Lista de obras - Anders Poulsen - Dominio Público Uruguay

2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1 ⬇️

artículo científico publicado el 27 de febrero de 2012

A Phenotypic Screen for Small-Molecule Inhibitors of Constitutively Active Mutant Thrombopoietin Receptor Implicated in Myeloproliferative Neoplasms.

artículo científico publicado en 2016

A pharmacophore model for NK2 antagonist comprising compounds from several structurally diverse classes

artículo científico publicado en 2002

Application of Fragment-Based Drug Discovery against DNA Gyrase B

scientific article published on 24 June 2015

Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques

artículo científico publicado en 2014

Correction to Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

artículo científico publicado en 2017

Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines

artículo científico publicado en 2016

Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat

artículo científico publicado en 2017

Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat

scientific article published on 11 September 2018

Discovery and Optimization of a Porcupine Inhibitor

scientific article published on 16 July 2015

Discovery and characterisation of the automethylation properties of PRDM9.

artículo científico publicado en 2017

Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile ⬇️

artículo científico publicado el 16 de junio de 2011

Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) [...]

artículo científico publicado en 2011

Drug design for flavivirus proteases: what are we missing?

artículo científico publicado en 2014

Exploring the binding of peptidic West Nile virus NS2B-NS3 protease inhibitors by NMR.

artículo científico publicado en 2012

Feedback regulation on PTEN/AKT pathway by the ER stress kinase PERK mediated by interaction with the Vault complex

artículo científico publicado en 2014

Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors.

artículo científico publicado en 2018

Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues

artículo científico publicado en 2019

Fragment-based ligand design of novel potent inhibitors of tankyrases

artículo científico publicado en 2013

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity

artículo científico publicado en 2016

Identification of covalent active site inhibitors of dengue virus protease

artículo científico publicado en 2015

Merging of ruxolitinib and vorinostat leads to highly potent inhibitors of JAK2 and histone deacetylase 6 (HDAC6)

artículo científico publicado en 2018

Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease.

artículo científico publicado en 2016

N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.

artículo científico publicado en 2009

Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.

artículo científico publicado en 2018

Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study.

artículo científico publicado en 2015

Pharmacophore Model for Wnt/Porcupine Inhibitors and Its Use in Drug Design

artículo científico publicado en 2015

Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations.

artículo científico publicado en 2014

SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies.

artículo científico publicado en 2011

Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.

artículo científico publicado en 2017

Structure and ligand-based design of mTOR and PI3-kinase inhibitors leading to the clinical candidates VS-5584 (SB2343) and SB2602.

artículo científico publicado en 2014

Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.

artículo científico publicado en 2016

Structure-based design of Aurora A & B inhibitors.

artículo científico publicado en 2008

Structure-based design of PDK1 inhibitors.

artículo científico publicado en 2011

Structure-based design of nitrogen-linked macrocyclic kinase inhibitors leading to the clinical candidate SB1317/TG02, a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3) ⬇️

artículo científico publicado el 22 de julio de 2012

Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3) ⬇️

artículo científico publicado el 22 de abril de 2012

Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors ⬇️

artículo científico publicado el 8 de diciembre de 2011

Substrate-based peptidomimetic inhibitors of the Murray Valley encephalitis virus NS2B/NS3 serine protease: a P1-P4 SAR study.

artículo científico publicado en 2013

Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors

artículo científico publicado en 2010

Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria

artículo científico publicado en 2015

Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors

scientific article published on 04 February 2019

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy

artículo científico publicado en 2015

Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening

artículo científico publicado en 2012

Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome

artículo científico publicado en 2017

Lista de obras de Anders Poulsen

2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1 ⬇️

A Phenotypic Screen for Small-Molecule Inhibitors of Constitutively Active Mutant Thrombopoietin Receptor Implicated in Myeloproliferative Neoplasms.

A pharmacophore model for NK2 antagonist comprising compounds from several structurally diverse classes

Application of Fragment-Based Drug Discovery against DNA Gyrase B

Characterization of the histone methyltransferase PRDM9 using biochemical, biophysical and chemical biology techniques

Correction to Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Design and Synthesis of Janus Kinase 2 (JAK2) and Histone Deacetlyase (HDAC) Bispecific Inhibitors Based on Pacritinib and Evidence of Dual Pathway Inhibition in Hematological Cell Lines

Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat

Design and synthesis of potent dual inhibitors of JAK2 and HDAC based on fusing the pharmacophores of XL019 and vorinostat

Discovery and Optimization of a Porcupine Inhibitor

Discovery and characterisation of the automethylation properties of PRDM9.

Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an Orally Active Histone Deacetylase Inhibitor with a Superior Preclinical Profile ⬇️

Discovery of the macrocycle 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (SB1518), a potent Janus kinase 2/fms-like tyrosine kinase-3 (JAK2/FLT3) [...]

Drug design for flavivirus proteases: what are we missing?

Exploring the binding of peptidic West Nile virus NS2B-NS3 protease inhibitors by NMR.

Feedback regulation on PTEN/AKT pathway by the ER stress kinase PERK mediated by interaction with the Vault complex

Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors.

Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues

Fragment-based ligand design of novel potent inhibitors of tankyrases

Hydrocarbon stapled B chain analogues of relaxin-3 retain biological activity

Identification of covalent active site inhibitors of dengue virus protease

Merging of ruxolitinib and vorinostat leads to highly potent inhibitors of JAK2 and histone deacetylase 6 (HDAC6)

Miniature bovine pancreatic trypsin inhibitors (m-BPTIs) of the West Nile virus NS2B-NS3 protease.

N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity.

Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia.

Peptidomimetic ethyl propenoate covalent inhibitors of the enterovirus 71 3C protease: a P2-P4 study.

Pharmacophore Model for Wnt/Porcupine Inhibitors and Its Use in Drug Design

Probing the binding mechanism of Mnk inhibitors by docking and molecular dynamics simulations.

SB1518, a novel macrocyclic pyrimidine-based JAK2 inhibitor for the treatment of myeloid and lymphoid malignancies.

Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.

Structure and ligand-based design of mTOR and PI3-kinase inhibitors leading to the clinical candidates VS-5584 (SB2343) and SB2602.

Structure-Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells.

Structure-based design of Aurora A & B inhibitors.

Structure-based design of PDK1 inhibitors.

Structure-based design of nitrogen-linked macrocyclic kinase inhibitors leading to the clinical candidate SB1317/TG02, a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3) ⬇️

Structure-based design of oxygen-linked macrocyclic kinase inhibitors: discovery of SB1518 and SB1578, potent inhibitors of Janus kinase 2 (JAK2) and Fms-like tyrosine kinase-3 (FLT3) ⬇️

Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors ⬇️

Substrate-based peptidomimetic inhibitors of the Murray Valley encephalitis virus NS2B/NS3 serine protease: a P1-P4 SAR study.

Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors

Target mechanism-based whole-cell screening identifies bortezomib as an inhibitor of caseinolytic protease in mycobacteria

Targeting the Bacterial Epitranscriptome for Antibiotic Development: Discovery of Novel tRNA-(N1G37) Methyltransferase (TrmD) Inhibitors

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy

Thieno[3,2-d]pyrimidin-4(3H)-one derivatives as PDK1 inhibitors discovered by fragment-based screening

Towards Selective Mycobacterial ClpP1P2 Inhibitors with Reduced Activity against the Human Proteasome