Lista de obras - Willem Nissink - Dominio Público Uruguay

A Generic Platform for Cellular Screening Against Ubiquitin Ligases

artículo científico publicado en 2016

A new test set for validating predictions of protein-ligand interaction.

artículo científico publicado en 2002

Analyzing compound and project progress through multi-objective-based compound quality assessment.

artículo científico publicado en 2013

Beyond the scope of free-Wilson analysis. 2: Can distance encoded R-group fingerprints provide interpretable nonlinear models?

artículo científico publicado en 2014

Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site ⬇️

artículo científico publicado en 2016

Combined use of physicochemical data and small-molecule crystallographic contact propensities to predict interactions in protein binding sites.

artículo científico publicado en 2004

Comparing protein-ligand docking programs is difficult.

artículo científico publicado en 2005

Development of a High-Throughput Fluorescence Polarization DNA Cleavage Assay for the Identification of FEN1 Inhibitors ⬇️

artículo científico publicado el 20 de febrero de 2013

Discovery and characterization of AZD6738, a potent inhibitor of ataxia telangiectasia mutated and rad3 related (ATR) kinase with application as an anti-cancer agent

article

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity

artículo científico publicado en 2013

Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models

scientific article published on 16 July 2019

Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase.

artículo científico publicado en 2011

Drugging ATR: progress in the development of specific inhibitors for the treatment of cancer.

artículo científico

Generation of Quantum Configurational Ensembles Using Approximate Potentials

artículo científico publicado en 2021

Increasing the delivery of next generation therapeutics from high throughput screening libraries

artículo científico publicado en 2015

MTH1 Substrate Recognition--An Example of Specific Promiscuity

artículo científico publicado en 2016

Mimicry by asx- and ST-turns of the four main types of beta-turn in proteins.

artículo científico publicado en 2004

Modeling water molecules in protein-ligand docking using GOLD.

artículo científico publicado en 2005

Myc Phosphorylation in its Basic Helix-Loop-Helix Region Destabilizes Transient α-Helical Structures, Disrupting Max and DNA Binding.

artículo científico publicado en 2018

Nuisance compounds in cellular assays

artículo científico publicado en 2021

PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.

artículo científico publicado en 2015

Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.

artículo científico publicado en 2015

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

artículo científico publicado en 2016

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold.

artículo científico publicado en 2015

Quantification of frequent-hitter behavior based on historical high-throughput screening data

artículo científico publicado en 2014

Recurring main-chain anion-binding motifs in short polypeptides: nests.

artículo científico publicado en 2004

Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017-Utility and Limitations.

artículo científico publicado en 2017

Stratified high-throughput screening sets enable flexible screening strategies from a single plated collection.

artículo científico publicado en 2013

Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives ⬇️

artículo científico publicado el 10 de diciembre de 2012

Lista de obras de Willem Nissink

A Generic Platform for Cellular Screening Against Ubiquitin Ligases

A new test set for validating predictions of protein-ligand interaction.

Analyzing compound and project progress through multi-objective-based compound quality assessment.

Beyond the scope of free-Wilson analysis. 2: Can distance encoded R-group fingerprints provide interpretable nonlinear models?

Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site ⬇️

Combined use of physicochemical data and small-molecule crystallographic contact propensities to predict interactions in protein binding sites.

Comparing protein-ligand docking programs is difficult.

Development of a High-Throughput Fluorescence Polarization DNA Cleavage Assay for the Identification of FEN1 Inhibitors ⬇️

Discovery and characterization of AZD6738, a potent inhibitor of ataxia telangiectasia mutated and rad3 related (ATR) kinase with application as an anti-cancer agent

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): a potent and selective inhibitor of ATR protein kinase with monotherapy in vivo antitumor activity

Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models

Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase.

Drugging ATR: progress in the development of specific inhibitors for the treatment of cancer.

Generation of Quantum Configurational Ensembles Using Approximate Potentials

Increasing the delivery of next generation therapeutics from high throughput screening libraries

MTH1 Substrate Recognition--An Example of Specific Promiscuity

Mimicry by asx- and ST-turns of the four main types of beta-turn in proteins.

Modeling water molecules in protein-ligand docking using GOLD.

Myc Phosphorylation in its Basic Helix-Loop-Helix Region Destabilizes Transient α-Helical Structures, Disrupting Max and DNA Binding.

Nuisance compounds in cellular assays

PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.

Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.

Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival

Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold.

Quantification of frequent-hitter behavior based on historical high-throughput screening data

Recurring main-chain anion-binding motifs in short polypeptides: nests.

Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017-Utility and Limitations.

Stratified high-throughput screening sets enable flexible screening strategies from a single plated collection.

Structures of the Human Poly (ADP-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by ADP-HPD Derivatives ⬇️