growing Old Together Study

artículo científico publicado en 2016

Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles

artículo científico publicado en 2012

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study.

artículo científico publicado en 2017

Metabolomic and lipidomic assessment of the metabolic syndrome in Dutch middle-aged individuals reveals novel biological signatures separating health and disease

article

Metabolomics Profile in Depression: A Pooled Analysis of 230 Metabolic Markers in 5283 Cases With Depression and 10,145 Controls

artículo científico publicado en 2019

Metabolomics analyses in non-diabetic middle-aged individuals reveal metabolites impacting early glucose disturbances and insulin sensitivity

artículo científico publicado en 2020

Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium

scientific article published on 12 August 2019

MethylAid: visual and interactive quality control of large Illumina 450k datasets.

artículo científico publicado en 2014

Methylation status of cKi-ras and MHC genes in rat pituitary glands during aging and tumorigenesis

artículo científico publicado en 1991

Microstructural brain tissue damage in metabolic syndrome

artículo científico publicado en 2013

Mobster: accurate detection of mobile element insertions in next generation sequencing data

artículo científico publicado en 2014

Molecular epidemiology, candidate genes versus genome-wide scans

artículo científico publicado en 2007

Morphometric skin characteristics dependent on chronological and biological age: the Leiden Longevity Study.

artículo científico publicado en 2011

Mortality risk in men is associated with a common mutation in the methylene-tetrahydrofolate reductase gene (MTHFR)

artículo científico publicado en 1999

Multicenter dizygotic twin cohort study confirms two linkage susceptibility loci for body mass index at 3q29 and 7q36 and identifies three further potential novel loci

artículo científico publicado en 2009

Multiethnic genome-wide association study of cerebral white matter hyperintensities on MRI

artículo científico publicado en 2015

Mutation analysis of candidate genes within the 2q33.3 linkage area for familial early-onset generalised osteoarthritis.

artículo científico publicado en 2007

N-glycomic biomarkers of biological aging and longevity: a link with inflammaging

artículo científico

Neo-cartilage engineered from primary chondrocytes is epigenetically similar to autologous cartilage, in contrast to using mesenchymal stem cells

artículo científico publicado en 2016

Netherlands twin family study of anxious depression (NETSAD).

artículo científico publicado en 2000

New genetic loci link adipose and insulin biology to body fat distribution

artículo científico publicado en 2015

New insights into osteoarthritis: early developmental features of an ageing-related disease.

scientific article published on September 2008

Ninety-nine independent genetic loci influencing general cognitive function include genes associated with brain health and structure (N = 280,360)

No causal association between 25-hydroxyvitamin D and features of skin aging: evidence from a bidirectional Mendelian Randomization Study

artículo científico publicado en 2017

No evidence for genome-wide interactions on plasma fibrinogen by smoking, alcohol consumption and body mass index: results from meta-analyses of 80,607 subjects

artículo científico publicado en 2014

No increase in mortality and morbidity among carriers of the C282Y mutation of the hereditary haemochromatosis gene in the oldest old: the Leiden 85-plus study

artículo científico publicado en 2002

No or only population-specific effect of PON1 on human longevity: a comprehensive meta-analysis

scientific article published on April 2010

Non-homologous end-joining pathway associated with occurrence of myocardial infarction: gene set analysis of genome-wide association study data

artículo científico publicado en 2013

Non-response to (statin) therapy: the importance of distinguishing non-responders from non-adherers in pharmacogenetic studies

artículo científico publicado en 2015

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

artículo científico publicado en 2009

Normal prevalence of factor V Leiden gene mutation in patients with severe unstable angina

artículo científico publicado en 1997

Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis

artículo científico publicado en 2016

Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects

artículo científico publicado en 2012

Novel loci and pathways significantly associated with longevity

artículo científico publicado en 2016

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

artículo científico publicado en 2012

Nutritional Factors Modulating Alu Methylation in an Italian Sample from The Mark-Age Study Including Offspring of Healthy Nonagenarians

scientific article published on 06 December 2019

Organisation of the human genome and our tools for identifying disease genes.

artículo científico publicado en 2002

Osteoarthritis susceptibility genes influence the association between hip morphology and osteoarthritis

artículo científico publicado en 2011

P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age.

artículo científico publicado en 2015

PASSion: a pattern growth algorithm-based pipeline for splice junction detection in paired-end RNA-Seq data

artículo científico publicado en 2012

PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly population

artículo científico publicado en 2013

Parameters of glucose metabolism and the aging brain: a magnetization transfer imaging study of brain macro- and micro-structure in older adults without diabetes

artículo científico publicado en 2015

Parental longevity correlates with offspring's optimism in two cohorts of community-dwelling older subjects

artículo científico publicado en 2011

Pathway analysis using genome-wide association study data for coronary restenosis--a potential role for the PARVB gene

artículo científico publicado en 2013

Periconception maternal smoking and low education are associated with methylation of INSIGF in children at the age of 17 months.

artículo científico publicado en 2012

Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child

artículo científico publicado en 2009

Persistent epigenetic differences associated with prenatal exposure to famine in humans

artículo científico publicado en 2008

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

artículo científico publicado en 2014

Pharmacogenetics of statins: achievements, whole-genome analyses and future perspectives

artículo científico

Phenome and genome based studies into human ageing and longevity: An overview.

artículo científico publicado en 2017

Phenotypic screening of cannabinoid receptor 2 ligands shows different sensitivity to genotype

artículo científico publicado en 2017

Plasma protein N-glycan profiles are associated with calendar age, familial longevity and health.

artículo científico

Polymorphisms associated with type 2 diabetes in familial longevity: The Leiden Longevity Study

artículo científico publicado en 2011

Polymorphisms in TLR4 and TLR2 genes, cytokine production and survival in rural Ghana.

artículo científico publicado en 2009

Population haplotype analysis and evolutionary relations of the COL2A1 gene

artículo científico publicado en 1996

Population-specific genotype imputations using minimac or IMPUTE2.

artículo científico publicado en 2015

Prenatal famine and genetic variation are independently and additively associated with DNA methylation at regulatory loci within IGF2/H19.

artículo científico publicado en 2012

Preserved white matter integrity is a marker of familial longevity

artículo científico publicado en 2013

Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength

artículo científico publicado en 2013

Progression of hand osteoarthritis over 2 years: a clinical and radiological follow-up study

scientific article published on 26 August 2008

Prolonged high-fat diet induces gradual and fat depot-specific DNA methylation changes in adult mice

artículo científico publicado en 2017

Proton magnetic resonance spectroscopy shows lower intramyocellular lipid accumulation in middle-aged subjects predisposed to familial longevity.

artículo científico publicado en 2011

QTLs for height: results of a full genome scan in Dutch sibling pairs

artículo científico publicado en 2004

Quantitative comparison of mRNA levels in mammalian tissues: 28S ribosomal RNA level as an accurate internal control

artículo científico publicado en 1989

RNA sequencing data integration reveals an miRNA interactome of osteoarthritis cartilage

artículo científico publicado en 2018

RUNX1 intronic SNP is not associated with rheumatoid arthritis susceptibility in Dutch Caucasians

artículo científico publicado en 2005

Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium

artículo científico publicado en 2010

Reduced insulin/IGF-1 signalling and human longevity.

artículo científico publicado en 2005

Reduced response to activated protein C is associated with increased risk for cerebrovascular disease.

artículo científico publicado en 1996

Relationship between the functional exon 3 deleted growth hormone receptor polymorphism and symptomatic osteoarthritis in women

artículo científico publicado en 2013

Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study.

artículo científico publicado en 2013

Reliability of cluster results for different types of time adjustments in complex disease research

artículo científico publicado en 2008

Renal function in familial longevity: the Leiden Longevity Study.

artículo científico publicado en 2014

Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response

artículo científico publicado en 2020

Repeat length variations in polyglutamine disease-associated genes affect body mass index

scientific article published on 17 August 2018

Repeat variations in polyglutamine disease-associated genes and cognitive function in old age

scientific article published on 09 August 2019

Replicated linkage for eye color on 15q using comparative ratings of sibling pairs

artículo científico publicado en 2005

Replication in genetic association studies: Comment on the editorial by Spector et al

scientific article published on 01 September 2006

Replication of LDL GWAs hits in PROSPER/PHASE as validation for future (pharmaco)genetic analyses

artículo científico publicado en 2011

Response to activated protein C in subjects with and without dementia. The Dutch Vascular Factors in Dementia Study.

artículo científico publicado en 1998

Risk factors in familial osteoarthritis: the GARP sibling study

artículo científico publicado en 2008

SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study.

artículo científico publicado en 2007

Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population

artículo científico publicado en 2009

Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction

scientific article published on 21 October 2019

Serum fatty acid chain length associates with prevalent symptomatic end-stage osteoarthritis, independent of BMI

scientific article published on 22 September 2020

Serum insulin-like growth factor 1 and facial ageing: high levels associate with reduced skin wrinkling in a cross-sectional study

artículo científico publicado en 2013

Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31.

artículo científico publicado en 2014

Sex Differences in Genetic Associations With Longevity

Sex differences in sum scores may be hard to interpret: the importance of measurement invariance

artículo científico publicado en 2009

Sex-specific effects of naturally occurring variants in the dopamine receptor D2 locus on insulin secretion and type 2 diabetes susceptibility.

artículo científico publicado en 2014

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

artículo científico publicado en 2020

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts.

artículo científico publicado en 2017

Shuttling between species for pathways of lifespan regulation: a central role for the vitellogenin gene family?

artículo científico publicado en 2005

Small nucleoli are a cellular hallmark of longevity

artículo científico

Somatic mutations and cellular aging: two-dimensional DNA typing of rat fibroblast clones

artículo científico publicado en 1991

Stress evokes stronger medial posterior cingulate deactivations during emotional distraction in slower paced aging

artículo científico publicado en 2018

Strong linkage on 2q33.3 to familial early-onset generalized osteoarthritis and a consideration of two positional candidate genes

artículo científico publicado en 2006

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ⬇️

artículo científico publicado en 2018

Subclass-specific IgG glycosylation is associated with markers of inflammation and metabolic health

artículo científico publicado en 2017

Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression

scientific article published on April 2009

Systematic discovery of complex insertions and deletions in human cancers.

artículo científico publicado en 2015

Systematic testing of literature reported genetic variation associated with coronary restenosis: results of the GENDER Study

artículo científico publicado en 2012

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process

artículo científico publicado en 2016

Targeted biomarker discovery by high throughput glycosylation profiling of human plasma alpha1-antitrypsin and immunoglobulin A.

artículo científico publicado en 2013

Telomere length predicts survival independent of genetic influences

artículo científico publicado en 2007

The 23K variant of the R23K polymorphism in the glucocorticoid receptor gene protects against postnatal growth failure and insulin resistance after preterm birth.

artículo científico publicado en 2007

The Adult Netherlands Twin Register: twenty-five years of survey and biological data collection

artículo científico publicado en 2013

The ApoE ε4 Isoform: Can the Risk of Diseases be Reduced by Environmental Factors?

article

The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway

artículo científico publicado en 2013

The Caenorhabditis elegans genome contains monomorphic minisatellites and simple sequences

artículo científico publicado en 1989

The DOT1L rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males

artículo científico publicado en 2013

The Genome of the Netherlands: design, and project goals

artículo científico publicado en 2014

The H63D variant in the HFE gene predisposes to arthralgia, chondrocalcinosis and osteoarthritis

artículo científico publicado en 2007

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study

artículo científico publicado en 2015

The Leiden Family Lab study on Social Anxiety Disorder: A multiplex, multigenerational family study on neurocognitive endophenotypes. ⬇️

artículo científico publicado en 2018

The MC1R Gene and Youthful Looks

artículo científico publicado en 2016

The Netherlands Twin Register biobank: a resource for genetic epidemiological studies

artículo científico publicado en 2010

The Prognostic Value of Metabolic Profiling in Older Patients With a Proximal Femoral Fracture

artículo científico publicado en 2020

The Val66Met polymorphism of the BDNF gene in anorexia nervosa: new data and a meta-analysis.

artículo científico publicado en 2011

The aging genome: determinant or target? Report of the EURAGE meeting on 'Genomic Instability and Aging', Nerja (Spain)

artículo científico publicado en 1990

The complex genetics of gait speed: genome-wide meta-analysis approach

scientific article published on 10 January 2017

The continuing value of twin studies in the omics era.

artículo científico

The dynamics of genome organization and expression during the aging process

artículo científico publicado en 1992

The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress

artículo científico publicado en 2014

The effect of standardized food intake on the association between BMI and 1H-NMR metabolites.

artículo científico publicado en 2016

The epigenome: archive of the prenatal environment.

artículo científico publicado en 2009

The impact of low-frequency and rare variants on lipid levels

artículo científico publicado en 2015

The influence of clan structure on the genetic variation in a single Ghanaian village.

artículo científico publicado en 2013

The multifaceted interplay between lipids and epigenetics.

artículo científico publicado en 2016

The number of p16INK4a positive cells in human skin reflects biological age.

artículo científico publicado en 2012

The place of genetics in ageing research.

artículo científico publicado en 2012

The risk of mortality and the factor V Leiden mutation in a population-based cohort.

artículo científico publicado en 1998

The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA

scientific article published on 25 October 2008

The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms

artículo científico publicado en 2010

The transcriptional landscape of age in human peripheral blood

artículo científico publicado en 2015

Thermolabile methylenetetrahydrofolate reductase gene and the risk of cognitive impairment in those over 85

artículo científico publicado en 1999

Thyroid status and mortality in nonagenarians from long-lived families and the general population

artículo científico publicado en 2017

Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage

artículo científico publicado en 2015

Transcriptional profiling of human familial longevity indicates a role for ASF1A and IL7R

artículo científico publicado en 2012

Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck

artículo científico publicado en 2016

Two subsets of human alphoid repetitive DNA show distinct preferential localization in the pericentric regions of chromosomes 13, 18, and 21

artículo científico publicado en 1986

Two-dimensional DNA fingerprinting of human individuals

artículo científico publicado en 1989

Two-locus Linkage Analysis Applied to Putative Quantitative Trait Loci for Lipoprotein(a) Levels

article

Uncompromised 10-year survival of oldest old carrying somatic mutations in DNMT3A and TET2.

artículo científico publicado en 2016

Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis

artículo científico publicado en 2014

Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis

scholarly article published 19 October 2018

Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP study

artículo científico publicado en 2005

VDR gene variants associate with cognitive function and depressive symptoms in old age.

artículo científico publicado en 2007

Validated inference of smoking habits from blood with a finite DNA methylation marker set

scientific article published on 07 September 2019

Variants of FOXO3 and RPA3 genes affecting IGF-1 levels alter the risk of development of primary osteoarthritis

artículo científico publicado en 2020

Variants of the IL-10 gene associate with muscle strength in elderly from rural Africa: a candidate gene study

artículo científico publicado en 2014

Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock

artículo científico publicado en 1999

Variation in the CBP gene involved in epigenetic control associates with cognitive function

artículo científico publicado en 2010

Variation in the SHC1 gene and longevity in humans

artículo científico publicado en 2004

Variation in the human TP53 gene affects old age survival and cancer mortality.

artículo científico publicado en 2005

Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology

artículo científico publicado en 2010

Visceral adipose tissue is associated with microstructural brain tissue damage.

artículo científico publicado en 2015

Visit-to-visit lipid variability: Clinical significance, effects of lipid-lowering treatment, and (pharmaco)genetics

artículo científico publicado en 2018

Vitamin D receptor gene polymorphisms have negligible effect on human height

artículo científico publicado en 2008

WORLDWIDE GENOME-WIDE ASSOCIATION STUDY OF LONGEVITY

scholarly article in Innovation in Aging, vol. 1, Suppl 1, June 2017

Weighted statistics for aggregation and linkage analysis of human longevity in selected families: the Leiden Longevity Study.

artículo científico publicado en 2009

White Matter Lesion Progression: Genome-Wide Search for Genetic Influences

artículo científico publicado en 2015

Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines

artículo científico publicado en 2015

Zygosity diagnosis in young twins by parental report.

artículo científico publicado en 2000

mRNA levels and methylation patterns of the tyrosine aminotransferase gene in aging inbred rats.

artículo científico publicado en 1990

Dominio Público Uruguay está sostenido por:

Acerca de Dominio Público Uruguay

Ayuda