Lista de obras - Matthew J Sykes - Dominio Público Uruguay

AFM study of the interaction of cytochrome P450 2C9 with phospholipid bilayers.

artículo científico publicado en 2009

An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis

artículo científico publicado en 2015

Biological effect of LOXL1 coding variants associated with pseudoexfoliation syndrome.

artículo científico publicado en 2016

Characterisation of the binding of cationic amphiphilic drugs to phospholipid bilayers using surface plasmon resonance.

artículo científico publicado en 2007

DNA binding of an organic dppz-based intercalator

artículo científico publicado en 2004

Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation

artículo científico publicado en 2014

Discovery of CDK5 Inhibitors through Structure-Guided Approach

scientific article published on 20 March 2019

Identification of a novel oligomerization disrupting mutation in CRYΑA associated with congenital cataract in a South Australian family.

artículo científico publicado en 2013

In Search of Novel CDK8 Inhibitors by Virtual Screening

artículo científico publicado en 2017

In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes

artículo científico publicado en 2016

Insights into the Importance of DFD-Motif and Insertion I1 in Stabilizing the DFD-Out Conformation of Mnk2 Kinase

artículo científico publicado en 2013

Kinetics membrane disruption due to drug interactions of chlorpromazine hydrochloride.

artículo científico publicado en 2009

Lateral heterogeneities in supported bilayers from pure and mixed phosphatidylethanolamine demonstrating hydrogen bonding capacity.

artículo científico publicado en 2008

Molecular Modeling Approaches for the Prediction of Selected Pharmacokinetic Properties

artículo científico publicado en 2018

Molecular modeling approaches for the prediction of the nonspecific binding of drugs to hepatic microsomes

artículo científico publicado en 2006

Pharmacologic Inhibition of MNKs in Acute Myeloid Leukemia.

artículo científico publicado en 2015

Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.

artículo científico publicado en 2014

Polymorphisms in the Mitochondrial Ribosome Recycling Factor EF-G2mt/MEF2 Compromise Cell Respiratory Function and Increase Atorvastatin Toxicity ⬇️

artículo científico publicado el 14 de junio de 2012

Quantum-mechanical QSAR/QSPR descriptors from momentum-space wave functions

scientific article published on 01 March 2003

Synthesis and extended activity of triazole-containing macrocyclic protease inhibitors

artículo científico publicado en 2013

Targeting Pim kinases for cancer treatment: opportunities and challenges

artículo científico publicado en 2015

The Gaussian Generalized Born model: application to small molecules.

artículo científico publicado en 2007

Tripeptide analogues of MG132 as protease inhibitors

artículo científico publicado en 2018

Lista de obras de Matthew J Sykes

AFM study of the interaction of cytochrome P450 2C9 with phospholipid bilayers.

An integrated approach for discovery of highly potent and selective Mnk inhibitors: Screening, synthesis and SAR analysis

Biological effect of LOXL1 coding variants associated with pseudoexfoliation syndrome.

Characterisation of the binding of cationic amphiphilic drugs to phospholipid bilayers using surface plasmon resonance.

DNA binding of an organic dppz-based intercalator

Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation

Discovery of CDK5 Inhibitors through Structure-Guided Approach

Identification of a novel oligomerization disrupting mutation in CRYΑA associated with congenital cataract in a South Australian family.

In Search of Novel CDK8 Inhibitors by Virtual Screening

In vitro metabolism of the anti-inflammatory clerodane diterpenoid polyandric acid A and its hydrolysis product by human liver microsomes and recombinant cytochrome P450 and UDP-glucuronosyltransferase enzymes

Insights into the Importance of DFD-Motif and Insertion I1 in Stabilizing the DFD-Out Conformation of Mnk2 Kinase

Kinetics membrane disruption due to drug interactions of chlorpromazine hydrochloride.

Lateral heterogeneities in supported bilayers from pure and mixed phosphatidylethanolamine demonstrating hydrogen bonding capacity.

Molecular Modeling Approaches for the Prediction of Selected Pharmacokinetic Properties

Molecular modeling approaches for the prediction of the nonspecific binding of drugs to hepatic microsomes

Pharmacologic Inhibition of MNKs in Acute Myeloid Leukemia.

Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells.

Polymorphisms in the Mitochondrial Ribosome Recycling Factor EF-G2mt/MEF2 Compromise Cell Respiratory Function and Increase Atorvastatin Toxicity ⬇️

Quantum-mechanical QSAR/QSPR descriptors from momentum-space wave functions

Synthesis and extended activity of triazole-containing macrocyclic protease inhibitors

Targeting Pim kinases for cancer treatment: opportunities and challenges

The Gaussian Generalized Born model: application to small molecules.

Tripeptide analogues of MG132 as protease inhibitors