Lista de obras - Federico Focher - Dominio Público Uruguay

"Programmed death" in Schopenhauer's World?

artículo científico publicado en 2002

5-(Trifluoromethyl)-beta-l-2'-deoxyuridine, the L-enantiomer of trifluorothymidine: stereospecific synthesis and antiherpetic evaluations

artículo científico publicado en 2001

9-(4-Hydroxybutyl)-N2-phenylguanine (HBPG), a thymidine kinase inhibitor, suppresses herpes virus reactivation in mice

artículo científico publicado en 1996

A double-loop model for the replication of eukaryotic DNA

artículo científico publicado en 1989

Activity profiles of enzymes that control the uracil incorporation into DNA during neuronal development

artículo científico publicado en 1990

An enzymatic method for microdetermination of aphidicolin: a promising anticancer drug

scientific article published on 01 February 1981

An ultrastructural study on ischemic lesions in rabbits' hearts with pressure overload and hyperlipidemia

artículo científico publicado en 1985

Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes

artículo científico publicado en 2000

Anti-(herpes simplex virus) activity of 4′-thio-2′-deoxyuridines: a biochemical investigation for viral and cellular target enzymes

article

Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development.

artículo científico publicado en 2003

Biochemical and functional characterization of Plasmodium falciparum DNA polymerase δ

artículo científico publicado en 2016

Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds

artículo científico publicado en 2011

DNA repair mechanisms in neurological diseases: facts and hypotheses

artículo científico publicado en 1992

Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity

artículo científico publicado en 2003

Detection of the effects of intercalating and non-intercalating drugs on DNA structure

artículo científico publicado en 1988

Do DNA polymerases delta and alpha act coordinately as leading and lagging strand replicases?

artículo científico publicado en 1988

Effect of combinations of antiviral drugs on herpes simplex encephalitis.

artículo científico publicado en 2009

Effect of divalent and monovalent cations on calf thymus PCNA-independent DNA polymerase delta and its 3'----5' exonuclease

artículo científico publicado en 1990

Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants

article

Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides.

artículo científico publicado en 2004

First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

artículo científico publicado en 2017

Herpes Simplex Virus Type 1 (HSV-1) Uracil-DNA Glycosylase: Functional Expression in Escherichia coli, Biochemical Characterization, and Selective Inhibition by 6-(p-n-Octylanilino)Uracil ⬇️

artículo científico publicado el 1 de agosto de 1995

Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11

artículo científico publicado en 2002

In vivo distribution and activity of aphidicolin on dividing and quiescent cells

artículo científico publicado en 1985

Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo

artículo científico publicado en 2005

Inhibitor analysis of calf thymus DNA polymerases alpha, delta and epsilon

artículo científico publicado en 1994

L-ATP is recognized by some cellular and viral enzymes: does chance drive enzymic enantioselectivity?

artículo científico publicado en 1999

Lack of enantioselectivity of herpes virus thymidine kinase allows safer imaging of gene delivery

artículo científico publicado en 2003

Lack of mutagenicity and metabolic inactivation of aphidicolin by rat liver microsomes

artículo científico publicado en 1980

Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides.

artículo científico publicado en 1995

Maupertuis: the 'old synthesis'.

artículo científico publicado en 2014

Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase

artículo científico publicado en 2004

Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides

artículo científico publicado en 1998

N(2)-Phenyl-9-(hydroxyalkyl)guanines and related compounds are substrates for Herpes simplex virus thymidine kinases

artículo científico publicado en 2012

N2-substituted guanine derivatives act as selective non substrate inhibitors of HSV I thymidine kinase

artículo científico publicado en 1988

Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.

artículo científico publicado en 2011

Novel nonsubstrate inhibitors of human thymidine phosphorylase, a potential target for tumor-dependent angiogenesis

artículo científico publicado en 2000

Prodrugs of herpes simplex thymidine kinase inhibitors.

artículo científico publicado en 2015

Replication of single-stranded porcine circovirus DNA by DNA polymerases alpha and delta

artículo científico publicado en 1988

Research on L-nucleosides. Synthesis and biological evaluation of a series of L- and D-2',3'-dideoxy-3'-[tris(methylthio)methyl]-beta-pentofuranosyl nucleosides.

artículo científico publicado en 2003

Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides

artículo científico publicado en 2007

Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity.

artículo científico publicado en 2006

Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors.

artículo científico publicado en 2015

Super-telomeres in transformed human fibroblasts

artículo científico publicado en 2013

Synthesis and in vitro activity of D- and L-enantiomers of 5-(trifluoromethyl)uracil nucleoside derivatives

artículo científico publicado en 2001

The control of cultural evolution has been tried, what's next?

artículo científico publicado en 2001

The effect of drugs on mitochondrial DNA synthesis can be tested in isolated synaptosomes.

artículo científico publicado en 1986

The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line.

artículo científico publicado en 2006

Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors.

artículo científico publicado en 2009

Two-step genetic screening of thrombophilia by pyrosequencing.

artículo científico publicado en 2005

Uracil in OriS of herpes simplex 1 alters its specific recognition by origin binding protein (OBP): does virus induced uracil-DNA glycosylase play a key role in viral reactivation and replication?

artículo científico publicado en 1992

Lista de obras de Federico Focher

"Programmed death" in Schopenhauer's World?

5-(Trifluoromethyl)-beta-l-2'-deoxyuridine, the L-enantiomer of trifluorothymidine: stereospecific synthesis and antiherpetic evaluations

9-(4-Hydroxybutyl)-N2-phenylguanine (HBPG), a thymidine kinase inhibitor, suppresses herpes virus reactivation in mice

A double-loop model for the replication of eukaryotic DNA

Activity profiles of enzymes that control the uracil incorporation into DNA during neuronal development

An enzymatic method for microdetermination of aphidicolin: a promising anticancer drug

An ultrastructural study on ischemic lesions in rabbits' hearts with pressure overload and hyperlipidemia

Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes

Anti-(herpes simplex virus) activity of 4′-thio-2′-deoxyuridines: a biochemical investigation for viral and cellular target enzymes

Antivirals at the mirror: the lack of stereospecificity of some viral and human enzymes offers novel opportunities in antiviral drug development.

Biochemical and functional characterization of Plasmodium falciparum DNA polymerase δ

Clostridium difficile DNA polymerase IIIC: basis for activity of antibacterial compounds

DNA repair mechanisms in neurological diseases: facts and hypotheses

Design and synthesis of phosphonoacetic acid (PPA) ester and amide bioisosters of ribofuranosylnucleoside diphosphates as potential ribonucleotide reductase inhibitors and evaluation of their enzyme inhibitory, cytostatic and antiviral activity

Detection of the effects of intercalating and non-intercalating drugs on DNA structure

Do DNA polymerases delta and alpha act coordinately as leading and lagging strand replicases?

Effect of combinations of antiviral drugs on herpes simplex encephalitis.

Effect of divalent and monovalent cations on calf thymus PCNA-independent DNA polymerase delta and its 3'----5' exonuclease

Enantioselective binding of second generation pyrrolobenzoxazepinones to the catalytic ternary complex of HIV-1 RT wild-type and L100I and K103N drug resistant mutants

Enantioselectivity of ribonucleotide reductase: a first study using stereoisomers of pyrimidine 2'-azido-2'-deoxynucleosides.

First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

Herpes Simplex Virus Type 1 (HSV-1) Uracil-DNA Glycosylase: Functional Expression in Escherichia coli, Biochemical Characterization, and Selective Inhibition by 6-(p-n-Octylanilino)Uracil ⬇️

Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11

In vivo distribution and activity of aphidicolin on dividing and quiescent cells

Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo

Inhibitor analysis of calf thymus DNA polymerases alpha, delta and epsilon

L-ATP is recognized by some cellular and viral enzymes: does chance drive enzymic enantioselectivity?

Lack of enantioselectivity of herpes virus thymidine kinase allows safer imaging of gene delivery

Lack of mutagenicity and metabolic inactivation of aphidicolin by rat liver microsomes

Lack of stereospecificity of some cellular and viral enzymes involved in the synthesis of deoxyribonucleotides and DNA: molecular basis for the antiviral activity of unnatural L-beta-nucleosides.

Maupertuis: the 'old synthesis'.

Microwave-assisted synthesis and biological evaluation of novel uracil derivatives inhibiting human thymidine phosphorylase

Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides

N(2)-Phenyl-9-(hydroxyalkyl)guanines and related compounds are substrates for Herpes simplex virus thymidine kinases

N2-substituted guanine derivatives act as selective non substrate inhibitors of HSV I thymidine kinase

Non-nucleoside inhibitors of human adenosine kinase: synthesis, molecular modeling, and biological studies.

Novel nonsubstrate inhibitors of human thymidine phosphorylase, a potential target for tumor-dependent angiogenesis

Prodrugs of herpes simplex thymidine kinase inhibitors.

Replication of single-stranded porcine circovirus DNA by DNA polymerases alpha and delta

Research on L-nucleosides. Synthesis and biological evaluation of a series of L- and D-2',3'-dideoxy-3'-[tris(methylthio)methyl]-beta-pentofuranosyl nucleosides.

Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides

Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity.

Site-directed Mutagenesis of Key Residues Unveiled a Novel Allosteric Site on Human Adenosine Kinase for Pyrrolobenzoxa(thia)zepinone Non-Nucleoside Inhibitors.

Super-telomeres in transformed human fibroblasts

Synthesis and in vitro activity of D- and L-enantiomers of 5-(trifluoromethyl)uracil nucleoside derivatives

The control of cultural evolution has been tried, what's next?

The effect of drugs on mitochondrial DNA synthesis can be tested in isolated synaptosomes.

The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line.

Thymidine kinase and uridine-cytidine kinase from Entamoeba histolytica: cloning, characterization, and search for specific inhibitors.

Two-step genetic screening of thrombophilia by pyrosequencing.

Uracil in OriS of herpes simplex 1 alters its specific recognition by origin binding protein (OBP): does virus induced uracil-DNA glycosylase play a key role in viral reactivation and replication?